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Protein

Niban-like protein 1

Gene

Fam129b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in apoptosis suppression.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Niban-like protein 1
Alternative name(s):
Protein FAM129B
Gene namesi
Name:Fam129b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442910 Fam129b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002131222 – 749Niban-like protein 1Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei568PhosphoserineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei607PhosphoserineBy similarity1
Modified residuei628PhosphoserineBy similarity1
Modified residuei647PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei669PhosphoserineBy similarity1
Modified residuei674PhosphoserineBy similarity1
Modified residuei685PhosphoserineBy similarity1
Modified residuei695PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1

Post-translational modificationi

As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ8R1F1
MaxQBiQ8R1F1
PaxDbiQ8R1F1
PeptideAtlasiQ8R1F1
PRIDEiQ8R1F1

PTM databases

iPTMnetiQ8R1F1
PhosphoSitePlusiQ8R1F1

Expressioni

Gene expression databases

BgeeiENSMUSG00000026796
ExpressionAtlasiQ8R1F1 baseline and differential
GenevisibleiQ8R1F1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230679, 2 interactors
IntActiQ8R1F1, 2 interactors
MINTiQ8R1F1
STRINGi10090.ENSMUSP00000028135

Structurei

3D structure databases

ProteinModelPortaliQ8R1F1
SMRiQ8R1F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 192PHPROSITE-ProRule annotationAdd BLAST125

Sequence similaritiesi

Belongs to the Niban family.Curated

Phylogenomic databases

eggNOGiENOG410IFR1 Eukaryota
ENOG41102BB LUCA
GeneTreeiENSGT00530000063284
HOVERGENiHBG026217
InParanoidiQ8R1F1
OMAiRHCNNGI
OrthoDBiEOG091G02BX
PhylomeDBiQ8R1F1
TreeFamiTF333351

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR026088 Niban-like
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR14392 PTHR14392, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R1F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVLSTHLD DARRQHIAEK TEKILTEFLR FYEDQYGVSL FNSMRHEIEG
60 70 80 90 100
TGPPQAQLLW RKVPLDERII FSGNLFQYQE DNKKWRNRFS LVPHNYGLVL
110 120 130 140 150
YENKVAYERQ IPPRAVINSA GYKVLTSVDQ YLELVGNSLP GTTSKSGSTP
160 170 180 190 200
ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ DKWQAVLQDC VRHCNNGIPE
210 220 230 240 250
NSKVEGPAFT DAIRMYRQSK EQYGTWEMLC GNEVQILSNL VMEELGPALK
260 270 280 290 300
AELGPRLKGK PQERQRQWIQ ISDAVYRLVF EQAKVHFEDV LCKLQRARPA
310 320 330 340 350
MEAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL
360 370 380 390 400
MVPTSQGFTE VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSQLAYHPL
410 420 430 440 450
KMQSCYEKME PLRLDGLQQR FDVSSTSVFK QRAQIHMREQ MDNAVYTFET
460 470 480 490 500
LLHQELGKGP TKEELCKSIQ RILERVLKKY DYDSSSVRKR FFREALLQIT
510 520 530 540 550
IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV VLQTVMKDIL
560 570 580 590 600
QAVKEAAVQR KHNLYRDSMV LHNSDPNLHL LAEGTPIDWG EQYGDSGDSG
610 620 630 640 650
GGDSGGSPCP SEAATLTEKR RRAKQVMSVV QDEESGLPFE AGVEPPSPAS
660 670 680 690 700
PDSVTELRGL LAQDLQAESS PPASPLLNGA PVQESSQPVA VPEASPPASP
710 720 730 740
LRHLPPGKAV DLEPPKPSDQ ETGEQVSSPG SRPPIHTTTE DSAGVQTEF
Length:749
Mass (Da):84,819
Last modified:August 13, 2002 - v2
Checksum:iDB578DEA188492C8
GO

Sequence cautioni

The sequence BAC28456 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81D → G in BAE31035 (PubMed:16141072).Curated1
Sequence conflicti140P → A in BAC28456 (PubMed:16141072).Curated1
Sequence conflicti193H → L in BAE29147 (PubMed:16141072).Curated1
Sequence conflicti333V → E in BAC34625 (PubMed:16141072).Curated1
Sequence conflicti344P → Q in BAE27562 (PubMed:16141072).Curated1
Sequence conflicti503F → S in BAE41849 (PubMed:16141072).Curated1
Sequence conflicti655T → A in BAE29147 (PubMed:16141072).Curated1
Sequence conflicti662A → G in BAE27562 (PubMed:16141072).Curated1
Sequence conflicti711D → V in BAE29730 (PubMed:16141072).Curated1
Sequence conflicti724E → K in BAE41849 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033735 mRNA Translation: BAC28456.1 Different initiation.
AK046583 mRNA Translation: BAC32795.1
AK051396 mRNA Translation: BAC34625.1
AK146953 mRNA Translation: BAE27562.1
AK149888 mRNA Translation: BAE29147.1
AK150642 mRNA Translation: BAE29730.1
AK152207 mRNA Translation: BAE31035.1
AK153489 mRNA Translation: BAE32037.1
AK170512 mRNA Translation: BAE41849.1
AL845471, AL929154 Genomic DNA Translation: CAM20729.1
AL929154, AL845471 Genomic DNA Translation: CAM27398.1
CH466542 Genomic DNA Translation: EDL08584.1
BC024639 mRNA Translation: AAH24639.1
BC027843 mRNA Translation: AAH27843.1
CCDSiCCDS15934.1
RefSeqiNP_666231.1, NM_146119.2
UniGeneiMm.301646

Genome annotation databases

EnsembliENSMUST00000028135; ENSMUSP00000028135; ENSMUSG00000026796
GeneIDi227737
KEGGimmu:227737
UCSCiuc008jhc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNIBL1_MOUSE
AccessioniPrimary (citable) accession number: Q8R1F1
Secondary accession number(s): Q3TCV6
, Q3U8I3, Q3UC84, Q3UDW4, Q3UIE4, Q543S7, Q8BQ71, Q8CC78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: March 28, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health