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Protein

Protein phosphatase 1 regulatory subunit 42

Gene

Ppp1r42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • dynein complex binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

GO - Biological processi

  • regulation of phosphatase activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 42
Alternative name(s):
Leucine-rich repeat-containing protein 67
Testis leucine-rich repeat protein
Short name:
TLRR
Gene namesi
Name:Ppp1r42
Synonyms:Lrrc67
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921138. Ppp1r42.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261771 – 357Protein phosphatase 1 regulatory subunit 42Add BLAST357

Post-translational modificationi

Phosphorylated; during the first round of spermatogenesis with a marginal increase at 21 days after birth.1 Publication

Proteomic databases

PaxDbiQ8R1Z4.
PRIDEiQ8R1Z4.

PTM databases

iPTMnetiQ8R1Z4.
PhosphoSitePlusiQ8R1Z4.

Expressioni

Tissue specificityi

Testis-specific. Expressed in spermatids (at protein level). Testis-specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000025916.
ExpressionAtlasiQ8R1Z4. baseline and differential.
GenevisibleiQ8R1Z4. MM.

Interactioni

Subunit structurei

Interacts with PPP1CC isoform gamma-2; the interaction is direct. Interacts with actin, dynein, KIF5B, KIFC1 and tubulin. Associates with microtubules.3 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • dynein complex binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027049.

Structurei

3D structure databases

ProteinModelPortaliQ8R1Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 50LRR 1Add BLAST22
Repeati51 – 72LRR 2Add BLAST22
Repeati73 – 94LRR 3Add BLAST22
Repeati95 – 116LRR 4Add BLAST22
Repeati117 – 138LRR 5Add BLAST22
Repeati147 – 168LRR 6Add BLAST22
Repeati169 – 190LRR 7Add BLAST22
Domaini204 – 242LRRCTAdd BLAST39

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2769. Eukaryota.
ENOG410XQV0. LUCA.
GeneTreeiENSGT00910000144294.
HOGENOMiHOG000068029.
HOVERGENiHBG061602.
InParanoidiQ8R1Z4.
KOiK17579.
OMAiLYLYDNC.
OrthoDBiEOG091G09ZV.
PhylomeDBiQ8R1Z4.
TreeFamiTF329227.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR032675. LRR_dom_sf.
PfamiView protein in Pfam
PF12799. LRR_4. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 6 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R1Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRLTVDLIA KNSNLKPRKE ETLAQCLKKI THINFSDRNI DSIDDLSLCR
60 70 80 90 100
NLSVLYLYDN RISQVTNLNY TTNLTHLYLQ NNCISCIENL SSLKKLEKLY
110 120 130 140 150
LGGNYIAVIE GLEGLEELRE LHVESQRLPL GEKLLFDPRT LRSLAKSLST
160 170 180 190 200
LNISNNNIDD IKDLEILENL NHLIAVDNQL MHVKDLELLL KKLMKLWKMD
210 220 230 240 250
LNGNPVCLKP KYRDKLILTS KSLEFLDGKE IKDMERQFLM NWKASKDAKK
260 270 280 290 300
ISKKRRSRSE DASNSYISNF ETVHHIVPVY YPQVGKPKVI FFSDVQRYLV
310 320 330 340 350
HGNASSKCSQ EDKTTITEDI GNLSLKESES SLTKNDIHEP HLLQNPKVKE

NLSEKKE
Length:357
Mass (Da):41,151
Last modified:June 1, 2002 - v1
Checksum:i46C5A57D53A604E1
GO
Isoform 2 (identifier: Q8R1Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-186: DL → VT
     187-357: Missing.

Show »
Length:186
Mass (Da):21,289
Checksum:iAF2991E547B8458F
GO
Isoform 3 (identifier: Q8R1Z4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-357: Missing.

Show »
Length:145
Mass (Da):16,663
Checksum:iF587814771732FA5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032589146 – 357Missing in isoform 3. 1 PublicationAdd BLAST212
Alternative sequenceiVSP_032590185 – 186DL → VT in isoform 2. 1 Publication2
Alternative sequenceiVSP_032591187 – 357Missing in isoform 2. 1 PublicationAdd BLAST171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005871 mRNA. Translation: BAB24290.1.
AK015164 mRNA. Translation: BAB29732.1.
AK076637 mRNA. Translation: BAC36427.1.
BC022722 mRNA. Translation: AAH22722.1.
CCDSiCCDS14817.1. [Q8R1Z4-1]
RefSeqiNP_663730.1. NM_145692.2. [Q8R1Z4-1]
UniGeneiMm.386795.

Genome annotation databases

EnsembliENSMUST00000027049; ENSMUSP00000027049; ENSMUSG00000025916. [Q8R1Z4-1]
ENSMUST00000130102; ENSMUSP00000115030; ENSMUSG00000025916. [Q8R1Z4-3]
GeneIDi69312.
KEGGimmu:69312.
UCSCiuc007ahb.2. mouse. [Q8R1Z4-1]
uc007ahd.2. mouse. [Q8R1Z4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPPR42_MOUSE
AccessioniPrimary (citable) accession number: Q8R1Z4
Secondary accession number(s): Q9D5M1, Q9DAF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome