Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R2I0

- FOXE1_MOUSE

UniProt

Q8R2I0 - FOXE1_MOUSE

Protein

Forkhead box protein E1

Gene

Foxe1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable transcription factor. Could be involved in thyroid gland organogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi55 – 14995Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. double-stranded DNA binding Source: Ensembl
    3. sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI

    GO - Biological processi

    1. cell migration Source: MGI
    2. embryonic organ morphogenesis Source: MGI
    3. hair follicle morphogenesis Source: MGI
    4. hard palate development Source: Ensembl
    5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    6. pharynx development Source: Ensembl
    7. positive regulation of transcription, DNA-templated Source: Ensembl
    8. soft palate development Source: Ensembl
    9. thymus development Source: Ensembl
    10. thyroid gland development Source: MGI
    11. thyroid hormone generation Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein E1
    Alternative name(s):
    Thyroid transcription factor 2
    Short name:
    TTF-2
    Gene namesi
    Name:Foxe1
    Synonyms:Titf2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1353500. Foxe1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Forkhead box protein E1PRO_0000091827Add
    BLAST

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8R2I0.

    PTM databases

    PhosphoSiteiQ8R2I0.

    Expressioni

    Tissue specificityi

    Expressed in Rathke pouch, in thyroid, and in the epithelium of the pharyngeal wall and arches, whereas it is absent in the epithelium of the pharyngeal pouches.1 Publication

    Developmental stagei

    At E13.5, it is present in endoderm derivatives, such as tongue, palate, epiglottis, pharynx, and esophagus. Later in embryogenesis, it is detected in the choanae and whiskers.1 Publication

    Gene expression databases

    BgeeiQ8R2I0.
    CleanExiMM_FOXE1.
    GenevestigatoriQ8R2I0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R2I0.
    SMRiQ8R2I0. Positions 55-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi166 – 308143Ala-richAdd
    BLAST
    Compositional biasi166 – 17611Poly-AlaAdd
    BLAST
    Compositional biasi179 – 23658Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00740000115067.
    HOGENOMiHOG000231286.
    HOVERGENiHBG051642.
    InParanoidiA2AM00.
    KOiK09398.
    OMAiMTAESGP.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiQ8R2I0.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R2I0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAESAPPPP PQPETLAAVK EERGEAAAAG AGVPAEAAGR GAGGRRRKRP    50
    LQRGKPPYSY IALIAMAIAH APERRLTLGG IYKFITERFP FYRDNPKKWQ 100
    NSIRHNLTLN DCFLKIPREA GRPGKGNYWA LDPNAEDMFE SGSFLRRRKR 150
    FKRSDLSTYP AYMHDAAAAA AAAAAAIFPG AVPAARPAYP GAVYAGYAPP 200
    LAAPPPVYYP AASPGPCRVF GLVPERPLSP DLGPAPSAAG GSCAFAAAAG 250
    AAGTGSFQPA VCTGARPVNP AAYAAAYAGP DGAYPQGASS ALFAAAAGRL 300
    AGPASPPAGG GSGGVEATVD FYGRTSPGQF GAALGPCYNP GGQLGAGGGG 350
    AYHSRHATAY PGAVDRFVSA M 371
    Length:371
    Mass (Da):37,768
    Last modified:October 1, 2003 - v2
    Checksum:i8AB92160F2DDFAFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ457047 Genomic DNA. Translation: CAD29716.2.
    AL806523 Genomic DNA. Translation: CAM23955.1.
    CCDSiCCDS18147.1.
    RefSeqiNP_899121.1. NM_183298.1.
    UniGeneiMm.354634.

    Genome annotation databases

    EnsembliENSMUST00000095097; ENSMUSP00000092715; ENSMUSG00000070990.
    GeneIDi110805.
    KEGGimmu:110805.
    UCSCiuc008sto.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ457047 Genomic DNA. Translation: CAD29716.2 .
    AL806523 Genomic DNA. Translation: CAM23955.1 .
    CCDSi CCDS18147.1.
    RefSeqi NP_899121.1. NM_183298.1.
    UniGenei Mm.354634.

    3D structure databases

    ProteinModelPortali Q8R2I0.
    SMRi Q8R2I0. Positions 55-150.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R2I0.

    Proteomic databases

    PRIDEi Q8R2I0.

    Protocols and materials databases

    DNASUi 110805.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095097 ; ENSMUSP00000092715 ; ENSMUSG00000070990 .
    GeneIDi 110805.
    KEGGi mmu:110805.
    UCSCi uc008sto.1. mouse.

    Organism-specific databases

    CTDi 2304.
    MGIi MGI:1353500. Foxe1.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00740000115067.
    HOGENOMi HOG000231286.
    HOVERGENi HBG051642.
    InParanoidi A2AM00.
    KOi K09398.
    OMAi MTAESGP.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi Q8R2I0.
    TreeFami TF316127.

    Miscellaneous databases

    NextBioi 364693.
    PROi Q8R2I0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R2I0.
    CleanExi MM_FOXE1.
    Genevestigatori Q8R2I0.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair."
      Dathan N., Parlato R., Rosica A., De Felice M., Di Lauro R.
      Dev. Dyn. 224:450-456(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PHOSPHORYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: 129/Sv.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiFOXE1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R2I0
    Secondary accession number(s): A2AM00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3