Q8R1I2 (GRP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gastrin-releasing peptide
Short name=GRP

Cleaved into the following chain:

1. Neuromedin-C
   Alternative name(s):
   GRP-10

Gene names

Name:

Grp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear. Ref.3
Subcellular location	Secreted.
Tissue specificity	Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus. Ref.3
Sequence similarities	Belongs to the bombesin/neuromedin-B/ranatensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Peptide	24 – 52	29	Gastrin-releasing peptide		PRO_0000262472
	Peptide	43 – 52	10	Neuromedin-C		PRO_0000262473
	Propeptide	56 – 146	91	By similarity		PRO_0000262474
Amino acid modifications
	Modified residue	52	1	Methionine amide By similarity
Experimental info
	Sequence conflict	134	1	L → Q in BAE23968. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8R1I2 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 83FD03C40E670CA5	FASTA	146	15,659
	10 20 30 40 50 60 MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH LMGKKSTDES 70 80 90 100 110 120 PSLYAADRDG LKEQLRGYVR WEEAARDLLD LLEAAGNQSH QPPQHPPLSL QPTWDPEDGS 130 140 YFNDVQTAKL VDSLLQVLKE KGGTAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain cortex.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[3]	"Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear." Shumyatsky G.P., Tsvetkov E., Malleret G., Vronskaya S., Hatton M., Hampton L., Battey J.F., Dulac C., Kandel E.R., Bolshakov V.Y. Cell 111:905-918(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION IN CONTROL OF FEAR.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK133508 mRNA. Translation: BAE21694.1. AK139345 mRNA. Translation: BAE23968.1. BC024515 mRNA. Translation: AAH24515.1.
IPI	IPI00153382.
RefSeq	NP_778177.1. NM_175012.2.
UniGene	Mm.20298.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8R1I2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025395; ENSMUSP00000025395; ENSMUSG00000024517. ENSMUST00000173985; ENSMUSP00000133437; ENSMUSG00000024517.
GeneID	225642.
KEGG	mmu:225642.
UCSC	uc008ffk.1. mouse.
Organism-specific databases
CTD	2922.
MGI	MGI:95833. Grp.
Phylogenomic databases
eggNOG	NOG45311.
GeneTree	ENSGT00390000017865.
HOGENOM	HOG000112821.
HOVERGEN	HBG005912.
InParanoid	Q8R1I2.
KO	K05224.
OMA	LTKMYPR.
OrthoDB	EOG4F4SCM.
Gene expression databases
Bgee	Q8R1I2.
CleanEx	MM_GRP.
Genevestigator	Q8R1I2.
GermOnline	ENSMUSG00000024517. Mus musculus.
Family and domain databases
InterPro	IPR000874. Bombesin. IPR015674. Gastrin-RP. [Graphical view]
PANTHER	PTHR16866. PTHR16866. 1 hit.
Pfam	PF02044. Bombesin. 1 hit. [Graphical view]
PROSITE	PS00257. BOMBESIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	377750.
SOURCE	Search...

Entry information

Entry name

GRP_MOUSE

Accession

Primary (citable) accession number: Q8R1I2
Secondary accession number(s): Q3UTL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program