ID   ZN830_MOUSE             Reviewed;         363 AA.
AC   Q8R1N0; Q3TR52; Q9CWV9; Q9CYI6;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   19-JAN-2010, entry version 65.
DE   RecName: Full=Zinc finger protein 830;
DE   AltName: Full=Coiled-coil domain-containing protein 16;
DE   AltName: Full=Ovus mutant candidate gene 1 protein;
GN   Name=Znf830; Synonyms=Ccdc16, Omcg1, Zfp830;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Kidney, Liver, Skin, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Brain;
RX   PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
RA   Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT   "Phosphoproteomic analysis of the developing mouse brain.";
RL   Mol. Cell. Proteomics 3:1093-1101(2004).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=15988037; DOI=10.1128/MCB.25.14.6289-6302.2005;
RA   Artus J., Vandormael-Pournin S., Froedin M., Nacerddine K.,
RA   Babinet C., Cohen-Tannoudji M.;
RT   "Impaired mitotic progression and preimplantation lethality in mice
RT   lacking OMCG1, a new evolutionarily conserved nuclear protein.";
RL   Mol. Cell. Biol. 25:6289-6302(2005).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-353, AND
RP   MASS SPECTROMETRY.
RX   PubMed=17525332; DOI=10.1126/science.1140321;
RA   Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
RA   Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
RA   Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
RT   "ATM and ATR substrate analysis reveals extensive protein networks
RT   responsive to DNA damage.";
RL   Science 316:1160-1166(2007).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342, AND MASS
RP   SPECTROMETRY.
RX   PubMed=18973353; DOI=10.1021/pr800599n;
RA   Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,
RA   Faessler R., Mann M.;
RT   "Solid tumor proteome and phosphoproteome analysis by high resolution
RT   mass spectrometry.";
RL   J. Proteome Res. 7:5314-5326(2008).
CC   -!- FUNCTION: Acts as an important regulator of the cell cycle in the
CC       preimplantation embryo by controlling different aspects of M
CC       phase.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Excluded from nucleolus. In
CC       metaphase II oocytes and in mitotic blastomeres, it is detected in
CC       cytoplasm, suggesting that it is not associated with chromosomes
CC       during mitosis.
CC   -!- TISSUE SPECIFICITY: Widely expressed at low level.
CC   -!- DEVELOPMENTAL STAGE: Expressed in preimplantation embryos.
CC   -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
CC   -!- DISRUPTION PHENOTYPE: Mice die by the end of preimplantation
CC       development and exhibit a dramatic reduction in the total cell
CC       number, a high mitotic index, and the presence of abnormal mitotic
CC       figures.
CC   -!- SIMILARITY: Contains 1 C2H2-type zinc finger.
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DR   EMBL; AK050043; BAC34045.1; -; mRNA.
DR   EMBL; AK010353; BAB26873.1; -; mRNA.
DR   EMBL; AK017640; BAB30851.1; -; mRNA.
DR   EMBL; AK132497; BAE21204.1; -; mRNA.
DR   EMBL; AK148058; BAE28318.1; -; mRNA.
DR   EMBL; AK163064; BAE37178.1; -; mRNA.
DR   EMBL; AK167656; BAE39707.1; -; mRNA.
DR   EMBL; AK168417; BAE40331.1; -; mRNA.
DR   EMBL; AL645594; CAI25093.1; -; Genomic_DNA.
DR   EMBL; BC024340; AAH24340.1; -; mRNA.
DR   IPI; IPI00320645; -.
DR   RefSeq; NP_080160.2; -.
DR   UniGene; Mm.29622; -.
DR   STRING; Q8R1N0; -.
DR   PhosphoSite; Q8R1N0; -.
DR   PRIDE; Q8R1N0; -.
DR   Ensembl; ENSMUST00000056677; ENSMUSP00000056154; ENSMUSG00000046010; Mus musculus.
DR   GeneID; 66983; -.
DR   KEGG; mmu:66983; -.
DR   UCSC; uc007kmy.1; mouse.
DR   CTD; 66983; -.
DR   MGI; MGI:1914233; Zfp830.
DR   eggNOG; roNOG15199; -.
DR   HOGENOM; HBG713871; -.
DR   HOVERGEN; Q8R1N0; -.
DR   InParanoid; Q8R1N0; -.
DR   OMA; THVLGKQ; -.
DR   OrthoDB; EOG9XWJHM; -.
DR   PhylomeDB; Q8R1N0; -.
DR   NextBio; 323216; -.
DR   ArrayExpress; Q8R1N0; -.
DR   Bgee; Q8R1N0; -.
DR   CleanEx; MM_ZFP830; -.
DR   Genevestigator; Q8R1N0; -.
DR   GermOnline; ENSMUSG00000046010; Mus musculus.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001832; P:blastocyst growth; IMP:MGI.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007067; P:mitosis; IEA:UniProtKB-KW.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; FALSE_NEG.
PE   1: Evidence at protein level;
KW   Acetylation; Cell cycle; Cell division; Coiled coil;
KW   Developmental protein; Metal-binding; Mitosis; Nucleus;
KW   Phosphoprotein; Zinc; Zinc-finger.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    363       Zinc finger protein 830.
FT                                /FTId=PRO_0000076194.
FT   ZN_FING      53     75       C2H2-type.
FT   COILED       16     40       Potential.
FT   COILED      303    331       Potential.
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
FT   MOD_RES     342    342       Phosphoserine.
FT   MOD_RES     353    353       Phosphoserine.
FT   CONFLICT     81     82       EL -> DV (in Ref. 1; BAB30851).
FT   CONFLICT    111    111       Q -> L (in Ref. 1; BAB26873).
FT   CONFLICT    305    305       C -> G (in Ref. 1; BAE37178).
FT   CONFLICT    309    309       V -> G (in Ref. 1; BAE37178).
SQ   SEQUENCE   363 AA;  40658 MW;  1247580A0D8B6E60 CRC64;
     MASSTSTRTP AGKRVVNQEE LRRLMREKQR LSTNRKRIES PFAKYNRLGQ LSCALCNTPV
     KSELLWQTHV LGKQHRERVA ELKGAKGATQ GPSTGTVPQA TKRRATDVES QDAKKAKASA
     GPQVQPSTSA SSANLDAARA APSKPGLGLL PDYDDEEEEE EEGGGEERRD SSKHLPDAQG
     KEHSLASPRE TTSNVLPNDP FNTNPPKAPL VPHSGSIEKA EIHEKVVERR ENTAEALPEG
     FFDDPEVDAK VRKVDAPKDQ MDKEWDEFQK AMRQVNTISE AIVAEEDEEG RLDRQIGEID
     EQIECYRRVE KLRNRQDEIK NKLKEVLTIK ELQKKEEENV DSDDEGELQD LLSQDWRVKG
     ALL
//