Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin beta

Gene

Itgb3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported
Biological processCell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:Itgb3Imported
Synonyms:itgb3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi628868. Itgb3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei718 – 740HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500431236226 – 787Integrin betaSequence analysisAdd BLAST762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 460UniRule annotation
Disulfide bondi38 ↔ 48UniRule annotation
Disulfide bondi41 ↔ 74UniRule annotation
Disulfide bondi51 ↔ 63UniRule annotation
Disulfide bondi202 ↔ 209UniRule annotation
Disulfide bondi257 ↔ 298UniRule annotation
Disulfide bondi399 ↔ 411UniRule annotation
Disulfide bondi431 ↔ 680UniRule annotation
Disulfide bondi458 ↔ 462UniRule annotation
Disulfide bondi473 ↔ 485UniRule annotation
Disulfide bondi482 ↔ 520UniRule annotation
Disulfide bondi487 ↔ 496UniRule annotation
Disulfide bondi498 ↔ 511UniRule annotation
Disulfide bondi526 ↔ 531UniRule annotation
Disulfide bondi528 ↔ 561UniRule annotation
Disulfide bondi533 ↔ 546UniRule annotation
Disulfide bondi548 ↔ 553UniRule annotation
Disulfide bondi567 ↔ 572UniRule annotation
Disulfide bondi569 ↔ 600UniRule annotation
Disulfide bondi574 ↔ 583UniRule annotation
Disulfide bondi585 ↔ 592UniRule annotation
Disulfide bondi606 ↔ 611UniRule annotation
Disulfide bondi608 ↔ 656UniRule annotation
Disulfide bondi613 ↔ 623UniRule annotation
Disulfide bondi626 ↔ 629UniRule annotation
Disulfide bondi633 ↔ 642UniRule annotation
Disulfide bondi639 ↔ 712UniRule annotation
Disulfide bondi660 ↔ 688UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PRIDEiQ8R2H2.

Expressioni

Gene expression databases

GenevisibleiQ8R2H2. RN.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8R2H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 75PSIInterPro annotationAdd BLAST47
Domaini37 – 460INBInterPro annotationAdd BLAST424
Domaini633 – 717Integrin_B_tailInterPro annotationAdd BLAST85
Domaini741 – 787Integrin_b_cytInterPro annotationAdd BLAST47

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG006190.
KOiK06493.
PhylomeDBiQ8R2H2.

Family and domain databases

Gene3Di1.20.5.100. 1 hit.
1.20.5.630. 1 hit.
InterProiView protein in InterPro
IPR021157. Cyt_c1_TM_anchor_C.
IPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR037076. Integrin_bsu_cyt_dom_sf.
IPR012896. Integrin_bsu_tail.
IPR036349. Integrin_bsu_tail_dom_sf.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom_sf.
IPR016201. PSI.
IPR036465. vWFA_dom_sf.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamiView protein in Pfam
PF07974. EGF_2. 2 hits.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiView protein in SMART
SM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiView protein in PROSITE
PS00243. INTEGRIN_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R2H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTRRPGQLW ATLLALGALA GVVVGESNIC TTRGVNSCQQ CLAVSPVCAW
60 70 80 90 100
CSDESLPQNS PRCNLKKNLL KDKCSPESIE FPVSEAQILE ALPLSSKGSG
110 120 130 140 150
DSAQITQVSP QRIALRLRPD DSKIFSLQVR QVEDYPVDIY YLMDLSFSMK
160 170 180 190 200
DDLSSIQTLG TKLASQMRKL TSNLRIGFGA FVDKPVSPYM FISPPQAIKN
210 220 230 240 250
PCYTMKSTCL PMFGYKHVLT LTDQVTRFND EVKKQSVSRN RDAPEGGFDA
260 270 280 290 300
IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VLPNDGRCHI
310 320 330 340 350
GPDNHYSAST TMDYPSLGLM TEKLSQKNIN LIFAVTENVV SLYQNYSELI
360 370 380 390 400
PGTTVGVLSD DSSNVLQLIV DAYGKIRSKV ELEVRDLPEE LSLSFNATCL
410 420 430 440 450
NNEVIPGLKS CVGLKIGDTV SFSIEAKVRG CPQQKEQSFT IKPVGFKDSL
460 470 480 490 500
TVQVTFDCDC DCQAFAQPLS PRCNNGNGTF ECGVCRCDQG WLGSMCECSE
510 520 530 540 550
EDYRPSQQEE CSPKEGQPIC SQRGECLCGQ CVCHSSDFGK ITGKYCECDD
560 570 580 590 600
FSCVRYKGEM CSGHGQCNCG DCVCDSDWTG YYCNCTTRTD TCMSTNGLLC
610 620 630 640 650
SGRGNCECGS CVCVQPGSYG DTCEKCPTCP DACSFKKDCV ECKKFNRGKL
660 670 680 690 700
HEENNCNRFC RDDIELVKEL TDTGKNAVNC TYKNEDDCVV RFQYYEDSSG
710 720 730 740 750
RAVLYVVEEP ECPKGPDILV VLLSVMGAIL LIGLATLLIW KLLITIHDRK
760 770 780
EFAKFEEERA RAKWDTANNP LYKEATSTFT NITYRGT
Length:787
Mass (Da):86,930
Last modified:June 1, 2002 - v1
Checksum:iC67826118411FE95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440952 mRNA. Translation: CAD29521.1.
PIRiPN0509.
RefSeqiNP_714942.1. NM_153720.1.
UniGeneiRn.229225.

Genome annotation databases

GeneIDi29302.
KEGGirno:29302.

Similar proteinsi

Entry informationi

Entry nameiQ8R2H2_RAT
AccessioniPrimary (citable) accession number: Q8R2H2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)