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Protein

Putative hydroxypyruvate isomerase

Gene

Hyi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).By similarity

Catalytic activityi

Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150Proton donor/acceptorBy similarity1
Active sitei249Proton donor/acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxypyruvate isomerase (EC:5.3.1.22)
Gene namesi
Name:Hyi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915430. Hyi.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892421 – 277Putative hydroxypyruvate isomeraseAdd BLAST277

Proteomic databases

MaxQBiQ8R1F5.
PeptideAtlasiQ8R1F5.
PRIDEiQ8R1F5.

2D gel databases

UCD-2DPAGEiQ8R1F5.

PTM databases

PhosphoSitePlusiQ8R1F5.

Expressioni

Gene expression databases

CleanExiMM_HYI.

Interactioni

Protein-protein interaction databases

IntActiQ8R1F5. 2 interactors.
MINTiMINT-1869510.

Structurei

3D structure databases

ProteinModelPortaliQ8R1F5.
SMRiQ8R1F5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hyi family.Curated

Phylogenomic databases

HOGENOMiHOG000218197.
HOVERGENiHBG056845.
InParanoidiQ8R1F5.
KOiK01816.
PhylomeDBiQ8R1F5.

Family and domain databases

InterProiView protein in InterPro
IPR026040. HyI-like.
IPR013022. Xyl_isomerase-like_TIM-brl.
PfamiView protein in Pfam
PF01261. AP_endonuc_2. 1 hit.
PIRSFiPIRSF006241. HyI. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R1F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLRFSANV SWLFPELPGL PERLHAAGRA GFKAAEVAWP YTESPQALAS
60 70 80 90 100
AAQTAGLRLV LINTPRGDHE KGEMGLGAVP GRQAAFREGL EQAVLYAKAL
110 120 130 140 150
GCPRIHLMAG RVPQGADRAA VKGEMETVFV ENLKHAAGVL AQENLVGLLE
160 170 180 190 200
PINTRITDPQ YFLDTPRQAA AILQKVGRPN LQLQMDIFHW QIMDGNLTGN
210 220 230 240 250
IREFLPTVGH VQVAQVPDRG EPGSSGELDF TYLFQLLEDE GYQGFVGCEY
260 270
RPRGDTVEGL SWLRSYWDRR GHPRTGQ
Length:277
Mass (Da):30,449
Last modified:May 29, 2007 - v2
Checksum:iEDAA961B61181444
GO

Sequence cautioni

The sequence CAM15196 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127T → A in AAH24619 (PubMed:15489334).Curated1
Sequence conflicti127T → A in AAI00402 (PubMed:15489334).Curated1
Sequence conflicti223G → S in AAH24619 (PubMed:15489334).Curated1
Sequence conflicti223G → S in AAI00402 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627212 Genomic DNA. Translation: CAM15196.1. Sequence problems.
BC024619 mRNA. Translation: AAH24619.1.
BC100401 mRNA. Translation: AAI00402.1.
RefSeqiNP_080877.3. NM_026601.3.
UniGeneiMm.193212.

Genome annotation databases

GeneIDi68180.
KEGGimmu:68180.
UCSCiuc008ujr.3. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHYI_MOUSE
AccessioniPrimary (citable) accession number: Q8R1F5
Secondary accession number(s): A2A9C1, Q497S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: July 5, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families