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Protein

Integrin beta

Gene

Itgb3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • peptide binding Source: RGD
  • receptor activity Source: InterPro

GO - Biological processi

  • angiogenesis involved in wound healing Source: InterPro
  • cell adhesion Source: RGD
  • cell-matrix adhesion Source: InterPro
  • cell-substrate junction assembly Source: InterPro
  • cellular calcium ion homeostasis Source: RGD
  • cellular response to drug Source: RGD
  • cellular response to insulin-like growth factor stimulus Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • embryo implantation Source: RGD
  • integrin-mediated signaling pathway Source: RGD
  • negative regulation of cell death Source: RGD
  • platelet aggregation Source: RGD
  • positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of bone resorption Source: RGD
  • positive regulation of cell adhesion mediated by integrin Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of fibroblast migration Source: RGD
  • positive regulation of glomerular mesangial cell proliferation Source: RGD
  • positive regulation of leukocyte migration Source: RGD
  • positive regulation of MAPK cascade Source: RGD
  • positive regulation of smooth muscle cell migration Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  • regulation of release of sequestered calcium ion into cytosol Source: RGD
  • response to activity Source: RGD
  • response to platelet-derived growth factor Source: RGD
  • response to radiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotationImported

Keywords - Biological processi

Cell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:Itgb3Imported
Synonyms:itgb3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi628868. Itgb3.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei718 – 74023HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • cell surface Source: RGD
  • integrin complex Source: RGD
  • membrane Source: RGD
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 787762Integrin betaSequence analysisPRO_5004312362Add
BLAST

Proteomic databases

PRIDEiQ8R2H2.

Expressioni

Gene expression databases

GenevisibleiQ8R2H2. RN.

Structurei

3D structure databases

ProteinModelPortaliQ8R2H2.
SMRiQ8R2H2. Positions 28-464, 710-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 460424INBInterPro annotationAdd
BLAST
Domaini633 – 71785Integrin_B_tailInterPro annotationAdd
BLAST
Domaini741 – 78747Integrin_b_cytInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation
Contains VWFA domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG006190.
KOiK06493.
PhylomeDBiQ8R2H2.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamiPF07974. EGF_2. 2 hits.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTRRPGQLW ATLLALGALA GVVVGESNIC TTRGVNSCQQ CLAVSPVCAW
60 70 80 90 100
CSDESLPQNS PRCNLKKNLL KDKCSPESIE FPVSEAQILE ALPLSSKGSG
110 120 130 140 150
DSAQITQVSP QRIALRLRPD DSKIFSLQVR QVEDYPVDIY YLMDLSFSMK
160 170 180 190 200
DDLSSIQTLG TKLASQMRKL TSNLRIGFGA FVDKPVSPYM FISPPQAIKN
210 220 230 240 250
PCYTMKSTCL PMFGYKHVLT LTDQVTRFND EVKKQSVSRN RDAPEGGFDA
260 270 280 290 300
IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VLPNDGRCHI
310 320 330 340 350
GPDNHYSAST TMDYPSLGLM TEKLSQKNIN LIFAVTENVV SLYQNYSELI
360 370 380 390 400
PGTTVGVLSD DSSNVLQLIV DAYGKIRSKV ELEVRDLPEE LSLSFNATCL
410 420 430 440 450
NNEVIPGLKS CVGLKIGDTV SFSIEAKVRG CPQQKEQSFT IKPVGFKDSL
460 470 480 490 500
TVQVTFDCDC DCQAFAQPLS PRCNNGNGTF ECGVCRCDQG WLGSMCECSE
510 520 530 540 550
EDYRPSQQEE CSPKEGQPIC SQRGECLCGQ CVCHSSDFGK ITGKYCECDD
560 570 580 590 600
FSCVRYKGEM CSGHGQCNCG DCVCDSDWTG YYCNCTTRTD TCMSTNGLLC
610 620 630 640 650
SGRGNCECGS CVCVQPGSYG DTCEKCPTCP DACSFKKDCV ECKKFNRGKL
660 670 680 690 700
HEENNCNRFC RDDIELVKEL TDTGKNAVNC TYKNEDDCVV RFQYYEDSSG
710 720 730 740 750
RAVLYVVEEP ECPKGPDILV VLLSVMGAIL LIGLATLLIW KLLITIHDRK
760 770 780
EFAKFEEERA RAKWDTANNP LYKEATSTFT NITYRGT
Length:787
Mass (Da):86,930
Last modified:June 1, 2002 - v1
Checksum:iC67826118411FE95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440952 mRNA. Translation: CAD29521.1.
PIRiPN0509.
RefSeqiNP_714942.1. NM_153720.1.
UniGeneiRn.229225.

Genome annotation databases

GeneIDi29302.
KEGGirno:29302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440952 mRNA. Translation: CAD29521.1.
PIRiPN0509.
RefSeqiNP_714942.1. NM_153720.1.
UniGeneiRn.229225.

3D structure databases

ProteinModelPortaliQ8R2H2.
SMRiQ8R2H2. Positions 28-464, 710-787.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8R2H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29302.
KEGGirno:29302.

Organism-specific databases

CTDi3690.
RGDi628868. Itgb3.

Phylogenomic databases

HOVERGENiHBG006190.
KOiK06493.
PhylomeDBiQ8R2H2.

Gene expression databases

GenevisibleiQ8R2H2. RN.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamiPF07974. EGF_2. 2 hits.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8R2H2_RAT
AccessioniPrimary (citable) accession number: Q8R2H2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.