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Protein

5-phosphohydroxy-L-lysine phospho-lyase

Gene

Phykpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde.By similarity

Caution

Does not seem to possess aminotransferase activity.By similarity

Catalytic activityi

(5R)-5-phosphonooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate.

Cofactori

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-71064 Lysine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
5-phosphohydroxy-L-lysine phospho-lyase (EC:4.2.3.134)
Alternative name(s):
Alanine--glyoxylate aminotransferase 2-like 2
Gene namesi
Name:Phykpl
Synonyms:Agxt2l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920197 Phykpl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876681 – 4675-phosphohydroxy-L-lysine phospho-lyaseAdd BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiQ8R1K4
PaxDbiQ8R1K4
PeptideAtlasiQ8R1K4
PRIDEiQ8R1K4

PTM databases

iPTMnetiQ8R1K4
PhosphoSitePlusiQ8R1K4

Expressioni

Gene expression databases

BgeeiENSMUSG00000020359
CleanExiMM_AGXT2L2
ExpressionAtlasiQ8R1K4 baseline and differential
GenevisibleiQ8R1K4 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132190

Structurei

3D structure databases

ProteinModelPortaliQ8R1K4
SMRiQ8R1K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1403 Eukaryota
COG0160 LUCA
GeneTreeiENSGT00530000062907
HOGENOMiHOG000020206
HOVERGENiHBG004196
InParanoidiQ8R1K4
KOiK18202
OMAiYKVISRA
OrthoDBiEOG091G08ZM
PhylomeDBiQ8R1K4
TreeFamiTF320468

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R1K4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADTRAKAV TLDLRRRLLS SSCRLFFPED PVKIIRGQGQ YLYDEQGREY
60 70 80 90 100
LDCINNVAHV GHCHPTVVQA AHEQNLVLNT NSRYLHDNIV DYAQRLSETL
110 120 130 140 150
PEQLSVFYFL NSGSEANDLA LRLARQYTGH QDVVVLDHAY HGHLSSLIDI
160 170 180 190 200
SPYKFRNLGG QKEWVHVAPL PDTYRGPYRE DHPNPAEAYA NEVKHVISSA
210 220 230 240 250
QQKGRKIAAF FAESLPSVSG QIIPPAGYFS QVAEHIHRAG GLFVADEIQV
260 270 280 290 300
GFGRIGKHFW AFQLEGEDFV PDIVTMGKSI GNGHPVACMA TTQAVSRAFE
310 320 330 340 350
ATGVEYFNTF GGNPVSCAVG LAVLDVLKTE QLQAHATNVG SFLLEHLTQQ
360 370 380 390 400
KAKHPIIGDV RGTGLFIGVD LIKDETLRTP ATEEAEYLVS RLKENYILLS
410 420 430 440 450
IDGPGKNILK FKPPMCFNVD NAQHVVAKLD DILTDMEEKV RSCETLRIKH
460
PPEDTHPTQI LLTRQQD
Length:467
Mass (Da):51,966
Last modified:June 1, 2002 - v1
Checksum:i85DE6A02090E6758
GO
Isoform 2 (identifier: Q8R1K4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     453-467: EDTHPTQILLTRQQD → GSTGPGCRAATGNRPS

Show »
Length:468
Mass (Da):51,660
Checksum:i5D89D137828A1614
GO
Isoform 3 (identifier: Q8R1K4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-184: APLPDTYRGPYREDHPN → VCIPTISNRSVSIPKPG
     185-467: Missing.

Show »
Length:184
Mass (Da):20,825
Checksum:iD8677E8C1238C66B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025586168 – 184APLPD…EDHPN → VCIPTISNRSVSIPKPG in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_025587185 – 467Missing in isoform 3. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_025588453 – 467EDTHP…TRQQD → GSTGPGCRAATGNRPS in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085984 mRNA Translation: BAC39584.1
AK087703 mRNA Translation: BAC39972.1
AK133235 mRNA Translation: BAE21570.1
AK160557 mRNA Translation: BAE35872.1
AL645602, AL662843 Genomic DNA Translation: CAM26934.1
AL662843, AL645602 Genomic DNA Translation: CAI35931.1
AL662843 Genomic DNA Translation: CAI35932.1
BC024461 mRNA Translation: AAH24461.1
CCDSiCCDS24653.1 [Q8R1K4-1]
RefSeqiNP_082674.1, NM_028398.2 [Q8R1K4-1]
UniGeneiMm.256875

Genome annotation databases

EnsembliENSMUST00000020625; ENSMUSP00000020625; ENSMUSG00000020359 [Q8R1K4-2]
ENSMUST00000167797; ENSMUSP00000132190; ENSMUSG00000020359 [Q8R1K4-1]
GeneIDi72947
KEGGimmu:72947
UCSCiuc007itw.1 mouse [Q8R1K4-3]
uc007itx.1 mouse [Q8R1K4-2]
uc007ity.1 mouse [Q8R1K4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAT2L2_MOUSE
AccessioniPrimary (citable) accession number: Q8R1K4
Secondary accession number(s): Q3TUU9, Q8BG04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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