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Q8R1F1

- NIBL1_MOUSE

UniProt

Q8R1F1 - NIBL1_MOUSE

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Protein
Niban-like protein 1
Gene
Fam129b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis suppression By similarity.

GO - Biological processi

  1. negative regulation of apoptotic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Niban-like protein 1
Alternative name(s):
Protein FAM129B
Gene namesi
Name:Fam129b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2442910. Fam129b.

Subcellular locationi

Cytoplasmcytosol. Cell junctionadherens junction By similarity
Note: In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase By similarity. Phosphorylation may play a role in relocalization to the membrane By similarity.1 Publication

GO - Cellular componenti

  1. adherens junction Source: UniProtKB-SubCell
  2. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Niban-like protein 1
PRO_0000213122Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei568 – 5681Phosphoserine By similarity
Modified residuei574 – 5741Phosphoserine By similarity
Modified residuei607 – 6071Phosphoserine By similarity
Modified residuei628 – 6281Phosphoserine By similarity
Modified residuei650 – 6501Phosphoserine By similarity
Modified residuei669 – 6691Phosphoserine By similarity
Modified residuei685 – 6851Phosphoserine By similarity
Modified residuei695 – 6951Phosphoserine By similarity
Modified residuei699 – 6991Phosphoserine By similarity

Post-translational modificationi

As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R1F1.
PaxDbiQ8R1F1.
PRIDEiQ8R1F1.

PTM databases

PhosphoSiteiQ8R1F1.

Expressioni

Gene expression databases

ArrayExpressiQ8R1F1.
BgeeiQ8R1F1.
GenevestigatoriQ8R1F1.

Interactioni

Protein-protein interaction databases

BioGridi230679. 2 interactions.
IntActiQ8R1F1. 2 interactions.
MINTiMINT-1849821.
STRINGi10090.ENSMUSP00000028135.

Structurei

3D structure databases

ProteinModelPortaliQ8R1F1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 192125PH
Add
BLAST

Sequence similaritiesi

Belongs to the Niban family.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG46977.
GeneTreeiENSGT00530000063284.
HOVERGENiHBG026217.
InParanoidiQ3UDW4.
OMAiRFYEDQY.
OrthoDBiEOG7GN2MC.
PhylomeDBiQ8R1F1.
TreeFamiTF333351.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR026088. Niban_like.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R1F1-1 [UniParc]FASTAAdd to Basket

« Hide

MGDVLSTHLD DARRQHIAEK TEKILTEFLR FYEDQYGVSL FNSMRHEIEG    50
TGPPQAQLLW RKVPLDERII FSGNLFQYQE DNKKWRNRFS LVPHNYGLVL 100
YENKVAYERQ IPPRAVINSA GYKVLTSVDQ YLELVGNSLP GTTSKSGSTP 150
ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ DKWQAVLQDC VRHCNNGIPE 200
NSKVEGPAFT DAIRMYRQSK EQYGTWEMLC GNEVQILSNL VMEELGPALK 250
AELGPRLKGK PQERQRQWIQ ISDAVYRLVF EQAKVHFEDV LCKLQRARPA 300
MEAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL 350
MVPTSQGFTE VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSQLAYHPL 400
KMQSCYEKME PLRLDGLQQR FDVSSTSVFK QRAQIHMREQ MDNAVYTFET 450
LLHQELGKGP TKEELCKSIQ RILERVLKKY DYDSSSVRKR FFREALLQIT 500
IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV VLQTVMKDIL 550
QAVKEAAVQR KHNLYRDSMV LHNSDPNLHL LAEGTPIDWG EQYGDSGDSG 600
GGDSGGSPCP SEAATLTEKR RRAKQVMSVV QDEESGLPFE AGVEPPSPAS 650
PDSVTELRGL LAQDLQAESS PPASPLLNGA PVQESSQPVA VPEASPPASP 700
LRHLPPGKAV DLEPPKPSDQ ETGEQVSSPG SRPPIHTTTE DSAGVQTEF 749
Length:749
Mass (Da):84,819
Last modified:August 13, 2002 - v2
Checksum:iDB578DEA188492C8
GO

