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Q8R2G4 (NAR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ecto-ADP-ribosyltransferase 3
EC=2.4.2.31
Alternative name(s):
Mono(ADP-ribosyl)transferase 3
NAD(P)(+)--arginine ADP-ribosyltransferase 3
Gene names
Name:Art3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

NADP+ + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor By similarity.

Sequence similarities

Belongs to the Arg-specific ADP-ribosyltransferase family.

Sequence caution

The sequence CAC84526.1 differs from that shown. Reason: 3'extension leads to out-of-frame translation.

The sequence CAC84539.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAC84540.1 differs from that shown. Reason: 3'extension leads to out-of-frame translation.

The sequence CAC84541.1 differs from that shown. Reason: 3'extension leads to out-of-frame translation.

The sequence CAC84543.1 differs from that shown. Reason: 3'extension leads to out-of-frame translation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandNAD
NADP
   Molecular functionGlycosyltransferase
Transferase
   PTMDisulfide bond
GPI-anchor
Glycoprotein
Lipoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processprotein ADP-ribosylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentanchored to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD(P)+-protein-arginine ADP-ribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 8 (identifier: Q8R2G4-5)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 5 (identifier: Q8R2G4-7)

The sequence of this isoform differs from the canonical sequence as follows:
     271-291: Missing.
Isoform 7 (identifier: Q8R2G4-8)

The sequence of this isoform differs from the canonical sequence as follows:
     321-331: DRSRGKANNPT → A
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 345319Ecto-ADP-ribosyltransferase 3
PRO_0000019327
Propeptide346 – 37126Removed in mature form By similarity
PRO_0000019328

Sites

Active site2281 By similarity
Binding site1011NAD By similarity
Binding site1821NAD By similarity

Amino acid modifications

Lipidation3451GPI-anchor amidated serine By similarity
Disulfide bond43 ↔ 255 By similarity

Natural variations

Alternative sequence271 – 29121Missing in isoform 5.
VSP_036193
Alternative sequence321 – 33111DRSRGKANNPT → A in isoform 7.
VSP_036199

Experimental info

Sequence conflict11 – 155TLLAA → AAGS in CAA69284. Ref.2
Sequence conflict3481Missing in AAI41070. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 8 [UniParc].

Last modified January 20, 2009. Version 2.
Checksum: 52F1B373A928182B

FASTA37142,015
        10         20         30         40         50         60 
MKMGHFEMVT TLLAAAVLMD IFQVKAEVLD MAENAFDDEY LKCKSRMESK YIPQMKREEW 

        70         80         90        100        110        120 
ANDALLRMVW DNAEIQWEAR KAQLFLPRNF KDTYGIALTA YVNEAQEQTS FYHTFSSAVK 

       130        140        150        160        170        180 
MAGLSRRRYI YNFPFKAFHF YLVRALQLLR RPCEKSYKTV VYSTSPDISF TFGEQNQARL 

       190        200        210        220        230        240 
GNFTLAYSAK PETADNQRVL TIQTCFGVAV GKFLNKEDDS VVLIPLSEVF QVSRKGTSND 

       250        260        270        280        290        300 
LVLQSINSTC SYYECAFLGG LKTENCIANA EYIDPRYLYN PDMDNQKLED SGRNNLDPDR 

       310        320        330        340        350        360 
MPEIKVLQTE ENPLLPDEKP DRSRGKANNP TPGLVPGPKS HPSASSGNTL LPSVMASTIL 

       370 
LVASAVNFIE L

« Hide

Isoform 5 [UniParc].

Checksum: B1F3BB4F6FD80415
Show »

FASTA35039,414
Isoform 7 [UniParc].

Checksum: 17386DF02015D673
Show »

FASTA36140,889

References

« Hide 'large scale' references
[1]"The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
Protein Sci. 11:1657-1670(2002) [PubMed: 12070318] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 5).
[2]"Molecular cloning of two ecto-mono(ADP-ribosyl)transferases operating in murine testis."
Koch-Nolte F., Firner K., Haag F., Khl M., Thiele H.G.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 8).
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ311768 Genomic DNA. Translation: CAC84539.1. Sequence problems.
AJ311769 mRNA. Translation: CAC84526.1. Sequence problems.
AJ311770 mRNA. Translation: CAC84540.1. Sequence problems.
AJ311771 mRNA. Translation: CAC84541.1. Sequence problems.
AJ311772 mRNA. Translation: CAC84542.1.
AJ311773 mRNA. Translation: CAC84543.1. Sequence problems.
Y08027 Genomic DNA. Translation: CAA69284.1.
BC141069 mRNA. Translation: AAI41070.1.
IPIIPI00229197.
IPI00880925.
IPI00919012.
RefSeqNP_859417.2. NM_181728.2.
UniGeneMm.263514.

3D structure databases

ProteinModelPortalQ8R2G4.
SMRQ8R2G4. Positions 27-258.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8R2G4.

Proteomic databases

PRIDEQ8R2G4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038654; ENSMUSP00000038935; ENSMUSG00000034842.
ENSMUST00000113083; ENSMUSP00000108706; ENSMUSG00000034842.
ENSMUST00000113087; ENSMUSP00000108710; ENSMUSG00000034842.
ENSMUST00000118106; ENSMUSP00000114083; ENSMUSG00000034842.
ENSMUST00000119587; ENSMUSP00000112648; ENSMUSG00000034842.
ENSMUST00000120193; ENSMUSP00000113074; ENSMUSG00000034842.
ENSMUST00000120416; ENSMUSP00000113493; ENSMUSG00000034842.
GeneID109979.
KEGGmmu:109979.
UCSCuc008ycw.1. mouse.
uc008ycy.2. mouse.

Organism-specific databases

CTD419.
MGIMGI:1202729. Art3.

Phylogenomic databases

eggNOGroNOG15561.
HOVERGENHBG006445.
InParanoidQ8R2G4.
OrthoDBEOG41JZCQ.

Gene expression databases

ArrayExpressQ8R2G4.
BgeeQ8R2G4.
CleanExMM_ART3.
GenevestigatorQ8R2G4.
GermOnlineENSMUSG00000034842. Mus musculus.

Family and domain databases

InterProIPR000768. ART.
[Graphical view]
KOK00775.
PANTHERPTHR10339. ART. 1 hit.
PfamPF01129. ART. 1 hit.
[Graphical view]
PRINTSPR00970. RIBTRNSFRASE.
ProtoNetSearch...

Other

NextBio363113.
SOURCESearch...

Entry information

Entry nameNAR3_MOUSE
AccessionPrimary (citable) accession number: Q8R2G4
Secondary accession number(s): B2RUC2 expand/collapse secondary AC list , O54738, Q8R2F9, Q8R2G0, Q8R2G1, Q8R2G2, Q8R2G3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: January 20, 2009
Last modified: November 16, 2011
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents