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Protein

Amyloid beta A4 precursor protein-binding family B member 3

Gene

Apbb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate the internalization of beta-amyloid precursor protein.By similarity

GO - Biological processi

  • negative regulation of apoptotic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 3
Gene namesi
Name:Apbb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:108404. Apbb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Amyloid beta A4 precursor protein-binding family B member 3PRO_0000076055Add
BLAST

Proteomic databases

MaxQBiQ8R1C9.
PaxDbiQ8R1C9.
PRIDEiQ8R1C9.

PTM databases

iPTMnetiQ8R1C9.
PhosphoSiteiQ8R1C9.

Expressioni

Gene expression databases

BgeeiQ8R1C9.
ExpressionAtlasiQ8R1C9. baseline and differential.
GenevisibleiQ8R1C9. MM.

Interactioni

Subunit structurei

Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8R1C9. 1 interaction.
STRINGi10090.ENSMUSP00000001415.

Structurei

3D structure databases

ProteinModelPortaliQ8R1C9.
SMRiQ8R1C9. Positions 31-61, 115-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 6133WWPROSITE-ProRule annotationAdd
BLAST
Domaini113 – 280168PID 1PROSITE-ProRule annotationAdd
BLAST
Domaini285 – 440156PID 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PID domains.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ8R1C9.
OMAiSDKDSCM.
OrthoDBiEOG79W94P.
PhylomeDBiQ8R1C9.
TreeFamiTF314331.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R1C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP
60 70 80 90 100
SGSTQWQRPT WELPGAEDPG RGTEGIWELR PPKGRSFSSL DSSLNRSNSL
110 120 130 140 150
TWYSEDSYVR SLEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL
160 170 180 190 200
AQTRNRSQPH DGTWGEGQNM LMILKKDAMS LLNPLDHSLI HCQPLVHIRV
210 220 230 240 250
WGVGSSKGRD RDFAFVAGDK DSCMLKCHVF HCDVPAKAIA SALQGLCAQI
260 270 280 290 300
LSERVGVSGE AACCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGILP
310 320 330 340 350
VTKAMGMDVL NEAIGTLTAR GDRKTWVPAM LSVSDSLMTA HAIQAEAGAE
360 370 380 390 400
EEPLWQCPVR LVTFIGVGRD PHTFGLIADL GCQSFQCAAF WCEPHAGGLS
410 420 430 440 450
EAVQAACMVQ YQKCLVASAA RGKAWGAQAR ARLRLKRTSS MDSPGGPLPP
460 470 480
PLLKGGAGGA GAAPRKRGVF SFLDAFRLKP SLLHMS
Length:486
Mass (Da):52,638
Last modified:June 1, 2002 - v1
Checksum:iBEF1F66CAF10A139
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024809 mRNA. Translation: AAH24809.1.
CCDSiCCDS29157.1.
RefSeqiNP_666197.1. NM_146085.1.
UniGeneiMm.89673.

Genome annotation databases

EnsembliENSMUST00000001415; ENSMUSP00000001415; ENSMUSG00000006050.
GeneIDi225372.
KEGGimmu:225372.
UCSCiuc033hgf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024809 mRNA. Translation: AAH24809.1.
CCDSiCCDS29157.1.
RefSeqiNP_666197.1. NM_146085.1.
UniGeneiMm.89673.

3D structure databases

ProteinModelPortaliQ8R1C9.
SMRiQ8R1C9. Positions 31-61, 115-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R1C9. 1 interaction.
STRINGi10090.ENSMUSP00000001415.

PTM databases

iPTMnetiQ8R1C9.
PhosphoSiteiQ8R1C9.

Proteomic databases

MaxQBiQ8R1C9.
PaxDbiQ8R1C9.
PRIDEiQ8R1C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001415; ENSMUSP00000001415; ENSMUSG00000006050.
GeneIDi225372.
KEGGimmu:225372.
UCSCiuc033hgf.1. mouse.

Organism-specific databases

CTDi10307.
MGIiMGI:108404. Apbb3.

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ8R1C9.
OMAiSDKDSCM.
OrthoDBiEOG79W94P.
PhylomeDBiQ8R1C9.
TreeFamiTF314331.

Miscellaneous databases

NextBioi377647.
PROiQ8R1C9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R1C9.
ExpressionAtlasiQ8R1C9. baseline and differential.
GenevisibleiQ8R1C9. MM.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiAPBB3_MOUSE
AccessioniPrimary (citable) accession number: Q8R1C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.