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Protein

Threonine aspartase 1

Gene

Tasp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei234 – 2341NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT02.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine aspartase 1 (EC:3.4.25.-)
Short name:
Taspase-1
Cleaved into the following 2 chains:
Gene namesi
Name:Tasp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923062. Tasp1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Threonine aspartase subunit alphaBy similarityPRO_0000002352Add
BLAST
Chaini234 – 420187Threonine aspartase subunit betaBy similarityPRO_0000002353Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

MaxQBiQ8R1G1.
PaxDbiQ8R1G1.
PRIDEiQ8R1G1.

PTM databases

iPTMnetiQ8R1G1.
PhosphoSiteiQ8R1G1.

Expressioni

Gene expression databases

BgeeiQ8R1G1.
CleanExiMM_TASP1.
ExpressionAtlasiQ8R1G1. baseline and differential.
GenevisibleiQ8R1G1. MM.

Interactioni

Subunit structurei

Intramolecular proteolysis generates 2 subunits, alpha and beta, which reassemble through a non-covalent association to form the fully active enzyme.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039546.

Structurei

3D structure databases

ProteinModelPortaliQ8R1G1.
SMRiQ8R1G1. Positions 41-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ntn-hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG1592. Eukaryota.
COG1446. LUCA.
GeneTreeiENSGT00530000063034.
HOGENOMiHOG000286029.
HOVERGENiHBG058647.
InParanoidiQ8R1G1.
KOiK08657.
OMAiCRLESPE.
OrthoDBiEOG78SQHV.
PhylomeDBiQ8R1G1.
TreeFamiTF106358.

Family and domain databases

InterProiIPR029055. Ntn_hydrolases_N.
IPR000246. Peptidase_T2.
[Graphical view]
PANTHERiPTHR10188. PTHR10188. 1 hit.
PfamiPF01112. Asparaginase_2. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q8R1G1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIMEKGMNSG EGLPSRSSQA SAAKVTVKEL ETQQPCKEKR GGFVLVHAGA
60 70 80 90 100
GYHSESKAKE YKHVCKRACQ KAIEKLQAGA LATDAVAAAL VELEDSPFTN
110 120 130 140 150
AGIGSNLNLL GEIECDASIM DGKSLNFGAV GALSGIKNPV SVAHRLLCEG
160 170 180 190 200
QKGKLSAGRI PPCFLVGEGA YRWAVDHGIP SCPPSTMTTR FSLAAFKRNK
210 220 230 240 250
RKLELAERVE TDFIQLKRRR QSSAKENDSG TLDTVGAVVV DHEGNVAAAV
260 270 280 290 300
SSGGLALKHP GRVGQAALYG CGCWAENTGA QNPYSTAVST SGCGEHLVRT
310 320 330 340 350
ILARECSHAL QAEDAHQALL ETMQNKFISS PFLACEDGVL GGVIVLRSCR
360 370 380 390 400
CSSESDSSQD KQTLLVEFLW SHTTESMCVG YMSAQDGKAK THISRLPPGA
410 420
VAGQSVAIEG GVCRLESPVN
Length:420
Mass (Da):44,360
Last modified:June 1, 2002 - v1
Checksum:i13F648362CF617C4
GO
Isoform 2 (identifier: Q8R1G1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-253: ENDSGTLDTVGAVVVDHEGNVAAAVSSG → VRRCLKNWLMHGRDVVDLLLEQYCPFEL
     254-420: Missing.

Show »
Length:253
Mass (Da):27,545
Checksum:iEBD9DBEB8E51EE16
GO

Sequence cautioni

The sequence AAH05776.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei226 – 25328ENDSG…AVSSG → VRRCLKNWLMHGRDVVDLLL EQYCPFEL in isoform 2. 1 PublicationVSP_000334Add
BLAST
Alternative sequencei254 – 420167Missing in isoform 2. 1 PublicationVSP_000335Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036512 mRNA. Translation: BAC29457.1.
AK050603 mRNA. Translation: BAC34335.1.
BC005776 mRNA. Translation: AAH05776.1. Different initiation.
BC024597 mRNA. Translation: AAH24597.1.
CCDSiCCDS16802.1. [Q8R1G1-1]
RefSeqiNP_001153112.1. NM_001159640.2. [Q8R1G1-1]
NP_001153113.1. NM_001159641.2.
NP_001276540.1. NM_001289611.1.
NP_780434.1. NM_175225.5. [Q8R1G1-1]
UniGeneiMm.293449.

Genome annotation databases

EnsembliENSMUST00000046656; ENSMUSP00000039546; ENSMUSG00000039033. [Q8R1G1-1]
ENSMUST00000110079; ENSMUSP00000105706; ENSMUSG00000039033. [Q8R1G1-1]
GeneIDi75812.
KEGGimmu:75812.
UCSCiuc008mpg.3. mouse. [Q8R1G1-1]
uc008mpm.2. mouse. [Q8R1G1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036512 mRNA. Translation: BAC29457.1.
AK050603 mRNA. Translation: BAC34335.1.
BC005776 mRNA. Translation: AAH05776.1. Different initiation.
BC024597 mRNA. Translation: AAH24597.1.
CCDSiCCDS16802.1. [Q8R1G1-1]
RefSeqiNP_001153112.1. NM_001159640.2. [Q8R1G1-1]
NP_001153113.1. NM_001159641.2.
NP_001276540.1. NM_001289611.1.
NP_780434.1. NM_175225.5. [Q8R1G1-1]
UniGeneiMm.293449.

3D structure databases

ProteinModelPortaliQ8R1G1.
SMRiQ8R1G1. Positions 41-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039546.

Protein family/group databases

MEROPSiT02.004.

PTM databases

iPTMnetiQ8R1G1.
PhosphoSiteiQ8R1G1.

Proteomic databases

MaxQBiQ8R1G1.
PaxDbiQ8R1G1.
PRIDEiQ8R1G1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046656; ENSMUSP00000039546; ENSMUSG00000039033. [Q8R1G1-1]
ENSMUST00000110079; ENSMUSP00000105706; ENSMUSG00000039033. [Q8R1G1-1]
GeneIDi75812.
KEGGimmu:75812.
UCSCiuc008mpg.3. mouse. [Q8R1G1-1]
uc008mpm.2. mouse. [Q8R1G1-2]

Organism-specific databases

CTDi55617.
MGIiMGI:1923062. Tasp1.

Phylogenomic databases

eggNOGiKOG1592. Eukaryota.
COG1446. LUCA.
GeneTreeiENSGT00530000063034.
HOGENOMiHOG000286029.
HOVERGENiHBG058647.
InParanoidiQ8R1G1.
KOiK08657.
OMAiCRLESPE.
OrthoDBiEOG78SQHV.
PhylomeDBiQ8R1G1.
TreeFamiTF106358.

Miscellaneous databases

ChiTaRSiTasp1. mouse.
PROiQ8R1G1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R1G1.
CleanExiMM_TASP1.
ExpressionAtlasiQ8R1G1. baseline and differential.
GenevisibleiQ8R1G1. MM.

Family and domain databases

InterProiIPR029055. Ntn_hydrolases_N.
IPR000246. Peptidase_T2.
[Graphical view]
PANTHERiPTHR10188. PTHR10188. 1 hit.
PfamiPF01112. Asparaginase_2. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Bone and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTASP1_MOUSE
AccessioniPrimary (citable) accession number: Q8R1G1
Secondary accession number(s): Q99JP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.