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Q8R1B5

- CPLX3_MOUSE

UniProt

Q8R1B5 - CPLX3_MOUSE

Protein

Complexin-3

Gene

Cplx3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Positively regulates a late step in synaptic vesicle exocytosis.1 Publication

    GO - Molecular functioni

    1. neurotransmitter transporter activity Source: UniProtKB
    2. SNARE binding Source: MGI

    GO - Biological processi

    1. insulin secretion Source: UniProtKB
    2. regulation of neurotransmitter secretion Source: MGI
    3. synaptic vesicle exocytosis Source: UniProtKB

    Keywords - Biological processi

    Exocytosis, Neurotransmitter transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complexin-3
    Alternative name(s):
    Complexin III
    Short name:
    CPX III
    Gene namesi
    Name:Cplx3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2384571. Cplx3.

    Subcellular locationi

    Membrane 1 Publication; Lipid-anchor 1 Publication. Cell junctionsynapse 1 Publication. Cell membrane 1 Publication; Lipid-anchor 1 Publication
    Note: Enriched at the synaptic terminal.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytosol Source: MGI
    3. membrane Source: UniProtKB
    4. plasma membrane Source: MGI
    5. synapse Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 155155Complexin-3PRO_0000239273Add
    BLAST
    Propeptidei156 – 1583Removed in mature formPRO_0000240234

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei155 – 1551Cysteine methyl ester1 Publication
    Lipidationi155 – 1551S-farnesyl cysteine1 Publication

    Post-translational modificationi

    Farnesylation mediates presynaptic targeting.

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ8R1B5.
    PaxDbiQ8R1B5.
    PRIDEiQ8R1B5.

    Expressioni

    Tissue specificityi

    Present in many brain regions, including hippocampus and cerebellum. In the retina, present both at conventional amacrine cell synapses and at photoreceptor ribbon synapses (at protein level).1 Publication

    Developmental stagei

    In the brain, expression starts at P6 and increases to reach a plateau at P20.1 Publication

    Gene expression databases

    BgeeiQ8R1B5.
    CleanExiMM_CPLX3.
    GenevestigatoriQ8R1B5.

    Interactioni

    Subunit structurei

    Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000046748.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R1B5.
    SMRiQ8R1B5. Positions 44-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili39 – 7436Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the complexin/synaphin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG38928.
    GeneTreeiENSGT00490000043378.
    HOGENOMiHOG000111927.
    HOVERGENiHBG060856.
    InParanoidiQ8R1B5.
    KOiK15295.
    OMAiTENCSLM.
    OrthoDBiEOG70CR8H.
    PhylomeDBiQ8R1B5.
    TreeFamiTF331867.

    Family and domain databases

    InterProiIPR008849. Synaphin.
    [Graphical view]
    PANTHERiPTHR16705. PTHR16705. 1 hit.
    PfamiPF05835. Synaphin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R1B5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFMVKSMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ    50
    LVEEKMERDA QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQLAGGDVE 100
    LPRELAKMIE EDTEEEEDKA SVLGQLASLP GLDLSSLKDK AQTTLGDLKQ 150
    SAEKCHIM 158
    Length:158
    Mass (Da):17,586
    Last modified:June 1, 2002 - v1
    Checksum:iE452E829DC019A70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY264290 mRNA. Translation: AAP22133.1.
    AK044211 mRNA. Translation: BAC31818.1.
    BC016632 mRNA. Translation: AAH16632.1.
    BC024854 mRNA. Translation: AAH24854.1.
    BC033343 mRNA. Translation: AAH33343.1.
    CCDSiCCDS23226.1.
    RefSeqiNP_666335.1. NM_146223.3.
    UniGeneiMm.35242.

    Genome annotation databases

    EnsembliENSMUST00000045068; ENSMUSP00000046748; ENSMUSG00000039714.
    GeneIDi235415.
    KEGGimmu:235415.
    UCSCiuc009pvg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY264290 mRNA. Translation: AAP22133.1 .
    AK044211 mRNA. Translation: BAC31818.1 .
    BC016632 mRNA. Translation: AAH16632.1 .
    BC024854 mRNA. Translation: AAH24854.1 .
    BC033343 mRNA. Translation: AAH33343.1 .
    CCDSi CCDS23226.1.
    RefSeqi NP_666335.1. NM_146223.3.
    UniGenei Mm.35242.

    3D structure databases

    ProteinModelPortali Q8R1B5.
    SMRi Q8R1B5. Positions 44-82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000046748.

    Proteomic databases

    MaxQBi Q8R1B5.
    PaxDbi Q8R1B5.
    PRIDEi Q8R1B5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045068 ; ENSMUSP00000046748 ; ENSMUSG00000039714 .
    GeneIDi 235415.
    KEGGi mmu:235415.
    UCSCi uc009pvg.2. mouse.

    Organism-specific databases

    CTDi 594855.
    MGIi MGI:2384571. Cplx3.

    Phylogenomic databases

    eggNOGi NOG38928.
    GeneTreei ENSGT00490000043378.
    HOGENOMi HOG000111927.
    HOVERGENi HBG060856.
    InParanoidi Q8R1B5.
    KOi K15295.
    OMAi TENCSLM.
    OrthoDBi EOG70CR8H.
    PhylomeDBi Q8R1B5.
    TreeFami TF331867.

    Miscellaneous databases

    NextBioi 382652.
    PROi Q8R1B5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R1B5.
    CleanExi MM_CPLX3.
    Genevestigatori Q8R1B5.

    Family and domain databases

    InterProi IPR008849. Synaphin.
    [Graphical view ]
    PANTHERi PTHR16705. PTHR16705. 1 hit.
    Pfami PF05835. Synaphin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structurally and functionally unique complexins at retinal ribbon synapses."
      Reim K., Wegmeyer H., Brandstaetter J.H., Xue M., Rosenmund C., Dresbach T., Hofmann K., Brose N.
      J. Cell Biol. 169:669-680(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-155, METHYLATION AT CYS-155, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Retina.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiCPLX3_MOUSE
    AccessioniPrimary (citable) accession number: Q8R1B5
    Secondary accession number(s): Q96AW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3