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Q8R1W8

- IMPG1_MOUSE

UniProt

Q8R1W8 - IMPG1_MOUSE

Protein

Interphotoreceptor matrix proteoglycan 1

Gene

Impg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.By similarity

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Sialic acid

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interphotoreceptor matrix proteoglycan 1
    Alternative name(s):
    Interphotoreceptor matrix proteoglycan of 150 kDa
    Short name:
    IPM-150
    Sialoprotein associated with cones and rods
    Gene namesi
    Name:Impg1Imported
    Synonyms:Spacr1 Publication
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1926876. Impg1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 798778Interphotoreceptor matrix proteoglycan 1Sequence AnalysisPRO_0000252239Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741O-linked (GalNAc...)Sequence Analysis
    Glycosylationi186 – 1861O-linked (GalNAc...)Sequence Analysis
    Glycosylationi457 – 4571O-linked (GalNAc...)Sequence Analysis
    Glycosylationi473 – 4731O-linked (GalNAc...)Sequence Analysis
    Glycosylationi474 – 4741O-linked (GalNAc...)Sequence Analysis
    Glycosylationi477 – 4771O-linked (GalNAc...)Sequence Analysis
    Glycosylationi559 – 5591O-linked (GalNAc...)Sequence Analysis
    Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Highly glycosylated (N- and O-linked carbohydrates and sialic acid).By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8R1W8.
    PRIDEiQ8R1W8.

    PTM databases

    PhosphoSiteiQ8R1W8.

    Expressioni

    Tissue specificityi

    Abundantly expressed in retina.2 Publications

    Gene expression databases

    BgeeiQ8R1W8.
    CleanExiMM_IMPG1.
    GenevestigatoriQ8R1W8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R1W8.
    SMRiQ8R1W8. Positions 579-635.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini235 – 357123SEA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini575 – 688114SEA 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 SEA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG73774.
    GeneTreeiENSGT00530000063503.
    HOGENOMiHOG000113063.
    HOVERGENiHBG081793.
    InParanoidiQ8R1W8.
    OMAiQMQKVFK.
    OrthoDBiEOG7TXKFR.
    PhylomeDBiQ8R1W8.
    TreeFamiTF331340.

    Family and domain databases

    Gene3Di3.30.70.960. 2 hits.
    InterProiIPR000082. SEA_dom.
    [Graphical view]
    PfamiPF01390. SEA. 2 hits.
    [Graphical view]
    SMARTiSM00200. SEA. 2 hits.
    [Graphical view]
    SUPFAMiSSF82671. SSF82671. 2 hits.
    PROSITEiPS50024. SEA. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 12 Publications (identifier: Q8R1W8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNLQIKHAIF VLGIFLQVQG IKDTSIKIFS SEIKNIDKTP RIETIESTST    50
    VHKVSTMKRI FDLPKLRTKR SALFPAANIC PQESLRQILA SLQEYYRLRV 100
    CQEVVWEAYR IFLDRIPDTE EYQDWVSLCQ KETFCLFDIG KNFSNSQEHL 150
    DLLQQRIKQR SFPGRKDETA SMETLEAPTE APVVPTDVSR MSLGPFPLPS 200
    DDTDLKEILS VTLKDIQKPT TESKTEPIHV SEFSSEEKVE FSISLPNHRF 250
    KAELTNSGSP YYQELVGQSQ LQLQKIFKKL PGFGEIRVLG FRPKKEEDGS 300
    SSTEIQLMAI FKRDHAEAKS PDSHLLSLDS NKIESERIHH GVIEDKQPET 350
    YLTATDLKKL IIQLLDGDLS LVEGKIPFGD EVTGTLFRPV TEPDLPKPLA 400
    DVTEDATLSP ELPFVEPRLE AVDREGSELP GMSSKDSSWS PPVSASISRS 450
    ENLPSFTPSI FSLDAQSPPP LMTTGPTALI PKPTLPTIDY STIRQLPLES 500
    SHWPASSSDR ELITSSHDTI RDLDGMDVSD TPALSEISEL SGYDSASGQF 550
    LEMTTPIPTV RFITTSSETI ATKGQELVVF FSLRVANMPF SYDLFNKSSL 600
    EYQALEQRFT DLLVPYLRSN LTGFKQLEIL SFRNGSVIVN SKVRFAKAVP 650
    YNLTQAVRGV LEDLRSTAAQ GLNLEIESYS LDIEPADQAD PCKLLDCGKF 700
    AQCVKNEWTE EAECRCRQGH ESHGTLDYQT LNLCPPGKTC VAGREQATPC 750
    RPPDHSTNQA QEPGVKKLRQ QNKVVKKRNS KLSAIGFEEF EDQDWEGN 798
    Length:798
    Mass (Da):89,474
    Last modified:June 1, 2002 - v1
    Checksum:iE875FB5587389D4C
    GO
    Isoform 21 Publication (identifier: Q8R1W8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-56: Missing.

    Show »
    Length:742
    Mass (Da):83,193
    Checksum:i73BDF075786A9B61
    GO
    Isoform 31 Publication (identifier: Q8R1W8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         23-99: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:721
    Mass (Da):80,568
    Checksum:i5EA086C3CDD59DD7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31L → F in AAG00796. (PubMed:10958699)Curated
    Sequence conflicti12 – 121L → F in AAG00796. (PubMed:10958699)Curated
    Sequence conflicti224 – 2241K → I in AAG32162. (PubMed:10995555)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5656Missing in isoform 2. 1 PublicationVSP_052171Add
    BLAST
    Alternative sequencei23 – 9977Missing in isoform 3. 1 PublicationVSP_052172Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229929 mRNA. Translation: AAG32162.1.
    AF266478 mRNA. Translation: AAG00796.1.
    BC022970 mRNA. Translation: AAH22970.1.
    AK020862 mRNA. Translation: BAB32231.3.
    CCDSiCCDS57685.1. [Q8R1W8-1]
    RefSeqiNP_071299.3. NM_022016.3. [Q8R1W8-1]
    XP_006511391.1. XM_006511328.1. [Q8R1W8-1]
    UniGeneiMm.422780.

    Genome annotation databases

    EnsembliENSMUST00000085289; ENSMUSP00000082395; ENSMUSG00000032343. [Q8R1W8-3]
    ENSMUST00000113250; ENSMUSP00000108876; ENSMUSG00000032343. [Q8R1W8-1]
    GeneIDi63859.
    KEGGimmu:63859.
    UCSCiuc009qvi.2. mouse. [Q8R1W8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229929 mRNA. Translation: AAG32162.1 .
    AF266478 mRNA. Translation: AAG00796.1 .
    BC022970 mRNA. Translation: AAH22970.1 .
    AK020862 mRNA. Translation: BAB32231.3 .
    CCDSi CCDS57685.1. [Q8R1W8-1 ]
    RefSeqi NP_071299.3. NM_022016.3. [Q8R1W8-1 ]
    XP_006511391.1. XM_006511328.1. [Q8R1W8-1 ]
    UniGenei Mm.422780.

    3D structure databases

    ProteinModelPortali Q8R1W8.
    SMRi Q8R1W8. Positions 579-635.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R1W8.

    Proteomic databases

    PaxDbi Q8R1W8.
    PRIDEi Q8R1W8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000085289 ; ENSMUSP00000082395 ; ENSMUSG00000032343 . [Q8R1W8-3 ]
    ENSMUST00000113250 ; ENSMUSP00000108876 ; ENSMUSG00000032343 . [Q8R1W8-1 ]
    GeneIDi 63859.
    KEGGi mmu:63859.
    UCSCi uc009qvi.2. mouse. [Q8R1W8-1 ]

    Organism-specific databases

    CTDi 3617.
    MGIi MGI:1926876. Impg1.

    Phylogenomic databases

    eggNOGi NOG73774.
    GeneTreei ENSGT00530000063503.
    HOGENOMi HOG000113063.
    HOVERGENi HBG081793.
    InParanoidi Q8R1W8.
    OMAi QMQKVFK.
    OrthoDBi EOG7TXKFR.
    PhylomeDBi Q8R1W8.
    TreeFami TF331340.

    Miscellaneous databases

    NextBioi 319787.
    PROi Q8R1W8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R1W8.
    CleanExi MM_IMPG1.
    Genevestigatori Q8R1W8.

    Family and domain databases

    Gene3Di 3.30.70.960. 2 hits.
    InterProi IPR000082. SEA_dom.
    [Graphical view ]
    Pfami PF01390. SEA. 2 hits.
    [Graphical view ]
    SMARTi SM00200. SEA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF82671. SSF82671. 2 hits.
    PROSITEi PS50024. SEA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SPACR in the interphotoreceptor matrix of the mouse retina: molecular, biochemical and immunohistochemical characterization."
      Lee J.W., Chen Q., Rayborn M.E., Shadrach K.G., Crabb J.W., Rodriguez I.R., Hollyfield J.G.
      Exp. Eye Res. 71:341-352(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
    2. "Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150."
      Kuehn M.H., Wietecki D.T., Hageman G.S.
      Mol. Vis. 6:148-156(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: EyeImported.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-293 (ISOFORM 3).
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.

    Entry informationi

    Entry nameiIMPG1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1W8
    Secondary accession number(s): Q9CTP8, Q9ES62, Q9ET31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3