Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R1Q8

- DC1L1_MOUSE

UniProt

Q8R1Q8 - DC1L1_MOUSE

Protein

Cytoplasmic dynein 1 light intermediate chain 1

Gene

Dync1li1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 818ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: MGI

    GO - Biological processi

    1. metabolic process Source: GOC
    2. microtubule-based movement Source: MGI
    3. mitotic nuclear division Source: UniProtKB-KW
    4. positive regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
    5. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytoplasmic dynein 1 light intermediate chain 1
    Alternative name(s):
    Dynein light chain A
    Short name:
    DLC-A
    Dynein light intermediate chain 1, cytosolic
    Gene namesi
    Name:Dync1li1
    Synonyms:Dncli1, Dnclic1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2135610. Dync1li1.

    Subcellular locationi

    Cytoplasm By similarity. Chromosomecentromerekinetochore By similarity. Cytoplasmcytoskeletonspindle pole By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. condensed chromosome kinetochore Source: UniProtKB-SubCell
    3. cytoplasmic dynein complex Source: UniProtKB
    4. kinetochore Source: UniProtKB
    5. microtubule Source: UniProtKB-KW
    6. plasma membrane Source: Ensembl
    7. spindle pole Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Dynein, Kinetochore, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Cytoplasmic dynein 1 light intermediate chain 1PRO_0000114667Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei207 – 2071Phosphoserine4 Publications
    Modified residuei213 – 2131PhosphothreonineBy similarity
    Modified residuei398 – 3981PhosphoserineBy similarity
    Modified residuei405 – 4051Phosphoserine1 Publication
    Modified residuei408 – 4081PhosphothreonineBy similarity
    Modified residuei419 – 4191PhosphoserineBy similarity
    Modified residuei421 – 4211PhosphoserineBy similarity
    Modified residuei486 – 4861PhosphoserineBy similarity
    Modified residuei510 – 5101Phosphoserine1 Publication
    Modified residuei512 – 5121PhosphothreonineBy similarity
    Modified residuei513 – 5131Phosphothreonine1 Publication
    Modified residuei515 – 5151Phosphothreonine1 Publication
    Modified residuei516 – 5161Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated during mitosis but not in interphase.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8R1Q8.
    PaxDbiQ8R1Q8.
    PRIDEiQ8R1Q8.

    PTM databases

    PhosphoSiteiQ8R1Q8.

    Expressioni

    Gene expression databases

    BgeeiQ8R1Q8.
    CleanExiMM_DYNC1LI1.
    GenevestigatoriQ8R1Q8.

    Interactioni

    Subunit structurei

    Homodimer By similarity. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with PCNT By similarity.By similarity

    Protein-protein interaction databases

    BioGridi231702. 2 interactions.
    IntActiQ8R1Q8. 1 interaction.
    MINTiMINT-4118631.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R1Q8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG265404.
    GeneTreeiENSGT00390000008295.
    HOGENOMiHOG000236263.
    HOVERGENiHBG005546.
    InParanoidiQ8R1Q8.
    KOiK10416.
    OMAiPNRSVTS.
    OrthoDBiEOG7V7668.
    PhylomeDBiQ8R1Q8.
    TreeFamiTF352602.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR008467. Dynein1_light_intermed_chain.
    IPR022780. Dynein_light_int_chain.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR12688. PTHR12688. 1 hit.
    PfamiPF05783. DLIC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q8R1Q8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVGRVGSF GSSPPGLAST YASGPLANEL ASGSGGPAAG DDEDGQNLWS    50
    CILSEVSTRS RSKLPTGKNV LLLGEDGAGK TSLIRRIQGI EEYKKGRGLE 100
    YLYLNVHDED RDDQTRCNVW ILDGDLYHKG LLKFSLDALS LRDTLVMLVV 150
    DMSKPWTALD SLQKWASVVR EHVDKLKIPP EEMKEMEQKL IRDFQEYVEP 200
    GEDFPASPQR RTTGAQEDRG DSVVLPLGAD TLTHNLGLPV LVVCTKCDAI 250
    SVLEKEHDYR DEHFDFIQSH IRKFCLQYGA ALIYTSVKEN KNIDLVYKYI 300
    VQKLYGFPYK IPAVVVEKDA VFIPAGWDND KKIGILHENF QTLKVEDNFE 350
    DIITKPPVRK FVHEKEIMAE DDQVFLMKLQ SLLAKQPPTA AGRPVDASPR 400
    VPGGSPRTPN RSVSSNVASV SPIPAGSKKI DPNMKAGATS EGVLANFFNS 450
    LLSKKTGSPG GPGVGGSPGG GAAGASPSLP PSAKKSGQKP VLSDVHAELD 500
    RITRKPASVS PTTPTSPTEG EAS 523
    Length:523
    Mass (Da):56,614
    Last modified:June 1, 2002 - v1
    Checksum:iF080D6865A399498
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC023347 mRNA. Translation: AAH23347.1.
    CCDSiCCDS23595.1.
    RefSeqiNP_666341.1. NM_146229.2.
    UniGeneiMm.128627.

    Genome annotation databases

    EnsembliENSMUST00000047404; ENSMUSP00000035366; ENSMUSG00000032435.
    GeneIDi235661.
    KEGGimmu:235661.
    UCSCiuc009rxy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC023347 mRNA. Translation: AAH23347.1 .
    CCDSi CCDS23595.1.
    RefSeqi NP_666341.1. NM_146229.2.
    UniGenei Mm.128627.

    3D structure databases

    ProteinModelPortali Q8R1Q8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231702. 2 interactions.
    IntActi Q8R1Q8. 1 interaction.
    MINTi MINT-4118631.

    PTM databases

    PhosphoSitei Q8R1Q8.

    Proteomic databases

    MaxQBi Q8R1Q8.
    PaxDbi Q8R1Q8.
    PRIDEi Q8R1Q8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047404 ; ENSMUSP00000035366 ; ENSMUSG00000032435 .
    GeneIDi 235661.
    KEGGi mmu:235661.
    UCSCi uc009rxy.1. mouse.

    Organism-specific databases

    CTDi 51143.
    MGIi MGI:2135610. Dync1li1.

    Phylogenomic databases

    eggNOGi NOG265404.
    GeneTreei ENSGT00390000008295.
    HOGENOMi HOG000236263.
    HOVERGENi HBG005546.
    InParanoidi Q8R1Q8.
    KOi K10416.
    OMAi PNRSVTS.
    OrthoDBi EOG7V7668.
    PhylomeDBi Q8R1Q8.
    TreeFami TF352602.

    Miscellaneous databases

    ChiTaRSi DYNC1LI1. mouse.
    NextBioi 382833.
    PROi Q8R1Q8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R1Q8.
    CleanExi MM_DYNC1LI1.
    Genevestigatori Q8R1Q8.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR008467. Dynein1_light_intermed_chain.
    IPR022780. Dynein_light_int_chain.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR12688. PTHR12688. 1 hit.
    Pfami PF05783. DLIC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    2. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 134-142, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207 AND SER-405, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207; SER-510; THR-513; THR-515 AND SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiDC1L1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3