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Q8R2H2 (Q8R2H2_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Integrin beta RuleBase RU000633
Gene names
Name:Itgb3 RGD 628868
Synonyms:itgb3 EMBL CAD29521.1
OrganismRattus norvegicus (Rat) EMBL CAD29521.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length787 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein By similarity RuleBase RU000633.

Sequence similarities

Belongs to the integrin beta chain family. RuleBase RU000633

Ontologies

Keywords
   Biological processCell adhesion RuleBase RU000633
   Cellular componentMembrane
   DomainTransmembrane RuleBase RU000633
   Molecular functionIntegrin RuleBase RU000633 EMBL CAD29521.1
Gene Ontology (GO)
   Biological_processangiogenesis involved in wound healing

Inferred from electronic annotation. Source: InterPro

cell adhesion

Inferred from direct assay PubMed 12639933. Source: RGD

cell-matrix adhesion

Inferred from electronic annotation. Source: InterPro

cell-substrate junction assembly

Inferred from electronic annotation. Source: InterPro

cellular calcium ion homeostasis

Inferred from direct assay PubMed 12639933. Source: RGD

cellular response to drug

Inferred from expression pattern PubMed 12242040. Source: RGD

cellular response to mechanical stimulus

Inferred from expression pattern PubMed 12856576. Source: RGD

embryo implantation

Inferred from expression pattern PubMed 16528553. Source: RGD

integrin-mediated signaling pathway

Inferred from direct assay PubMed 12639933. Source: RGD

negative regulation of cell death

Inferred from mutant phenotype PubMed 9585425. Source: RGD

platelet aggregation

Inferred from mutant phenotype PubMed 17924279. Source: RGD

positive regulation of ERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 17620283. Source: RGD

positive regulation of MAPK cascade

Inferred from direct assay PubMed 12639933. Source: RGD

positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway

Inferred from mutant phenotype PubMed 17157995. Source: RGD

positive regulation of angiogenesis

Inferred from mutant phenotype PubMed 19331142. Source: RGD

positive regulation of bone resorption

Inferred from mutant phenotype PubMed 8603604. Source: RGD

positive regulation of cell adhesion mediated by integrin

Inferred from mutant phenotype PubMed 17868879. Source: RGD

positive regulation of fibroblast migration

Inferred from mutant phenotype PubMed 10869268. Source: RGD

positive regulation of glomerular mesangial cell proliferation

Inferred from mutant phenotype PubMed 20135641. Source: RGD

positive regulation of leukocyte migration

Inferred from mutant phenotype PubMed 11705748. Source: RGD

positive regulation of smooth muscle cell migration

Inferred from mutant phenotype PubMed 18209569. Source: RGD

positive regulation of smooth muscle cell proliferation

Inferred from mutant phenotype PubMed 19723557. Source: RGD

regulation of G-protein coupled receptor protein signaling pathway

Inferred from mutant phenotype PubMed 17157995. Source: RGD

response to radiation

Inferred from expression pattern PubMed 20159792. Source: RGD

   Cellular_componentapical plasma membrane

Inferred from direct assay PubMed 21426865. Source: RGD

cell surface

Inferred from direct assay PubMed 11278919. Source: RGD

integrin complex

Inferred from direct assay PubMed 17157995. Source: RGD

membrane

Inferred from direct assay PubMed 17157995. Source: RGD

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpeptide binding

Inferred from direct assay PubMed 12639933. Source: RGD

receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8R2H2 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: C67826118411FE95

FASTA78786,930
        10         20         30         40         50         60 
MRTRRPGQLW ATLLALGALA GVVVGESNIC TTRGVNSCQQ CLAVSPVCAW CSDESLPQNS 

        70         80         90        100        110        120 
PRCNLKKNLL KDKCSPESIE FPVSEAQILE ALPLSSKGSG DSAQITQVSP QRIALRLRPD 

       130        140        150        160        170        180 
DSKIFSLQVR QVEDYPVDIY YLMDLSFSMK DDLSSIQTLG TKLASQMRKL TSNLRIGFGA 

       190        200        210        220        230        240 
FVDKPVSPYM FISPPQAIKN PCYTMKSTCL PMFGYKHVLT LTDQVTRFND EVKKQSVSRN 

       250        260        270        280        290        300 
RDAPEGGFDA IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VLPNDGRCHI 

       310        320        330        340        350        360 
GPDNHYSAST TMDYPSLGLM TEKLSQKNIN LIFAVTENVV SLYQNYSELI PGTTVGVLSD 

       370        380        390        400        410        420 
DSSNVLQLIV DAYGKIRSKV ELEVRDLPEE LSLSFNATCL NNEVIPGLKS CVGLKIGDTV 

       430        440        450        460        470        480 
SFSIEAKVRG CPQQKEQSFT IKPVGFKDSL TVQVTFDCDC DCQAFAQPLS PRCNNGNGTF 

       490        500        510        520        530        540 
ECGVCRCDQG WLGSMCECSE EDYRPSQQEE CSPKEGQPIC SQRGECLCGQ CVCHSSDFGK 

       550        560        570        580        590        600 
ITGKYCECDD FSCVRYKGEM CSGHGQCNCG DCVCDSDWTG YYCNCTTRTD TCMSTNGLLC 

       610        620        630        640        650        660 
SGRGNCECGS CVCVQPGSYG DTCEKCPTCP DACSFKKDCV ECKKFNRGKL HEENNCNRFC 

       670        680        690        700        710        720 
RDDIELVKEL TDTGKNAVNC TYKNEDDCVV RFQYYEDSSG RAVLYVVEEP ECPKGPDILV 

       730        740        750        760        770        780 
VLLSVMGAIL LIGLATLLIW KLLITIHDRK EFAKFEEERA RAKWDTANNP LYKEATSTFT 


NITYRGT 

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References

[1]"A comparative analysis of cDNA-derived sequences for rat and mouse beta 3 integrins (GPIIIA) with their human counterpart."
Cieutat A.M., Rosa J.P., Letourneur F., Poncz M., Rifat S.
Biochem. Biophys. Res. Commun. 193:771-778(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Cloning of the rat integrin beta3 subunit."
Stephan C., Hamacher M.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Wistar EMBL CAD29521.1.
Tissue: Kidney EMBL CAD29521.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ440952 mRNA. Translation: CAD29521.1.
PIRPN0509.
RefSeqNP_714942.1. NM_153720.1.
UniGeneRn.229225.

3D structure databases

ProteinModelPortalQ8R2H2.
SMRQ8R2H2. Positions 28-464, 710-787.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000060211.

Proteomic databases

PRIDEQ8R2H2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29302.
KEGGrno:29302.

Organism-specific databases

CTD3690.
RGD628868. Itgb3.

Phylogenomic databases

eggNOGNOG287997.
HOVERGENHBG006190.
KOK06493.
PhylomeDBQ8R2H2.

Gene expression databases

GenevestigatorQ8R2H2.

Family and domain databases

Gene3D1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProIPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFPIRSF002512. Integrin_B. 1 hit.
PRINTSPR01186. INTEGRINB.
SMARTSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio608724.

Entry information

Entry nameQ8R2H2_RAT
AccessionPrimary (citable) accession number: Q8R2H2
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)