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Protein

FAS-associated death domain protein

Gene

Fadd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.UniRule annotation

GO - Molecular functioni

  • caspase binding Source: Ensembl
  • death effector domain binding Source: Ensembl
  • death receptor binding Source: RGD
  • identical protein binding Source: Ensembl
  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • receptor serine/threonine kinase binding Source: RGD
  • tumor necrosis factor receptor binding Source: RGD

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotation, Immunity, Innate immunityUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-3371378. Regulation by c-FLIP.
R-RNO-5213460. RIPK1-mediated regulated necrosis.
R-RNO-5218900. CASP8 activity is inhibited.
R-RNO-5357786. TNFR1-induced proapoptotic signaling.
R-RNO-69416. Dimerization of procaspase-8.
R-RNO-75157. FasL/ CD95L signaling.
R-RNO-75158. TRAIL signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated death domain proteinUniRule annotation
Alternative name(s):
FAS-associating death domain-containing proteinUniRule annotation
Protein FADDUniRule annotation
Gene namesi
Name:FaddImported
Synonyms:faddImported
ORF Names:rCG_48606Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628700. Fadd.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000047035.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Casp8Q9JHX42EBI-4326723,EBI-4326675

GO - Molecular functioni

  • caspase binding Source: Ensembl
  • death effector domain binding Source: Ensembl
  • death receptor binding Source: RGD
  • identical protein binding Source: Ensembl
  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • receptor serine/threonine kinase binding Source: RGD
  • tumor necrosis factor receptor binding Source: RGD

Protein-protein interaction databases

IntActiQ8R2E7. 2 interactors.
STRINGi10116.ENSRNOP00000066289.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81DEDInterPro annotationAdd BLAST79
Domaini97 – 181DeathInterPro annotationAdd BLAST85

Phylogenomic databases

eggNOGiENOG410J0KM. Eukaryota.
ENOG41122TX. LUCA.
GeneTreeiENSGT00390000002105.
HOGENOMiHOG000112490.
HOVERGENiHBG000853.
KOiK02373.
OMAiCQMNLVA.
OrthoDBiEOG091G0SHT.
TreeFamiTF102046.

Family and domain databases

InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001875. DED_dom.
IPR016729. FADD.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF01335. DED. 1 hit.
PIRSFiPIRSF018586. FADD. 1 hit.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00031. DED. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS50168. DED. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R2E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFLVLLHS LSSSLSGNDL TDLKFLCRER VSKRKLERVQ SGLDLFSVLL
60 70 80 90 100
EQNDLERGHT GLLRELLASL GRHDLLQRLD DFEAGATTAA TPGEADLRVA
110 120 130 140 150
FDIVCDNVGR DWKRLARELK VSEAKIDGIE ERYPRSLSDR VRETLRVWKN
160 170 180 190 200
VEKENASVAG LVKALRACRL NLVADLVEEA LMAQGSVSKS DDTSSALRDS

TVSFSETP
Length:208
Mass (Da):23,124
Last modified:June 1, 2002 - v1
Checksum:iABA3305406137CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110851 Genomic DNA. No translation available.
AF406779 mRNA. Translation: AAN01113.1.
AJ441127 mRNA. Translation: CAD29628.1.
CH473953 Genomic DNA. Translation: EDM12244.1.
RefSeqiNP_690920.1. NM_152937.2.
UniGeneiRn.16183.

Genome annotation databases

EnsembliENSRNOT00000075089; ENSRNOP00000066289; ENSRNOG00000047035.
GeneIDi266610.
KEGGirno:266610.
UCSCiRGD:628700. rat.

Similar proteinsi

Entry informationi

Entry nameiQ8R2E7_RAT
AccessioniPrimary (citable) accession number: Q8R2E7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported