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Q8R1F9 (RPP40_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein subunit p40

Short name=RNaseP protein p40
EC=3.1.26.5
Gene names
Name:Rpp40
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subunit structure

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40 By similarity.

Subcellular location

Nucleusnucleolus Potential.

Sequence caution

The sequence AAH24607.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC33465.1 differs from that shown. Reason: Erroneous initiation.

The sequence EDL40907.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Ribonuclease P protein subunit p40
PRO_0000354076

Experimental info

Sequence conflict751H → Y in BAC33465. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8R1F9 [UniParc].

Last modified May 26, 2009. Version 2.
Checksum: B62F8025633C2B8E

FASTA36341,547
        10         20         30         40         50         60 
MATLRRLQEA PRHLLVCEKS NFGHDKSRHK HLVETHYHNY RVSFLIPECG LLSKELKSLV 

        70         80         90        100        110        120 
MDIGPYYSVK NLPLHELITH EFINTFVKKG SFSALTYNTS IDEDNTVALL PNGKLILSLD 

       130        140        150        160        170        180 
KDTYEETGLQ GRPSRYSGRK SMKFVISIDL MDLSLNLDSK KYRRISWSFK EKKPLKFDFL 

       190        200        210        220        230        240 
LAWHPTGTEE STMMSYFSKY QIQEHQPKVA LSTVRELQCP VLRSSGLAGE PEEACSALEF 

       250        260        270        280        290        300 
FDWLGAVFCS ADLNNEPYNF ISTYCCPQPS AVVAQAFLCT ITGFILPEKI HVLLEQLCHY 

       310        320        330        340        350        360 
FDEPKLAPWV TLTVQGFADS PVAWREKEHG FHKGGEHLYN FVVFNNQDYW LQMAVGANDD 


CPP 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-363.
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK048810 mRNA. Translation: BAC33465.1. Different initiation.
CH466546 Genomic DNA. Translation: EDL40907.1. Different initiation.
BC024607 mRNA. Translation: AAH24607.1. Different initiation.
RefSeqNP_666050.3. NM_145938.4.
UniGeneMm.35545.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8R1F9. 1 interaction.
MINTMINT-4118578.

PTM databases

PhosphoSiteQ8R1F9.

Proteomic databases

PaxDbQ8R1F9.
PRIDEQ8R1F9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000171686; ENSMUSP00000130290; ENSMUSG00000021418.
GeneID208366.
KEGGmmu:208366.
UCSCuc011yyj.1. mouse.

Organism-specific databases

CTD10799.
MGIMGI:1346084. Rpp40.

Phylogenomic databases

eggNOGNOG42164.
GeneTreeENSGT00390000014167.
HOGENOMHOG000006875.
HOVERGENHBG055018.
InParanoidQ8R1F9.
KOK14530.
OMAKGSCYAL.
OrthoDBEOG7ZPNK2.
PhylomeDBQ8R1F9.
TreeFamTF330967.

Gene expression databases

ArrayExpressQ8R1F9.
BgeeQ8R1F9.
GenevestigatorQ8R1F9.

Family and domain databases

InterProIPR013893. RNase_P_Rpp40.
[Graphical view]
PfamPF08584. Ribonuc_P_40. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio372258.
PROQ8R1F9.
SOURCESearch...

Entry information

Entry nameRPP40_MOUSE
AccessionPrimary (citable) accession number: Q8R1F9
Secondary accession number(s): Q8BX66
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 26, 2009
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot