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Protein

Beta-defensin 15

Gene

Defb15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 15
Short name:
BD-15
Short name:
mBD-15
Alternative name(s):
Defensin, beta 15
Gene namesi
Name:Defb15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2179202. Defb15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000694321 – 79Beta-defensin 15Add BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 53By similarity
Disulfide bondi33 ↔ 47By similarity
Disulfide bondi37 ↔ 54By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8R2I5.
PRIDEiQ8R2I5.

Expressioni

Tissue specificityi

Expressed in testis and to a lesser extent in epididymis (caput, corpus and cauda). Also weakly expressed in kidneys and colon.1 Publication

Gene expression databases

BgeeiENSMUSG00000048500.
CleanExiMM_DEFB15.
GenevisibleiQ8R2I5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059763.

Structurei

3D structure databases

ProteinModelPortaliQ8R2I5.
SMRiQ8R2I5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J77C. Eukaryota.
ENOG4111545. LUCA.
GeneTreeiENSGT00390000005938.
HOGENOMiHOG000112137.
HOVERGENiHBG051285.
InParanoidiQ8R2I5.
OMAiFCQKSLK.
OrthoDBiEOG091G18F8.
PhylomeDBiQ8R2I5.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R2I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFLFLFAV LFFLDPAKNA FFDEKCSRVN GRCTASCLKN EELVALCQKN
60 70
LKCCVTVQPC GKSKSNQSDE GSGHMGTWG
Length:79
Mass (Da):8,730
Last modified:June 1, 2002 - v1
Checksum:i5B04603D0E17787F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ437648 mRNA. Translation: CAD26897.1.
AJ575428 mRNA. Translation: CAE01401.1.
AL590619 Genomic DNA. Translation: CAM22058.1.
CCDSiCCDS40288.1.
RefSeqiNP_631968.1. NM_139222.3.
UniGeneiMm.390015.

Genome annotation databases

EnsembliENSMUST00000062586; ENSMUSP00000059763; ENSMUSG00000048500.
GeneIDi246082.
KEGGimmu:246082.
UCSCiuc009lce.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ437648 mRNA. Translation: CAD26897.1.
AJ575428 mRNA. Translation: CAE01401.1.
AL590619 Genomic DNA. Translation: CAM22058.1.
CCDSiCCDS40288.1.
RefSeqiNP_631968.1. NM_139222.3.
UniGeneiMm.390015.

3D structure databases

ProteinModelPortaliQ8R2I5.
SMRiQ8R2I5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059763.

Proteomic databases

PaxDbiQ8R2I5.
PRIDEiQ8R2I5.

Protocols and materials databases

DNASUi246082.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062586; ENSMUSP00000059763; ENSMUSG00000048500.
GeneIDi246082.
KEGGimmu:246082.
UCSCiuc009lce.1. mouse.

Organism-specific databases

CTDi246082.
MGIiMGI:2179202. Defb15.

Phylogenomic databases

eggNOGiENOG410J77C. Eukaryota.
ENOG4111545. LUCA.
GeneTreeiENSGT00390000005938.
HOGENOMiHOG000112137.
HOVERGENiHBG051285.
InParanoidiQ8R2I5.
OMAiFCQKSLK.
OrthoDBiEOG091G18F8.
PhylomeDBiQ8R2I5.

Miscellaneous databases

ChiTaRSiDefb15. mouse.
PROiQ8R2I5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048500.
CleanExiMM_DEFB15.
GenevisibleiQ8R2I5. MM.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDFB15_MOUSE
AccessioniPrimary (citable) accession number: Q8R2I5
Secondary accession number(s): A2A4E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.