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Protein

FAS-associated death domain protein

Gene

Fadd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.UniRule annotation

GO - Molecular functioni

  • death receptor binding Source: RGD
  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • receptor serine/threonine kinase binding Source: RGD
  • tumor necrosis factor receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisUniRule annotation, Immunity, Innate immunityUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-3371378. Regulation by c-FLIP.
R-RNO-5213460. RIPK1-mediated regulated necrosis.
R-RNO-5218900. CASP8 activity is inhibited.
R-RNO-5357786. TNFR1-induced proapoptotic signaling.
R-RNO-69416. Dimerization of procaspase-8.
R-RNO-75157. FasL/ CD95L signaling.
R-RNO-75158. TRAIL signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated death domain proteinUniRule annotation
Alternative name(s):
FAS-associating death domain-containing proteinUniRule annotation
Protein FADDUniRule annotation
Gene namesi
Name:FaddImported
Synonyms:faddImported
ORF Names:rCG_48606Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628700. Fadd.

Subcellular locationi

GO - Cellular componenti

  • CD95 death-inducing signaling complex Source: RGD
  • cell body Source: RGD
  • cytoplasm Source: RGD
  • death-inducing signaling complex Source: RGD
  • membrane raft Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
  • protein complex Source: RGD
  • ripoptosome Source: UniProtKB
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSRNOG00000047035.

Interactioni

GO - Molecular functioni

  • death receptor binding Source: RGD
  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • receptor serine/threonine kinase binding Source: RGD
  • tumor necrosis factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066289.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81DED (death effector)InterPro annotationAdd BLAST79
Domaini97 – 181DeathInterPro annotationAdd BLAST85

Phylogenomic databases

eggNOGiENOG410J0KM. Eukaryota.
ENOG41122TX. LUCA.
GeneTreeiENSGT00390000002105.
HOGENOMiHOG000112490.
HOVERGENiHBG000853.
KOiK02373.
OMAiCQMNLVA.
OrthoDBiEOG091G0SHT.
TreeFamiTF102046.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001875. DED_dom.
IPR016729. FADD.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF01335. DED. 1 hit.
[Graphical view]
PIRSFiPIRSF018586. FADD. 1 hit.
SMARTiSM00005. DEATH. 1 hit.
SM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50168. DED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R2E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFLVLLHS LSSSLSGNDL TDLKFLCRER VSKRKLERVQ SGLDLFSVLL
60 70 80 90 100
EQNDLERGHT GLLRELLASL GRHDLLQRLD DFEAGATTAA TPGEADLRVA
110 120 130 140 150
FDIVCDNVGR DWKRLARELK VSEAKIDGIE ERYPRSLSDR VRETLRVWKN
160 170 180 190 200
VEKENASVAG LVKALRACRL NLVADLVEEA LMAQGSVSKS DDTSSALRDS

TVSFSETP
Length:208
Mass (Da):23,124
Last modified:June 1, 2002 - v1
Checksum:iABA3305406137CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110851 Genomic DNA. No translation available.
AF406779 mRNA. Translation: AAN01113.1.
AJ441127 mRNA. Translation: CAD29628.1.
CH473953 Genomic DNA. Translation: EDM12244.1.
RefSeqiNP_690920.1. NM_152937.2.
UniGeneiRn.16183.

Genome annotation databases

EnsembliENSRNOT00000075089; ENSRNOP00000066289; ENSRNOG00000047035.
GeneIDi266610.
KEGGirno:266610.
UCSCiRGD:628700. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110851 Genomic DNA. No translation available.
AF406779 mRNA. Translation: AAN01113.1.
AJ441127 mRNA. Translation: CAD29628.1.
CH473953 Genomic DNA. Translation: EDM12244.1.
RefSeqiNP_690920.1. NM_152937.2.
UniGeneiRn.16183.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075089; ENSRNOP00000066289; ENSRNOG00000047035.
GeneIDi266610.
KEGGirno:266610.
UCSCiRGD:628700. rat.

Organism-specific databases

CTDi8772.
RGDi628700. Fadd.

Phylogenomic databases

eggNOGiENOG410J0KM. Eukaryota.
ENOG41122TX. LUCA.
GeneTreeiENSGT00390000002105.
HOGENOMiHOG000112490.
HOVERGENiHBG000853.
KOiK02373.
OMAiCQMNLVA.
OrthoDBiEOG091G0SHT.
TreeFamiTF102046.

Enzyme and pathway databases

ReactomeiR-RNO-3371378. Regulation by c-FLIP.
R-RNO-5213460. RIPK1-mediated regulated necrosis.
R-RNO-5218900. CASP8 activity is inhibited.
R-RNO-5357786. TNFR1-induced proapoptotic signaling.
R-RNO-69416. Dimerization of procaspase-8.
R-RNO-75157. FasL/ CD95L signaling.
R-RNO-75158. TRAIL signaling.

Gene expression databases

BgeeiENSRNOG00000047035.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001875. DED_dom.
IPR016729. FADD.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF01335. DED. 1 hit.
[Graphical view]
PIRSFiPIRSF018586. FADD. 1 hit.
SMARTiSM00005. DEATH. 1 hit.
SM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50168. DED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8R2E7_RAT
AccessioniPrimary (citable) accession number: Q8R2E7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.