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Q8R1P8

- Q8R1P8_MOUSE

UniProt

Q8R1P8 - Q8R1P8_MOUSE

Protein

Guanylate cyclase

Gene

Npr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP = 3',5'-cyclic GMP + diphosphate.

    GO - Molecular functioni

    1. ATP binding Source: Ensembl
    2. GTP binding Source: Ensembl
    3. guanylate cyclase activity Source: MGI
    4. identical protein binding Source: MGI
    5. natriuretic peptide receptor activity Source: MGI
    6. peptide hormone binding Source: Ensembl
    7. protein kinase activity Source: InterPro

    GO - Biological processi

    1. bone development Source: MGI
    2. cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
    3. cGMP biosynthetic process Source: MGI
    4. intracellular signal transduction Source: InterPro
    5. negative regulation of meiotic cell cycle Source: MGI
    6. negative regulation of oocyte maturation Source: MGI
    7. receptor guanylyl cyclase signaling pathway Source: Ensembl
    8. single organism reproductive process Source: MGI

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    cGMP biosynthesisUniRule annotation

    Keywords - Ligandi

    Nucleotide-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate cyclaseUniRule annotation (EC:4.6.1.2UniRule annotation)
    Gene namesi
    Name:Npr2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97372. Npr2.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R1P8.
    BgeeiQ8R1P8.
    GenevestigatoriQ8R1P8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R1P8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG051862.
    InParanoidiQ8R1P8.

    Family and domain databases

    Gene3Di3.30.70.1230. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR011645. Haem_no_assoc-bd.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 1 hit.
    PF07701. HNOBA. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8R1P8-1 [UniParc]FASTAAdd to Basket

    « Hide

    KADVYSFAII LQEIALRSGP FYLEGLDLSP KEIVQKVRNG QRPYFRPSID    50
    RTQLNEELVL LMERCWAQDP TERPDFGQIK GFIRRFNKEG GTSILDNLLL 100
    RMEQYANNLE KLVEERTQAY LEEKRKAEAL LYQILPHSVA EQLKRGETVQ 150
    AEAFDSVTIY FSDIVGFTAL SAESTPMQVV TLLNDLYTCF DAIIDNFDVY 200
    KVETIGDAYM VVSGLPGRNG QRHAPEIARM ALALLDAVSS FRIRHRPHDQ 250
    LRLRIGVHTG PVCAGVVGLK MPRYCLFGDT VNTASRMESN GQALKIHVSS 300
    TTKDALDELG CFQLELRGDV EMKGKGKMRT YWLLGEQKGP PGLL 344
    Length:344
    Mass (Da):38,791
    Last modified:June 1, 2002 - v1
    Checksum:i6694E6B27146CAE5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC023420 mRNA. Translation: AAH23420.1.
    UniGeneiMm.103477.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC023420 mRNA. Translation: AAH23420.1 .
    UniGenei Mm.103477.

    3D structure databases

    ProteinModelPortali Q8R1P8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97372. Npr2.

    Phylogenomic databases

    HOVERGENi HBG051862.
    InParanoidi Q8R1P8.

    Miscellaneous databases

    ChiTaRSi NPR2. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R1P8.
    Bgeei Q8R1P8.
    Genevestigatori Q8R1P8.

    Family and domain databases

    Gene3Di 3.30.70.1230. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR011645. Haem_no_assoc-bd.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 1 hit.
    PF07701. HNOBA. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SMARTi SM00044. CYCc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ8R1P8_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1P8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)