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Q8R1C0 (KCNC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily C member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv3.4
Gene names
Name:Kcnc4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient By similarity.

Subunit structure

Homotetramer Probable. Heterotetramer of potassium channel proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments By similarity.

Post-translational modification

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure By similarity.

Sequence similarities

Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Potassium voltage-gated channel subfamily C member 4
PRO_0000054059

Regions

Topological domain1 – 230230Cytoplasmic Potential
Transmembrane231 – 25121Helical; Name=Segment S1; Potential
Transmembrane282 – 30221Helical; Name=Segment S2; Potential
Topological domain303 – 31614Cytoplasmic Potential
Transmembrane317 – 33721Helical; Name=Segment S3; Potential
Transmembrane349 – 36820Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain369 – 38416Cytoplasmic Potential
Transmembrane385 – 40521Helical; Name=Segment S5; Potential
Transmembrane456 – 47621Helical; Name=Segment S6; Potential
Topological domain477 – 628152Cytoplasmic Potential
Region1 – 2828Inactivation gate
Motif440 – 4456Selectivity filter By similarity

Amino acid modifications

Modified residue81Phosphoserine By similarity
Modified residue91Phosphoserine By similarity
Modified residue151Phosphoserine By similarity
Modified residue211Phosphoserine By similarity
Glycosylation2601N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8R1C0 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: E9D7B3EC6A03EBF8

FASTA62868,655
        10         20         30         40         50         60 
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY RSTLRTLPGT 

        70         80         90        100        110        120 
RLAWLADPDG GGRPESDGGG AGSSGSSGGG GGGGGCEFFF DRHPGVFAYV LNYYRTGKLH 

       130        140        150        160        170        180 
CPADVCGPLF EEELTFWGID ETDVEPCCWM TYRQHRDAEE ALDIFESPDG GGGGAGPGDE 

       190        200        210        220        230        240 
AGDDERELAL QRLGPHEGGS GPGAGSGGCR GWQPRMWALF EDPYSSRAAR VVAFASLFFI 

       250        260        270        280        290        300 
LVSITTFCLE THEAFNIDRN VTEIHRVGNI TSVRFRREVE TEPILTYIEG VCVMWFTLEF 

       310        320        330        340        350        360 
LVRIVCCPDT LDFVKNLLNI IDFVAILPFY LEVGLSGLSS KAARDVLGFL RVVRFVRILR 

       370        380        390        400        410        420 
IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA TMIYYAERIG ARPSDPRGND 

       430        440        450        460        470        480 
HTDFKNIPIG FWWAVVTMTT LGYGDMYPKT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG 

       490        500        510        520        530        540 
MYYSLAMAKQ KLPKKRKKHV PRPPQLESPI YCKSEETSPR DSTYSDTSPP AREEGVVERK 

       550        560        570        580        590        600 
RADSKQNGDA NAVLSDEEGA GLTQPLALAP TPEERRALRR SGTRDRNKKA AACFLLSAGD 

       610        620 
YACADGSVRK EGNVEPKACV PVSHTCAL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC024837 mRNA. Translation: AAH24837.1.
RefSeqNP_666034.1. NM_145922.2.
UniGeneMm.101976.

3D structure databases

ProteinModelPortalQ8R1C0.
SMRQ8R1C0. Positions 1-30, 35-483.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8R1C0.

Proteomic databases

PaxDbQ8R1C0.
PRIDEQ8R1C0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009617; ENSMUSP00000009617; ENSMUSG00000027895.
GeneID99738.
KEGGmmu:99738.
UCSCuc008qxa.1. mouse.

Organism-specific databases

CTD3749.
MGIMGI:96670. Kcnc4.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00740000115365.
HOGENOMHOG000231012.
HOVERGENHBG105862.
InParanoidQ8R1C0.
KOK04890.
OMAMYCKSEE.
OrthoDBEOG7CRTPP.
PhylomeDBQ8R1C0.
TreeFamTF352511.

Gene expression databases

BgeeQ8R1C0.
GenevestigatorQ8R1C0.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005405. K_chnl_volt-dep_Kv3.4.
IPR021105. K_chnl_volt-dep_Kv3_ID.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11404. Potassium_chann. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01583. KV34CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio354099.
PROQ8R1C0.
SOURCESearch...

Entry information

Entry nameKCNC4_MOUSE
AccessionPrimary (citable) accession number: Q8R1C0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot