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Protein

Ecto-ADP-ribosyltransferase 3

Gene

Art3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011NADBy similarity
Binding sitei182 – 1821NADBy similarity
Active sitei228 – 2281By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-ADP-ribosyltransferase 3 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 3
Short name:
ARTC3
Mono(ADP-ribosyl)transferase 3
NAD(P)(+)--arginine ADP-ribosyltransferase 3
Gene namesi
Name:Art3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1202729. Art3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 345319Ecto-ADP-ribosyltransferase 3PRO_0000019327Add
BLAST
Propeptidei346 – 37126Removed in mature formBy similarityPRO_0000019328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 255By similarity
Lipidationi345 – 3451GPI-anchor amidated serineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ8R2G4.
PaxDbiQ8R2G4.
PRIDEiQ8R2G4.

Expressioni

Gene expression databases

BgeeiQ8R2G4.
CleanExiMM_ART3.
ExpressionAtlasiQ8R2G4. baseline and differential.
GenevisibleiQ8R2G4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108706.

Structurei

3D structure databases

ProteinModelPortaliQ8R2G4.
SMRiQ8R2G4. Positions 28-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8VA. Eukaryota.
ENOG411167J. LUCA.
GeneTreeiENSGT00530000062975.
HOVERGENiHBG006445.
InParanoidiQ8R2G4.
KOiK00775.
PhylomeDBiQ8R2G4.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 8 (identifier: Q8R2G4-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMGHFEMVT TLLAAAVLMD IFQVKAEVLD MAENAFDDEY LKCKSRMESK
60 70 80 90 100
YIPQMKREEW ANDALLRMVW DNAEIQWEAR KAQLFLPRNF KDTYGIALTA
110 120 130 140 150
YVNEAQEQTS FYHTFSSAVK MAGLSRRRYI YNFPFKAFHF YLVRALQLLR
160 170 180 190 200
RPCEKSYKTV VYSTSPDISF TFGEQNQARL GNFTLAYSAK PETADNQRVL
210 220 230 240 250
TIQTCFGVAV GKFLNKEDDS VVLIPLSEVF QVSRKGTSND LVLQSINSTC
260 270 280 290 300
SYYECAFLGG LKTENCIANA EYIDPRYLYN PDMDNQKLED SGRNNLDPDR
310 320 330 340 350
MPEIKVLQTE ENPLLPDEKP DRSRGKANNP TPGLVPGPKS HPSASSGNTL
360 370
LPSVMASTIL LVASAVNFIE L
Length:371
Mass (Da):42,015
Last modified:January 20, 2009 - v2
Checksum:i52F1B373A928182B
GO
Isoform 5 (identifier: Q8R2G4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-291: Missing.

Show »
Length:350
Mass (Da):39,414
Checksum:iB1F3BB4F6FD80415
GO
Isoform 7 (identifier: Q8R2G4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-331: DRSRGKANNPT → A

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):40,889
Checksum:i17386DF02015D673
GO

Sequence cautioni

The sequence CAC84526.1 differs from that shown.3'extension leads to out-of-frame translation.Curated
The sequence CAC84539.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAC84540.1 differs from that shown.3'extension leads to out-of-frame translation.Curated
The sequence CAC84541.1 differs from that shown.3'extension leads to out-of-frame translation.Curated
The sequence CAC84543.1 differs from that shown.3'extension leads to out-of-frame translation.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 155TLLAA → AAGS in CAA69284 (Ref. 2) Curated
Sequence conflicti348 – 3481Missing in AAI41070 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 29121Missing in isoform 5. 1 PublicationVSP_036193Add
BLAST
Alternative sequencei321 – 33111DRSRGKANNPT → A in isoform 7. 1 PublicationVSP_036199Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311768 Genomic DNA. Translation: CAC84539.1. Sequence problems.
AJ311769 mRNA. Translation: CAC84526.1. Sequence problems.
AJ311770 mRNA. Translation: CAC84540.1. Sequence problems.
AJ311771 mRNA. Translation: CAC84541.1. Sequence problems.
AJ311772 mRNA. Translation: CAC84542.1.
AJ311773 mRNA. Translation: CAC84543.1. Sequence problems.
Y08027 Genomic DNA. Translation: CAA69284.1.
BC141069 mRNA. Translation: AAI41070.1.
CCDSiCCDS51546.1. [Q8R2G4-8]
RefSeqiNP_001297594.1. NM_001310665.1. [Q8R2G4-7]
NP_859417.2. NM_181728.3. [Q8R2G4-8]
XP_006534780.1. XM_006534717.2. [Q8R2G4-5]
XP_006534781.1. XM_006534718.2. [Q8R2G4-8]
UniGeneiMm.263514.

Genome annotation databases

EnsembliENSMUST00000113083; ENSMUSP00000108706; ENSMUSG00000034842. [Q8R2G4-8]
ENSMUST00000119587; ENSMUSP00000112648; ENSMUSG00000034842. [Q8R2G4-7]
GeneIDi109979.
KEGGimmu:109979.
UCSCiuc008ycw.1. mouse. [Q8R2G4-5]
uc008ycy.2. mouse. [Q8R2G4-8]
uc008ydg.2. mouse. [Q8R2G4-7]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311768 Genomic DNA. Translation: CAC84539.1. Sequence problems.
AJ311769 mRNA. Translation: CAC84526.1. Sequence problems.
AJ311770 mRNA. Translation: CAC84540.1. Sequence problems.
AJ311771 mRNA. Translation: CAC84541.1. Sequence problems.
AJ311772 mRNA. Translation: CAC84542.1.
AJ311773 mRNA. Translation: CAC84543.1. Sequence problems.
Y08027 Genomic DNA. Translation: CAA69284.1.
BC141069 mRNA. Translation: AAI41070.1.
CCDSiCCDS51546.1. [Q8R2G4-8]
RefSeqiNP_001297594.1. NM_001310665.1. [Q8R2G4-7]
NP_859417.2. NM_181728.3. [Q8R2G4-8]
XP_006534780.1. XM_006534717.2. [Q8R2G4-5]
XP_006534781.1. XM_006534718.2. [Q8R2G4-8]
UniGeneiMm.263514.

3D structure databases

ProteinModelPortaliQ8R2G4.
SMRiQ8R2G4. Positions 28-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108706.

Proteomic databases

MaxQBiQ8R2G4.
PaxDbiQ8R2G4.
PRIDEiQ8R2G4.

Protocols and materials databases

DNASUi109979.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113083; ENSMUSP00000108706; ENSMUSG00000034842. [Q8R2G4-8]
ENSMUST00000119587; ENSMUSP00000112648; ENSMUSG00000034842. [Q8R2G4-7]
GeneIDi109979.
KEGGimmu:109979.
UCSCiuc008ycw.1. mouse. [Q8R2G4-5]
uc008ycy.2. mouse. [Q8R2G4-8]
uc008ydg.2. mouse. [Q8R2G4-7]

Organism-specific databases

CTDi419.
MGIiMGI:1202729. Art3.

Phylogenomic databases

eggNOGiENOG410J8VA. Eukaryota.
ENOG411167J. LUCA.
GeneTreeiENSGT00530000062975.
HOVERGENiHBG006445.
InParanoidiQ8R2G4.
KOiK00775.
PhylomeDBiQ8R2G4.
TreeFamiTF335356.

Miscellaneous databases

PROiQ8R2G4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R2G4.
CleanExiMM_ART3.
ExpressionAtlasiQ8R2G4. baseline and differential.
GenevisibleiQ8R2G4. MM.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
    Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
    Protein Sci. 11:1657-1670(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 5).
  2. "Molecular cloning of two ecto-mono(ADP-ribosyl)transferases operating in murine testis."
    Koch-Nolte F., Firner K., Haag F., Khl M., Thiele H.G.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 8).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Lung and Testis.

Entry informationi

Entry nameiNAR3_MOUSE
AccessioniPrimary (citable) accession number: Q8R2G4
Secondary accession number(s): B2RUC2
, O54738, Q8R2F9, Q8R2G0, Q8R2G1, Q8R2G2, Q8R2G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: January 20, 2009
Last modified: June 8, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.