Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine dehydratase-like

Gene

Sdsl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has low serine dehydratase and threonine dehydratase activity.By similarity

Catalytic activityi

L-serine = pyruvate + NH3.
L-threonine = 2-oxobutanoate + NH3.

Cofactori

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Serine dehydratase-like (EC:4.3.1.17)
Alternative name(s):
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase (EC:4.3.1.19)
Short name:
TDH
SDH
Gene namesi
Name:Sdsl
Synonyms:Sds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2182607. Sdsl.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Serine dehydratase-likePRO_0000264625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei48 – 481N6-(pyridoxal phosphate)lysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R238.
PaxDbiQ8R238.
PeptideAtlasiQ8R238.
PRIDEiQ8R238.

PTM databases

iPTMnetiQ8R238.
PhosphoSiteiQ8R238.

Expressioni

Tissue specificityi

Abundantly expressed in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000029596.
CleanExiMM_SDS.
MM_SDSL.
ExpressionAtlasiQ8R238. baseline and differential.
GenevisibleiQ8R238. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8R238. 2 interactions.
MINTiMINT-4118714.
STRINGi10090.ENSMUSP00000031594.

Structurei

3D structure databases

ProteinModelPortaliQ8R238.
SMRiQ8R238. Positions 12-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1250. Eukaryota.
COG1171. LUCA.
GeneTreeiENSGT00550000074775.
HOGENOMiHOG000046976.
HOVERGENiHBG017784.
InParanoidiQ8R238.
KOiK17989.
OMAiKCENMQP.
OrthoDBiEOG091G0FCF.
PhylomeDBiQ8R238.
TreeFamiTF329014.

Family and domain databases

InterProiIPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGALAERVG AEPFHRVTPL LESWALSQVA GMPVFLKYEN VQIAGSFKIR
60 70 80 90 100
GIGHFCQQMA KRGCRHLVCS SGGNAGIAAA YSARKLGIPV TIVLPEGTSV
110 120 130 140 150
QVVRRLEGEG AEVQLTGKVW DEANVKAQEL ATRDGWVNVS PFDHPLIWEG
160 170 180 190 200
HASLVRELKE SLGTPPGAVV LAVGGGGLLA GVTAGLLEVG WQHVPIVAME
210 220 230 240 250
TRGAHSFNSA LQAGRPVTLP DITSVAKSLG AKTVAARTLE CAKECEVLSE
260 270 280 290 300
VVEDREAVSA VQRFLDDERM LVEPACGAAL AAIYSGILWR LQAEGRLSSA
310 320
LASVVVIVCG GNNISSQQLQ ELKIQLGCS
Length:329
Mass (Da):34,732
Last modified:June 1, 2002 - v1
Checksum:iA2F7FB869350B43B
GO

Sequence cautioni

The sequence AAL56988 differs from that shown. Reason: Frameshift at positions 324 and 328. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328927 mRNA. Translation: AAL56988.1. Frameshift.
BC022601 mRNA. Translation: AAH22601.1.
CCDSiCCDS19618.1.
RefSeqiNP_598663.2. NM_133902.2.
XP_011246505.1. XM_011248203.1.
UniGeneiMm.5162.

Genome annotation databases

EnsembliENSMUST00000031594; ENSMUSP00000031594; ENSMUSG00000029596.
ENSMUST00000052258; ENSMUSP00000058198; ENSMUSG00000029596.
GeneIDi257635.
KEGGimmu:257635.
UCSCiuc008zhe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328927 mRNA. Translation: AAL56988.1. Frameshift.
BC022601 mRNA. Translation: AAH22601.1.
CCDSiCCDS19618.1.
RefSeqiNP_598663.2. NM_133902.2.
XP_011246505.1. XM_011248203.1.
UniGeneiMm.5162.

3D structure databases

ProteinModelPortaliQ8R238.
SMRiQ8R238. Positions 12-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R238. 2 interactions.
MINTiMINT-4118714.
STRINGi10090.ENSMUSP00000031594.

PTM databases

iPTMnetiQ8R238.
PhosphoSiteiQ8R238.

Proteomic databases

MaxQBiQ8R238.
PaxDbiQ8R238.
PeptideAtlasiQ8R238.
PRIDEiQ8R238.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031594; ENSMUSP00000031594; ENSMUSG00000029596.
ENSMUST00000052258; ENSMUSP00000058198; ENSMUSG00000029596.
GeneIDi257635.
KEGGimmu:257635.
UCSCiuc008zhe.1. mouse.

Organism-specific databases

CTDi113675.
MGIiMGI:2182607. Sdsl.

Phylogenomic databases

eggNOGiKOG1250. Eukaryota.
COG1171. LUCA.
GeneTreeiENSGT00550000074775.
HOGENOMiHOG000046976.
HOVERGENiHBG017784.
InParanoidiQ8R238.
KOiK17989.
OMAiKCENMQP.
OrthoDBiEOG091G0FCF.
PhylomeDBiQ8R238.
TreeFamiTF329014.

Miscellaneous databases

ChiTaRSiSdsl. mouse.
PROiQ8R238.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029596.
CleanExiMM_SDS.
MM_SDSL.
ExpressionAtlasiQ8R238. baseline and differential.
GenevisibleiQ8R238. MM.

Family and domain databases

InterProiIPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSDSL_MOUSE
AccessioniPrimary (citable) accession number: Q8R238
Secondary accession number(s): Q8VI05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.