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Protein

Thyroid transcription factor 1-associated protein 26

Gene

Ccdc59

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid transcription factor 1-associated protein 26
Short name:
TTF-1-associated protein 26
Alternative name(s):
Coiled-coil domain-containing protein 59
Gene namesi
Name:Ccdc59
Synonyms:D10Ertd718e, Tap26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1289302. Ccdc59.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Thyroid transcription factor 1-associated protein 26PRO_0000298942Add
BLAST

Proteomic databases

EPDiQ8R2N0.
MaxQBiQ8R2N0.
PaxDbiQ8R2N0.
PeptideAtlasiQ8R2N0.
PRIDEiQ8R2N0.

PTM databases

PhosphoSiteiQ8R2N0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019897.
CleanExiMM_CCDC59.
GenevisibleiQ8R2N0. MM.

Interactioni

Subunit structurei

Interacts with NKX2-1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020049.

Structurei

3D structure databases

ProteinModelPortaliQ8R2N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAP26 family.Curated

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
KOG4819. Eukaryota.
ENOG4111ZBH. LUCA.
GeneTreeiENSGT00390000006546.
HOGENOMiHOG000154507.
HOVERGENiHBG108545.
InParanoidiQ8R2N0.
OMAiKIQQNYK.
OrthoDBiEOG091G0QX3.
PhylomeDBiQ8R2N0.
TreeFamiTF324429.

Family and domain databases

InterProiIPR013730. Fyv7/TAP26.
[Graphical view]
PANTHERiPTHR15657. PTHR15657. 1 hit.
PfamiPF08524. rRNA_processing. 1 hit.
[Graphical view]
PRINTSiPR01854. BR22PROTEIN.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R2N0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSRPSSKW RTGGFAARGE GISQVRFGNQ NGKRRTWRPN PQQAFRGSVR
60 70 80 90 100
KGQGFAFRRK LKIQQNYKKL LWKVKEAPAS QESQFTDRYP EHLKHLYLAE
110 120 130 140 150
EERLRKQQRK AGLALSEEQV DRPLPEEEGS TEQTSSEEPP GGHQPQPEEL
160 170 180 190 200
NTGSSVTFPK NKKKKTSNQK AQEEYERVQA KRAAKKFEFE MRKQEREEAQ
210 220 230 240
RLYKKKKMEA FKILSKKTKK GQPNLNLQME YLLQKIQENS
Length:240
Mass (Da):28,034
Last modified:August 21, 2007 - v2
Checksum:i17DCB43406E5A909
GO
Isoform 2 (identifier: Q8R2N0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-154: S → R
     155-240: Missing.

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,710
Checksum:i269477781CE9A30A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051R → S in AAH27401 (PubMed:15489334).Curated
Sequence conflicti118 – 1181Missing in AAH27401 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei154 – 1541S → R in isoform 2. 1 PublicationVSP_027489
Alternative sequencei155 – 24086Missing in isoform 2. 1 PublicationVSP_027490Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009028 mRNA. Translation: BAB26036.1.
AK012917 mRNA. Translation: BAB28548.1.
AK019970 mRNA. Translation: BAB31941.1.
AK036330 mRNA. Translation: BAC29386.1.
AK135550 mRNA. Translation: BAE22578.1.
BC027401 mRNA. Translation: AAH27401.1.
CCDSiCCDS24158.1. [Q8R2N0-1]
RefSeqiNP_079878.1. NM_025602.3. [Q8R2N0-1]
UniGeneiMm.339224.

Genome annotation databases

EnsembliENSMUST00000020049; ENSMUSP00000020049; ENSMUSG00000019897. [Q8R2N0-1]
GeneIDi52713.
KEGGimmu:52713.
UCSCiuc007gyp.1. mouse. [Q8R2N0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009028 mRNA. Translation: BAB26036.1.
AK012917 mRNA. Translation: BAB28548.1.
AK019970 mRNA. Translation: BAB31941.1.
AK036330 mRNA. Translation: BAC29386.1.
AK135550 mRNA. Translation: BAE22578.1.
BC027401 mRNA. Translation: AAH27401.1.
CCDSiCCDS24158.1. [Q8R2N0-1]
RefSeqiNP_079878.1. NM_025602.3. [Q8R2N0-1]
UniGeneiMm.339224.

3D structure databases

ProteinModelPortaliQ8R2N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020049.

PTM databases

PhosphoSiteiQ8R2N0.

Proteomic databases

EPDiQ8R2N0.
MaxQBiQ8R2N0.
PaxDbiQ8R2N0.
PeptideAtlasiQ8R2N0.
PRIDEiQ8R2N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020049; ENSMUSP00000020049; ENSMUSG00000019897. [Q8R2N0-1]
GeneIDi52713.
KEGGimmu:52713.
UCSCiuc007gyp.1. mouse. [Q8R2N0-1]

Organism-specific databases

CTDi29080.
MGIiMGI:1289302. Ccdc59.

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
KOG4819. Eukaryota.
ENOG4111ZBH. LUCA.
GeneTreeiENSGT00390000006546.
HOGENOMiHOG000154507.
HOVERGENiHBG108545.
InParanoidiQ8R2N0.
OMAiKIQQNYK.
OrthoDBiEOG091G0QX3.
PhylomeDBiQ8R2N0.
TreeFamiTF324429.

Enzyme and pathway databases

ReactomeiR-MMU-5683826. Surfactant metabolism.

Miscellaneous databases

PROiQ8R2N0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019897.
CleanExiMM_CCDC59.
GenevisibleiQ8R2N0. MM.

Family and domain databases

InterProiIPR013730. Fyv7/TAP26.
[Graphical view]
PANTHERiPTHR15657. PTHR15657. 1 hit.
PfamiPF08524. rRNA_processing. 1 hit.
[Graphical view]
PRINTSiPR01854. BR22PROTEIN.
ProtoNetiSearch...

Entry informationi

Entry nameiTAP26_MOUSE
AccessioniPrimary (citable) accession number: Q8R2N0
Secondary accession number(s): Q8BZ86, Q9CR69, Q9CV91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.