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Protein

Forkhead box protein E1

Gene

Foxe1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor (PubMed:21177256). Also implicated in thyroid gland morphogenesis (PubMed:9697704). May indirectly play a role in cell growth and migration through the regulation of WNT5A expression (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi55 – 149Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • cell migration Source: MGI
  • cranial skeletal system development Source: UniProtKB
  • embryonic organ morphogenesis Source: MGI
  • hair follicle morphogenesis Source: MGI
  • hard palate development Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • pharynx development Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription by RNA polymerase II Source: UniProtKB
  • roof of mouth development Source: UniProtKB
  • soft palate development Source: MGI
  • thymus development Source: Ensembl
  • thyroid gland development Source: MGI
  • thyroid hormone generation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E1
Alternative name(s):
Thyroid transcription factor 2
Short name:
TTF-2
Gene namesi
Name:Foxe1
Synonyms:Titf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1353500 Foxe1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Knockout mice die before hair formation. They exhibit cleft palate and either a sublingual or completely absent thyroid gland and show neonatal hypothyroidism.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918271 – 371Forkhead box protein E1Add BLAST371

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R2I0
PRIDEiQ8R2I0

PTM databases

iPTMnetiQ8R2I0
PhosphoSitePlusiQ8R2I0

Expressioni

Tissue specificityi

Expressed in Rathke pouch, in thyroid, and in the epithelium of the pharyngeal wall and arches, whereas it is absent in the epithelium of the pharyngeal pouches.1 Publication

Developmental stagei

At E13.5, it is present in endoderm derivatives, such as tongue, palate, epiglottis, pharynx, and esophagus. Later in embryogenesis, it is detected in the choanae and whiskers.1 Publication

Gene expression databases

BgeeiENSMUSG00000070990
CleanExiMM_FOXE1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092715

Structurei

3D structure databases

ProteinModelPortaliQ8R2I0
SMRiQ8R2I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 308Ala-richAdd BLAST143
Compositional biasi166 – 176Poly-AlaAdd BLAST11
Compositional biasi179 – 236Pro-richAdd BLAST58

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00900000140781
HOGENOMiHOG000231286
HOVERGENiHBG051642
InParanoidiQ8R2I0
KOiK09398
OMAiMTAESGP
OrthoDBiEOG091G0HW9
PhylomeDBiQ8R2I0
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R2I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAESAPPPP PQPETLAAVK EERGEAAAAG AGVPAEAAGR GAGGRRRKRP
60 70 80 90 100
LQRGKPPYSY IALIAMAIAH APERRLTLGG IYKFITERFP FYRDNPKKWQ
110 120 130 140 150
NSIRHNLTLN DCFLKIPREA GRPGKGNYWA LDPNAEDMFE SGSFLRRRKR
160 170 180 190 200
FKRSDLSTYP AYMHDAAAAA AAAAAAIFPG AVPAARPAYP GAVYAGYAPP
210 220 230 240 250
LAAPPPVYYP AASPGPCRVF GLVPERPLSP DLGPAPSAAG GSCAFAAAAG
260 270 280 290 300
AAGTGSFQPA VCTGARPVNP AAYAAAYAGP DGAYPQGASS ALFAAAAGRL
310 320 330 340 350
AGPASPPAGG GSGGVEATVD FYGRTSPGQF GAALGPCYNP GGQLGAGGGG
360 370
AYHSRHATAY PGAVDRFVSA M
Length:371
Mass (Da):37,768
Last modified:October 1, 2003 - v2
Checksum:i8AB92160F2DDFAFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457047 Genomic DNA Translation: CAD29716.2
AL806523 Genomic DNA Translation: CAM23955.1
CCDSiCCDS18147.1
RefSeqiNP_899121.1, NM_183298.1
UniGeneiMm.354634

Genome annotation databases

EnsembliENSMUST00000095097; ENSMUSP00000092715; ENSMUSG00000070990
GeneIDi110805
KEGGimmu:110805
UCSCiuc008sto.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFOXE1_MOUSE
AccessioniPrimary (citable) accession number: Q8R2I0
Secondary accession number(s): A2AM00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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