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Q8R1F1 (NIBL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Niban-like protein 1
Alternative name(s):
Protein FAM129B
Gene names
Name:Fam129b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length749 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in apoptosis suppression By similarity.

Subcellular location

Cytoplasmcytosol. Cell junctionadherens junction By similarity. Note: In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase By similarity. Phosphorylation may play a role in relocalization to the membrane By similarity. Ref.5

Post-translational modification

As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases By similarity.

Sequence similarities

Belongs to the Niban family.

Contains 1 PH domain.

Sequence caution

The sequence BAC28456.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCell junction
Cytoplasm
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentadherens junction

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Inferred from direct assay Ref.5. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 749749Niban-like protein 1
PRO_0000213122

Regions

Domain68 – 192125PH

Amino acid modifications

Modified residue5681Phosphoserine By similarity
Modified residue5741Phosphoserine By similarity
Modified residue6071Phosphoserine By similarity
Modified residue6281Phosphoserine By similarity
Modified residue6501Phosphoserine By similarity
Modified residue6691Phosphoserine By similarity
Modified residue6851Phosphoserine By similarity
Modified residue6951Phosphoserine By similarity
Modified residue6991Phosphoserine By similarity

Experimental info

Sequence conflict811D → G in BAE31035. Ref.1
Sequence conflict1401P → A in BAC28456. Ref.1
Sequence conflict1931H → L in BAE29147. Ref.1
Sequence conflict3331V → E in BAC34625. Ref.1
Sequence conflict3441P → Q in BAE27562. Ref.1
Sequence conflict5031F → S in BAE41849. Ref.1
Sequence conflict6551T → A in BAE29147. Ref.1
Sequence conflict6621A → G in BAE27562. Ref.1
Sequence conflict7111D → V in BAE29730. Ref.1
Sequence conflict7241E → K in BAE41849. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8R1F1 [UniParc].

Last modified August 13, 2002. Version 2.
Checksum: DB578DEA188492C8

FASTA74984,819
        10         20         30         40         50         60 
MGDVLSTHLD DARRQHIAEK TEKILTEFLR FYEDQYGVSL FNSMRHEIEG TGPPQAQLLW 

        70         80         90        100        110        120 
RKVPLDERII FSGNLFQYQE DNKKWRNRFS LVPHNYGLVL YENKVAYERQ IPPRAVINSA 

       130        140        150        160        170        180 
GYKVLTSVDQ YLELVGNSLP GTTSKSGSTP ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ 

       190        200        210        220        230        240 
DKWQAVLQDC VRHCNNGIPE NSKVEGPAFT DAIRMYRQSK EQYGTWEMLC GNEVQILSNL 

       250        260        270        280        290        300 
VMEELGPALK AELGPRLKGK PQERQRQWIQ ISDAVYRLVF EQAKVHFEDV LCKLQRARPA 

       310        320        330        340        350        360 
MEAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL MVPTSQGFTE 

       370        380        390        400        410        420 
VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSQLAYHPL KMQSCYEKME PLRLDGLQQR 

       430        440        450        460        470        480 
FDVSSTSVFK QRAQIHMREQ MDNAVYTFET LLHQELGKGP TKEELCKSIQ RILERVLKKY 

       490        500        510        520        530        540 
DYDSSSVRKR FFREALLQIT IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV 

       550        560        570        580        590        600 
VLQTVMKDIL QAVKEAAVQR KHNLYRDSMV LHNSDPNLHL LAEGTPIDWG EQYGDSGDSG 

       610        620        630        640        650        660 
GGDSGGSPCP SEAATLTEKR RRAKQVMSVV QDEESGLPFE AGVEPPSPAS PDSVTELRGL 

       670        680        690        700        710        720 
LAQDLQAESS PPASPLLNGA PVQESSQPVA VPEASPPASP LRHLPPGKAV DLEPPKPSDQ 

       730        740 
ETGEQVSSPG SRPPIHTTTE DSAGVQTEF 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Adipose tissue, Cecum, Dendritic cell, Embryonic heart, Embryonic spinal ganglion and Macrophage.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells."
Chen S., Evans H.G., Evans D.R.
J. Biol. Chem. 286:10201-10209(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK033735 mRNA. Translation: BAC28456.1. Different initiation.
AK046583 mRNA. Translation: BAC32795.1.
AK051396 mRNA. Translation: BAC34625.1.
AK146953 mRNA. Translation: BAE27562.1.
AK149888 mRNA. Translation: BAE29147.1.
AK150642 mRNA. Translation: BAE29730.1.
AK152207 mRNA. Translation: BAE31035.1.
AK153489 mRNA. Translation: BAE32037.1.
AK170512 mRNA. Translation: BAE41849.1.
AL845471, AL929154 Genomic DNA. Translation: CAM20729.1.
AL929154, AL845471 Genomic DNA. Translation: CAM27398.1.
CH466542 Genomic DNA. Translation: EDL08584.1.
BC024639 mRNA. Translation: AAH24639.1.
BC027843 mRNA. Translation: AAH27843.1.
RefSeqNP_666231.1. NM_146119.2.
UniGeneMm.301646.

3D structure databases

ProteinModelPortalQ8R1F1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid230679. 1 interaction.
IntActQ8R1F1. 2 interactions.
MINTMINT-1849821.
STRING10090.ENSMUSP00000028135.

PTM databases

PhosphoSiteQ8R1F1.

Proteomic databases

PaxDbQ8R1F1.
PRIDEQ8R1F1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028135; ENSMUSP00000028135; ENSMUSG00000026796.
GeneID227737.
KEGGmmu:227737.
UCSCuc008jhc.2. mouse.

Organism-specific databases

CTD64855.
MGIMGI:2442910. Fam129b.

Phylogenomic databases

eggNOGNOG46977.
GeneTreeENSGT00530000063284.
HOVERGENHBG026217.
InParanoidQ3UDW4.
OMARFYEDQY.
OrthoDBEOG7GN2MC.
PhylomeDBQ8R1F1.
TreeFamTF333351.

Gene expression databases

ArrayExpressQ8R1F1.
BgeeQ8R1F1.
GenevestigatorQ8R1F1.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR026088. Niban_like.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PANTHERPTHR14392. PTHR14392. 1 hit.
SMARTSM00233. PH. 1 hit.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM129B. mouse.
NextBio378808.
PROQ8R1F1.
SOURCESearch...

Entry information

Entry nameNIBL1_MOUSE
AccessionPrimary (citable) accession number: Q8R1F1
Secondary accession number(s): Q3TCV6 expand/collapse secondary AC list , Q3U8I3, Q3UC84, Q3UDW4, Q3UIE4, Q543S7, Q8BQ71, Q8CC78
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot