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Q8R1C0

- KCNC4_MOUSE

UniProt

Q8R1C0 - KCNC4_MOUSE

Protein

Potassium voltage-gated channel subfamily C member 4

Gene

Kcnc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro
    2. regulation of neurotransmitter secretion Source: MGI

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily C member 4
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv3.4
    Gene namesi
    Name:Kcnc4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:96670. Kcnc4.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: MGI
    2. neuromuscular junction Source: MGI
    3. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628Potassium voltage-gated channel subfamily C member 4PRO_0000054059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81PhosphoserineBy similarity
    Modified residuei9 – 91PhosphoserineBy similarity
    Modified residuei15 – 151PhosphoserineBy similarity
    Modified residuei21 – 211PhosphoserineBy similarity
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8R1C0.
    PRIDEiQ8R1C0.

    PTM databases

    PhosphoSiteiQ8R1C0.

    Expressioni

    Gene expression databases

    BgeeiQ8R1C0.
    GenevestigatoriQ8R1C0.

    Interactioni

    Subunit structurei

    Homotetramer Probable. Heterotetramer of potassium channel proteins By similarity.By similarityCurated

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R1C0.
    SMRiQ8R1C0. Positions 1-30, 35-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 230230CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini303 – 31614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini369 – 38416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini477 – 628152CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei231 – 25121Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei349 – 36820Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828Inactivation gateAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi440 – 4456Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115365.
    HOGENOMiHOG000231012.
    HOVERGENiHBG105862.
    InParanoidiQ8R1C0.
    KOiK04890.
    OMAiMYCKSEE.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiQ8R1C0.
    TreeFamiTF352511.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005405. K_chnl_volt-dep_Kv3.4.
    IPR021105. K_chnl_volt-dep_Kv3_ID.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF11404. Potassium_chann. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01583. KV34CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8R1C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY    50
    RSTLRTLPGT RLAWLADPDG GGRPESDGGG AGSSGSSGGG GGGGGCEFFF 100
    DRHPGVFAYV LNYYRTGKLH CPADVCGPLF EEELTFWGID ETDVEPCCWM 150
    TYRQHRDAEE ALDIFESPDG GGGGAGPGDE AGDDERELAL QRLGPHEGGS 200
    GPGAGSGGCR GWQPRMWALF EDPYSSRAAR VVAFASLFFI LVSITTFCLE 250
    THEAFNIDRN VTEIHRVGNI TSVRFRREVE TEPILTYIEG VCVMWFTLEF 300
    LVRIVCCPDT LDFVKNLLNI IDFVAILPFY LEVGLSGLSS KAARDVLGFL 350
    RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA 400
    TMIYYAERIG ARPSDPRGND HTDFKNIPIG FWWAVVTMTT LGYGDMYPKT 450
    WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKRKKHV 500
    PRPPQLESPI YCKSEETSPR DSTYSDTSPP AREEGVVERK RADSKQNGDA 550
    NAVLSDEEGA GLTQPLALAP TPEERRALRR SGTRDRNKKA AACFLLSAGD 600
    YACADGSVRK EGNVEPKACV PVSHTCAL 628
    Length:628
    Mass (Da):68,655
    Last modified:June 1, 2002 - v1
    Checksum:iE9D7B3EC6A03EBF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC024837 mRNA. Translation: AAH24837.1.
    CCDSiCCDS17738.1.
    RefSeqiNP_666034.1. NM_145922.2.
    UniGeneiMm.101976.

    Genome annotation databases

    EnsembliENSMUST00000009617; ENSMUSP00000009617; ENSMUSG00000027895.
    GeneIDi99738.
    KEGGimmu:99738.
    UCSCiuc008qxa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC024837 mRNA. Translation: AAH24837.1 .
    CCDSi CCDS17738.1.
    RefSeqi NP_666034.1. NM_145922.2.
    UniGenei Mm.101976.

    3D structure databases

    ProteinModelPortali Q8R1C0.
    SMRi Q8R1C0. Positions 1-30, 35-483.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R1C0.

    Proteomic databases

    PaxDbi Q8R1C0.
    PRIDEi Q8R1C0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009617 ; ENSMUSP00000009617 ; ENSMUSG00000027895 .
    GeneIDi 99738.
    KEGGi mmu:99738.
    UCSCi uc008qxa.1. mouse.

    Organism-specific databases

    CTDi 3749.
    MGIi MGI:96670. Kcnc4.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115365.
    HOGENOMi HOG000231012.
    HOVERGENi HBG105862.
    InParanoidi Q8R1C0.
    KOi K04890.
    OMAi MYCKSEE.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi Q8R1C0.
    TreeFami TF352511.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 354099.
    PROi Q8R1C0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R1C0.
    Genevestigatori Q8R1C0.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005405. K_chnl_volt-dep_Kv3.4.
    IPR021105. K_chnl_volt-dep_Kv3_ID.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF11404. Potassium_chann. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01583. KV34CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiKCNC4_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3