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Protein

Complexin-3

Gene

Cplx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates a late step in synaptic vesicle exocytosis.1 Publication

GO - Molecular functioni

  • neurotransmitter transporter activity Source: UniProtKB
  • SNARE binding Source: MGI

GO - Biological processi

  • insulin secretion Source: UniProtKB
  • regulation of neurotransmitter secretion Source: MGI
  • synaptic vesicle exocytosis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-3
Alternative name(s):
Complexin III
Short name:
CPX III
Gene namesi
Name:Cplx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2384571. Cplx3.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytosol Source: MGI
  • membrane Source: UniProtKB
  • plasma membrane Source: MGI
  • presynapse Source: GOC
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392731 – 155Complexin-3Add BLAST155
PropeptideiPRO_0000240234156 – 158Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155Cysteine methyl ester1 Publication1
Lipidationi155S-farnesyl cysteine1 Publication1

Post-translational modificationi

Farnesylation mediates presynaptic targeting.

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ8R1B5.
PaxDbiQ8R1B5.
PeptideAtlasiQ8R1B5.
PRIDEiQ8R1B5.

PTM databases

PhosphoSitePlusiQ8R1B5.

Expressioni

Tissue specificityi

Present in many brain regions, including hippocampus and cerebellum. In the retina, present both at conventional amacrine cell synapses and at photoreceptor ribbon synapses (at protein level).1 Publication

Developmental stagei

In the brain, expression starts at P6 and increases to reach a plateau at P20.1 Publication

Gene expression databases

BgeeiENSMUSG00000039714.
CleanExiMM_CPLX3.
GenevisibleiQ8R1B5. MM.

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.1 Publication

GO - Molecular functioni

  • SNARE binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046748.

Structurei

3D structure databases

ProteinModelPortaliQ8R1B5.
SMRiQ8R1B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili39 – 74Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWE3. Eukaryota.
ENOG4111I8F. LUCA.
GeneTreeiENSGT00490000043378.
HOGENOMiHOG000111927.
HOVERGENiHBG060856.
InParanoidiQ8R1B5.
KOiK15295.
OMAiTENCSLM.
OrthoDBiEOG091G0X1S.
PhylomeDBiQ8R1B5.
TreeFamiTF331867.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R1B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFMVKSMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ
60 70 80 90 100
LVEEKMERDA QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQLAGGDVE
110 120 130 140 150
LPRELAKMIE EDTEEEEDKA SVLGQLASLP GLDLSSLKDK AQTTLGDLKQ

SAEKCHIM
Length:158
Mass (Da):17,586
Last modified:June 1, 2002 - v1
Checksum:iE452E829DC019A70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264290 mRNA. Translation: AAP22133.1.
AK044211 mRNA. Translation: BAC31818.1.
BC016632 mRNA. Translation: AAH16632.1.
BC024854 mRNA. Translation: AAH24854.1.
BC033343 mRNA. Translation: AAH33343.1.
CCDSiCCDS23226.1.
RefSeqiNP_666335.1. NM_146223.3.
UniGeneiMm.35242.

Genome annotation databases

EnsembliENSMUST00000045068; ENSMUSP00000046748; ENSMUSG00000039714.
GeneIDi235415.
KEGGimmu:235415.
UCSCiuc009pvg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264290 mRNA. Translation: AAP22133.1.
AK044211 mRNA. Translation: BAC31818.1.
BC016632 mRNA. Translation: AAH16632.1.
BC024854 mRNA. Translation: AAH24854.1.
BC033343 mRNA. Translation: AAH33343.1.
CCDSiCCDS23226.1.
RefSeqiNP_666335.1. NM_146223.3.
UniGeneiMm.35242.

3D structure databases

ProteinModelPortaliQ8R1B5.
SMRiQ8R1B5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046748.

PTM databases

PhosphoSitePlusiQ8R1B5.

Proteomic databases

MaxQBiQ8R1B5.
PaxDbiQ8R1B5.
PeptideAtlasiQ8R1B5.
PRIDEiQ8R1B5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045068; ENSMUSP00000046748; ENSMUSG00000039714.
GeneIDi235415.
KEGGimmu:235415.
UCSCiuc009pvg.2. mouse.

Organism-specific databases

CTDi594855.
MGIiMGI:2384571. Cplx3.

Phylogenomic databases

eggNOGiENOG410IWE3. Eukaryota.
ENOG4111I8F. LUCA.
GeneTreeiENSGT00490000043378.
HOGENOMiHOG000111927.
HOVERGENiHBG060856.
InParanoidiQ8R1B5.
KOiK15295.
OMAiTENCSLM.
OrthoDBiEOG091G0X1S.
PhylomeDBiQ8R1B5.
TreeFamiTF331867.

Miscellaneous databases

PROiQ8R1B5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039714.
CleanExiMM_CPLX3.
GenevisibleiQ8R1B5. MM.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPLX3_MOUSE
AccessioniPrimary (citable) accession number: Q8R1B5
Secondary accession number(s): Q96AW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.