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Protein

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

Gene

Taf6l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Alternative name(s):
PCAF-associated factor 65-alpha
Short name:
PAF65-alpha
Gene namesi
Name:Taf6l
Synonyms:Paf65a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2444957. Taf6l.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188801 – 616TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6LAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei494PhosphoserineBy similarity1
Modified residuei500PhosphoserineBy similarity1
Modified residuei549Asymmetric dimethylarginineCombined sources1
Modified residuei555Asymmetric dimethylarginineCombined sources1
Modified residuei587Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8R2K4.
PRIDEiQ8R2K4.

PTM databases

iPTMnetiQ8R2K4.
PhosphoSitePlusiQ8R2K4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003680.
ExpressionAtlasiQ8R2K4. baseline and differential.
GenevisibleiQ8R2K4. MM.

Interactioni

Subunit structurei

The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3 (By similarity). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230442. 2 interactors.
IntActiQ8R2K4. 2 interactors.
STRINGi10090.ENSMUSP00000135193.

Structurei

3D structure databases

ProteinModelPortaliQ8R2K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiKOG2549. Eukaryota.
COG5095. LUCA.
GeneTreeiENSGT00640000091486.
HOGENOMiHOG000059613.
HOVERGENiHBG061566.
InParanoidiQ8R2K4.
KOiK03131.
PhylomeDBiQ8R2K4.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR009072. Histone-fold.
IPR011442. TAF6_C.
IPR004823. TAF_TATA-bd.
PfamiView protein in Pfam
PF02969. TAF. 1 hit.
PF07571. TAF6_C. 1 hit.
SMARTiView protein in SMART
SM00803. TAF. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R2K4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEREERRFV EIPRESVRLM AESTGLELSD EVAALLAEDV CYRLREATQN
60 70 80 90 100
SSQFMKHTKR RKLTVEDFNR ALRWSSVEAV CGYGSQEALP LRPAREGDLY
110 120 130 140 150
FPEDREVSLV ELALATNIPK GCAETAVRVH VSYLDGKGNL APQGSVPSAV
160 170 180 190 200
SSLTDDLLKY YQQVTRAVLG DDPQLMKVAL QDLQTNSKIA ALLPYFVYVV
210 220 230 240 250
SGVKSVSHDL EQLHRLLQVA RSLIRNPHLC LGPYVRSLVG SVLYCVLEPL
260 270 280 290 300
AASINPLNDH WTLRDGAALL LSHIFWTHGD LVSGLYQQIL LSLQKVLTDP
310 320 330 340 350
VRPLCSHYGA VVGLHALGWK AVERVLYPHL PTYWTNLQAV LDDYSVSNAQ
360 370 380 390 400
VKADGHKVYG AILVAVERLL KMKAQAAEPN RGGLGGRGYR PAEDLPWDSL
410 420 430 440 450
LLQESPPGGS SETGFGSGLP PPSGVAGPED PSSLTLADIY RELYSFFGDS
460 470 480 490 500
LATRFGTGQP APTAPRPPGD KKEPAAAPDS VRKMPQLTAS AVVSPQGDES
510 520 530 540 550
PCGGTLATAT AASESRPLPR VHRARGAPRQ QGPGAGTRDV FQKSRFAPRG
560 570 580 590 600
APHFRFIIAG RQAGRRCRGR LFQTAFPAPY GPSPASRYVQ KLPMIGRTGR
610
PARRWALSDY SLYLPL
Length:616
Mass (Da):67,236
Last modified:June 1, 2002 - v1
Checksum:i42584DC7F09E75AE
GO
Isoform 2 (identifier: Q8R2K4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-203: Missing.

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):64,544
Checksum:iC00F1D55AE9209CC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010158179 – 203Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077149 mRNA. Translation: BAC36645.1.
BC028647 mRNA. Translation: AAH28647.1.
RefSeqiNP_001171269.1. NM_001177798.1.
NP_666204.2. NM_146092.2.
UniGeneiMm.220886.
Mm.491275.

Genome annotation databases

EnsembliENSMUST00000177056; ENSMUSP00000135028; ENSMUSG00000003680. [Q8R2K4-1]
GeneIDi225895.
KEGGimmu:225895.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTAF6L_MOUSE
AccessioniPrimary (citable) accession number: Q8R2K4
Secondary accession number(s): Q8C5T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2002
Last modified: January 31, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families