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Protein

Amyloid beta A4 precursor protein-binding family B member 3

Gene

Apbb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate the internalization of beta-amyloid precursor protein.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of apoptotic process Source: MGI
  • regulation of transcription, DNA-templated Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 3
Gene namesi
Name:Apbb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:108404. Apbb3.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760551 – 486Amyloid beta A4 precursor protein-binding family B member 3Add BLAST486

Proteomic databases

PaxDbiQ8R1C9.
PRIDEiQ8R1C9.

PTM databases

iPTMnetiQ8R1C9.
PhosphoSitePlusiQ8R1C9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001379.
ExpressionAtlasiQ8R1C9. baseline and differential.
GenevisibleiQ8R1C9. MM.

Interactioni

Subunit structurei

Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R1C9. 1 interactor.
STRINGi10090.ENSMUSP00000001415.

Structurei

3D structure databases

ProteinModelPortaliQ8R1C9.
SMRiQ8R1C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 61WWPROSITE-ProRule annotationAdd BLAST33
Domaini113 – 280PID 1PROSITE-ProRule annotationAdd BLAST168
Domaini285 – 440PID 2PROSITE-ProRule annotationAdd BLAST156

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ8R1C9.
OMAiCQPHAGG.
OrthoDBiEOG091G04HV.
PhylomeDBiQ8R1C9.
TreeFamiTF314331.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF00640. PID. 1 hit.
SMARTiView protein in SMART
SM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R1C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP
60 70 80 90 100
SGSTQWQRPT WELPGAEDPG RGTEGIWELR PPKGRSFSSL DSSLNRSNSL
110 120 130 140 150
TWYSEDSYVR SLEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL
160 170 180 190 200
AQTRNRSQPH DGTWGEGQNM LMILKKDAMS LLNPLDHSLI HCQPLVHIRV
210 220 230 240 250
WGVGSSKGRD RDFAFVAGDK DSCMLKCHVF HCDVPAKAIA SALQGLCAQI
260 270 280 290 300
LSERVGVSGE AACCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGILP
310 320 330 340 350
VTKAMGMDVL NEAIGTLTAR GDRKTWVPAM LSVSDSLMTA HAIQAEAGAE
360 370 380 390 400
EEPLWQCPVR LVTFIGVGRD PHTFGLIADL GCQSFQCAAF WCEPHAGGLS
410 420 430 440 450
EAVQAACMVQ YQKCLVASAA RGKAWGAQAR ARLRLKRTSS MDSPGGPLPP
460 470 480
PLLKGGAGGA GAAPRKRGVF SFLDAFRLKP SLLHMS
Length:486
Mass (Da):52,638
Last modified:June 1, 2002 - v1
Checksum:iBEF1F66CAF10A139
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024809 mRNA. Translation: AAH24809.1.
CCDSiCCDS29157.1.
RefSeqiNP_666197.1. NM_146085.1.
UniGeneiMm.89673.

Genome annotation databases

EnsembliENSMUST00000001415; ENSMUSP00000001415; ENSMUSG00000006050.
GeneIDi225372.
KEGGimmu:225372.
UCSCiuc033hgf.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAPBB3_MOUSE
AccessioniPrimary (citable) accession number: Q8R1C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2002
Last modified: June 7, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot