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Q8R2I0

- FOXE1_MOUSE

UniProt

Q8R2I0 - FOXE1_MOUSE

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Protein
Forkhead box protein E1
Gene
Foxe1, Titf2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable transcription factor. Could be involved in thyroid gland organogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi55 – 14995Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. DNA binding, bending Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. double-stranded DNA binding Source: RefGenome
  5. sequence-specific DNA binding Source: Ensembl
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  7. transcription factor binding Source: RefGenome

GO - Biological processi

  1. cell migration Source: MGI
  2. embryonic organ morphogenesis Source: MGI
  3. hair follicle morphogenesis Source: MGI
  4. hard palate development Source: RefGenome
  5. lens morphogenesis in camera-type eye Source: RefGenome
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. pattern specification process Source: RefGenome
  8. pharynx development Source: Ensembl
  9. positive regulation of transcription, DNA-templated Source: Ensembl
  10. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  11. soft palate development Source: RefGenome
  12. thymus development Source: Ensembl
  13. thyroid gland development Source: MGI
  14. thyroid hormone generation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E1
Alternative name(s):
Thyroid transcription factor 2
Short name:
TTF-2
Gene namesi
Name:Foxe1
Synonyms:Titf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1353500. Foxe1.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Forkhead box protein E1
PRO_0000091827Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8R2I0.

PTM databases

PhosphoSiteiQ8R2I0.

Expressioni

Tissue specificityi

Expressed in Rathke pouch, in thyroid, and in the epithelium of the pharyngeal wall and arches, whereas it is absent in the epithelium of the pharyngeal pouches.1 Publication

Developmental stagei

At E13.5, it is present in endoderm derivatives, such as tongue, palate, epiglottis, pharynx, and esophagus. Later in embryogenesis, it is detected in the choanae and whiskers.1 Publication

Gene expression databases

BgeeiQ8R2I0.
CleanExiMM_FOXE1.
GenevestigatoriQ8R2I0.

Structurei

3D structure databases

ProteinModelPortaliQ8R2I0.
SMRiQ8R2I0. Positions 55-150.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi166 – 308143Ala-rich
Add
BLAST
Compositional biasi166 – 17611Poly-Ala
Add
BLAST
Compositional biasi179 – 23658Pro-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00740000115067.
HOGENOMiHOG000231286.
HOVERGENiHBG051642.
InParanoidiA2AM00.
KOiK09398.
OMAiMTAESGP.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ8R2I0.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2I0-1 [UniParc]FASTAAdd to Basket

« Hide

MTAESAPPPP PQPETLAAVK EERGEAAAAG AGVPAEAAGR GAGGRRRKRP    50
LQRGKPPYSY IALIAMAIAH APERRLTLGG IYKFITERFP FYRDNPKKWQ 100
NSIRHNLTLN DCFLKIPREA GRPGKGNYWA LDPNAEDMFE SGSFLRRRKR 150
FKRSDLSTYP AYMHDAAAAA AAAAAAIFPG AVPAARPAYP GAVYAGYAPP 200
LAAPPPVYYP AASPGPCRVF GLVPERPLSP DLGPAPSAAG GSCAFAAAAG 250
AAGTGSFQPA VCTGARPVNP AAYAAAYAGP DGAYPQGASS ALFAAAAGRL 300
AGPASPPAGG GSGGVEATVD FYGRTSPGQF GAALGPCYNP GGQLGAGGGG 350
AYHSRHATAY PGAVDRFVSA M 371
Length:371
Mass (Da):37,768
Last modified:October 1, 2003 - v2
Checksum:i8AB92160F2DDFAFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ457047 Genomic DNA. Translation: CAD29716.2.
AL806523 Genomic DNA. Translation: CAM23955.1.
CCDSiCCDS18147.1.
RefSeqiNP_899121.1. NM_183298.1.
UniGeneiMm.354634.

Genome annotation databases

EnsembliENSMUST00000095097; ENSMUSP00000092715; ENSMUSG00000070990.
GeneIDi110805.
KEGGimmu:110805.
UCSCiuc008sto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ457047 Genomic DNA. Translation: CAD29716.2 .
AL806523 Genomic DNA. Translation: CAM23955.1 .
CCDSi CCDS18147.1.
RefSeqi NP_899121.1. NM_183298.1.
UniGenei Mm.354634.

3D structure databases

ProteinModelPortali Q8R2I0.
SMRi Q8R2I0. Positions 55-150.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R2I0.

Proteomic databases

PRIDEi Q8R2I0.

Protocols and materials databases

DNASUi 110805.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095097 ; ENSMUSP00000092715 ; ENSMUSG00000070990 .
GeneIDi 110805.
KEGGi mmu:110805.
UCSCi uc008sto.1. mouse.

Organism-specific databases

CTDi 2304.
MGIi MGI:1353500. Foxe1.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00740000115067.
HOGENOMi HOG000231286.
HOVERGENi HBG051642.
InParanoidi A2AM00.
KOi K09398.
OMAi MTAESGP.
OrthoDBi EOG7C8GHD.
PhylomeDBi Q8R2I0.
TreeFami TF316127.

Miscellaneous databases

NextBioi 364693.
PROi Q8R2I0.
SOURCEi Search...

Gene expression databases

Bgeei Q8R2I0.
CleanExi MM_FOXE1.
Genevestigatori Q8R2I0.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair."
    Dathan N., Parlato R., Rosica A., De Felice M., Di Lauro R.
    Dev. Dyn. 224:450-456(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PHOSPHORYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/Sv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFOXE1_MOUSE
AccessioniPrimary (citable) accession number: Q8R2I0
Secondary accession number(s): A2AM00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi