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Protein

5-aminolevulinate synthase

Gene

Alas2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.UniRule annotation

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-aminolevulinate from glycine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas1), 5-aminolevulinate synthase, erythroid-specific, mitochondrial (Alas2), 5-aminolevulinate synthase, nonspecific, mitochondrial (Alas1), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas1)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from glycine, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processHeme biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthaseUniRule annotation (EC:2.3.1.37UniRule annotation)
Alternative name(s):
5-aminolevulinic acid synthaseUniRule annotation
Delta-ALA synthaseUniRule annotation
Delta-aminolevulinate synthaseUniRule annotation
Gene namesi
Name:Alas2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87990 Alas2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8R1G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 351Aminotran_1_2InterPro annotationAdd BLAST347

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1360 Eukaryota
COG0156 LUCA
HOVERGENiHBG005954

Family and domain databases

Gene3Di3.40.640.101 hit
3.90.1150.102 hits
InterProiView protein in InterPro
IPR010961 4pyrrol_synth_NH2levulA_synth
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01821 5aminolev_synth, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R1G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKDVSVWC SNDYLGISRH PRVLQAIEET LKNHGAGAGG TRNISGTSKF
60 70 80 90 100
HVELEQELAE LHQKDSALLF SSCFVANDST LFTLAKLLPG CEIYSDAGNH
110 120 130 140 150
ASMIQGIRNS GAAKFVFRHN DPGHLKKLLE KSDPKTPKIV AFETVHSMDG
160 170 180 190 200
AICPLEELCD VAHQYGALTF VDEVHAVGLY GARGAGIGER DGIMHKLDII
210 220 230 240 250
SGTLGKAFGC VGGYIASTRD LVDMVRSYAA GFIFTTSLPP MVLSGALESV
260 270 280 290 300
RLLKGEEGQA LRRAHQRNVK HMRQLLMDRG FPVIPCPSHI IPIRVGNAAL
310 320 330 340 350
NSKICDLLLS KHSIYVQAIN YPTVPRGEEL LRLAPSPHHS PQMMENFVEK
360 370 380 390 400
LLLAWTEVGL PLQDVSVAAC NFCHRPVHFE LMSEWERSYF GNMGPQYVTT

YA
Length:402
Mass (Da):44,106
Last modified:June 1, 2002 - v1
Checksum:iE19B6C4D1677A4A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024575 mRNA Translation: AAH24575.1
UniGeneiMm.302724

Similar proteinsi

Entry informationi

Entry nameiQ8R1G3_MOUSE
AccessioniPrimary (citable) accession number: Q8R1G3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)