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Protein

Forkhead box protein E1

Gene

Foxe1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor. Could be involved in thyroid gland organogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi55 – 14995Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: GO_Central
  2. cell migration Source: MGI
  3. embryonic organ morphogenesis Source: MGI
  4. hair follicle morphogenesis Source: MGI
  5. hard palate development Source: MGI
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. pharynx development Source: Ensembl
  8. positive regulation of transcription, DNA-templated Source: MGI
  9. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  10. soft palate development Source: MGI
  11. thymus development Source: Ensembl
  12. thyroid gland development Source: MGI
  13. thyroid hormone generation Source: MGI
  14. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E1
Alternative name(s):
Thyroid transcription factor 2
Short name:
TTF-2
Gene namesi
Name:Foxe1
Synonyms:Titf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1353500. Foxe1.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Forkhead box protein E1PRO_0000091827Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8R2I0.

PTM databases

PhosphoSiteiQ8R2I0.

Expressioni

Tissue specificityi

Expressed in Rathke pouch, in thyroid, and in the epithelium of the pharyngeal wall and arches, whereas it is absent in the epithelium of the pharyngeal pouches.1 Publication

Developmental stagei

At E13.5, it is present in endoderm derivatives, such as tongue, palate, epiglottis, pharynx, and esophagus. Later in embryogenesis, it is detected in the choanae and whiskers.1 Publication

Gene expression databases

BgeeiQ8R2I0.
CleanExiMM_FOXE1.
GenevestigatoriQ8R2I0.

Structurei

3D structure databases

SMRiQ8R2I0. Positions 55-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi166 – 308143Ala-richAdd
BLAST
Compositional biasi166 – 17611Poly-AlaAdd
BLAST
Compositional biasi179 – 23658Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231286.
HOVERGENiHBG051642.
InParanoidiQ8R2I0.
KOiK09398.
OMAiMTAESGP.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ8R2I0.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAESAPPPP PQPETLAAVK EERGEAAAAG AGVPAEAAGR GAGGRRRKRP
60 70 80 90 100
LQRGKPPYSY IALIAMAIAH APERRLTLGG IYKFITERFP FYRDNPKKWQ
110 120 130 140 150
NSIRHNLTLN DCFLKIPREA GRPGKGNYWA LDPNAEDMFE SGSFLRRRKR
160 170 180 190 200
FKRSDLSTYP AYMHDAAAAA AAAAAAIFPG AVPAARPAYP GAVYAGYAPP
210 220 230 240 250
LAAPPPVYYP AASPGPCRVF GLVPERPLSP DLGPAPSAAG GSCAFAAAAG
260 270 280 290 300
AAGTGSFQPA VCTGARPVNP AAYAAAYAGP DGAYPQGASS ALFAAAAGRL
310 320 330 340 350
AGPASPPAGG GSGGVEATVD FYGRTSPGQF GAALGPCYNP GGQLGAGGGG
360 370
AYHSRHATAY PGAVDRFVSA M
Length:371
Mass (Da):37,768
Last modified:October 1, 2003 - v2
Checksum:i8AB92160F2DDFAFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457047 Genomic DNA. Translation: CAD29716.2.
AL806523 Genomic DNA. Translation: CAM23955.1.
CCDSiCCDS18147.1.
RefSeqiNP_899121.1. NM_183298.1.
UniGeneiMm.354634.

Genome annotation databases

EnsembliENSMUST00000095097; ENSMUSP00000092715; ENSMUSG00000070990.
GeneIDi110805.
KEGGimmu:110805.
UCSCiuc008sto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457047 Genomic DNA. Translation: CAD29716.2.
AL806523 Genomic DNA. Translation: CAM23955.1.
CCDSiCCDS18147.1.
RefSeqiNP_899121.1. NM_183298.1.
UniGeneiMm.354634.

3D structure databases

SMRiQ8R2I0. Positions 55-150.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8R2I0.

Proteomic databases

PRIDEiQ8R2I0.

Protocols and materials databases

DNASUi110805.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095097; ENSMUSP00000092715; ENSMUSG00000070990.
GeneIDi110805.
KEGGimmu:110805.
UCSCiuc008sto.1. mouse.

Organism-specific databases

CTDi2304.
MGIiMGI:1353500. Foxe1.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231286.
HOVERGENiHBG051642.
InParanoidiQ8R2I0.
KOiK09398.
OMAiMTAESGP.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ8R2I0.
TreeFamiTF316127.

Miscellaneous databases

NextBioi364693.
PROiQ8R2I0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R2I0.
CleanExiMM_FOXE1.
GenevestigatoriQ8R2I0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair."
    Dathan N., Parlato R., Rosica A., De Felice M., Di Lauro R.
    Dev. Dyn. 224:450-456(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PHOSPHORYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/Sv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFOXE1_MOUSE
AccessioniPrimary (citable) accession number: Q8R2I0
Secondary accession number(s): A2AM00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: April 29, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.