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Protein

Potassium voltage-gated channel subfamily C member 4

Gene

Kcnc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv3.4
Gene namesi
Name:Kcnc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96670 Kcnc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 230CytoplasmicSequence analysisAdd BLAST230
Transmembranei231 – 251Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei282 – 302Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini303 – 316CytoplasmicSequence analysisAdd BLAST14
Transmembranei317 – 337Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei349 – 368Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST20
Topological domaini369 – 384CytoplasmicSequence analysisAdd BLAST16
Transmembranei385 – 405Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei456 – 476Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini477 – 628CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540591 – 628Potassium voltage-gated channel subfamily C member 4Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8R1C0
PRIDEiQ8R1C0

PTM databases

iPTMnetiQ8R1C0
PhosphoSitePlusiQ8R1C0

Expressioni

Gene expression databases

BgeeiENSMUSG00000027895
GenevisibleiQ8R1C0 MM

Interactioni

Subunit structurei

Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009617

Structurei

3D structure databases

ProteinModelPortaliQ8R1C0
SMRiQ8R1C0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28Inactivation gateAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi440 – 445Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231012
HOVERGENiHBG105862
InParanoidiQ8R1C0
KOiK04890
OMAiGCEFFFD
OrthoDBiEOG091G0EJL
PhylomeDBiQ8R1C0
TreeFamiTF352511

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003974 K_chnl_volt-dep_Kv3
IPR005405 K_chnl_volt-dep_Kv3.4
IPR021105 K_chnl_volt-dep_Kv3_ID
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PF11404 Potassium_chann, 1 hit
PRINTSiPR00169 KCHANNEL
PR01583 KV34CHANNEL
PR01491 KVCHANNEL
PR01498 SHAWCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R1C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY
60 70 80 90 100
RSTLRTLPGT RLAWLADPDG GGRPESDGGG AGSSGSSGGG GGGGGCEFFF
110 120 130 140 150
DRHPGVFAYV LNYYRTGKLH CPADVCGPLF EEELTFWGID ETDVEPCCWM
160 170 180 190 200
TYRQHRDAEE ALDIFESPDG GGGGAGPGDE AGDDERELAL QRLGPHEGGS
210 220 230 240 250
GPGAGSGGCR GWQPRMWALF EDPYSSRAAR VVAFASLFFI LVSITTFCLE
260 270 280 290 300
THEAFNIDRN VTEIHRVGNI TSVRFRREVE TEPILTYIEG VCVMWFTLEF
310 320 330 340 350
LVRIVCCPDT LDFVKNLLNI IDFVAILPFY LEVGLSGLSS KAARDVLGFL
360 370 380 390 400
RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA
410 420 430 440 450
TMIYYAERIG ARPSDPRGND HTDFKNIPIG FWWAVVTMTT LGYGDMYPKT
460 470 480 490 500
WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKRKKHV
510 520 530 540 550
PRPPQLESPI YCKSEETSPR DSTYSDTSPP AREEGVVERK RADSKQNGDA
560 570 580 590 600
NAVLSDEEGA GLTQPLALAP TPEERRALRR SGTRDRNKKA AACFLLSAGD
610 620
YACADGSVRK EGNVEPKACV PVSHTCAL
Length:628
Mass (Da):68,655
Last modified:June 1, 2002 - v1
Checksum:iE9D7B3EC6A03EBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024837 mRNA Translation: AAH24837.1
CCDSiCCDS17738.1
RefSeqiNP_666034.1, NM_145922.2
UniGeneiMm.101976

Genome annotation databases

EnsembliENSMUST00000009617; ENSMUSP00000009617; ENSMUSG00000027895
GeneIDi99738
KEGGimmu:99738
UCSCiuc008qxa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKCNC4_MOUSE
AccessioniPrimary (citable) accession number: Q8R1C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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