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Protein

Guanylate cyclase

Gene

Npr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. GTP binding Source: Ensembl
  3. guanylate cyclase activity Source: MGI
  4. hormone binding Source: MGI
  5. identical protein binding Source: MGI
  6. natriuretic peptide receptor activity Source: MGI
  7. peptide hormone binding Source: Ensembl
  8. protein kinase activity Source: InterPro

GO - Biological processi

  1. bone development Source: MGI
  2. cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
  3. cGMP biosynthetic process Source: MGI
  4. intracellular signal transduction Source: InterPro
  5. negative regulation of meiotic cell cycle Source: MGI
  6. negative regulation of oocyte maturation Source: MGI
  7. receptor guanylyl cyclase signaling pathway Source: MGI
  8. single organism reproductive process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

cGMP biosynthesisUniRule annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclaseUniRule annotation (EC:4.6.1.2UniRule annotation)
Gene namesi
Name:Npr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97372. Npr2.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8R1P8.
ExpressionAtlasiQ8R1P8. baseline and differential.
GenevestigatoriQ8R1P8.

Structurei

3D structure databases

ProteinModelPortaliQ8R1P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG051862.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8R1P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KADVYSFAII LQEIALRSGP FYLEGLDLSP KEIVQKVRNG QRPYFRPSID
60 70 80 90 100
RTQLNEELVL LMERCWAQDP TERPDFGQIK GFIRRFNKEG GTSILDNLLL
110 120 130 140 150
RMEQYANNLE KLVEERTQAY LEEKRKAEAL LYQILPHSVA EQLKRGETVQ
160 170 180 190 200
AEAFDSVTIY FSDIVGFTAL SAESTPMQVV TLLNDLYTCF DAIIDNFDVY
210 220 230 240 250
KVETIGDAYM VVSGLPGRNG QRHAPEIARM ALALLDAVSS FRIRHRPHDQ
260 270 280 290 300
LRLRIGVHTG PVCAGVVGLK MPRYCLFGDT VNTASRMESN GQALKIHVSS
310 320 330 340
TTKDALDELG CFQLELRGDV EMKGKGKMRT YWLLGEQKGP PGLL
Length:344
Mass (Da):38,791
Last modified:June 1, 2002 - v1
Checksum:i6694E6B27146CAE5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023420 mRNA. Translation: AAH23420.1.
UniGeneiMm.103477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023420 mRNA. Translation: AAH23420.1.
UniGeneiMm.103477.

3D structure databases

ProteinModelPortaliQ8R1P8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97372. Npr2.

Phylogenomic databases

HOVERGENiHBG051862.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ8R1P8.
ExpressionAtlasiQ8R1P8. baseline and differential.
GenevestigatoriQ8R1P8.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ8R1P8_MOUSE
AccessioniPrimary (citable) accession number: Q8R1P8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.