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Q8R1W8 (IMPG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interphotoreceptor matrix proteoglycan 1
Alternative name(s):
Interphotoreceptor matrix proteoglycan of 150 kDa
Short name=IPM-150
Sialoprotein associated with cones and rods
Gene names
Name:Impg1
Synonyms:Spacr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length798 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix By similarity. UniProtKB Q17R60

Subcellular location

Secreted Potential Ref.1.

Tissue specificity

Abundantly expressed in retina. Ref.1 Ref.2

Post-translational modification

Highly glycosylated (N- and O-linked carbohydrates and sialic acid) By similarity. UniProtKB Q17R60

Sequence similarities

Contains 2 SEA domains.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
   LigandSialic acid
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 Ref.3 (identifier: Q8R1W8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q8R1W8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
Isoform 3 Ref.4 (identifier: Q8R1W8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     23-99: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 798778Interphotoreceptor matrix proteoglycan 1
PRO_0000252239

Regions

Domain235 – 357123SEA 1
Domain575 – 688114SEA 2

Amino acid modifications

Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1741O-linked (GalNAc...) Potential
Glycosylation1861O-linked (GalNAc...) Potential
Glycosylation4571O-linked (GalNAc...) Potential
Glycosylation4731O-linked (GalNAc...) Potential
Glycosylation4741O-linked (GalNAc...) Potential
Glycosylation4771O-linked (GalNAc...) Potential
Glycosylation5591O-linked (GalNAc...) Potential
Glycosylation5961N-linked (GlcNAc...) Potential
Glycosylation6201N-linked (GlcNAc...) Potential
Glycosylation6341N-linked (GlcNAc...) Potential
Glycosylation6521N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 5656Missing in isoform 2. Ref.1
VSP_052171
Alternative sequence23 – 9977Missing in isoform 3. Ref.4
VSP_052172

Experimental info

Sequence conflict31L → F in AAG00796. Ref.2
Sequence conflict121L → F in AAG00796. Ref.2
Sequence conflict2241K → I in AAG32162. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: E875FB5587389D4C

FASTA79889,474
        10         20         30         40         50         60 
MNLQIKHAIF VLGIFLQVQG IKDTSIKIFS SEIKNIDKTP RIETIESTST VHKVSTMKRI 

        70         80         90        100        110        120 
FDLPKLRTKR SALFPAANIC PQESLRQILA SLQEYYRLRV CQEVVWEAYR IFLDRIPDTE 

       130        140        150        160        170        180 
EYQDWVSLCQ KETFCLFDIG KNFSNSQEHL DLLQQRIKQR SFPGRKDETA SMETLEAPTE 

       190        200        210        220        230        240 
APVVPTDVSR MSLGPFPLPS DDTDLKEILS VTLKDIQKPT TESKTEPIHV SEFSSEEKVE 

       250        260        270        280        290        300 
FSISLPNHRF KAELTNSGSP YYQELVGQSQ LQLQKIFKKL PGFGEIRVLG FRPKKEEDGS 

       310        320        330        340        350        360 
SSTEIQLMAI FKRDHAEAKS PDSHLLSLDS NKIESERIHH GVIEDKQPET YLTATDLKKL 

       370        380        390        400        410        420 
IIQLLDGDLS LVEGKIPFGD EVTGTLFRPV TEPDLPKPLA DVTEDATLSP ELPFVEPRLE 

       430        440        450        460        470        480 
AVDREGSELP GMSSKDSSWS PPVSASISRS ENLPSFTPSI FSLDAQSPPP LMTTGPTALI 

       490        500        510        520        530        540 
PKPTLPTIDY STIRQLPLES SHWPASSSDR ELITSSHDTI RDLDGMDVSD TPALSEISEL 

       550        560        570        580        590        600 
SGYDSASGQF LEMTTPIPTV RFITTSSETI ATKGQELVVF FSLRVANMPF SYDLFNKSSL 

       610        620        630        640        650        660 
EYQALEQRFT DLLVPYLRSN LTGFKQLEIL SFRNGSVIVN SKVRFAKAVP YNLTQAVRGV 

       670        680        690        700        710        720 
LEDLRSTAAQ GLNLEIESYS LDIEPADQAD PCKLLDCGKF AQCVKNEWTE EAECRCRQGH 

       730        740        750        760        770        780 
ESHGTLDYQT LNLCPPGKTC VAGREQATPC RPPDHSTNQA QEPGVKKLRQ QNKVVKKRNS 

       790 
KLSAIGFEEF EDQDWEGN 

« Hide

Isoform 2 [UniParc].

Checksum: 73BDF075786A9B61
Show »

FASTA74283,193
Isoform 3 [UniParc].

Checksum: 5EA086C3CDD59DD7
Show »

FASTA72180,568

References

« Hide 'large scale' references
[1]"SPACR in the interphotoreceptor matrix of the mouse retina: molecular, biochemical and immunohistochemical characterization."
Lee J.W., Chen Q., Rayborn M.E., Shadrach K.G., Crabb J.W., Rodriguez I.R., Hollyfield J.G.
Exp. Eye Res. 71:341-352(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
[2]"Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150."
Kuehn M.H., Wietecki D.T., Hageman G.S.
Mol. Vis. 6:148-156(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-293 (ISOFORM 3).
Strain: C57BL/6J.
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF229929 mRNA. Translation: AAG32162.1.
AF266478 mRNA. Translation: AAG00796.1.
BC022970 mRNA. Translation: AAH22970.1.
AK020862 mRNA. Translation: BAB32231.3.
CCDSCCDS57685.1. [Q8R1W8-1]
RefSeqNP_071299.3. NM_022016.3. [Q8R1W8-1]
XP_006511391.1. XM_006511328.1. [Q8R1W8-1]
UniGeneMm.422780.

3D structure databases

ProteinModelPortalQ8R1W8.
SMRQ8R1W8. Positions 579-635.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8R1W8.

Proteomic databases

PaxDbQ8R1W8.
PRIDEQ8R1W8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000085289; ENSMUSP00000082395; ENSMUSG00000032343. [Q8R1W8-3]
ENSMUST00000113250; ENSMUSP00000108876; ENSMUSG00000032343. [Q8R1W8-1]
GeneID63859.
KEGGmmu:63859.
UCSCuc009qvi.2. mouse. [Q8R1W8-1]

Organism-specific databases

CTD3617.
MGIMGI:1926876. Impg1.

Phylogenomic databases

eggNOGNOG73774.
GeneTreeENSGT00530000063503.
HOGENOMHOG000113063.
HOVERGENHBG081793.
InParanoidQ8R1W8.
OMAQMQKVFK.
OrthoDBEOG7TXKFR.
PhylomeDBQ8R1W8.
TreeFamTF331340.

Gene expression databases

BgeeQ8R1W8.
CleanExMM_IMPG1.
GenevestigatorQ8R1W8.

Family and domain databases

Gene3D3.30.70.960. 2 hits.
InterProIPR000082. SEA_dom.
[Graphical view]
PfamPF01390. SEA. 2 hits.
[Graphical view]
SMARTSM00200. SEA. 2 hits.
[Graphical view]
SUPFAMSSF82671. SSF82671. 2 hits.
PROSITEPS50024. SEA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio319787.
PROQ8R1W8.
SOURCESearch...

Entry information

Entry nameIMPG1_MOUSE
AccessionPrimary (citable) accession number: Q8R1W8
Secondary accession number(s): Q9CTP8, Q9ES62, Q9ET31
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot