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Protein

Serine dehydratase-like

Gene

Sdsl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has low serine dehydratase and threonine dehydratase activity.By similarity

Catalytic activityi

L-serine = pyruvate + NH3.
L-threonine = 2-oxobutanoate + NH3.

Cofactori

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-MMU-8849175 Threonine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine dehydratase-like (EC:4.3.1.17)
Alternative name(s):
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase (EC:4.3.1.19)
Short name:
TDH
SDH
Gene namesi
Name:Sdsl
Synonyms:Sds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2182607 Sdsl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646251 – 329Serine dehydratase-likeAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei48N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R238
PaxDbiQ8R238
PeptideAtlasiQ8R238
PRIDEiQ8R238

PTM databases

iPTMnetiQ8R238
PhosphoSitePlusiQ8R238

Expressioni

Tissue specificityi

Abundantly expressed in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000029596
CleanExiMM_SDS
MM_SDSL
ExpressionAtlasiQ8R238 baseline and differential
GenevisibleiQ8R238 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R238, 2 interactors
MINTiQ8R238
STRINGi10090.ENSMUSP00000031594

Structurei

3D structure databases

ProteinModelPortaliQ8R238
SMRiQ8R238
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1250 Eukaryota
COG1171 LUCA
GeneTreeiENSGT00550000074775
HOGENOMiHOG000046976
HOVERGENiHBG017784
InParanoidiQ8R238
KOiK17989
OMAiGCRHLVC
OrthoDBiEOG091G0FCF
PhylomeDBiQ8R238
TreeFamiTF329014

Family and domain databases

InterProiView protein in InterPro
IPR001926 PLP-dep
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGALAERVG AEPFHRVTPL LESWALSQVA GMPVFLKYEN VQIAGSFKIR
60 70 80 90 100
GIGHFCQQMA KRGCRHLVCS SGGNAGIAAA YSARKLGIPV TIVLPEGTSV
110 120 130 140 150
QVVRRLEGEG AEVQLTGKVW DEANVKAQEL ATRDGWVNVS PFDHPLIWEG
160 170 180 190 200
HASLVRELKE SLGTPPGAVV LAVGGGGLLA GVTAGLLEVG WQHVPIVAME
210 220 230 240 250
TRGAHSFNSA LQAGRPVTLP DITSVAKSLG AKTVAARTLE CAKECEVLSE
260 270 280 290 300
VVEDREAVSA VQRFLDDERM LVEPACGAAL AAIYSGILWR LQAEGRLSSA
310 320
LASVVVIVCG GNNISSQQLQ ELKIQLGCS
Length:329
Mass (Da):34,732
Last modified:June 1, 2002 - v1
Checksum:iA2F7FB869350B43B
GO

Sequence cautioni

The sequence AAL56988 differs from that shown. Reason: Frameshift at positions 324 and 328.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328927 mRNA Translation: AAL56988.1 Frameshift.
BC022601 mRNA Translation: AAH22601.1
CCDSiCCDS19618.1
RefSeqiNP_598663.2, NM_133902.2
XP_011246504.2, XM_011248202.2
XP_011246505.1, XM_011248203.2
UniGeneiMm.5162

Genome annotation databases

EnsembliENSMUST00000031594; ENSMUSP00000031594; ENSMUSG00000029596
ENSMUST00000052258; ENSMUSP00000058198; ENSMUSG00000029596
GeneIDi257635
KEGGimmu:257635
UCSCiuc008zhe.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSDSL_MOUSE
AccessioniPrimary (citable) accession number: Q8R238
Secondary accession number(s): Q8VI05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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