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Q8R1F9

- RPP40_MOUSE

UniProt

Q8R1F9 - RPP40_MOUSE

Protein

Ribonuclease P protein subunit p40

Gene

Rpp40

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: MGI

    GO - Biological processi

    1. RNA phosphodiester bond hydrolysis Source: GOC
    2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    3. tRNA 5'-leader removal Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p40 (EC:3.1.26.5)
    Short name:
    RNaseP protein p40
    Gene namesi
    Name:Rpp40
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1346084. Rpp40.

    Subcellular locationi

    Nucleusnucleolus Curated

    GO - Cellular componenti

    1. nucleolar ribonuclease P complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Ribonuclease P protein subunit p40PRO_0000354076Add
    BLAST

    Proteomic databases

    MaxQBiQ8R1F9.
    PaxDbiQ8R1F9.
    PRIDEiQ8R1F9.

    PTM databases

    PhosphoSiteiQ8R1F9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R1F9.
    BgeeiQ8R1F9.
    GenevestigatoriQ8R1F9.

    Interactioni

    Subunit structurei

    RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

    Protein-protein interaction databases

    IntActiQ8R1F9. 1 interaction.
    MINTiMINT-4118578.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG42164.
    GeneTreeiENSGT00390000014167.
    HOGENOMiHOG000006875.
    HOVERGENiHBG055018.
    InParanoidiQ8R1F9.
    KOiK14530.
    OMAiKGSCYAL.
    OrthoDBiEOG7ZPNK2.
    PhylomeDBiQ8R1F9.
    TreeFamiTF330967.

    Family and domain databases

    InterProiIPR013893. RNase_P_Rpp40.
    [Graphical view]
    PfamiPF08584. Ribonuc_P_40. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R1F9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLRRLQEA PRHLLVCEKS NFGHDKSRHK HLVETHYHNY RVSFLIPECG    50
    LLSKELKSLV MDIGPYYSVK NLPLHELITH EFINTFVKKG SFSALTYNTS 100
    IDEDNTVALL PNGKLILSLD KDTYEETGLQ GRPSRYSGRK SMKFVISIDL 150
    MDLSLNLDSK KYRRISWSFK EKKPLKFDFL LAWHPTGTEE STMMSYFSKY 200
    QIQEHQPKVA LSTVRELQCP VLRSSGLAGE PEEACSALEF FDWLGAVFCS 250
    ADLNNEPYNF ISTYCCPQPS AVVAQAFLCT ITGFILPEKI HVLLEQLCHY 300
    FDEPKLAPWV TLTVQGFADS PVAWREKEHG FHKGGEHLYN FVVFNNQDYW 350
    LQMAVGANDD CPP 363
    Length:363
    Mass (Da):41,547
    Last modified:May 26, 2009 - v2
    Checksum:iB62F8025633C2B8E
    GO

    Sequence cautioni

    The sequence AAH24607.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC33465.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EDL40907.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751H → Y in BAC33465. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK048810 mRNA. Translation: BAC33465.1. Different initiation.
    CH466546 Genomic DNA. Translation: EDL40907.1. Different initiation.
    BC024607 mRNA. Translation: AAH24607.1. Different initiation.
    CCDSiCCDS26451.2.
    RefSeqiNP_666050.3. NM_145938.4.
    UniGeneiMm.35545.

    Genome annotation databases

    EnsembliENSMUST00000171686; ENSMUSP00000130290; ENSMUSG00000021418.
    GeneIDi208366.
    KEGGimmu:208366.
    UCSCiuc011yyj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK048810 mRNA. Translation: BAC33465.1 . Different initiation.
    CH466546 Genomic DNA. Translation: EDL40907.1 . Different initiation.
    BC024607 mRNA. Translation: AAH24607.1 . Different initiation.
    CCDSi CCDS26451.2.
    RefSeqi NP_666050.3. NM_145938.4.
    UniGenei Mm.35545.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R1F9. 1 interaction.
    MINTi MINT-4118578.

    PTM databases

    PhosphoSitei Q8R1F9.

    Proteomic databases

    MaxQBi Q8R1F9.
    PaxDbi Q8R1F9.
    PRIDEi Q8R1F9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000171686 ; ENSMUSP00000130290 ; ENSMUSG00000021418 .
    GeneIDi 208366.
    KEGGi mmu:208366.
    UCSCi uc011yyj.1. mouse.

    Organism-specific databases

    CTDi 10799.
    MGIi MGI:1346084. Rpp40.

    Phylogenomic databases

    eggNOGi NOG42164.
    GeneTreei ENSGT00390000014167.
    HOGENOMi HOG000006875.
    HOVERGENi HBG055018.
    InParanoidi Q8R1F9.
    KOi K14530.
    OMAi KGSCYAL.
    OrthoDBi EOG7ZPNK2.
    PhylomeDBi Q8R1F9.
    TreeFami TF330967.

    Miscellaneous databases

    NextBioi 372258.
    PROi Q8R1F9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R1F9.
    Bgeei Q8R1F9.
    Genevestigatori Q8R1F9.

    Family and domain databases

    InterProi IPR013893. RNase_P_Rpp40.
    [Graphical view ]
    Pfami PF08584. Ribonuc_P_40. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-363.
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiRPP40_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1F9
    Secondary accession number(s): Q8BX66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3