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Protein

Interphotoreceptor matrix proteoglycan 1

Gene

Impg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.By similarity

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Interphotoreceptor matrix proteoglycan 1
Alternative name(s):
Interphotoreceptor matrix proteoglycan of 150 kDa
Short name:
IPM-150
Sialoprotein associated with cones and rods
Gene namesi
Name:Impg1Imported
Synonyms:Spacr1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926876. Impg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025223921 – 798Interphotoreceptor matrix proteoglycan 1Sequence analysisAdd BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174O-linked (GalNAc...)Sequence analysis1
Glycosylationi186O-linked (GalNAc...)Sequence analysis1
Glycosylationi457O-linked (GalNAc...)Sequence analysis1
Glycosylationi473O-linked (GalNAc...)Sequence analysis1
Glycosylationi474O-linked (GalNAc...)Sequence analysis1
Glycosylationi477O-linked (GalNAc...)Sequence analysis1
Glycosylationi559O-linked (GalNAc...)Sequence analysis1
Glycosylationi596N-linked (GlcNAc...)Sequence analysis1
Glycosylationi620N-linked (GlcNAc...)Sequence analysis1
Glycosylationi634N-linked (GlcNAc...)Sequence analysis1
Glycosylationi652N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Highly glycosylated (N- and O-linked carbohydrates and sialic acid).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R1W8.
PRIDEiQ8R1W8.

PTM databases

iPTMnetiQ8R1W8.
PhosphoSitePlusiQ8R1W8.

Expressioni

Tissue specificityi

Abundantly expressed in retina.2 Publications

Gene expression databases

BgeeiENSMUSG00000032343.
CleanExiMM_IMPG1.
ExpressionAtlasiQ8R1W8. baseline and differential.
GenevisibleiQ8R1W8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108876.

Structurei

3D structure databases

ProteinModelPortaliQ8R1W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 357SEA 1PROSITE-ProRule annotationAdd BLAST123
Domaini575 – 688SEA 2PROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Contains 2 SEA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH0G. Eukaryota.
ENOG410Y9FF. LUCA.
GeneTreeiENSGT00530000063503.
HOGENOMiHOG000113063.
HOVERGENiHBG081793.
InParanoidiQ8R1W8.
KOiK19016.
OMAiGKSQLQM.
OrthoDBiEOG091G094N.
PhylomeDBiQ8R1W8.
TreeFamiTF331340.

Family and domain databases

Gene3Di3.30.70.960. 2 hits.
InterProiIPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 2 hits.
[Graphical view]
SMARTiSM00200. SEA. 2 hits.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 2 hits.
PROSITEiPS50024. SEA. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q8R1W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLQIKHAIF VLGIFLQVQG IKDTSIKIFS SEIKNIDKTP RIETIESTST
60 70 80 90 100
VHKVSTMKRI FDLPKLRTKR SALFPAANIC PQESLRQILA SLQEYYRLRV
110 120 130 140 150
CQEVVWEAYR IFLDRIPDTE EYQDWVSLCQ KETFCLFDIG KNFSNSQEHL
160 170 180 190 200
DLLQQRIKQR SFPGRKDETA SMETLEAPTE APVVPTDVSR MSLGPFPLPS
210 220 230 240 250
DDTDLKEILS VTLKDIQKPT TESKTEPIHV SEFSSEEKVE FSISLPNHRF
260 270 280 290 300
KAELTNSGSP YYQELVGQSQ LQLQKIFKKL PGFGEIRVLG FRPKKEEDGS
310 320 330 340 350
SSTEIQLMAI FKRDHAEAKS PDSHLLSLDS NKIESERIHH GVIEDKQPET
360 370 380 390 400
YLTATDLKKL IIQLLDGDLS LVEGKIPFGD EVTGTLFRPV TEPDLPKPLA
410 420 430 440 450
DVTEDATLSP ELPFVEPRLE AVDREGSELP GMSSKDSSWS PPVSASISRS
460 470 480 490 500
ENLPSFTPSI FSLDAQSPPP LMTTGPTALI PKPTLPTIDY STIRQLPLES
510 520 530 540 550
SHWPASSSDR ELITSSHDTI RDLDGMDVSD TPALSEISEL SGYDSASGQF
560 570 580 590 600
LEMTTPIPTV RFITTSSETI ATKGQELVVF FSLRVANMPF SYDLFNKSSL
610 620 630 640 650
EYQALEQRFT DLLVPYLRSN LTGFKQLEIL SFRNGSVIVN SKVRFAKAVP
660 670 680 690 700
YNLTQAVRGV LEDLRSTAAQ GLNLEIESYS LDIEPADQAD PCKLLDCGKF
710 720 730 740 750
AQCVKNEWTE EAECRCRQGH ESHGTLDYQT LNLCPPGKTC VAGREQATPC
760 770 780 790
RPPDHSTNQA QEPGVKKLRQ QNKVVKKRNS KLSAIGFEEF EDQDWEGN
Length:798
Mass (Da):89,474
Last modified:June 1, 2002 - v1
Checksum:iE875FB5587389D4C
GO
Isoform 21 Publication (identifier: Q8R1W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:742
Mass (Da):83,193
Checksum:i73BDF075786A9B61
GO
Isoform 31 Publication (identifier: Q8R1W8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-99: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:721
Mass (Da):80,568
Checksum:i5EA086C3CDD59DD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → F in AAG00796 (PubMed:10958699).Curated1
Sequence conflicti12L → F in AAG00796 (PubMed:10958699).Curated1
Sequence conflicti224K → I in AAG32162 (PubMed:10995555).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0521711 – 56Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_05217223 – 99Missing in isoform 3. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229929 mRNA. Translation: AAG32162.1.
AF266478 mRNA. Translation: AAG00796.1.
BC022970 mRNA. Translation: AAH22970.1.
AK020862 mRNA. Translation: BAB32231.3.
CCDSiCCDS57685.1. [Q8R1W8-1]
RefSeqiNP_071299.3. NM_022016.3. [Q8R1W8-1]
XP_006511391.1. XM_006511328.3. [Q8R1W8-1]
UniGeneiMm.422780.

Genome annotation databases

EnsembliENSMUST00000085289; ENSMUSP00000082395; ENSMUSG00000032343. [Q8R1W8-3]
ENSMUST00000113250; ENSMUSP00000108876; ENSMUSG00000032343. [Q8R1W8-1]
GeneIDi63859.
KEGGimmu:63859.
UCSCiuc009qvi.2. mouse. [Q8R1W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229929 mRNA. Translation: AAG32162.1.
AF266478 mRNA. Translation: AAG00796.1.
BC022970 mRNA. Translation: AAH22970.1.
AK020862 mRNA. Translation: BAB32231.3.
CCDSiCCDS57685.1. [Q8R1W8-1]
RefSeqiNP_071299.3. NM_022016.3. [Q8R1W8-1]
XP_006511391.1. XM_006511328.3. [Q8R1W8-1]
UniGeneiMm.422780.

3D structure databases

ProteinModelPortaliQ8R1W8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108876.

PTM databases

iPTMnetiQ8R1W8.
PhosphoSitePlusiQ8R1W8.

Proteomic databases

PaxDbiQ8R1W8.
PRIDEiQ8R1W8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085289; ENSMUSP00000082395; ENSMUSG00000032343. [Q8R1W8-3]
ENSMUST00000113250; ENSMUSP00000108876; ENSMUSG00000032343. [Q8R1W8-1]
GeneIDi63859.
KEGGimmu:63859.
UCSCiuc009qvi.2. mouse. [Q8R1W8-1]

Organism-specific databases

CTDi3617.
MGIiMGI:1926876. Impg1.

Phylogenomic databases

eggNOGiENOG410IH0G. Eukaryota.
ENOG410Y9FF. LUCA.
GeneTreeiENSGT00530000063503.
HOGENOMiHOG000113063.
HOVERGENiHBG081793.
InParanoidiQ8R1W8.
KOiK19016.
OMAiGKSQLQM.
OrthoDBiEOG091G094N.
PhylomeDBiQ8R1W8.
TreeFamiTF331340.

Miscellaneous databases

PROiQ8R1W8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032343.
CleanExiMM_IMPG1.
ExpressionAtlasiQ8R1W8. baseline and differential.
GenevisibleiQ8R1W8. MM.

Family and domain databases

Gene3Di3.30.70.960. 2 hits.
InterProiIPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 2 hits.
[Graphical view]
SMARTiSM00200. SEA. 2 hits.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 2 hits.
PROSITEiPS50024. SEA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMPG1_MOUSE
AccessioniPrimary (citable) accession number: Q8R1W8
Secondary accession number(s): Q9CTP8, Q9ES62, Q9ET31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.