Reviewed, UniProtKB/Swiss-Prot Q8R1I2 (GRP_MOUSE)

Names and origin

Protein names

Recommended name:
    Gastrin-releasing peptide
      Short name=GRP
Cleaved into the following chain:
    1- Recommended name:
            Neuromedin-C
        Alternative name(s):
            GRP-10

Gene names

Name:

Grp

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear. Ref.3
Subcellular location	Secreted.
Tissue specificity	Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus. Ref.3
Sequence similarities	Belongs to the bombesin/neuromedin-B/ranatensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Amidation Cleavage on pair of basic residues
Gene Ontology (GO)
Biological process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Peptide	24 – 52	29	Gastrin-releasing peptide		PRO_0000262472
	Peptide	43 – 52	10	Neuromedin-C		PRO_0000262473
	Propeptide	56 – 146	91	By similarity		PRO_0000262474
Amino acid modifications
	Modified residue	52	1	Methionine amide By similarity
Experimental info
	Sequence conflict	134	1	L → Q in BAE23968. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8R1I2-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 83FD03C40E670CA5	FASTA	146	15,659
	10 20 30 40 50 60 MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH LMGKKSTDES 70 80 90 100 110 120 PSLYAADRDG LKEQLRGYVR WEEAARDLLD LLEAAGNQSH QPPQHPPLSL QPTWDPEDGS 130 140 YFNDVQTAKL VDSLLQVLKE KGGTAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain cortex.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[3]	"Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear." Shumyatsky G.P., Tsvetkov E., Malleret G., Vronskaya S., Hatton M., Hampton L., Battey J.F., Dulac C., Kandel E.R., Bolshakov V.Y. Cell 111:905-918(2002) [PubMed: 12526815] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION IN CONTROL OF FEAR.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK133508 mRNA. Translation: BAE21694.1. AK139345 mRNA. Translation: BAE23968.1. BC024515 mRNA. Translation: AAH24515.1.
IPI	IPI00153382.
RefSeq	NP_778177.1.
UniGene	Mm.20298
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000024517. Mus musculus. [Contig view]
GeneID	225642.
KEGG	mmu:225642.
Organism-specific databases
MGI	MGI:95833. Grp.
Phylogenomic databases
HOVERGEN	Q8R1I2.
OMA	Q8R1I2. GRELPLV.
Gene expression databases
ArrayExpress	Q8R1I2.
Bgee	Q8R1I2.
CleanEx	MM_GRP.
GermOnline	ENSMUSG00000024517. Mus musculus.
Family and domain databases
InterPro	IPR000874. Bombesin. IPR015674. Gastrin-RP. [Graphical view]
PANTHER	PTHR16866. Gastrin-RP. 1 hit.
Pfam	PF02044. Bombesin. 1 hit. [Graphical view]
PROSITE	PS00257. BOMBESIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	377750.
SOURCE	Search...

Entry information

Entry name

GRP_MOUSE

Accession

Primary (citable) accession number: Q8R1I2
Secondary accession number(s): Q3UTL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)