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Q8R1G3

- Q8R1G3_MOUSE

UniProt

Q8R1G3 - Q8R1G3_MOUSE

Protein

5-aminolevulinate synthase

Gene

Alas2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: MGI
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular iron ion homeostasis Source: MGI
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    3. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Heme biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthaseUniRule annotation (EC:2.3.1.37UniRule annotation)
    Alternative name(s):
    5-aminolevulinic acid synthaseUniRule annotation
    Delta-ALA synthaseUniRule annotation
    Delta-aminolevulinate synthaseUniRule annotation
    Gene namesi
    Name:Alas2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:87990. Alas2.

    Subcellular locationi

    Mitochondrion matrix UniRule annotation

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    MitochondrionUniRule annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R1G3.
    BgeeiQ8R1G3.
    GenevestigatoriQ8R1G3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R1G3.
    SMRiQ8R1G3. Positions 3-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG005954.
    InParanoidiQ8R1G3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R1G3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKDVSVWC SNDYLGISRH PRVLQAIEET LKNHGAGAGG TRNISGTSKF    50
    HVELEQELAE LHQKDSALLF SSCFVANDST LFTLAKLLPG CEIYSDAGNH 100
    ASMIQGIRNS GAAKFVFRHN DPGHLKKLLE KSDPKTPKIV AFETVHSMDG 150
    AICPLEELCD VAHQYGALTF VDEVHAVGLY GARGAGIGER DGIMHKLDII 200
    SGTLGKAFGC VGGYIASTRD LVDMVRSYAA GFIFTTSLPP MVLSGALESV 250
    RLLKGEEGQA LRRAHQRNVK HMRQLLMDRG FPVIPCPSHI IPIRVGNAAL 300
    NSKICDLLLS KHSIYVQAIN YPTVPRGEEL LRLAPSPHHS PQMMENFVEK 350
    LLLAWTEVGL PLQDVSVAAC NFCHRPVHFE LMSEWERSYF GNMGPQYVTT 400
    YA 402
    Length:402
    Mass (Da):44,106
    Last modified:June 1, 2002 - v1
    Checksum:iE19B6C4D1677A4A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC024575 mRNA. Translation: AAH24575.1.
    UniGeneiMm.302724.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC024575 mRNA. Translation: AAH24575.1 .
    UniGenei Mm.302724.

    3D structure databases

    ProteinModelPortali Q8R1G3.
    SMRi Q8R1G3. Positions 3-353.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:87990. Alas2.

    Phylogenomic databases

    HOVERGENi HBG005954.
    InParanoidi Q8R1G3.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R1G3.
    Bgeei Q8R1G3.
    Genevestigatori Q8R1G3.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ8R1G3_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1G3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.UniRule annotation

    External Data

    Dasty 3