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Q8R1P8

- Q8R1P8_MOUSE

UniProt

Q8R1P8 - Q8R1P8_MOUSE

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Protein

Guanylate cyclase

Gene
Npr2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. GTP binding Source: Ensembl
  3. guanylate cyclase activity Source: MGI
  4. identical protein binding Source: MGI
  5. natriuretic peptide receptor activity Source: MGI
  6. peptide hormone binding Source: Ensembl
  7. protein kinase activity Source: InterPro

GO - Biological processi

  1. bone development Source: MGI
  2. cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
  3. cGMP biosynthetic process Source: MGI
  4. intracellular signal transduction Source: InterPro
  5. negative regulation of meiotic cell cycle Source: MGI
  6. negative regulation of oocyte maturation Source: MGI
  7. receptor guanylyl cyclase signaling pathway Source: Ensembl
  8. single organism reproductive process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotations

Keywords - Biological processi

cGMP biosynthesisUniRule annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclaseUniRule annotation (EC:4.6.1.2UniRule annotation)
Gene namesi
Name:Npr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97372. Npr2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ8R1P8.
BgeeiQ8R1P8.
GenevestigatoriQ8R1P8.

Structurei

3D structure databases

ProteinModelPortaliQ8R1P8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG051862.
InParanoidiQ8R1P8.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8R1P8-1 [UniParc]FASTAAdd to Basket

« Hide

KADVYSFAII LQEIALRSGP FYLEGLDLSP KEIVQKVRNG QRPYFRPSID    50
RTQLNEELVL LMERCWAQDP TERPDFGQIK GFIRRFNKEG GTSILDNLLL 100
RMEQYANNLE KLVEERTQAY LEEKRKAEAL LYQILPHSVA EQLKRGETVQ 150
AEAFDSVTIY FSDIVGFTAL SAESTPMQVV TLLNDLYTCF DAIIDNFDVY 200
KVETIGDAYM VVSGLPGRNG QRHAPEIARM ALALLDAVSS FRIRHRPHDQ 250
LRLRIGVHTG PVCAGVVGLK MPRYCLFGDT VNTASRMESN GQALKIHVSS 300
TTKDALDELG CFQLELRGDV EMKGKGKMRT YWLLGEQKGP PGLL 344
Length:344
Mass (Da):38,791
Last modified:June 1, 2002 - v1
Checksum:i6694E6B27146CAE5
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC023420 mRNA. Translation: AAH23420.1.
UniGeneiMm.103477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC023420 mRNA. Translation: AAH23420.1 .
UniGenei Mm.103477.

3D structure databases

ProteinModelPortali Q8R1P8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97372. Npr2.

Phylogenomic databases

HOVERGENi HBG051862.
InParanoidi Q8R1P8.

Miscellaneous databases

ChiTaRSi NPR2. mouse.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R1P8.
Bgeei Q8R1P8.
Genevestigatori Q8R1P8.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ8R1P8_MOUSE
AccessioniPrimary (citable) accession number: Q8R1P8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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