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Protein

FAS-associated death domain protein

Gene

Fadd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotation, Immunity, Innate immunityUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-3371378 Regulation by c-FLIP
R-RNO-5213460 RIPK1-mediated regulated necrosis
R-RNO-5218900 CASP8 activity is inhibited
R-RNO-5357786 TNFR1-induced proapoptotic signaling
R-RNO-69416 Dimerization of procaspase-8
R-RNO-75157 FasL/ CD95L signaling
R-RNO-75158 TRAIL signaling

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated death domain proteinUniRule annotation
Alternative name(s):
FAS-associating death domain-containing proteinUniRule annotation
Protein FADDUniRule annotation
Gene namesi
Name:FaddImported
Synonyms:faddImported
ORF Names:rCG_48606Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628700 Fadd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ8R2E7

Expressioni

Gene expression databases

BgeeiENSRNOG00000047035

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Casp8Q9JHX42EBI-4326723,EBI-4326675

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R2E7, 2 interactors
STRINGi10116.ENSRNOP00000066289

Structurei

3D structure databases

SMRiQ8R2E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81DEDInterPro annotationAdd BLAST79
Domaini97 – 181DeathInterPro annotationAdd BLAST85

Phylogenomic databases

eggNOGiENOG410J0KM Eukaryota
ENOG41122TX LUCA
GeneTreeiENSGT00390000002105
HOGENOMiHOG000112490
HOVERGENiHBG000853
KOiK02373
OMAiCQMNLVA
OrthoDBiEOG091G0SHT
TreeFamiTF102046

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001875 DED_dom
IPR016729 FADD
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF01335 DED, 1 hit
PIRSFiPIRSF018586 FADD, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50168 DED, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R2E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFLVLLHS LSSSLSGNDL TDLKFLCRER VSKRKLERVQ SGLDLFSVLL
60 70 80 90 100
EQNDLERGHT GLLRELLASL GRHDLLQRLD DFEAGATTAA TPGEADLRVA
110 120 130 140 150
FDIVCDNVGR DWKRLARELK VSEAKIDGIE ERYPRSLSDR VRETLRVWKN
160 170 180 190 200
VEKENASVAG LVKALRACRL NLVADLVEEA LMAQGSVSKS DDTSSALRDS

TVSFSETP
Length:208
Mass (Da):23,124
Last modified:June 1, 2002 - v1
Checksum:iABA3305406137CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110851 Genomic DNA No translation available.
AF406779 mRNA Translation: AAN01113.1
AJ441127 mRNA Translation: CAD29628.1
CH473953 Genomic DNA Translation: EDM12244.1
RefSeqiNP_690920.1, NM_152937.2
UniGeneiRn.16183

Genome annotation databases

EnsembliENSRNOT00000075089; ENSRNOP00000066289; ENSRNOG00000047035
GeneIDi266610
KEGGirno:266610
UCSCiRGD:628700 rat

Similar proteinsi

Entry informationi

Entry nameiQ8R2E7_RAT
AccessioniPrimary (citable) accession number: Q8R2E7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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