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Protein

Potassium voltage-gated channel subfamily C member 4

Gene

Kcnc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • protein homooligomerization Source: InterPro
  • regulation of neurotransmitter secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv3.4
Gene namesi
Name:Kcnc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96670. Kcnc4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 230CytoplasmicSequence analysisAdd BLAST230
Transmembranei231 – 251Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei282 – 302Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini303 – 316CytoplasmicSequence analysisAdd BLAST14
Transmembranei317 – 337Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei349 – 368Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST20
Topological domaini369 – 384CytoplasmicSequence analysisAdd BLAST16
Transmembranei385 – 405Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei456 – 476Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini477 – 628CytoplasmicSequence analysisAdd BLAST152

GO - Cellular componenti

  • axon terminus Source: MGI
  • integral component of membrane Source: GO_Central
  • neuromuscular junction Source: MGI
  • voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540591 – 628Potassium voltage-gated channel subfamily C member 4Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8R1C0.
PRIDEiQ8R1C0.

PTM databases

iPTMnetiQ8R1C0.
PhosphoSitePlusiQ8R1C0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027895.
GenevisibleiQ8R1C0. MM.

Interactioni

Subunit structurei

Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009617.

Structurei

3D structure databases

ProteinModelPortaliQ8R1C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28Inactivation gateAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi440 – 445Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiQ8R1C0.
KOiK04890.
OMAiGCEFFFD.
OrthoDBiEOG091G0EJL.
PhylomeDBiQ8R1C0.
TreeFamiTF352511.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005405. K_chnl_volt-dep_Kv3.4.
IPR021105. K_chnl_volt-dep_Kv3_ID.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11404. Potassium_chann. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01583. KV34CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R1C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY
60 70 80 90 100
RSTLRTLPGT RLAWLADPDG GGRPESDGGG AGSSGSSGGG GGGGGCEFFF
110 120 130 140 150
DRHPGVFAYV LNYYRTGKLH CPADVCGPLF EEELTFWGID ETDVEPCCWM
160 170 180 190 200
TYRQHRDAEE ALDIFESPDG GGGGAGPGDE AGDDERELAL QRLGPHEGGS
210 220 230 240 250
GPGAGSGGCR GWQPRMWALF EDPYSSRAAR VVAFASLFFI LVSITTFCLE
260 270 280 290 300
THEAFNIDRN VTEIHRVGNI TSVRFRREVE TEPILTYIEG VCVMWFTLEF
310 320 330 340 350
LVRIVCCPDT LDFVKNLLNI IDFVAILPFY LEVGLSGLSS KAARDVLGFL
360 370 380 390 400
RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA
410 420 430 440 450
TMIYYAERIG ARPSDPRGND HTDFKNIPIG FWWAVVTMTT LGYGDMYPKT
460 470 480 490 500
WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKRKKHV
510 520 530 540 550
PRPPQLESPI YCKSEETSPR DSTYSDTSPP AREEGVVERK RADSKQNGDA
560 570 580 590 600
NAVLSDEEGA GLTQPLALAP TPEERRALRR SGTRDRNKKA AACFLLSAGD
610 620
YACADGSVRK EGNVEPKACV PVSHTCAL
Length:628
Mass (Da):68,655
Last modified:June 1, 2002 - v1
Checksum:iE9D7B3EC6A03EBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024837 mRNA. Translation: AAH24837.1.
CCDSiCCDS17738.1.
RefSeqiNP_666034.1. NM_145922.2.
UniGeneiMm.101976.

Genome annotation databases

EnsembliENSMUST00000009617; ENSMUSP00000009617; ENSMUSG00000027895.
GeneIDi99738.
KEGGimmu:99738.
UCSCiuc008qxa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024837 mRNA. Translation: AAH24837.1.
CCDSiCCDS17738.1.
RefSeqiNP_666034.1. NM_145922.2.
UniGeneiMm.101976.

3D structure databases

ProteinModelPortaliQ8R1C0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009617.

PTM databases

iPTMnetiQ8R1C0.
PhosphoSitePlusiQ8R1C0.

Proteomic databases

PaxDbiQ8R1C0.
PRIDEiQ8R1C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009617; ENSMUSP00000009617; ENSMUSG00000027895.
GeneIDi99738.
KEGGimmu:99738.
UCSCiuc008qxa.1. mouse.

Organism-specific databases

CTDi3749.
MGIiMGI:96670. Kcnc4.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiQ8R1C0.
KOiK04890.
OMAiGCEFFFD.
OrthoDBiEOG091G0EJL.
PhylomeDBiQ8R1C0.
TreeFamiTF352511.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiQ8R1C0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027895.
GenevisibleiQ8R1C0. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005405. K_chnl_volt-dep_Kv3.4.
IPR021105. K_chnl_volt-dep_Kv3_ID.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11404. Potassium_chann. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01583. KV34CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNC4_MOUSE
AccessioniPrimary (citable) accession number: Q8R1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.