Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R1I2

- GRP_MOUSE

UniProt

Q8R1I2 - GRP_MOUSE

Protein

Gastrin-releasing peptide

Gene

Grp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear.1 Publication

    GO - Biological processi

    1. neuropeptide signaling pathway Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastrin-releasing peptide
    Short name:
    GRP
    Cleaved into the following chain:
    Alternative name(s):
    GRP-10
    Gene namesi
    Name:Grp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:95833. Grp.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Peptidei24 – 5229Gastrin-releasing peptidePRO_0000262472Add
    BLAST
    Peptidei43 – 5210Neuromedin-CPRO_0000262473
    Propeptidei56 – 14691By similarityPRO_0000262474Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521Methionine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    MaxQBiQ8R1I2.
    PRIDEiQ8R1I2.

    Expressioni

    Tissue specificityi

    Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus.1 Publication

    Gene expression databases

    BgeeiQ8R1I2.
    CleanExiMM_GRP.
    GenevestigatoriQ8R1I2.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45311.
    GeneTreeiENSGT00390000017865.
    HOGENOMiHOG000112821.
    HOVERGENiHBG005912.
    InParanoidiQ8R1I2.
    KOiK05224.
    OMAiCQAPRGP.
    OrthoDBiEOG71G9XW.
    PhylomeDBiQ8R1I2.
    TreeFamiTF336391.

    Family and domain databases

    InterProiIPR000874. Bombesin.
    IPR015674. Gastrin-RP.
    [Graphical view]
    PANTHERiPTHR16866:SF1. PTHR16866:SF1. 1 hit.
    PfamiPF02044. Bombesin. 1 hit.
    [Graphical view]
    PROSITEiPS00257. BOMBESIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R1I2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH    50
    LMGKKSTDES PSLYAADRDG LKEQLRGYVR WEEAARDLLD LLEAAGNQSH 100
    QPPQHPPLSL QPTWDPEDGS YFNDVQTAKL VDSLLQVLKE KGGTAS 146
    Length:146
    Mass (Da):15,659
    Last modified:June 1, 2002 - v1
    Checksum:i83FD03C40E670CA5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341L → Q in BAE23968. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK133508 mRNA. Translation: BAE21694.1.
    AK139345 mRNA. Translation: BAE23968.1.
    BC024515 mRNA. Translation: AAH24515.1.
    CCDSiCCDS29310.1.
    RefSeqiNP_778177.1. NM_175012.3.
    XP_006525949.1. XM_006525886.1.
    UniGeneiMm.20298.
    Mm.394498.

    Genome annotation databases

    EnsembliENSMUST00000025395; ENSMUSP00000025395; ENSMUSG00000024517.
    ENSMUST00000173985; ENSMUSP00000133437; ENSMUSG00000024517.
    GeneIDi225642.
    KEGGimmu:225642.
    UCSCiuc008ffk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK133508 mRNA. Translation: BAE21694.1 .
    AK139345 mRNA. Translation: BAE23968.1 .
    BC024515 mRNA. Translation: AAH24515.1 .
    CCDSi CCDS29310.1.
    RefSeqi NP_778177.1. NM_175012.3.
    XP_006525949.1. XM_006525886.1.
    UniGenei Mm.20298.
    Mm.394498.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q8R1I2.
    PRIDEi Q8R1I2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025395 ; ENSMUSP00000025395 ; ENSMUSG00000024517 .
    ENSMUST00000173985 ; ENSMUSP00000133437 ; ENSMUSG00000024517 .
    GeneIDi 225642.
    KEGGi mmu:225642.
    UCSCi uc008ffk.1. mouse.

    Organism-specific databases

    CTDi 2922.
    MGIi MGI:95833. Grp.

    Phylogenomic databases

    eggNOGi NOG45311.
    GeneTreei ENSGT00390000017865.
    HOGENOMi HOG000112821.
    HOVERGENi HBG005912.
    InParanoidi Q8R1I2.
    KOi K05224.
    OMAi CQAPRGP.
    OrthoDBi EOG71G9XW.
    PhylomeDBi Q8R1I2.
    TreeFami TF336391.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 377750.
    PROi Q8R1I2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R1I2.
    CleanExi MM_GRP.
    Genevestigatori Q8R1I2.

    Family and domain databases

    InterProi IPR000874. Bombesin.
    IPR015674. Gastrin-RP.
    [Graphical view ]
    PANTHERi PTHR16866:SF1. PTHR16866:SF1. 1 hit.
    Pfami PF02044. Bombesin. 1 hit.
    [Graphical view ]
    PROSITEi PS00257. BOMBESIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear."
      Shumyatsky G.P., Tsvetkov E., Malleret G., Vronskaya S., Hatton M., Hampton L., Battey J.F., Dulac C., Kandel E.R., Bolshakov V.Y.
      Cell 111:905-918(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION IN CONTROL OF FEAR.

    Entry informationi

    Entry nameiGRP_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1I2
    Secondary accession number(s): Q3UTL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3