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Protein

Ribonuclease P protein subunit p40

Gene

Rpp40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p40 (EC:3.1.26.5)
Short name:
RNaseP protein p40
Gene namesi
Name:Rpp40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1346084. Rpp40.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003540761 – 363Ribonuclease P protein subunit p40Add BLAST363

Proteomic databases

EPDiQ8R1F9.
MaxQBiQ8R1F9.
PaxDbiQ8R1F9.
PRIDEiQ8R1F9.

PTM databases

iPTMnetiQ8R1F9.
PhosphoSitePlusiQ8R1F9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021418.
ExpressionAtlasiQ8R1F9. baseline and differential.
GenevisibleiQ8R1F9. MM.

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

Protein-protein interaction databases

IntActiQ8R1F9. 1 interactor.
MINTiMINT-4118578.
STRINGi10090.ENSMUSP00000130290.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHPQ. Eukaryota.
ENOG410ZDGJ. LUCA.
GeneTreeiENSGT00390000014167.
HOGENOMiHOG000006875.
HOVERGENiHBG055018.
InParanoidiQ8R1F9.
KOiK14530.
OMAiKKGSCYA.
OrthoDBiEOG091G0D13.
PhylomeDBiQ8R1F9.
TreeFamiTF330967.

Family and domain databases

InterProiView protein in InterPro
IPR013893. RNase_P_Rpp40.
PfamiView protein in Pfam
PF08584. Ribonuc_P_40. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R1F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLRRLQEA PRHLLVCEKS NFGHDKSRHK HLVETHYHNY RVSFLIPECG
60 70 80 90 100
LLSKELKSLV MDIGPYYSVK NLPLHELITH EFINTFVKKG SFSALTYNTS
110 120 130 140 150
IDEDNTVALL PNGKLILSLD KDTYEETGLQ GRPSRYSGRK SMKFVISIDL
160 170 180 190 200
MDLSLNLDSK KYRRISWSFK EKKPLKFDFL LAWHPTGTEE STMMSYFSKY
210 220 230 240 250
QIQEHQPKVA LSTVRELQCP VLRSSGLAGE PEEACSALEF FDWLGAVFCS
260 270 280 290 300
ADLNNEPYNF ISTYCCPQPS AVVAQAFLCT ITGFILPEKI HVLLEQLCHY
310 320 330 340 350
FDEPKLAPWV TLTVQGFADS PVAWREKEHG FHKGGEHLYN FVVFNNQDYW
360
LQMAVGANDD CPP
Length:363
Mass (Da):41,547
Last modified:May 26, 2009 - v2
Checksum:iB62F8025633C2B8E
GO

Sequence cautioni

The sequence AAH24607 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33465 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EDL40907 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75H → Y in BAC33465 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048810 mRNA. Translation: BAC33465.1. Different initiation.
CH466546 Genomic DNA. Translation: EDL40907.1. Different initiation.
BC024607 mRNA. Translation: AAH24607.1. Different initiation.
CCDSiCCDS26451.2.
RefSeqiNP_666050.3. NM_145938.4.
XP_011242604.1. XM_011244302.1.
UniGeneiMm.35545.

Genome annotation databases

EnsembliENSMUST00000171686; ENSMUSP00000130290; ENSMUSG00000021418.
GeneIDi208366.
KEGGimmu:208366.
UCSCiuc011yyj.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRPP40_MOUSE
AccessioniPrimary (citable) accession number: Q8R1F9
Secondary accession number(s): Q8BX66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 26, 2009
Last modified: May 10, 2017
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot