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Protein

Di-N-acetylchitobiase

Gene

Ctbs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Di-N-acetylchitobiase (EC:3.2.1.-)
Gene namesi
Name:Ctbs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1921495 Ctbs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001196223 – 366Di-N-acetylchitobiaseAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8R242
PeptideAtlasiQ8R242
PRIDEiQ8R242

PTM databases

PhosphoSitePlusiQ8R242

Expressioni

Gene expression databases

BgeeiENSMUSG00000028189
CleanExiMM_CTBS
ExpressionAtlasiQ8R242 baseline and differential
GenevisibleiQ8R242 MM

Interactioni

Protein-protein interaction databases

IntActiQ8R242, 1 interactor
MINTiQ8R242

Structurei

3D structure databases

ProteinModelPortaliQ8R242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000012891
HOGENOMiHOG000007829
HOVERGENiHBG005486
InParanoidiQ8R242
KOiK12310
OMAiANCLDYS
OrthoDBiEOG091G0CA1
PhylomeDBiQ8R242
TreeFamiTF332677

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
PROSITEiView protein in PROSITE
PS01095 CHITINASE_18, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALCGLPEFT LLLLPLLARL SAGDCPCSEA ALCQPIRHRP DFEVFVFDVG
60 70 80 90 100
QKTWKSYDWS QITTVAAFGK YDPELMCYAH SKGARVVLKG DISLKNIIDP
110 120 130 140 150
TFRASWIAQK VDLAKAQYMD GINIDIEQEV NCSSPEYEAL TALVKETTES
160 170 180 190 200
FQREIEGSQV TFDVAWSPKR IDKRCYNYTG IADACDFLFV MSYDEQSQIW
210 220 230 240 250
SECIAAANAP YNQTLTGYID YIKMGISPKK LVMGVPWYGY DYICLNLSKD
260 270 280 290 300
DICTITKVPF RGAPCSDAAG HQVPYKVIMK QVNGSVSGSQ WNKDQQAPYY
310 320 330 340 350
NYKDPAGRFH QVWYDNPQSI SLKAAYVKNY GLRGIGMWNA NCLDYSDDAL
360
AREQTQEMWG ALKPRL
Length:366
Mass (Da):41,295
Last modified:June 7, 2005 - v2
Checksum:i1075F6EAD7AD024A
GO
Isoform 2 (identifier: Q8R242-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-304: Missing.

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):35,307
Checksum:iA0B75A7C0F5BB512
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013909251 – 304Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008791 mRNA Translation: BAB25896.1
AC124987 Genomic DNA No translation available.
BC022594 mRNA Translation: AAH22594.1
CCDSiCCDS17902.1 [Q8R242-2]
CCDS80048.1 [Q8R242-1]
RefSeqiNP_001280601.1, NM_001293672.1 [Q8R242-1]
NP_083112.1, NM_028836.4 [Q8R242-2]
UniGeneiMm.45396

Genome annotation databases

EnsembliENSMUST00000029840; ENSMUSP00000029840; ENSMUSG00000028189 [Q8R242-2]
ENSMUST00000061937; ENSMUSP00000059167; ENSMUSG00000028189 [Q8R242-1]
GeneIDi74245
KEGGimmu:74245
UCSCiuc008rrg.2 mouse [Q8R242-2]
uc008rrh.2 mouse [Q8R242-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDIAC_MOUSE
AccessioniPrimary (citable) accession number: Q8R242
Secondary accession number(s): Q9D7V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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