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Protein

Guanylate cyclase

Gene

Npr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processcGMP biosynthesisUniRule annotation
LigandNucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclaseUniRule annotation (EC:4.6.1.2UniRule annotation)
Gene namesi
Name:Npr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97372. Npr2.

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8R1P8.
PeptideAtlasiQ8R1P8.

Structurei

3D structure databases

ProteinModelPortaliQ8R1P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 83Protein kinaseInterPro annotationAdd BLAST83
Domaini158 – 288Guanylate cyclaseInterPro annotationAdd BLAST131

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili95 – 122Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
HOVERGENiHBG051862.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiView protein in InterPro
IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
SMARTiView protein in SMART
SM00044. CYCc. 1 hit.
SUPFAMiSSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8R1P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KADVYSFAII LQEIALRSGP FYLEGLDLSP KEIVQKVRNG QRPYFRPSID
60 70 80 90 100
RTQLNEELVL LMERCWAQDP TERPDFGQIK GFIRRFNKEG GTSILDNLLL
110 120 130 140 150
RMEQYANNLE KLVEERTQAY LEEKRKAEAL LYQILPHSVA EQLKRGETVQ
160 170 180 190 200
AEAFDSVTIY FSDIVGFTAL SAESTPMQVV TLLNDLYTCF DAIIDNFDVY
210 220 230 240 250
KVETIGDAYM VVSGLPGRNG QRHAPEIARM ALALLDAVSS FRIRHRPHDQ
260 270 280 290 300
LRLRIGVHTG PVCAGVVGLK MPRYCLFGDT VNTASRMESN GQALKIHVSS
310 320 330 340
TTKDALDELG CFQLELRGDV EMKGKGKMRT YWLLGEQKGP PGLL
Length:344
Mass (Da):38,791
Last modified:June 1, 2002 - v1
Checksum:i6694E6B27146CAE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023420 mRNA. Translation: AAH23420.1.
UniGeneiMm.103477.

Similar proteinsi

Entry informationi

Entry nameiQ8R1P8_MOUSE
AccessioniPrimary (citable) accession number: Q8R1P8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)