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Protein

Ubiquitin-like-conjugating enzyme ATG10

Gene

Atg10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165Glycyl thioester intermediateCurated1

GO - Molecular functioni

  • Atg12 transferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAutophagy, Protein transport, Transport, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like-conjugating enzyme ATG10 (EC:2.3.2.-)
Alternative name(s):
Autophagy-related protein 10
Short name:
APG10-like
Short name:
mAPG10
Gene namesi
Name:Atg10
Synonyms:Apg10l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914045 Atg10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi165C → S: Instead of the formation of an intermediate complex with a thiol ester bond between ATG10 (E2-like enzyme) and ATG12 (substrate), a stable complex with an O-ester bond is formed. Does not affect ATG12 conjugation to ATG3. 3 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000961841 – 215Ubiquitin-like-conjugating enzyme ATG10Add BLAST215

Proteomic databases

MaxQBiQ8R1P4
PaxDbiQ8R1P4
PRIDEiQ8R1P4

PTM databases

iPTMnetiQ8R1P4
PhosphoSitePlusiQ8R1P4

Expressioni

Gene expression databases

CleanExiMM_ATG10

Interactioni

Subunit structurei

Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7.2 Publications

Protein-protein interaction databases

BioGridi211724, 3 interactors
IntActiQ8R1P4, 3 interactors
MINTiQ8R1P4
STRINGi10090.ENSMUSP00000022119

Structurei

3D structure databases

ProteinModelPortaliQ8R1P4
SMRiQ8R1P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG10 family.Curated

Phylogenomic databases

eggNOGiKOG4741 Eukaryota
ENOG4111W4Q LUCA
HOGENOMiHOG000034127
HOVERGENiHBG080874
InParanoidiQ8R1P4
KOiK17888
PhylomeDBiQ8R1P4
TreeFamiTF314016

Family and domain databases

InterProiView protein in InterPro
IPR007135 Autophagy-rel_prot_3
PfamiView protein in Pfam
PF03987 Autophagy_act_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R1P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDEFFGEKS FQHYCAEFIR HSQQIGDGWE WRTAKECSDG YMCKTQFRIK
60 70 80 90 100
NEASTPHVGT PASVLTCLPT EENLELPMDD SEVTRPAAVA EVIKHEYHVL
110 120 130 140 150
YSCSYQVPVL YFRASFLDGR PLALEDIWEG VHECYKPRLL QGPWDTITQQ
160 170 180 190 200
EHPILGQPFF VLHPCKTNEF MTAVLKNSQK INRNVNYITS WLSLVGPVVG
210
LNLPLSYAKA TSQSE
Length:215
Mass (Da):24,577
Last modified:June 1, 2002 - v1
Checksum:i8239CC22A8727B2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42M → I in BAB30705 (PubMed:16141072).Curated1
Sequence conflicti53 – 54AS → TL in BAC77060 (PubMed:12890687).Curated2
Sequence conflicti53 – 54AS → TL in BAB30705 (PubMed:16141072).Curated2
Sequence conflicti53 – 54AS → TL in BAC36756 (PubMed:16141072).Curated2
Sequence conflicti58 – 61Missing in BAC77060 (PubMed:12890687).Curated4
Sequence conflicti58 – 61Missing in BAB30705 (PubMed:16141072).Curated4
Sequence conflicti58 – 61Missing in BAC36756 (PubMed:16141072).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091691 mRNA Translation: BAC55163.1
AB079383 mRNA Translation: BAC77060.1
AK017355 mRNA Translation: BAB30705.1
AK077333 mRNA Translation: BAC36756.1
BC023455 mRNA Translation: AAH23455.1
RefSeqiNP_080046.3, NM_025770.3
XP_006517389.1, XM_006517326.3
UniGeneiMm.235385

Genome annotation databases

GeneIDi66795
KEGGimmu:66795
UCSCiuc007rjr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATG10_MOUSE
AccessioniPrimary (citable) accession number: Q8R1P4
Secondary accession number(s): Q8BPA9, Q9D3J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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