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Q8R2H2

- Q8R2H2_RAT

UniProt

Q8R2H2 - Q8R2H2_RAT

Protein

Integrin beta

Gene

Itgb3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. peptide binding Source: RGD
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis involved in wound healing Source: InterPro
    2. cell adhesion Source: RGD
    3. cell-matrix adhesion Source: InterPro
    4. cell-substrate junction assembly Source: InterPro
    5. cellular calcium ion homeostasis Source: RGD
    6. cellular response to drug Source: RGD
    7. cellular response to mechanical stimulus Source: RGD
    8. embryo implantation Source: RGD
    9. integrin-mediated signaling pathway Source: RGD
    10. negative regulation of cell death Source: RGD
    11. platelet aggregation Source: RGD
    12. positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway Source: RGD
    13. positive regulation of angiogenesis Source: RGD
    14. positive regulation of bone resorption Source: RGD
    15. positive regulation of cell adhesion mediated by integrin Source: RGD
    16. positive regulation of ERK1 and ERK2 cascade Source: RGD
    17. positive regulation of fibroblast migration Source: RGD
    18. positive regulation of glomerular mesangial cell proliferation Source: RGD
    19. positive regulation of leukocyte migration Source: RGD
    20. positive regulation of MAPK cascade Source: RGD
    21. positive regulation of smooth muscle cell migration Source: RGD
    22. positive regulation of smooth muscle cell proliferation Source: RGD
    23. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
    24. response to radiation Source: RGD

    Keywords - Molecular functioni

    IntegrinUniRule annotationImported

    Keywords - Biological processi

    Cell adhesionUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin betaUniRule annotation
    Gene namesi
    Name:Itgb3Imported
    Synonyms:itgb3Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi628868. Itgb3.

    Subcellular locationi

    Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. cell surface Source: RGD
    3. integrin complex Source: RGD
    4. membrane Source: RGD
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8R2H2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8R2H2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000060211.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R2H2.
    SMRiQ8R2H2. Positions 28-464, 710-787.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the integrin beta chain family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    eggNOGiNOG287997.
    HOVERGENiHBG006190.
    KOiK06493.
    PhylomeDBiQ8R2H2.

    Family and domain databases

    Gene3Di1.20.5.630. 1 hit.
    3.40.50.410. 1 hit.
    InterProiIPR027068. Integrin_beta-3.
    IPR015812. Integrin_bsu.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view]
    PANTHERiPTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF25. PTHR10082:SF25. 1 hit.
    PfamiPF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002512. Integrin_B. 1 hit.
    PRINTSiPR01186. INTEGRINB.
    SMARTiSM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R2H2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTRRPGQLW ATLLALGALA GVVVGESNIC TTRGVNSCQQ CLAVSPVCAW    50
    CSDESLPQNS PRCNLKKNLL KDKCSPESIE FPVSEAQILE ALPLSSKGSG 100
    DSAQITQVSP QRIALRLRPD DSKIFSLQVR QVEDYPVDIY YLMDLSFSMK 150
    DDLSSIQTLG TKLASQMRKL TSNLRIGFGA FVDKPVSPYM FISPPQAIKN 200
    PCYTMKSTCL PMFGYKHVLT LTDQVTRFND EVKKQSVSRN RDAPEGGFDA 250
    IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VLPNDGRCHI 300
    GPDNHYSAST TMDYPSLGLM TEKLSQKNIN LIFAVTENVV SLYQNYSELI 350
    PGTTVGVLSD DSSNVLQLIV DAYGKIRSKV ELEVRDLPEE LSLSFNATCL 400
    NNEVIPGLKS CVGLKIGDTV SFSIEAKVRG CPQQKEQSFT IKPVGFKDSL 450
    TVQVTFDCDC DCQAFAQPLS PRCNNGNGTF ECGVCRCDQG WLGSMCECSE 500
    EDYRPSQQEE CSPKEGQPIC SQRGECLCGQ CVCHSSDFGK ITGKYCECDD 550
    FSCVRYKGEM CSGHGQCNCG DCVCDSDWTG YYCNCTTRTD TCMSTNGLLC 600
    SGRGNCECGS CVCVQPGSYG DTCEKCPTCP DACSFKKDCV ECKKFNRGKL 650
    HEENNCNRFC RDDIELVKEL TDTGKNAVNC TYKNEDDCVV RFQYYEDSSG 700
    RAVLYVVEEP ECPKGPDILV VLLSVMGAIL LIGLATLLIW KLLITIHDRK 750
    EFAKFEEERA RAKWDTANNP LYKEATSTFT NITYRGT 787
    Length:787
    Mass (Da):86,930
    Last modified:June 1, 2002 - v1
    Checksum:iC67826118411FE95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ440952 mRNA. Translation: CAD29521.1.
    PIRiPN0509.
    RefSeqiNP_714942.1. NM_153720.1.
    UniGeneiRn.229225.

    Genome annotation databases

    GeneIDi29302.
    KEGGirno:29302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ440952 mRNA. Translation: CAD29521.1 .
    PIRi PN0509.
    RefSeqi NP_714942.1. NM_153720.1.
    UniGenei Rn.229225.

    3D structure databases

    ProteinModelPortali Q8R2H2.
    SMRi Q8R2H2. Positions 28-464, 710-787.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000060211.

    Proteomic databases

    PRIDEi Q8R2H2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29302.
    KEGGi rno:29302.

    Organism-specific databases

    CTDi 3690.
    RGDi 628868. Itgb3.

    Phylogenomic databases

    eggNOGi NOG287997.
    HOVERGENi HBG006190.
    KOi K06493.
    PhylomeDBi Q8R2H2.

    Miscellaneous databases

    NextBioi 608724.

    Gene expression databases

    Genevestigatori Q8R2H2.

    Family and domain databases

    Gene3Di 1.20.5.630. 1 hit.
    3.40.50.410. 1 hit.
    InterProi IPR027068. Integrin_beta-3.
    IPR015812. Integrin_bsu.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view ]
    PANTHERi PTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF25. PTHR10082:SF25. 1 hit.
    Pfami PF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002512. Integrin_B. 1 hit.
    PRINTSi PR01186. INTEGRINB.
    SMARTi SM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEi PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparative analysis of cDNA-derived sequences for rat and mouse beta 3 integrins (GPIIIA) with their human counterpart."
      Cieutat A.M., Rosa J.P., Letourneur F., Poncz M., Rifat S.
      Biochem. Biophys. Res. Commun. 193:771-778(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Cloning of the rat integrin beta3 subunit."
      Stephan C., Hamacher M.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiQ8R2H2_RAT
    AccessioniPrimary (citable) accession number: Q8R2H2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)