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Q8R1B8 (RORB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor ROR-beta
Alternative name(s):
Nuclear receptor RZR-beta
Nuclear receptor subfamily 1 group F member 2
Retinoid-related orphan receptor-beta
Gene names
Name:Rorb
Synonyms:Nr1f2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter. Ref.1 Ref.4

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in inner and outer neuroblastic layer as well as in the ganglion cell layer of the developing retina. Ref.1

Developmental stage

Highest level in retina of stage E17.5 embryos. Lower level in postnatal and adult retina. Ref.1

Disruption phenotype

Mice are blind, show juvenile ataxia, adult gait pecularities as well as delayed onset of male fertility. They show degeneration of the retina during postnatal development with severe defects in photoreceptor cell morphology as well as failure to express Opn1sw in cone photoreceptor cells. Ref.1 Ref.4

Sequence similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence caution

The sequence AAH24842.2 differs from that shown. Reason: Intron retention.

The sequence AAH58269.1 differs from that shown. Reason: Intron retention.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: Q8R1B8-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q8R1B8-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MCENQPKTKADGT → MR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Nuclear receptor ROR-beta
PRO_0000053515

Regions

DNA binding18 – 9376Nuclear receptor
Zinc finger21 – 4121NR C4-type
Zinc finger57 – 8125NR C4-type
Region94 – 221128Hinge Potential
Region222 – 470249Ligand-binding Potential

Natural variations

Alternative sequence1 – 1313MCENQ…KADGT → MR in isoform 1.
VSP_022576

Experimental info

Sequence conflict1071E → G in BAE93688. Ref.2
Sequence conflict2201M → L in BAE93688. Ref.2
Sequence conflict2471Q → H in BAE93688. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6E2F30DB56E94B86

FASTA47053,118
        10         20         30         40         50         60 
MCENQPKTKA DGTAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ NNASYSCPRQ 

        70         80         90        100        110        120 
RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLYAEVQK HQQRLQEQRQ 

       130        140        150        160        170        180 
QQSGEAEALA RVYSSSISNG LSNLNTETGG TYANGHVIDL PKSEGYYSID SGQPSPDQSG 

       190        200        210        220        230        240 
LDMTGIKQIK QEPIYDLTSV PNLFTYSSFN NGQLAPGITM SEIDRIAQNI IKSHLETCQY 

       250        260        270        280        290        300 
TMEELHQLAW QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN 

       310        320        330        340        350        360 
DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV NEAFDFAKNL 

       370        380        390        400        410        420 
CSLQLTEEEI ALFSSAVLIS PDRAWLIEPR KVQKLQEKIY FALQHVIQKN HLDDETLAKL 

       430        440        450        460        470 
IAKIPTITAV CNLHGEKLQV FKQSHPDIVN TLFPPLYKEL FNPDCAAVCK 

« Hide

Isoform 1 [UniParc].

Checksum: 8A22F5C8D104B269
Show »

FASTA45952,000

References

« Hide 'large scale' references
[1]"Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta."
Srinivas M., Ng L., Liu H., Jia L., Forrest D.
Mol. Endocrinol. 20:1728-1741(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
Strain: C57BL/6.
Tissue: Embryonic eye.
[2]"Mouse ROR beta partial cDNA."
Takano A., Katsuyama Y.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Retina.
[4]"Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice."
Andre E., Conquet F., Steinmayr M., Stratton S.C., Porciatti V., Becker-Andre M.
EMBO J. 17:3867-3877(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC024842 mRNA. Translation: AAH24842.2. Sequence problems.
BC058269 mRNA. Translation: AAH58269.1. Sequence problems.
DQ779923 mRNA. Translation: ABG77269.1.
DQ779924 mRNA. Translation: ABG77270.1.
AB258405 mRNA. Translation: BAE93688.1.
RefSeqNP_001036819.1. NM_001043354.2.
NP_666207.3. NM_146095.4.
UniGeneMm.234641.

3D structure databases

ProteinModelPortalQ8R1B8.
SMRQ8R1B8. Positions 18-462.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid230457. 6 interactions.

PTM databases

PhosphoSiteQ8R1B8.

Proteomic databases

PRIDEQ8R1B8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040153; ENSMUSP00000047597; ENSMUSG00000036192. [Q8R1B8-2]
ENSMUST00000112828; ENSMUSP00000108447; ENSMUSG00000036192.
ENSMUST00000112832; ENSMUSP00000108451; ENSMUSG00000036192. [Q8R1B8-1]
GeneID225998.
KEGGmmu:225998.
UCSCuc008gyc.2. mouse. [Q8R1B8-2]
uc008gye.2. mouse. [Q8R1B8-1]

Organism-specific databases

CTD6096.
MGIMGI:1343464. Rorb.

Phylogenomic databases

eggNOGNOG324222.
GeneTreeENSGT00740000114909.
HOGENOMHOG000010200.
HOVERGENHBG106848.
KOK08533.
OMAWEQLHDY.
OrthoDBEOG79PJNW.
PhylomeDBQ8R1B8.
TreeFamTF319910.

Gene expression databases

BgeeQ8R1B8.
CleanExMM_RORB.
GenevestigatorQ8R1B8.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio377911.
PROQ8R1B8.
SOURCESearch...

Entry information

Entry nameRORB_MOUSE
AccessionPrimary (citable) accession number: Q8R1B8
Secondary accession number(s): Q0PQZ2, Q0PQZ3, Q1MVR9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot