Reviewed, UniProtKB/Swiss-Prot Q8R2H9 (PHOP1_MOUSE)

Names and origin

Protein names

Recommended name:
    Phosphoethanolamine/phosphocholine phosphatase
    EC=3.1.3.75

Gene names

Name:

Phospho1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). May be involved in the generation of inorganic phosphate for bone mineralization By similarity.
Catalytic activity	O-phosphoethanolamine + H2O = ethanolamine + phosphate. Phosphocholine + H2O = choline + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoethanolamine/phosphocholine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Phosphoethanolamine/phosphocholine phosphatase		PRO_0000068830
Sites
	Active site	32	1	Nucleophile By similarity
	Active site	34	1	Proton donor By similarity
	Metal binding	32	1	Magnesium By similarity
	Metal binding	34	1	Magnesium By similarity
	Metal binding	203	1	Magnesium By similarity
	Binding site	43	1	Substrate By similarity
	Binding site	123	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R2H9-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 0CEEE66019C0CEA7	FASTA	267	29,911
	10 20 30 40 50 60 MSGCFPAVGL RCLSRDGRMA APGAPRFLLT FDFDETIVDE NSDDSIVRAA PGQQLPESLR 70 80 90 100 110 120 ATYREGYYNE YMQRVFKYLG EQGVRPRDLR AVYETIPLSP GMGDLLQFIA KQGSCFEVIL 130 140 150 160 170 180 ISDANTFGVE SALRAAGHHS LFRRILSNPS GPDARGLLTL RPFHTHSCSR CPANMCKHKV 190 200 210 220 230 240 LSEYLRERAR DGVHFERLFY VGDGANDFCP MGLLAGGDVA FPRRGYPMHR LIQEAQKAEP 250 260 SSFRAHVVPW ETAADVRQHL QQVLKMC

References

[1]	"Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene." Houston B., Paton I.R., Burt D.W., Farquharson C. Anim. Genet. 33:451-454(2002) [PubMed: 12464021] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ457190 mRNA. Translation: CAD29804.1.
IPI	IPI00153582.
RefSeq	NP_694744.1.
UniGene	Mm.133075
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8R2H9.
Genome annotation databases
Ensembl	ENSMUSG00000050860. Mus musculus. [Contig view]
GeneID	237928.
KEGG	mmu:237928.
Organism-specific databases
MGI	MGI:2447348. Phospho1.
Phylogenomic databases
HOGENOM	Q8R2H9.
HOVERGEN	Q8R2H9.
OMA	Q8R2H9. VAFPRRG.
Enzyme and pathway databases
BRENDA	3.1.3.75. 244.
Gene expression databases
Bgee	Q8R2H9.
GermOnline	ENSMUSG00000050860. Mus musculus.
Family and domain databases
InterPro	IPR006383. HAD-SF_hydro_IB_PSP-like. IPR006384. PyrdxlP_Pase-rel. IPR016965. PyrdxlP_Pase_PHOSPHO2. [Graphical view]
Pfam	PF06888. Put_Phosphatase. 1 hit. [Graphical view]
PIRSF	PIRSF031051. PyrdxlP_Pase_PHOSPHO2. 1 hit.
TIGRFAMs	TIGR01489. DKMTPPase-SF. 1 hit. TIGR01488. HAD-SF-IB. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	383578.
SOURCE	Search...

Entry information

Entry name

PHOP1_MOUSE

Accession

Primary (citable) accession number: Q8R2H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	June 1, 2002
Last modified:	May 5, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)