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Q8R1R4 (IL34_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-34

Short name=IL-34
Gene names
Name:Il34
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 By similarity.

Subunit structure

Homodimer. Interacts with CSF1R By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the IL-34 family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8R1R4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8R1R4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     135-235: DVEIGPHVEA...SPSSSHGSLP → AVGVHLPGHV...GHGTAVLFLL
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8R1R4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 235215Interleukin-34
PRO_0000294349

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence811Missing in isoform 3.
VSP_035080
Alternative sequence135 – 235101DVEIG…HGSLP → AVGVHLPGHVLVTLLSQLPG LPSPWARSFDTSWELLMMKG CGDWPSRGSCVISSEYSRPK PEAGAAQSLAGQLLPGHGTA VLFLL in isoform 2.
VSP_026632

Secondary structure

.............................. 235
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 4D30E33C977FD54D

FASTA23526,764
        10         20         30         40         50         60 
MPWGLAWLYC LGILLDVALG NENLEIWTLT QDKECDLTGY LRGKLQYKNR LQYMKHYFPI 

        70         80         90        100        110        120 
NYRIAVPYEG VLRVANITRL QKAHVSEREL RYLWVLVSLN ATESVMDVLL EGHPSWKYLQ 

       130        140        150        160        170        180 
EVQTLLENVQ RSLMDVEIGP HVEAVLSLLS TPGLSLKLVR PKALLDNCFR VMELLYCSCC 

       190        200        210        220        230 
KQSPILKWQD CELPRLHPHS PGSLMQCTAT NVYPLSRQTP TSLPGSPSSS HGSLP 

« Hide

Isoform 2 [UniParc].

Checksum: 55AD04CEB406C73C
Show »

FASTA21924,736
Isoform 3 [UniParc].

Checksum: 33A081F6099F1C12
Show »

FASTA23426,636

References

« Hide 'large scale' references
[1]"Discovery of a cytokine and its receptor by functional screening of the extracellular proteome."
Lin H., Lee E., Hestir K., Leo C., Huang M., Bosch E., Halenbeck R., Wu G., Zhou A., Behrens D., Hollenbaugh D., Linnemann T., Qin M., Wong J., Chu K., Doberstein S.K., Williams L.T.
Science 320:807-811(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Small intestine.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU636995 mRNA. Translation: ACD13453.1.
EU636996 mRNA. Translation: ACD13454.1.
AK008082 mRNA. Translation: BAB25448.1.
BC016254 mRNA. Translation: AAH16254.1.
CCDSCCDS52669.1. [Q8R1R4-1]
CCDS52670.1. [Q8R1R4-2]
RefSeqNP_001128572.1. NM_001135100.2. [Q8R1R4-1]
NP_083922.1. NM_029646.3. [Q8R1R4-2]
XP_006531548.1. XM_006531485.1. [Q8R1R4-3]
UniGeneMm.77697.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4EXNX-ray2.70A/B/E/F21-194[»]
4EXPX-ray2.80A21-194[»]
ProteinModelPortalQ8R1R4.
SMRQ8R1R4. Positions 23-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000034200.

Proteomic databases

PRIDEQ8R1R4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000076846; ENSMUSP00000076120; ENSMUSG00000031750. [Q8R1R4-1]
ENSMUST00000150680; ENSMUSP00000114398; ENSMUSG00000031750. [Q8R1R4-2]
GeneID76527.
KEGGmmu:76527.
UCSCuc009nkz.2. mouse. [Q8R1R4-2]
uc009nla.2. mouse. [Q8R1R4-1]
uc012gko.1. mouse. [Q8R1R4-3]

Organism-specific databases

CTD146433.
MGIMGI:1923777. Il34.

Phylogenomic databases

eggNOGNOG46280.
GeneTreeENSGT00390000000932.
HOGENOMHOG000113048.
HOVERGENHBG108003.
OMAAWLHYLG.
OrthoDBEOG7H7936.
PhylomeDBQ8R1R4.
TreeFamTF337386.

Gene expression databases

BgeeQ8R1R4.
GenevestigatorQ8R1R4.

Family and domain databases

InterProIPR020415. IL-34.
[Graphical view]
PfamPF15036. IL34. 1 hit.
[Graphical view]
PRINTSPR01938. INTRLEUKIN34.
ProtoNetSearch...

Other

NextBio345322.
PROQ8R1R4.
SOURCESearch...

Entry information

Entry nameIL34_MOUSE
AccessionPrimary (citable) accession number: Q8R1R4
Secondary accession number(s): B2ZC71, B2ZC72, Q9D8F2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot