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Protein

Potassium channel subfamily K member 13

Gene

Kcnk13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel displaying weak inward rectification in symmetrical K+ solution.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1299287. Tandem pore domain halothane-inhibited K+ channel (THIK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 13
Alternative name(s):
Tandem pore domain halothane-inhibited potassium channel 1
Short name:
THIK-1
Gene namesi
Name:Kcnk13
Synonyms:Gm1570
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2384976. Kcnk13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence analysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Intramembranei95 – 11521Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Topological domaini146 – 19348CytoplasmicSequence analysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence analysisAdd
BLAST
Intramembranei224 – 24421Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Topological domaini284 – 405122CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Potassium channel subfamily K member 13PRO_0000101763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R1P5.
PRIDEiQ8R1P5.

PTM databases

iPTMnetiQ8R1P5.
PhosphoSiteiQ8R1P5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045404.
CleanExiMM_KCNK13.
ExpressionAtlasiQ8R1P5. baseline and differential.
GenevisibleiQ8R1P5. MM.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051846.

Structurei

3D structure databases

ProteinModelPortaliQ8R1P5.
SMRiQ8R1P5. Positions 30-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ8R1P5.
KOiK04922.
OMAiVNWILRK.
OrthoDBiEOG091G06SB.
PhylomeDBiQ8R1P5.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q8R1P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGCGCSP GHLNEDNARF LLLAGLILLY LLGGAAVFSA LELAQELQAK
60 70 80 90 100
QRWEERLANF SRGHNLSREE LRGFLRHYEE ATRAGIRMDS VRPRWDFTGA
110 120 130 140 150
FYFVGTVVST IGFGMTTPAT TGGKIFLIFY GLIGCASTIL FFNLFLERLI
160 170 180 190 200
TVIACVMRSC HQQQLRRRGA VTQDNMKAPE KGEADSLTGW KPSVYYVMLI
210 220 230 240 250
LCLASVAISC GASALYTTME GWSYFDSVYF CFVAFSTIGF GDLVSSQNAQ
260 270 280 290 300
YESQGLYRFF NFFLILMGVC CIYSLFNVIS ILIKQTVNWI LRKLDSGCFP
310 320 330 340 350
PCQRGLLRSR RNVVMPGNIR NRCNISIETD GVMESDTDGR RLSGEMISMK
360 370 380 390 400
DTNKVSLAIL QKQLSEMANG GPHQNSASSR DDEFSGGVGA FAVMNNRLAE

TSGDR
Length:405
Mass (Da):44,926
Last modified:June 1, 2002 - v1
Checksum:iC462A95FB57F1548
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023443 mRNA. Translation: AAH23443.1.
CCDSiCCDS26106.1.
RefSeqiNP_001157898.1. NM_001164426.1.
NP_001157899.1. NM_001164427.1.
NP_666149.1. NM_146037.2.
XP_011242394.1. XM_011244092.1.
UniGeneiMm.312335.

Genome annotation databases

EnsembliENSMUST00000049788; ENSMUSP00000051846; ENSMUSG00000045404.
ENSMUST00000160413; ENSMUSP00000123916; ENSMUSG00000045404.
ENSMUST00000177549; ENSMUSP00000136882; ENSMUSG00000045404.
GeneIDi217826.
KEGGimmu:217826.
UCSCiuc007osi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023443 mRNA. Translation: AAH23443.1.
CCDSiCCDS26106.1.
RefSeqiNP_001157898.1. NM_001164426.1.
NP_001157899.1. NM_001164427.1.
NP_666149.1. NM_146037.2.
XP_011242394.1. XM_011244092.1.
UniGeneiMm.312335.

3D structure databases

ProteinModelPortaliQ8R1P5.
SMRiQ8R1P5. Positions 30-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051846.

PTM databases

iPTMnetiQ8R1P5.
PhosphoSiteiQ8R1P5.

Proteomic databases

PaxDbiQ8R1P5.
PRIDEiQ8R1P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049788; ENSMUSP00000051846; ENSMUSG00000045404.
ENSMUST00000160413; ENSMUSP00000123916; ENSMUSG00000045404.
ENSMUST00000177549; ENSMUSP00000136882; ENSMUSG00000045404.
GeneIDi217826.
KEGGimmu:217826.
UCSCiuc007osi.2. mouse.

Organism-specific databases

CTDi56659.
MGIiMGI:2384976. Kcnk13.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
HOVERGENiHBG052238.
InParanoidiQ8R1P5.
KOiK04922.
OMAiVNWILRK.
OrthoDBiEOG091G06SB.
PhylomeDBiQ8R1P5.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiR-MMU-1299287. Tandem pore domain halothane-inhibited K+ channel (THIK).

Miscellaneous databases

PROiQ8R1P5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045404.
CleanExiMM_KCNK13.
ExpressionAtlasiQ8R1P5. baseline and differential.
GenevisibleiQ8R1P5. MM.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNKD_MOUSE
AccessioniPrimary (citable) accession number: Q8R1P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The current is enhanced by arachidonic acid and inhibited by halothane.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.