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Protein

Gastrin-releasing peptide

Gene

Grp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (PubMed:28280205, PubMed:17653196, PubMed:26658875). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). Contributes to long-term fear memory, but not normal spatial memory (PubMed:12526815). Contributes to the regulation of food intake (PubMed:12176666).By similarity5 Publications

GO - Molecular functioni

GO - Biological processi

  • neuropeptide signaling pathway Source: MGI
  • positive regulation of peptide hormone secretion Source: UniProtKB
  • positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • psychomotor behavior Source: UniProtKB
  • response to external biotic stimulus Source: UniProtKB
  • social behavior Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide
Short name:
GRP
Cleaved into the following chain:
Alternative name(s):
GRP-10
Gene namesi
Name:Grp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95833. Grp.

Subcellular locationi

  • Secreted By similarity
  • Cytoplasmic vesiclesecretory vesicle lumen By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Disruption phenotypei

Contrary to wild-type, mutant mice do not display imitative scratching after observing spontaneous scratching behavior in another mouse (PubMed:28280205).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PeptideiPRO_000026247224 – 52Gastrin-releasing peptideAdd BLAST29
PeptideiPRO_000026247343 – 52Neuromedin-C10
PropeptideiPRO_000026247456 – 146By similarityAdd BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MaxQBiQ8R1I2.
PaxDbiQ8R1I2.
PRIDEiQ8R1I2.

PTM databases

PhosphoSitePlusiQ8R1I2.

Expressioni

Tissue specificityi

Detected in the suprachiasmatic nucleus in the hypothalamus (PubMed:28280205). Detected in peptidergic dorsal root ganglion neurons (at protein level) (PubMed:17653196). Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus (PubMed:12526815).3 Publications

Gene expression databases

BgeeiENSMUSG00000024517.
CleanExiMM_GRP.
ExpressionAtlasiQ8R1I2. baseline and differential.
GenevisibleiQ8R1I2. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025395.

Structurei

3D structure databases

SMRiQ8R1I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ53. Eukaryota.
ENOG4111D8H. LUCA.
GeneTreeiENSGT00390000017865.
HOGENOMiHOG000112821.
HOVERGENiHBG005912.
InParanoidiQ8R1I2.
KOiK05224.
OMAiYIRWEEA.
OrthoDBiEOG091G0VOZ.
PhylomeDBiQ8R1I2.
TreeFamiTF336391.

Family and domain databases

InterProiView protein in InterPro
IPR000874. Bombesin.
IPR015674. Gastrin-RP.
PANTHERiPTHR16866:SF4. PTHR16866:SF4. 1 hit.
PfamiView protein in Pfam
PF02044. Bombesin. 1 hit.
PROSITEiView protein in PROSITE
PS00257. BOMBESIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R1I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH
60 70 80 90 100
LMGKKSTDES PSLYAADRDG LKEQLRGYVR WEEAARDLLD LLEAAGNQSH
110 120 130 140
QPPQHPPLSL QPTWDPEDGS YFNDVQTAKL VDSLLQVLKE KGGTAS
Length:146
Mass (Da):15,659
Last modified:June 1, 2002 - v1
Checksum:i83FD03C40E670CA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134L → Q in BAE23968 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133508 mRNA. Translation: BAE21694.1.
AK139345 mRNA. Translation: BAE23968.1.
BC024515 mRNA. Translation: AAH24515.1.
CCDSiCCDS29310.1.
RefSeqiNP_778177.1. NM_175012.4.
XP_006525949.1. XM_006525886.3.
UniGeneiMm.20298.
Mm.394498.

Genome annotation databases

EnsembliENSMUST00000025395; ENSMUSP00000025395; ENSMUSG00000024517.
ENSMUST00000173985; ENSMUSP00000133437; ENSMUSG00000024517.
GeneIDi225642.
KEGGimmu:225642.
UCSCiuc008ffk.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGRP_MOUSE
AccessioniPrimary (citable) accession number: Q8R1I2
Secondary accession number(s): Q3UTL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2002
Last modified: June 7, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families