Q8R2H2 (Q8R2H2_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Integrin beta RuleBase RU000633

Gene names

Name:	Itgb3 RGD 628868
Synonyms:	itgb3 EMBL CAD29521.1

Organism

Rattus norvegicus (Rat) EMBL CAD29521.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	787 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein By similarity RuleBase RU000633.
Sequence similarities	Belongs to the integrin beta chain family. RuleBase RU000633

Ontologies

Keywords
Biological process	Cell adhesion RuleBase RU000633
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000633
Molecular function	Integrin RuleBase RU000633 EMBL CAD29521.1
Gene Ontology (GO)
Biological_process	angiogenesis involved in wound healing Inferred from electronic annotation. Source: InterPro cell-matrix adhesion Inferred from electronic annotation. Source: InterPro cell-substrate junction assembly Inferred from electronic annotation. Source: InterPro cellular calcium ion homeostasis Inferred from direct assay PubMed 12639933. Source: RGD cellular response to drug Inferred from expression pattern PubMed 12242040. Source: RGD cellular response to mechanical stimulus Inferred from expression pattern PubMed 12856576. Source: RGD embryo implantation Inferred from expression pattern PubMed 16528553. Source: RGD integrin-mediated signaling pathway Inferred from direct assay PubMed 12639933. Source: RGD negative regulation of cell death Inferred from mutant phenotype PubMed 9585425. Source: RGD platelet aggregation Inferred from mutant phenotype PubMed 17924279. Source: RGD positive regulation of ERK1 and ERK2 cascade Inferred from mutant phenotype PubMed 17620283. Source: RGD positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway Inferred from mutant phenotype PubMed 17157995. Source: RGD positive regulation of angiogenesis Inferred from mutant phenotype PubMed 19331142. Source: RGD positive regulation of bone resorption Inferred from mutant phenotype PubMed 8603604. Source: RGD positive regulation of cell adhesion mediated by integrin Inferred from mutant phenotype PubMed 17868879. Source: RGD positive regulation of fibroblast migration Inferred from mutant phenotype PubMed 10869268. Source: RGD positive regulation of glomerular mesangial cell proliferation Inferred from mutant phenotype PubMed 20135641. Source: RGD positive regulation of leukocyte migration Inferred from mutant phenotype PubMed 11705748. Source: RGD positive regulation of smooth muscle cell migration Inferred from mutant phenotype PubMed 18209569. Source: RGD positive regulation of smooth muscle cell proliferation Inferred from mutant phenotype PubMed 19723557. Source: RGD response to radiation Inferred from expression pattern PubMed 20159792. Source: RGD
Cellular_component	apical plasma membrane Inferred from direct assay PubMed 21426865. Source: RGD cell surface Inferred from direct assay PubMed 11278919. Source: RGD integrin complex Inferred from direct assay PubMed 17157995. Source: RGD
Molecular_function	peptide binding Inferred from direct assay PubMed 12639933. Source: RGD receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8R2H2 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: C67826118411FE95	FASTA	787	86,930
	10 20 30 40 50 60 MRTRRPGQLW ATLLALGALA GVVVGESNIC TTRGVNSCQQ CLAVSPVCAW CSDESLPQNS 70 80 90 100 110 120 PRCNLKKNLL KDKCSPESIE FPVSEAQILE ALPLSSKGSG DSAQITQVSP QRIALRLRPD 130 140 150 160 170 180 DSKIFSLQVR QVEDYPVDIY YLMDLSFSMK DDLSSIQTLG TKLASQMRKL TSNLRIGFGA 190 200 210 220 230 240 FVDKPVSPYM FISPPQAIKN PCYTMKSTCL PMFGYKHVLT LTDQVTRFND EVKKQSVSRN 250 260 270 280 290 300 RDAPEGGFDA IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VLPNDGRCHI 310 320 330 340 350 360 GPDNHYSAST TMDYPSLGLM TEKLSQKNIN LIFAVTENVV SLYQNYSELI PGTTVGVLSD 370 380 390 400 410 420 DSSNVLQLIV DAYGKIRSKV ELEVRDLPEE LSLSFNATCL NNEVIPGLKS CVGLKIGDTV 430 440 450 460 470 480 SFSIEAKVRG CPQQKEQSFT IKPVGFKDSL TVQVTFDCDC DCQAFAQPLS PRCNNGNGTF 490 500 510 520 530 540 ECGVCRCDQG WLGSMCECSE EDYRPSQQEE CSPKEGQPIC SQRGECLCGQ CVCHSSDFGK 550 560 570 580 590 600 ITGKYCECDD FSCVRYKGEM CSGHGQCNCG DCVCDSDWTG YYCNCTTRTD TCMSTNGLLC 610 620 630 640 650 660 SGRGNCECGS CVCVQPGSYG DTCEKCPTCP DACSFKKDCV ECKKFNRGKL HEENNCNRFC 670 680 690 700 710 720 RDDIELVKEL TDTGKNAVNC TYKNEDDCVV RFQYYEDSSG RAVLYVVEEP ECPKGPDILV 730 740 750 760 770 780 VLLSVMGAIL LIGLATLLIW KLLITIHDRK EFAKFEEERA RAKWDTANNP LYKEATSTFT NITYRGT

References

[1]	"A comparative analysis of cDNA-derived sequences for rat and mouse beta 3 integrins (GPIIIA) with their human counterpart." Cieutat A.M., Rosa J.P., Letourneur F., Poncz M., Rifat S. Biochem. Biophys. Res. Commun. 193:771-778(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Cloning of the rat integrin beta3 subunit." Stephan C., Hamacher M. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL CAD29521.1. Tissue: Kidney EMBL CAD29521.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ440952 mRNA. Translation: CAD29521.1.
IPI	IPI00198695.
PIR	PN0509.
RefSeq	NP_714942.1. NM_153720.1.
UniGene	Rn.229225.
3D structure databases
HSSP	HSSP built from PDB template 1M8O based on UniProtKB P05106.
ProteinModelPortal	Q8R2H2.
SMR	Q8R2H2. Positions 28-464, 710-787.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000060211. Q8R2H2.
Proteomic databases
PRIDE	Q8R2H2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	29302.
KEGG	rno:29302.
Organism-specific databases
CTD	3690.
RGD	628868. Itgb3.
Phylogenomic databases
eggNOG	NOG287997.
HOVERGEN	HBG006190.
KO	K06493.
Gene expression databases
Genevestigator	Q8R2H2.
Family and domain databases
Gene3D	1.20.5.630. 1 hit.
InterPro	IPR027068. Integrin_beta-3. IPR015812. Integrin_bsu. IPR014836. Integrin_bsu_cyt_dom. IPR002369. Integrin_bsu_N. IPR012896. Integrin_bsu_tail. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR002035. VWF_A. [Graphical view]
PANTHER	PTHR10082. PTHR10082. 1 hit. PTHR10082:SF25. PTHR10082:SF25. 1 hit.
Pfam	PF08725. Integrin_b_cyt. 1 hit. PF07965. Integrin_B_tail. 1 hit. PF00362. Integrin_beta. 1 hit. [Graphical view]
PIRSF	PIRSF002512. Integrin_B. 1 hit.
PRINTS	PR01186. INTEGRINB.
SMART	SM00187. INB. 1 hit. SM00423. PSI. 1 hit. SM00327. VWA. 1 hit. [Graphical view]
SUPFAM	SSF69687. Integrin_bsu_tail. 1 hit. SSF103575. Plexin-like_fold. 1 hit.
PROSITE	PS00243. INTEGRIN_BETA. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	608724.

Entry information

Entry name

Q8R2H2_RAT

Accession

Primary (citable) accession number: Q8R2H2

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)