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Protein

NF-kappa-B inhibitor-like protein 1

Gene

Nfkbil1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-like protein 1
Alternative name(s):
Inhibitor of kappa B-like protein
Short name:
I-kappa-B-like protein
Short name:
IkappaBL
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Gene namesi
Name:Nfkbil1
Synonyms:Ikbl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303310. Nfkbil1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381NF-kappa-B inhibitor-like protein 1PRO_0000067014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R2H1.
PRIDEiQ8R2H1.

Expressioni

Gene expression databases

ExpressionAtlasiQ8R2H1. baseline and differential.
GenevisibleiQ8R2H1. RN.

Interactioni

Subunit structurei

Interacts with CACTIN (via N-terminal domain); the interaction occurs in a proinflammatory-independent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001113.

Structurei

3D structure databases

ProteinModelPortaliQ8R2H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 9330ANK 1Add
BLAST
Repeati97 – 13337ANK 2Add
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IZ7E. Eukaryota.
ENOG4111NZ2. LUCA.
GeneTreeiENSGT00390000013929.
HOGENOMiHOG000043101.
HOVERGENiHBG048799.
InParanoidiQ8R2H1.
KOiK09256.
OMAiHSWRQQE.
OrthoDBiEOG7JX350.
PhylomeDBiQ8R2H1.
TreeFamiTF333242.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPSPQAPE EEASTSVCRP QSSMASVSRR HRRERRFRRY LSAGRLVRAQ
60 70 80 90 100
ALLQRHPGLD VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT
110 120 130 140 150
ALHAAARQGP NAYTDFFLPL LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS
160 170 180 190 200
AEEEEDEEVS KEREWRQKLQ GELEDEWQEV IGRFEDDASR ETQEPESFSA
210 220 230 240 250
WSERLAREHA QKQRRQQLEA EGSRRPPRAE GSSHSWRQQE EEQRLFRERA
260 270 280 290 300
RVKEKELCES RARRAQEAQG DRGPAPPRAR PRAEHPRGAG RGSLWRFGDV
310 320 330 340 350
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL KRYLRVQQVR WHPDRFLQRF
360 370 380
RNQIETWELG RVMGAVTALS QALNRHAEAL K
Length:381
Mass (Da):43,293
Last modified:March 1, 2004 - v2
Checksum:i21C415DEA6F9617B
GO

Sequence cautioni

The sequence AAL98918.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883046 Genomic DNA. Translation: CAE84005.1.
BC099772 mRNA. Translation: AAH99772.1.
AF387339 Genomic DNA. Translation: AAL98918.1. Sequence problems.
RefSeqiNP_997674.1. NM_212509.2.
UniGeneiRn.38632.

Genome annotation databases

EnsembliENSRNOT00000001113; ENSRNOP00000001113; ENSRNOG00000000839.
GeneIDi361794.
KEGGirno:361794.
UCSCiRGD:1303310. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883046 Genomic DNA. Translation: CAE84005.1.
BC099772 mRNA. Translation: AAH99772.1.
AF387339 Genomic DNA. Translation: AAL98918.1. Sequence problems.
RefSeqiNP_997674.1. NM_212509.2.
UniGeneiRn.38632.

3D structure databases

ProteinModelPortaliQ8R2H1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001113.

Proteomic databases

PaxDbiQ8R2H1.
PRIDEiQ8R2H1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001113; ENSRNOP00000001113; ENSRNOG00000000839.
GeneIDi361794.
KEGGirno:361794.
UCSCiRGD:1303310. rat.

Organism-specific databases

CTDi4795.
RGDi1303310. Nfkbil1.

Phylogenomic databases

eggNOGiENOG410IZ7E. Eukaryota.
ENOG4111NZ2. LUCA.
GeneTreeiENSGT00390000013929.
HOGENOMiHOG000043101.
HOVERGENiHBG048799.
InParanoidiQ8R2H1.
KOiK09256.
OMAiHSWRQQE.
OrthoDBiEOG7JX350.
PhylomeDBiQ8R2H1.
TreeFamiTF333242.

Miscellaneous databases

PROiQ8R2H1.

Gene expression databases

ExpressionAtlasiQ8R2H1. baseline and differential.
GenevisibleiQ8R2H1. RN.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-110.
    Strain: Lewis.

Entry informationi

Entry nameiIKBL1_RAT
AccessioniPrimary (citable) accession number: Q8R2H1
Secondary accession number(s): Q499T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: July 6, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.