Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R1R4

- IL34_MOUSE

UniProt

Q8R1R4 - IL34_MOUSE

Protein

Interleukin-34

Gene

Il34

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 By similarity.By similarity

    GO - Molecular functioni

    1. macrophage colony-stimulating factor receptor binding Source: UniProtKB

    GO - Biological processi

    1. inflammatory response Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW
    3. positive regulation of cell proliferation Source: UniProtKB
    4. positive regulation of protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-34
    Short name:
    IL-34
    Gene namesi
    Name:Il34
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1923777. Il34.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 235215Interleukin-34PRO_0000294349Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8R1R4.

    Expressioni

    Gene expression databases

    BgeeiQ8R1R4.
    GenevestigatoriQ8R1R4.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CSF1R By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034200.

    Structurei

    Secondary structure

    1
    235
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi31 – 333
    Helixi37 – 448
    Helixi47 – 548
    Turni55 – 573
    Beta strandi64 – 663
    Helixi68 – 703
    Helixi74 – 818
    Turni82 – 843
    Helixi87 – 10620
    Helixi116 – 13116
    Turni132 – 1354
    Helixi140 – 15011
    Beta strandi157 – 1593
    Helixi161 – 18020
    Beta strandi181 – 1844
    Helixi186 – 1883
    Beta strandi189 – 1913

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4EXNX-ray2.70A/B/E/F21-194[»]
    4EXPX-ray2.80A21-194[»]
    ProteinModelPortaliQ8R1R4.
    SMRiQ8R1R4. Positions 23-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-34 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46280.
    GeneTreeiENSGT00390000000932.
    HOGENOMiHOG000113048.
    HOVERGENiHBG108003.
    OMAiAWLHYLG.
    OrthoDBiEOG7H7936.
    PhylomeDBiQ8R1R4.
    TreeFamiTF337386.

    Family and domain databases

    InterProiIPR020415. IL-34.
    [Graphical view]
    PfamiPF15036. IL34. 1 hit.
    [Graphical view]
    PRINTSiPR01938. INTRLEUKIN34.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8R1R4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPWGLAWLYC LGILLDVALG NENLEIWTLT QDKECDLTGY LRGKLQYKNR    50
    LQYMKHYFPI NYRIAVPYEG VLRVANITRL QKAHVSEREL RYLWVLVSLN 100
    ATESVMDVLL EGHPSWKYLQ EVQTLLENVQ RSLMDVEIGP HVEAVLSLLS 150
    TPGLSLKLVR PKALLDNCFR VMELLYCSCC KQSPILKWQD CELPRLHPHS 200
    PGSLMQCTAT NVYPLSRQTP TSLPGSPSSS HGSLP 235
    Length:235
    Mass (Da):26,764
    Last modified:June 1, 2002 - v1
    Checksum:i4D30E33C977FD54D
    GO
    Isoform 2 (identifier: Q8R1R4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         135-235: DVEIGPHVEA...SPSSSHGSLP → AVGVHLPGHV...GHGTAVLFLL

    Note: No experimental confirmation available.

    Show »
    Length:219
    Mass (Da):24,736
    Checksum:i55AD04CEB406C73C
    GO
    Isoform 3 (identifier: Q8R1R4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-81: Missing.

    Show »
    Length:234
    Mass (Da):26,636
    Checksum:i33A081F6099F1C12
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 811Missing in isoform 3. 1 PublicationVSP_035080
    Alternative sequencei135 – 235101DVEIG…HGSLP → AVGVHLPGHVLVTLLSQLPG LPSPWARSFDTSWELLMMKG CGDWPSRGSCVISSEYSRPK PEAGAAQSLAGQLLPGHGTA VLFLL in isoform 2. 1 PublicationVSP_026632Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU636995 mRNA. Translation: ACD13453.1.
    EU636996 mRNA. Translation: ACD13454.1.
    AK008082 mRNA. Translation: BAB25448.1.
    BC016254 mRNA. Translation: AAH16254.1.
    CCDSiCCDS52669.1. [Q8R1R4-1]
    CCDS52670.1. [Q8R1R4-2]
    RefSeqiNP_001128572.1. NM_001135100.2. [Q8R1R4-1]
    NP_083922.1. NM_029646.3. [Q8R1R4-2]
    XP_006531548.1. XM_006531485.1. [Q8R1R4-3]
    UniGeneiMm.77697.

    Genome annotation databases

    EnsembliENSMUST00000076846; ENSMUSP00000076120; ENSMUSG00000031750. [Q8R1R4-1]
    ENSMUST00000150680; ENSMUSP00000114398; ENSMUSG00000031750. [Q8R1R4-2]
    GeneIDi76527.
    KEGGimmu:76527.
    UCSCiuc009nkz.2. mouse. [Q8R1R4-2]
    uc009nla.2. mouse. [Q8R1R4-1]
    uc012gko.1. mouse. [Q8R1R4-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU636995 mRNA. Translation: ACD13453.1 .
    EU636996 mRNA. Translation: ACD13454.1 .
    AK008082 mRNA. Translation: BAB25448.1 .
    BC016254 mRNA. Translation: AAH16254.1 .
    CCDSi CCDS52669.1. [Q8R1R4-1 ]
    CCDS52670.1. [Q8R1R4-2 ]
    RefSeqi NP_001128572.1. NM_001135100.2. [Q8R1R4-1 ]
    NP_083922.1. NM_029646.3. [Q8R1R4-2 ]
    XP_006531548.1. XM_006531485.1. [Q8R1R4-3 ]
    UniGenei Mm.77697.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4EXN X-ray 2.70 A/B/E/F 21-194 [» ]
    4EXP X-ray 2.80 A 21-194 [» ]
    ProteinModelPortali Q8R1R4.
    SMRi Q8R1R4. Positions 23-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034200.

    Proteomic databases

    PRIDEi Q8R1R4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076846 ; ENSMUSP00000076120 ; ENSMUSG00000031750 . [Q8R1R4-1 ]
    ENSMUST00000150680 ; ENSMUSP00000114398 ; ENSMUSG00000031750 . [Q8R1R4-2 ]
    GeneIDi 76527.
    KEGGi mmu:76527.
    UCSCi uc009nkz.2. mouse. [Q8R1R4-2 ]
    uc009nla.2. mouse. [Q8R1R4-1 ]
    uc012gko.1. mouse. [Q8R1R4-3 ]

    Organism-specific databases

    CTDi 146433.
    MGIi MGI:1923777. Il34.

    Phylogenomic databases

    eggNOGi NOG46280.
    GeneTreei ENSGT00390000000932.
    HOGENOMi HOG000113048.
    HOVERGENi HBG108003.
    OMAi AWLHYLG.
    OrthoDBi EOG7H7936.
    PhylomeDBi Q8R1R4.
    TreeFami TF337386.

    Miscellaneous databases

    NextBioi 345322.
    PROi Q8R1R4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R1R4.
    Genevestigatori Q8R1R4.

    Family and domain databases

    InterProi IPR020415. IL-34.
    [Graphical view ]
    Pfami PF15036. IL34. 1 hit.
    [Graphical view ]
    PRINTSi PR01938. INTRLEUKIN34.
    ProtoNeti Search...

    Publicationsi

    1. "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome."
      Lin H., Lee E., Hestir K., Leo C., Huang M., Bosch E., Halenbeck R., Wu G., Zhou A., Behrens D., Hollenbaugh D., Linnemann T., Qin M., Wong J., Chu K., Doberstein S.K., Williams L.T.
      Science 320:807-811(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Small intestine.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiIL34_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1R4
    Secondary accession number(s): B2ZC71, B2ZC72, Q9D8F2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3