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Protein

Gastrin-releasing peptide

Gene

Grp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_324802. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide
Short name:
GRP
Cleaved into the following chain:
Alternative name(s):
GRP-10
Gene namesi
Name:Grp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95833. Grp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Peptidei24 – 5229Gastrin-releasing peptidePRO_0000262472Add
BLAST
Peptidei43 – 5210Neuromedin-CPRO_0000262473
Propeptidei56 – 14691By similarityPRO_0000262474Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521Methionine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MaxQBiQ8R1I2.
PRIDEiQ8R1I2.

Expressioni

Tissue specificityi

Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus.1 Publication

Gene expression databases

BgeeiQ8R1I2.
CleanExiMM_GRP.
ExpressionAtlasiQ8R1I2. baseline and differential.
GenevestigatoriQ8R1I2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45311.
GeneTreeiENSGT00390000017865.
HOGENOMiHOG000112821.
HOVERGENiHBG005912.
InParanoidiQ8R1I2.
KOiK05224.
OMAiCQAPRGP.
OrthoDBiEOG71G9XW.
PhylomeDBiQ8R1I2.
TreeFamiTF336391.

Family and domain databases

InterProiIPR000874. Bombesin.
IPR015674. Gastrin-RP.
[Graphical view]
PANTHERiPTHR16866:SF1. PTHR16866:SF1. 1 hit.
PfamiPF02044. Bombesin. 1 hit.
[Graphical view]
PROSITEiPS00257. BOMBESIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R1I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH
60 70 80 90 100
LMGKKSTDES PSLYAADRDG LKEQLRGYVR WEEAARDLLD LLEAAGNQSH
110 120 130 140
QPPQHPPLSL QPTWDPEDGS YFNDVQTAKL VDSLLQVLKE KGGTAS
Length:146
Mass (Da):15,659
Last modified:June 1, 2002 - v1
Checksum:i83FD03C40E670CA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341L → Q in BAE23968 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133508 mRNA. Translation: BAE21694.1.
AK139345 mRNA. Translation: BAE23968.1.
BC024515 mRNA. Translation: AAH24515.1.
CCDSiCCDS29310.1.
RefSeqiNP_778177.1. NM_175012.3.
XP_006525949.1. XM_006525886.2.
UniGeneiMm.20298.
Mm.394498.

Genome annotation databases

EnsembliENSMUST00000025395; ENSMUSP00000025395; ENSMUSG00000024517.
ENSMUST00000173985; ENSMUSP00000133437; ENSMUSG00000024517.
GeneIDi225642.
KEGGimmu:225642.
UCSCiuc008ffk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133508 mRNA. Translation: BAE21694.1.
AK139345 mRNA. Translation: BAE23968.1.
BC024515 mRNA. Translation: AAH24515.1.
CCDSiCCDS29310.1.
RefSeqiNP_778177.1. NM_175012.3.
XP_006525949.1. XM_006525886.2.
UniGeneiMm.20298.
Mm.394498.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ8R1I2.
PRIDEiQ8R1I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025395; ENSMUSP00000025395; ENSMUSG00000024517.
ENSMUST00000173985; ENSMUSP00000133437; ENSMUSG00000024517.
GeneIDi225642.
KEGGimmu:225642.
UCSCiuc008ffk.1. mouse.

Organism-specific databases

CTDi2922.
MGIiMGI:95833. Grp.

Phylogenomic databases

eggNOGiNOG45311.
GeneTreeiENSGT00390000017865.
HOGENOMiHOG000112821.
HOVERGENiHBG005912.
InParanoidiQ8R1I2.
KOiK05224.
OMAiCQAPRGP.
OrthoDBiEOG71G9XW.
PhylomeDBiQ8R1I2.
TreeFamiTF336391.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_324802. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi377750.
PROiQ8R1I2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R1I2.
CleanExiMM_GRP.
ExpressionAtlasiQ8R1I2. baseline and differential.
GenevestigatoriQ8R1I2.

Family and domain databases

InterProiIPR000874. Bombesin.
IPR015674. Gastrin-RP.
[Graphical view]
PANTHERiPTHR16866:SF1. PTHR16866:SF1. 1 hit.
PfamiPF02044. Bombesin. 1 hit.
[Graphical view]
PROSITEiPS00257. BOMBESIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear."
    Shumyatsky G.P., Tsvetkov E., Malleret G., Vronskaya S., Hatton M., Hampton L., Battey J.F., Dulac C., Kandel E.R., Bolshakov V.Y.
    Cell 111:905-918(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION IN CONTROL OF FEAR.

Entry informationi

Entry nameiGRP_MOUSE
AccessioniPrimary (citable) accession number: Q8R1I2
Secondary accession number(s): Q3UTL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2002
Last modified: April 1, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.