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Q8R1W8

- IMPG1_MOUSE

UniProt

Q8R1W8 - IMPG1_MOUSE

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Protein

Interphotoreceptor matrix proteoglycan 1

Gene

Impg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.By similarity

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Interphotoreceptor matrix proteoglycan 1
Alternative name(s):
Interphotoreceptor matrix proteoglycan of 150 kDa
Short name:
IPM-150
Sialoprotein associated with cones and rods
Gene namesi
Name:Impg1Imported
Synonyms:Spacr1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1926876. Impg1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 798778Interphotoreceptor matrix proteoglycan 1Sequence AnalysisPRO_0000252239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741O-linked (GalNAc...)Sequence Analysis
Glycosylationi186 – 1861O-linked (GalNAc...)Sequence Analysis
Glycosylationi457 – 4571O-linked (GalNAc...)Sequence Analysis
Glycosylationi473 – 4731O-linked (GalNAc...)Sequence Analysis
Glycosylationi474 – 4741O-linked (GalNAc...)Sequence Analysis
Glycosylationi477 – 4771O-linked (GalNAc...)Sequence Analysis
Glycosylationi559 – 5591O-linked (GalNAc...)Sequence Analysis
Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Highly glycosylated (N- and O-linked carbohydrates and sialic acid).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R1W8.
PRIDEiQ8R1W8.

PTM databases

PhosphoSiteiQ8R1W8.

Expressioni

Tissue specificityi

Abundantly expressed in retina.2 Publications

Gene expression databases

BgeeiQ8R1W8.
CleanExiMM_IMPG1.
GenevestigatoriQ8R1W8.

Structurei

3D structure databases

ProteinModelPortaliQ8R1W8.
SMRiQ8R1W8. Positions 579-635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 357123SEA 1PROSITE-ProRule annotationAdd
BLAST
Domaini575 – 688114SEA 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 SEA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG73774.
GeneTreeiENSGT00530000063503.
HOGENOMiHOG000113063.
HOVERGENiHBG081793.
InParanoidiQ8R1W8.
OMAiQMQKVFK.
OrthoDBiEOG7TXKFR.
PhylomeDBiQ8R1W8.
TreeFamiTF331340.

Family and domain databases

Gene3Di3.30.70.960. 2 hits.
InterProiIPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 2 hits.
[Graphical view]
SMARTiSM00200. SEA. 2 hits.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 2 hits.
PROSITEiPS50024. SEA. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 12 Publications (identifier: Q8R1W8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLQIKHAIF VLGIFLQVQG IKDTSIKIFS SEIKNIDKTP RIETIESTST
60 70 80 90 100
VHKVSTMKRI FDLPKLRTKR SALFPAANIC PQESLRQILA SLQEYYRLRV
110 120 130 140 150
CQEVVWEAYR IFLDRIPDTE EYQDWVSLCQ KETFCLFDIG KNFSNSQEHL
160 170 180 190 200
DLLQQRIKQR SFPGRKDETA SMETLEAPTE APVVPTDVSR MSLGPFPLPS
210 220 230 240 250
DDTDLKEILS VTLKDIQKPT TESKTEPIHV SEFSSEEKVE FSISLPNHRF
260 270 280 290 300
KAELTNSGSP YYQELVGQSQ LQLQKIFKKL PGFGEIRVLG FRPKKEEDGS
310 320 330 340 350
SSTEIQLMAI FKRDHAEAKS PDSHLLSLDS NKIESERIHH GVIEDKQPET
360 370 380 390 400
YLTATDLKKL IIQLLDGDLS LVEGKIPFGD EVTGTLFRPV TEPDLPKPLA
410 420 430 440 450
DVTEDATLSP ELPFVEPRLE AVDREGSELP GMSSKDSSWS PPVSASISRS
460 470 480 490 500
ENLPSFTPSI FSLDAQSPPP LMTTGPTALI PKPTLPTIDY STIRQLPLES
510 520 530 540 550
SHWPASSSDR ELITSSHDTI RDLDGMDVSD TPALSEISEL SGYDSASGQF
560 570 580 590 600
LEMTTPIPTV RFITTSSETI ATKGQELVVF FSLRVANMPF SYDLFNKSSL
610 620 630 640 650
EYQALEQRFT DLLVPYLRSN LTGFKQLEIL SFRNGSVIVN SKVRFAKAVP
660 670 680 690 700
YNLTQAVRGV LEDLRSTAAQ GLNLEIESYS LDIEPADQAD PCKLLDCGKF
710 720 730 740 750
AQCVKNEWTE EAECRCRQGH ESHGTLDYQT LNLCPPGKTC VAGREQATPC
760 770 780 790
RPPDHSTNQA QEPGVKKLRQ QNKVVKKRNS KLSAIGFEEF EDQDWEGN
Length:798
Mass (Da):89,474
Last modified:June 1, 2002 - v1
Checksum:iE875FB5587389D4C
GO
Isoform 21 Publication (identifier: Q8R1W8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:742
Mass (Da):83,193
Checksum:i73BDF075786A9B61
GO
Isoform 31 Publication (identifier: Q8R1W8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-99: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:721
Mass (Da):80,568
Checksum:i5EA086C3CDD59DD7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31L → F in AAG00796. (PubMed:10958699)Curated
Sequence conflicti12 – 121L → F in AAG00796. (PubMed:10958699)Curated
Sequence conflicti224 – 2241K → I in AAG32162. (PubMed:10995555)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5656Missing in isoform 2. 1 PublicationVSP_052171Add
BLAST
Alternative sequencei23 – 9977Missing in isoform 3. 1 PublicationVSP_052172Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229929 mRNA. Translation: AAG32162.1.
AF266478 mRNA. Translation: AAG00796.1.
BC022970 mRNA. Translation: AAH22970.1.
AK020862 mRNA. Translation: BAB32231.3.
CCDSiCCDS57685.1. [Q8R1W8-1]
RefSeqiNP_071299.3. NM_022016.3. [Q8R1W8-1]
XP_006511391.1. XM_006511328.1. [Q8R1W8-1]
UniGeneiMm.422780.

Genome annotation databases

EnsembliENSMUST00000085289; ENSMUSP00000082395; ENSMUSG00000032343. [Q8R1W8-3]
ENSMUST00000113250; ENSMUSP00000108876; ENSMUSG00000032343. [Q8R1W8-1]
ENSMUST00000185068; ENSMUSP00000139151; ENSMUSG00000032343.
GeneIDi63859.
KEGGimmu:63859.
UCSCiuc009qvi.2. mouse. [Q8R1W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229929 mRNA. Translation: AAG32162.1 .
AF266478 mRNA. Translation: AAG00796.1 .
BC022970 mRNA. Translation: AAH22970.1 .
AK020862 mRNA. Translation: BAB32231.3 .
CCDSi CCDS57685.1. [Q8R1W8-1 ]
RefSeqi NP_071299.3. NM_022016.3. [Q8R1W8-1 ]
XP_006511391.1. XM_006511328.1. [Q8R1W8-1 ]
UniGenei Mm.422780.

3D structure databases

ProteinModelPortali Q8R1W8.
SMRi Q8R1W8. Positions 579-635.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R1W8.

Proteomic databases

PaxDbi Q8R1W8.
PRIDEi Q8R1W8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085289 ; ENSMUSP00000082395 ; ENSMUSG00000032343 . [Q8R1W8-3 ]
ENSMUST00000113250 ; ENSMUSP00000108876 ; ENSMUSG00000032343 . [Q8R1W8-1 ]
ENSMUST00000185068 ; ENSMUSP00000139151 ; ENSMUSG00000032343 .
GeneIDi 63859.
KEGGi mmu:63859.
UCSCi uc009qvi.2. mouse. [Q8R1W8-1 ]

Organism-specific databases

CTDi 3617.
MGIi MGI:1926876. Impg1.

Phylogenomic databases

eggNOGi NOG73774.
GeneTreei ENSGT00530000063503.
HOGENOMi HOG000113063.
HOVERGENi HBG081793.
InParanoidi Q8R1W8.
OMAi QMQKVFK.
OrthoDBi EOG7TXKFR.
PhylomeDBi Q8R1W8.
TreeFami TF331340.

Miscellaneous databases

NextBioi 319787.
PROi Q8R1W8.
SOURCEi Search...

Gene expression databases

Bgeei Q8R1W8.
CleanExi MM_IMPG1.
Genevestigatori Q8R1W8.

Family and domain databases

Gene3Di 3.30.70.960. 2 hits.
InterProi IPR000082. SEA_dom.
[Graphical view ]
Pfami PF01390. SEA. 2 hits.
[Graphical view ]
SMARTi SM00200. SEA. 2 hits.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 2 hits.
PROSITEi PS50024. SEA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SPACR in the interphotoreceptor matrix of the mouse retina: molecular, biochemical and immunohistochemical characterization."
    Lee J.W., Chen Q., Rayborn M.E., Shadrach K.G., Crabb J.W., Rodriguez I.R., Hollyfield J.G.
    Exp. Eye Res. 71:341-352(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  2. "Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150."
    Kuehn M.H., Wietecki D.T., Hageman G.S.
    Mol. Vis. 6:148-156(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: EyeImported.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-293 (ISOFORM 3).
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.

Entry informationi

Entry nameiIMPG1_MOUSE
AccessioniPrimary (citable) accession number: Q8R1W8
Secondary accession number(s): Q9CTP8, Q9ES62, Q9ET31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3