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Protein

NudC domain-containing protein 3

Gene

Nudcd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 3
Gene namesi
Name:Nudcd3
Synonyms:Kiaa1068
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144158. Nudcd3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579861 – 363NudC domain-containing protein 3Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei342PhosphoserineBy similarity1
Modified residuei357PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R1N4.
PaxDbiQ8R1N4.
PeptideAtlasiQ8R1N4.
PRIDEiQ8R1N4.

PTM databases

iPTMnetiQ8R1N4.
PhosphoSitePlusiQ8R1N4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053838.
CleanExiMM_NUDCD3.
ExpressionAtlasiQ8R1N4. baseline and differential.
GenevisibleiQ8R1N4. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R1N4. 1 interactor.
STRINGi10090.ENSMUSP00000064668.

Structurei

3D structure databases

ProteinModelPortaliQ8R1N4.
SMRiQ8R1N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 279CSPROSITE-ProRule annotationAdd BLAST93

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOVERGENiHBG100537.
InParanoidiQ8R1N4.
OMAiQILYGAM.
OrthoDBiEOG091G0BZ5.
PhylomeDBiQ8R1N4.
TreeFamiTF300147.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiView protein in InterPro
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR025934. NudC_N_dom.
IPR027761. NUDCD3.
PANTHERiPTHR12356:SF19. PTHR12356:SF19. 1 hit.
PfamiView protein in Pfam
PF04969. CS. 1 hit.
PF14050. Nudc_N. 1 hit.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiView protein in PROSITE
PS51203. CS. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R1N4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR
60 70 80 90 100
MGFPPGAAQA LVLQVFKTFD HMARQDDEKR KKELEEKIRK KEEEAKALPA
110 120 130 140 150
AETEKVAVPV PVQEVEIDAA ADLSGPQEVE KEEPPGSQDP EHTVTHGLEK
160 170 180 190 200
AEAPGTVSSA AEGPKDPPVL PRIQEQFQKN PDSYNGAIRE NYIWSQDYTD
210 220 230 240 250
LEVRVPVPKH VMKGKQVSVA LSSGTIRVAM VEENGERVLM EGKLTHKINT
260 270 280 290 300
ESSLWSLEPG RCVLVNLSKV GEYWWSAILE GEEPIDIDKI NKERSMATVD
310 320 330 340 350
EEEQAVLDRL TFDYHQKLQG KPQSHELKVH EMLKKGWDAE GSPFRGQRFD
360
PAMFNISPGA VQF
Length:363
Mass (Da):40,890
Last modified:November 23, 2004 - v3
Checksum:iD5FD1DE3CB724042
GO
Isoform 2 (identifier: Q8R1N4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-264: Missing.

Note: No experimental confirmation available.
Show »
Length:315
Mass (Da):35,680
Checksum:i8698CF4A89FCD037
GO
Isoform 3 (identifier: Q8R1N4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-300: NLSKVGEYWWSAILEGEEPIDIDKINKERSMATVD → SEVTCVQSSHQGFAPAMMTCVQVFPIISEVFNYSN
     301-363: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,422
Checksum:i78332B8FE99AF53F
GO
Isoform 4 (identifier: Q8R1N4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-295: Missing.

Note: No experimental confirmation available.
Show »
Length:68
Mass (Da):7,819
Checksum:iA425E792241C7233
GO

Sequence cautioni

The sequence BAC98086 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0136771 – 295Missing in isoform 4. 1 PublicationAdd BLAST295
Alternative sequenceiVSP_013678217 – 264Missing in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_013679266 – 300NLSKV…MATVD → SEVTCVQSSHQGFAPAMMTC VQVFPIISEVFNYSN in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_013680301 – 363Missing in isoform 3. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129276 mRNA. Translation: BAC98086.1. Different initiation.
AK046219 mRNA. Translation: BAC32642.1.
AK049739 mRNA. Translation: BAC33899.1.
AK050476 mRNA. Translation: BAC34277.1.
AK159391 mRNA. Translation: BAE35045.1.
AK159458 mRNA. Translation: BAE35100.1.
AK169797 mRNA. Translation: BAE41373.1.
AK170329 mRNA. Translation: BAE41723.1.
AK171224 mRNA. Translation: BAE42326.1.
AL607152, AL611926 Genomic DNA. Translation: CAI24394.1.
AL611926, AL607152 Genomic DNA. Translation: CAI24956.1.
AL611926 Genomic DNA. Translation: CAI24961.1.
BC024322 mRNA. Translation: AAH24322.3.
BC037090 mRNA. Translation: AAH37090.1.
BC057603 mRNA. Translation: AAH57603.1.
CCDSiCCDS24412.1. [Q8R1N4-1]
RefSeqiNP_776109.1. NM_173748.4. [Q8R1N4-1]
XP_006514666.1. XM_006514603.2. [Q8R1N4-2]
UniGeneiMm.25321.
Mm.472975.

Genome annotation databases

EnsembliENSMUST00000066496; ENSMUSP00000064668; ENSMUSG00000053838. [Q8R1N4-1]
GeneIDi209586.
KEGGimmu:209586.
UCSCiuc007hxy.2. mouse. [Q8R1N4-1]
uc007hxz.2. mouse. [Q8R1N4-2]
uc007hya.2. mouse. [Q8R1N4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNUDC3_MOUSE
AccessioniPrimary (citable) accession number: Q8R1N4
Secondary accession number(s): Q3TX16
, Q5SVV6, Q5SVV7, Q6PFE4, Q6ZPZ2, Q8BL70, Q8BWN3, Q8BWW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot