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Protein

Conserved oligomeric Golgi complex subunit 4

Gene

Cog4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 4
Short name:
COG complex subunit 4
Alternative name(s):
Component of oligomeric Golgi complex 4
Gene namesi
Name:Cog4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142808. Cog4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 785784Conserved oligomeric Golgi complex subunit 4PRO_0000213505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8R1U1.
MaxQBiQ8R1U1.
PaxDbiQ8R1U1.
PRIDEiQ8R1U1.

PTM databases

iPTMnetiQ8R1U1.
PhosphoSiteiQ8R1U1.

Expressioni

Gene expression databases

BgeeiQ8R1U1.
CleanExiMM_COG4.
ExpressionAtlasiQ8R1U1. baseline and differential.
GenevisibleiQ8R1U1. MM.

Interactioni

Subunit structurei

Monomer. Component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Mediates interaction of SCFD1 with the COG complex. Interacts with STX5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034203.

Structurei

3D structure databases

ProteinModelPortaliQ8R1U1.
SMRiQ8R1U1. Positions 536-785.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 8483Interacts with SCFD1By similarityAdd
BLAST
Regioni85 – 15369Interacts with STX5By similarityAdd
BLAST
Regioni618 – 740123D domainBy similarityAdd
BLAST
Regioni741 – 78545E domain; essential for proper cell surface glycosylationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the COG4 family.Curated

Phylogenomic databases

eggNOGiKOG0412. Eukaryota.
ENOG410XS60. LUCA.
GeneTreeiENSGT00390000003662.
HOGENOMiHOG000006874.
HOVERGENiHBG031403.
InParanoidiQ8R1U1.
OMAiYYITMEE.
PhylomeDBiQ8R1U1.
TreeFamiTF105835.

Family and domain databases

InterProiIPR013167. COG_su4.
[Graphical view]
PfamiPF08318. COG4. 1 hit.
[Graphical view]
SMARTiSM00762. Cog4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R1U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVESPLKL SGAPPPPEGV GGGHCSEIST ELIRSLTELQ ELEAVYERLC
60 70 80 90 100
GEEKAVEKEL DALLEQQNTI ESKMVTLHRM GPSLQLIEGD AKQLAGMITF
110 120 130 140 150
TCSLAENVSS KVRQLDLAKN RLYQAIQRAD DILDLKFCMD GVQTALRNED
160 170 180 190 200
YEQAAAHIHR YLCLDKSVIE LSRQGKEGSM IDANLKLLQE AEQRLKAIVA
210 220 230 240 250
EKFAIATKEG DLPQVERFFK IFPLLGLHED GLSKFSEYLC KQVASKAEEN
260 270 280 290 300
LLLVLGSDMS DRRAAVIFAD TLTLLFEGIA RIVETHQPIV ETYYGPGRLF
310 320 330 340 350
TLIKYLQVEC DTQVEKVVNK FIKQRDYHQQ FRLVQSNLMR NSATEKIEPR
360 370 380 390 400
ELDPVLTEVT LMNARSELYL RFLRKRISAD FEVGDSMASE EVKQEHQKCL
410 420 430 440 450
DKLLNNCLLS CTMQELIGFY ITMEEYFMRE TVNKAVALDT YEKGQLTSSM
460 470 480 490 500
VDDVFYIVKK CIGRALSSSN IDCLCAMINL ATRELEADFR DVLCNKLRMG
510 520 530 540 550
FPATTLQDIQ RGVTSAVNIM HSSLQQGKFD TKGIESTDEA KLSFLVTLNN
560 570 580 590 600
VEVCSENIST LKKTLESDCT KLFSQGIGGE QAQAKFDSCL SDLAAVSNKF
610 620 630 640 650
RDLLQEGLAE LNSSAVKPQV QPWINTFLSV SHSIEEEEFN DYEANDPWVQ
660 670 680 690 700
QFILNLEQQM AEFKASLSPV IYDSLTGLMT SLVAVELEKV VLKSTFNRLG
710 720 730 740 750
GLQFDKELRS LIAYLTTVTT WTIRDKFARL SQMATILNLE RVTEILDYWG
760 770 780
ANSGPLTWRL TPAEVRQVLA LRIDFRNEDI KRLRL
Length:785
Mass (Da):88,661
Last modified:June 1, 2002 - v1
Checksum:i057D846C5319E4EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172465 mRNA. Translation: BAE43019.1.
CH466525 Genomic DNA. Translation: EDL11474.1.
BC023120 mRNA. Translation: AAH23120.1.
CCDSiCCDS40477.1.
RefSeqiNP_598734.1. NM_133973.2.
UniGeneiMm.272930.

Genome annotation databases

EnsembliENSMUST00000034203; ENSMUSP00000034203; ENSMUSG00000031753.
GeneIDi102339.
KEGGimmu:102339.
UCSCiuc009nle.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172465 mRNA. Translation: BAE43019.1.
CH466525 Genomic DNA. Translation: EDL11474.1.
BC023120 mRNA. Translation: AAH23120.1.
CCDSiCCDS40477.1.
RefSeqiNP_598734.1. NM_133973.2.
UniGeneiMm.272930.

3D structure databases

ProteinModelPortaliQ8R1U1.
SMRiQ8R1U1. Positions 536-785.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034203.

PTM databases

iPTMnetiQ8R1U1.
PhosphoSiteiQ8R1U1.

Proteomic databases

EPDiQ8R1U1.
MaxQBiQ8R1U1.
PaxDbiQ8R1U1.
PRIDEiQ8R1U1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034203; ENSMUSP00000034203; ENSMUSG00000031753.
GeneIDi102339.
KEGGimmu:102339.
UCSCiuc009nle.1. mouse.

Organism-specific databases

CTDi25839.
MGIiMGI:2142808. Cog4.

Phylogenomic databases

eggNOGiKOG0412. Eukaryota.
ENOG410XS60. LUCA.
GeneTreeiENSGT00390000003662.
HOGENOMiHOG000006874.
HOVERGENiHBG031403.
InParanoidiQ8R1U1.
OMAiYYITMEE.
PhylomeDBiQ8R1U1.
TreeFamiTF105835.

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiQ8R1U1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R1U1.
CleanExiMM_COG4.
ExpressionAtlasiQ8R1U1. baseline and differential.
GenevisibleiQ8R1U1. MM.

Family and domain databases

InterProiIPR013167. COG_su4.
[Graphical view]
PfamiPF08318. COG4. 1 hit.
[Graphical view]
SMARTiSM00762. Cog4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCOG4_MOUSE
AccessioniPrimary (citable) accession number: Q8R1U1
Secondary accession number(s): Q3T9K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.