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Protein

Interleukin-34

Gene

Il34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).By similarity

GO - Molecular functioni

  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-34
Short name:
IL-34
Gene namesi
Name:Il34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1923777. Il34.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029434921 – 235Interleukin-34Add BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R1R4.
PRIDEiQ8R1R4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031750.
GenevisibleiQ8R1R4. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with CSF1R (By similarity).By similarity

GO - Molecular functioni

  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076120.

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi37 – 44Combined sources8
Helixi47 – 54Combined sources8
Turni55 – 57Combined sources3
Beta strandi64 – 66Combined sources3
Helixi68 – 70Combined sources3
Helixi74 – 81Combined sources8
Turni82 – 84Combined sources3
Helixi87 – 106Combined sources20
Helixi116 – 131Combined sources16
Turni132 – 135Combined sources4
Helixi140 – 150Combined sources11
Beta strandi157 – 159Combined sources3
Helixi161 – 180Combined sources20
Beta strandi181 – 184Combined sources4
Helixi186 – 188Combined sources3
Beta strandi189 – 191Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EXNX-ray2.70A/B/E/F21-194[»]
4EXPX-ray2.80A21-194[»]
ProteinModelPortaliQ8R1R4.
SMRiQ8R1R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-34 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX9Y. Eukaryota.
ENOG410Z6RS. LUCA.
GeneTreeiENSGT00390000000932.
HOGENOMiHOG000113048.
HOVERGENiHBG108003.
InParanoidiQ8R1R4.
OMAiTQLYPPP.
OrthoDBiEOG091G0I1D.
PhylomeDBiQ8R1R4.
TreeFamiTF337386.

Family and domain databases

InterProiIPR020415. IL-34.
[Graphical view]
PfamiPF15036. IL34. 1 hit.
[Graphical view]
PRINTSiPR01938. INTRLEUKIN34.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R1R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPWGLAWLYC LGILLDVALG NENLEIWTLT QDKECDLTGY LRGKLQYKNR
60 70 80 90 100
LQYMKHYFPI NYRIAVPYEG VLRVANITRL QKAHVSEREL RYLWVLVSLN
110 120 130 140 150
ATESVMDVLL EGHPSWKYLQ EVQTLLENVQ RSLMDVEIGP HVEAVLSLLS
160 170 180 190 200
TPGLSLKLVR PKALLDNCFR VMELLYCSCC KQSPILKWQD CELPRLHPHS
210 220 230
PGSLMQCTAT NVYPLSRQTP TSLPGSPSSS HGSLP
Length:235
Mass (Da):26,764
Last modified:June 1, 2002 - v1
Checksum:i4D30E33C977FD54D
GO
Isoform 2 (identifier: Q8R1R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-235: DVEIGPHVEA...SPSSSHGSLP → AVGVHLPGHV...GHGTAVLFLL

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,736
Checksum:i55AD04CEB406C73C
GO
Isoform 3 (identifier: Q8R1R4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: Missing.

Show »
Length:234
Mass (Da):26,636
Checksum:i33A081F6099F1C12
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03508081Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_026632135 – 235DVEIG…HGSLP → AVGVHLPGHVLVTLLSQLPG LPSPWARSFDTSWELLMMKG CGDWPSRGSCVISSEYSRPK PEAGAAQSLAGQLLPGHGTA VLFLL in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU636995 mRNA. Translation: ACD13453.1.
EU636996 mRNA. Translation: ACD13454.1.
AK008082 mRNA. Translation: BAB25448.1.
BC016254 mRNA. Translation: AAH16254.1.
CCDSiCCDS52669.1. [Q8R1R4-1]
CCDS52670.1. [Q8R1R4-2]
RefSeqiNP_001128572.1. NM_001135100.2. [Q8R1R4-1]
NP_083922.1. NM_029646.3. [Q8R1R4-2]
XP_006531548.1. XM_006531485.3. [Q8R1R4-3]
UniGeneiMm.77697.

Genome annotation databases

EnsembliENSMUST00000076846; ENSMUSP00000076120; ENSMUSG00000031750. [Q8R1R4-1]
ENSMUST00000150680; ENSMUSP00000114398; ENSMUSG00000031750. [Q8R1R4-2]
GeneIDi76527.
KEGGimmu:76527.
UCSCiuc009nkz.3. mouse. [Q8R1R4-2]
uc009nla.3. mouse. [Q8R1R4-1]
uc012gko.1. mouse. [Q8R1R4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU636995 mRNA. Translation: ACD13453.1.
EU636996 mRNA. Translation: ACD13454.1.
AK008082 mRNA. Translation: BAB25448.1.
BC016254 mRNA. Translation: AAH16254.1.
CCDSiCCDS52669.1. [Q8R1R4-1]
CCDS52670.1. [Q8R1R4-2]
RefSeqiNP_001128572.1. NM_001135100.2. [Q8R1R4-1]
NP_083922.1. NM_029646.3. [Q8R1R4-2]
XP_006531548.1. XM_006531485.3. [Q8R1R4-3]
UniGeneiMm.77697.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EXNX-ray2.70A/B/E/F21-194[»]
4EXPX-ray2.80A21-194[»]
ProteinModelPortaliQ8R1R4.
SMRiQ8R1R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076120.

Proteomic databases

PaxDbiQ8R1R4.
PRIDEiQ8R1R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076846; ENSMUSP00000076120; ENSMUSG00000031750. [Q8R1R4-1]
ENSMUST00000150680; ENSMUSP00000114398; ENSMUSG00000031750. [Q8R1R4-2]
GeneIDi76527.
KEGGimmu:76527.
UCSCiuc009nkz.3. mouse. [Q8R1R4-2]
uc009nla.3. mouse. [Q8R1R4-1]
uc012gko.1. mouse. [Q8R1R4-3]

Organism-specific databases

CTDi146433.
MGIiMGI:1923777. Il34.

Phylogenomic databases

eggNOGiENOG410IX9Y. Eukaryota.
ENOG410Z6RS. LUCA.
GeneTreeiENSGT00390000000932.
HOGENOMiHOG000113048.
HOVERGENiHBG108003.
InParanoidiQ8R1R4.
OMAiTQLYPPP.
OrthoDBiEOG091G0I1D.
PhylomeDBiQ8R1R4.
TreeFamiTF337386.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiQ8R1R4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031750.
GenevisibleiQ8R1R4. MM.

Family and domain databases

InterProiIPR020415. IL-34.
[Graphical view]
PfamiPF15036. IL34. 1 hit.
[Graphical view]
PRINTSiPR01938. INTRLEUKIN34.
ProtoNetiSearch...

Entry informationi

Entry nameiIL34_MOUSE
AccessioniPrimary (citable) accession number: Q8R1R4
Secondary accession number(s): B2ZC71, B2ZC72, Q9D8F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.