Sequence cautioni

The sequence BAC28456.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811D → G in BAE31035. 1 Publication
Sequence conflicti140 – 1401P → A in BAC28456. 1 Publication
Sequence conflicti193 – 1931H → L in BAE29147. 1 Publication
Sequence conflicti333 – 3331V → E in BAC34625. 1 Publication
Sequence conflicti344 – 3441P → Q in BAE27562. 1 Publication
Sequence conflicti503 – 5031F → S in BAE41849. 1 Publication
Sequence conflicti655 – 6551T → A in BAE29147. 1 Publication
Sequence conflicti662 – 6621A → G in BAE27562. 1 Publication
Sequence conflicti711 – 7111D → V in BAE29730. 1 Publication
Sequence conflicti724 – 7241E → K in BAE41849. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK033735 mRNA. Translation: BAC28456.1. Different initiation.
AK046583 mRNA. Translation: BAC32795.1.
AK051396 mRNA. Translation: BAC34625.1.
AK146953 mRNA. Translation: BAE27562.1.
AK149888 mRNA. Translation: BAE29147.1.
AK150642 mRNA. Translation: BAE29730.1.
AK152207 mRNA. Translation: BAE31035.1.
AK153489 mRNA. Translation: BAE32037.1.
AK170512 mRNA. Translation: BAE41849.1.
AL845471, AL929154 Genomic DNA. Translation: CAM20729.1.
AL929154, AL845471 Genomic DNA. Translation: CAM27398.1.
CH466542 Genomic DNA. Translation: EDL08584.1.
BC024639 mRNA. Translation: AAH24639.1.
BC027843 mRNA. Translation: AAH27843.1.
CCDSiCCDS15934.1.
RefSeqiNP_666231.1. NM_146119.2.
UniGeneiMm.301646.

Genome annotation databases

EnsembliENSMUST00000028135; ENSMUSP00000028135; ENSMUSG00000026796.
GeneIDi227737.
KEGGimmu:227737.
UCSCiuc008jhc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK033735 mRNA. Translation: BAC28456.1 . Different initiation.
AK046583 mRNA. Translation: BAC32795.1 .
AK051396 mRNA. Translation: BAC34625.1 .
AK146953 mRNA. Translation: BAE27562.1 .
AK149888 mRNA. Translation: BAE29147.1 .
AK150642 mRNA. Translation: BAE29730.1 .
AK152207 mRNA. Translation: BAE31035.1 .
AK153489 mRNA. Translation: BAE32037.1 .
AK170512 mRNA. Translation: BAE41849.1 .
AL845471 , AL929154 Genomic DNA. Translation: CAM20729.1 .
AL929154 , AL845471 Genomic DNA. Translation: CAM27398.1 .
CH466542 Genomic DNA. Translation: EDL08584.1 .
BC024639 mRNA. Translation: AAH24639.1 .
BC027843 mRNA. Translation: AAH27843.1 .
CCDSi CCDS15934.1.
RefSeqi NP_666231.1. NM_146119.2.
UniGenei Mm.301646.

3D structure databases

ProteinModelPortali Q8R1F1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230679. 2 interactions.
IntActi Q8R1F1. 2 interactions.
MINTi MINT-1849821.
STRINGi 10090.ENSMUSP00000028135.

PTM databases

PhosphoSitei Q8R1F1.

Proteomic databases

MaxQBi Q8R1F1.
PaxDbi Q8R1F1.
PRIDEi Q8R1F1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028135 ; ENSMUSP00000028135 ; ENSMUSG00000026796 .
GeneIDi 227737.
KEGGi mmu:227737.
UCSCi uc008jhc.2. mouse.

Organism-specific databases

CTDi 64855.
MGIi MGI:2442910. Fam129b.

Phylogenomic databases

eggNOGi NOG46977.
GeneTreei ENSGT00530000063284.
HOVERGENi HBG026217.
InParanoidi Q3UDW4.
OMAi RFYEDQY.
OrthoDBi EOG7GN2MC.
PhylomeDBi Q8R1F1.
TreeFami TF333351.

Miscellaneous databases

ChiTaRSi FAM129B. mouse.
NextBioi 378808.
PROi Q8R1F1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R1F1.
Bgeei Q8R1F1.
Genevestigatori Q8R1F1.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR026088. Niban_like.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR14392. PTHR14392. 1 hit.
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Adipose tissue, Cecum, Dendritic cell, Embryonic heart, Embryonic spinal ganglion and Macrophage.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells."
    Chen S., Evans H.G., Evans D.R.
    J. Biol. Chem. 286:10201-10209(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNIBL1_MOUSE
AccessioniPrimary (citable) accession number: Q8R1F1
Secondary accession number(s): Q3TCV6
, Q3U8I3, Q3UC84, Q3UDW4, Q3UIE4, Q543S7, Q8BQ71, Q8CC78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi