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Protein

Charged multivesicular body protein 7

Gene

Chmp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1632852. Macroautophagy.
R-MMU-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 7
Alternative name(s):
Chromatin-modifying protein 7
Gene namesi
Name:Chmp7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1913922. Chmp7.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus envelope By similarity

  • Note: Diffused localization, with some punctate distribution, especially in the perinuclear area. Localizes to the nucleus envelope during late anaphase.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Charged multivesicular body protein 7PRO_0000211517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei232 – 2321PhosphoserineCombined sources
Modified residuei409 – 4091PhosphothreonineBy similarity
Modified residuei411 – 4111PhosphoserineBy similarity
Modified residuei432 – 4321PhosphoserineBy similarity
Modified residuei442 – 4421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R1T1.
MaxQBiQ8R1T1.
PaxDbiQ8R1T1.
PeptideAtlasiQ8R1T1.
PRIDEiQ8R1T1.

PTM databases

iPTMnetiQ8R1T1.
PhosphoSiteiQ8R1T1.

Expressioni

Gene expression databases

BgeeiQ8R1T1.
CleanExiMM_CHMP7.
GenevisibleiQ8R1T1. MM.

Interactioni

Subunit structurei

Interacts with CHMP4B, but not with VPS25.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047700.

Structurei

3D structure databases

ProteinModelPortaliQ8R1T1.
SMRiQ8R1T1. Positions 35-107, 238-313, 339-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili248 – 31265Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2911. Eukaryota.
ENOG4110IXB. LUCA.
GeneTreeiENSGT00720000108860.
HOGENOMiHOG000290682.
HOVERGENiHBG081151.
InParanoidiQ8R1T1.
KOiK15053.
OMAiMAKTYLR.
OrthoDBiEOG7M3J0G.
PhylomeDBiQ8R1T1.
TreeFamiTF312851.

Family and domain databases

InterProiIPR005024. Snf7_fam.
[Graphical view]
PfamiPF03357. Snf7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R1T1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSPEREAQA PTGGDPAGLL PPEWEEDEER MSFLFSAFKR SREVNSTDWD
60 70 80 90 100
SKMGFWAPLV LSHSRRQGVV RLRLRDLQEA FQRKGSVPLG LATVLQDLLR
110 120 130 140 150
RGELQRESDF MASVDSSWIS WGVGVFLLKP LKWTLSNMLG DHKVPAEEVL
160 170 180 190 200
VAVELLKEKA EEVYRLYQNS PLSSHPVVAL SELSALCANS CPDERTFYLV
210 220 230 240 250
LLQLQKEKRV TVLEQNGEKI VKFARGPHAK VSPVNDVDVG VYQLMQSEQL
260 270 280 290 300
LSRKVESLSQ ESERCKEEAR RACRAGKKQL ALRSLKAKQR TEKRIEALHA
310 320 330 340 350
KLDTVQGILD RIYASQTDQM VFNAYQAGVG ALKLSMKDVT VEKAESLVDQ
360 370 380 390 400
IQELCDTQDE VSQTLAGGVT NGLDFDSEEL EKELDILLQD TTTEPLSLLE
410 420 430 440 450
TPQETTLYTN SVPKPRILDA ELEAELEKLS LSEGGLIPSS KSPKRQLEPT

L
Length:451
Mass (Da):50,633
Last modified:June 1, 2002 - v1
Checksum:iF52C0B3F72CBA827
GO
Isoform 2 (identifier: Q8R1T1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-370: FNAYQAGVGA...VSQTLAGGVT → ATPLRALWSQ...LGSLTSLGVR
     371-451: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):41,670
Checksum:i2FAB3E728D99C8A5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei322 – 37049FNAYQ…AGGVT → ATPLRALWSQSPTLQLPPLW SAVSGNPGFFQRVAGFSFLL GSLTSLGVR in isoform 2. 1 PublicationVSP_015343Add
BLAST
Alternative sequencei371 – 45181Missing in isoform 2. 1 PublicationVSP_015344Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024115 mRNA. Translation: AAH24115.1.
BC033365 mRNA. Translation: AAH33365.1.
CCDSiCCDS27242.1. [Q8R1T1-1]
RefSeqiNP_598839.2. NM_134078.4. [Q8R1T1-1]
UniGeneiMm.159637.

Genome annotation databases

EnsembliENSMUST00000036381; ENSMUSP00000047700; ENSMUSG00000034190. [Q8R1T1-1]
GeneIDi105513.
KEGGimmu:105513.
UCSCiuc007ums.2. mouse. [Q8R1T1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024115 mRNA. Translation: AAH24115.1.
BC033365 mRNA. Translation: AAH33365.1.
CCDSiCCDS27242.1. [Q8R1T1-1]
RefSeqiNP_598839.2. NM_134078.4. [Q8R1T1-1]
UniGeneiMm.159637.

3D structure databases

ProteinModelPortaliQ8R1T1.
SMRiQ8R1T1. Positions 35-107, 238-313, 339-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047700.

PTM databases

iPTMnetiQ8R1T1.
PhosphoSiteiQ8R1T1.

Proteomic databases

EPDiQ8R1T1.
MaxQBiQ8R1T1.
PaxDbiQ8R1T1.
PeptideAtlasiQ8R1T1.
PRIDEiQ8R1T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036381; ENSMUSP00000047700; ENSMUSG00000034190. [Q8R1T1-1]
GeneIDi105513.
KEGGimmu:105513.
UCSCiuc007ums.2. mouse. [Q8R1T1-1]

Organism-specific databases

CTDi91782.
MGIiMGI:1913922. Chmp7.

Phylogenomic databases

eggNOGiKOG2911. Eukaryota.
ENOG4110IXB. LUCA.
GeneTreeiENSGT00720000108860.
HOGENOMiHOG000290682.
HOVERGENiHBG081151.
InParanoidiQ8R1T1.
KOiK15053.
OMAiMAKTYLR.
OrthoDBiEOG7M3J0G.
PhylomeDBiQ8R1T1.
TreeFamiTF312851.

Enzyme and pathway databases

ReactomeiR-MMU-1632852. Macroautophagy.
R-MMU-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Miscellaneous databases

ChiTaRSiChmp7. mouse.
PROiQ8R1T1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R1T1.
CleanExiMM_CHMP7.
GenevisibleiQ8R1T1. MM.

Family and domain databases

InterProiIPR005024. Snf7_fam.
[Graphical view]
PfamiPF03357. Snf7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Eye and Liver.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung and Testis.

Entry informationi

Entry nameiCHMP7_MOUSE
AccessioniPrimary (citable) accession number: Q8R1T1
Secondary accession number(s): Q8CFW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.