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Q8R1P8 (Q8R1P8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length344 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

GTP = 3',5'-cyclic GMP + diphosphate.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. RuleBase RU000405

Ontologies

Keywords
   Biological processcGMP biosynthesis RuleBase RU003431
   LigandNucleotide-binding SAAS SAAS018297
   Molecular functionLyase RuleBase RU000405 RuleBase RU003431 SAAS SAAS018297
Gene Ontology (GO)
   Biological_processbone development

Inferred from mutant phenotype PubMed 624676. Source: MGI

cGMP biosynthetic process

Inferred from direct assay PubMed 14514678. Source: MGI

cellular response to granulocyte macrophage colony-stimulating factor stimulus

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

negative regulation of meiotic cell cycle

Inferred from mutant phenotype PubMed 20947764. Source: MGI

negative regulation of oocyte maturation

Inferred from mutant phenotype PubMed 20947764. Source: MGI

receptor guanylyl cyclase signaling pathway

Inferred from electronic annotation. Source: Ensembl

single organism reproductive process

Inferred from mutant phenotype PubMed 20947764. Source: MGI

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement PubMed 14514678. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: Ensembl

GTP binding

Inferred from electronic annotation. Source: Ensembl

guanylate cyclase activity

Inferred from direct assay PubMed 14514678. Source: MGI

identical protein binding

Inferred from physical interaction PubMed 14514678. Source: MGI

natriuretic peptide receptor activity

Inferred from direct assay PubMed 14514678. Source: MGI

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

protein kinase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAH23420.1

Sequences

Sequence LengthMass (Da)Tools
Q8R1P8 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 6694E6B27146CAE5

FASTA34438,791
        10         20         30         40         50         60 
KADVYSFAII LQEIALRSGP FYLEGLDLSP KEIVQKVRNG QRPYFRPSID RTQLNEELVL 

        70         80         90        100        110        120 
LMERCWAQDP TERPDFGQIK GFIRRFNKEG GTSILDNLLL RMEQYANNLE KLVEERTQAY 

       130        140        150        160        170        180 
LEEKRKAEAL LYQILPHSVA EQLKRGETVQ AEAFDSVTIY FSDIVGFTAL SAESTPMQVV 

       190        200        210        220        230        240 
TLLNDLYTCF DAIIDNFDVY KVETIGDAYM VVSGLPGRNG QRHAPEIARM ALALLDAVSS 

       250        260        270        280        290        300 
FRIRHRPHDQ LRLRIGVHTG PVCAGVVGLK MPRYCLFGDT VNTASRMESN GQALKIHVSS 

       310        320        330        340 
TTKDALDELG CFQLELRGDV EMKGKGKMRT YWLLGEQKGP PGLL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH23420.1.
Tissue: Liver EMBL AAH23420.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC023420 mRNA. Translation: AAH23420.1.
UniGeneMm.103477.

3D structure databases

ProteinModelPortalQ8R1P8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97372. Npr2.

Phylogenomic databases

HOVERGENHBG051862.
InParanoidQ8R1P8.

Gene expression databases

ArrayExpressQ8R1P8.
BgeeQ8R1P8.
GenevestigatorQ8R1P8.

Family and domain databases

Gene3D3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamPF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMSSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNPR2. mouse.
SOURCESearch...

Entry information

Entry nameQ8R1P8_MOUSE
AccessionPrimary (citable) accession number: Q8R1P8
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)