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Q8R1C0

- KCNC4_MOUSE

UniProt

Q8R1C0 - KCNC4_MOUSE

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Protein

Potassium voltage-gated channel subfamily C member 4

Gene

Kcnc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
  2. regulation of neurotransmitter secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv3.4
Gene namesi
Name:Kcnc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:96670. Kcnc4.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: MGI
  2. neuromuscular junction Source: MGI
  3. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Potassium voltage-gated channel subfamily C member 4PRO_0000054059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei21 – 211PhosphoserineBy similarity
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8R1C0.
PRIDEiQ8R1C0.

PTM databases

PhosphoSiteiQ8R1C0.

Expressioni

Gene expression databases

BgeeiQ8R1C0.
GenevestigatoriQ8R1C0.

Interactioni

Subunit structurei

Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity).By similarityCurated

Structurei

3D structure databases

ProteinModelPortaliQ8R1C0.
SMRiQ8R1C0. Positions 1-30, 35-483.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 230230CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini303 – 31614CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini369 – 38416CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini477 – 628152CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei231 – 25121Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei317 – 33721Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei349 – 36820Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei385 – 40521Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei456 – 47621Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828Inactivation gateAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi440 – 4456Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiQ8R1C0.
KOiK04890.
OMAiMYCKSEE.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ8R1C0.
TreeFamiTF352511.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005405. K_chnl_volt-dep_Kv3.4.
IPR021105. K_chnl_volt-dep_Kv3_ID.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11404. Potassium_chann. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01583. KV34CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R1C0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY
60 70 80 90 100
RSTLRTLPGT RLAWLADPDG GGRPESDGGG AGSSGSSGGG GGGGGCEFFF
110 120 130 140 150
DRHPGVFAYV LNYYRTGKLH CPADVCGPLF EEELTFWGID ETDVEPCCWM
160 170 180 190 200
TYRQHRDAEE ALDIFESPDG GGGGAGPGDE AGDDERELAL QRLGPHEGGS
210 220 230 240 250
GPGAGSGGCR GWQPRMWALF EDPYSSRAAR VVAFASLFFI LVSITTFCLE
260 270 280 290 300
THEAFNIDRN VTEIHRVGNI TSVRFRREVE TEPILTYIEG VCVMWFTLEF
310 320 330 340 350
LVRIVCCPDT LDFVKNLLNI IDFVAILPFY LEVGLSGLSS KAARDVLGFL
360 370 380 390 400
RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA
410 420 430 440 450
TMIYYAERIG ARPSDPRGND HTDFKNIPIG FWWAVVTMTT LGYGDMYPKT
460 470 480 490 500
WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKRKKHV
510 520 530 540 550
PRPPQLESPI YCKSEETSPR DSTYSDTSPP AREEGVVERK RADSKQNGDA
560 570 580 590 600
NAVLSDEEGA GLTQPLALAP TPEERRALRR SGTRDRNKKA AACFLLSAGD
610 620
YACADGSVRK EGNVEPKACV PVSHTCAL
Length:628
Mass (Da):68,655
Last modified:June 1, 2002 - v1
Checksum:iE9D7B3EC6A03EBF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC024837 mRNA. Translation: AAH24837.1.
CCDSiCCDS17738.1.
RefSeqiNP_666034.1. NM_145922.2.
UniGeneiMm.101976.

Genome annotation databases

EnsembliENSMUST00000009617; ENSMUSP00000009617; ENSMUSG00000027895.
GeneIDi99738.
KEGGimmu:99738.
UCSCiuc008qxa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC024837 mRNA. Translation: AAH24837.1 .
CCDSi CCDS17738.1.
RefSeqi NP_666034.1. NM_145922.2.
UniGenei Mm.101976.

3D structure databases

ProteinModelPortali Q8R1C0.
SMRi Q8R1C0. Positions 1-30, 35-483.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R1C0.

Proteomic databases

PaxDbi Q8R1C0.
PRIDEi Q8R1C0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009617 ; ENSMUSP00000009617 ; ENSMUSG00000027895 .
GeneIDi 99738.
KEGGi mmu:99738.
UCSCi uc008qxa.1. mouse.

Organism-specific databases

CTDi 3749.
MGIi MGI:96670. Kcnc4.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118846.
HOGENOMi HOG000231012.
HOVERGENi HBG105862.
InParanoidi Q8R1C0.
KOi K04890.
OMAi MYCKSEE.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q8R1C0.
TreeFami TF352511.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 354099.
PROi Q8R1C0.
SOURCEi Search...

Gene expression databases

Bgeei Q8R1C0.
Genevestigatori Q8R1C0.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005405. K_chnl_volt-dep_Kv3.4.
IPR021105. K_chnl_volt-dep_Kv3_ID.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11404. Potassium_chann. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01583. KV34CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKCNC4_MOUSE
AccessioniPrimary (citable) accession number: Q8R1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3