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Q8R1B5

- CPLX3_MOUSE

UniProt

Q8R1B5 - CPLX3_MOUSE

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Protein

Complexin-3

Gene
Cplx3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Positively regulates a late step in synaptic vesicle exocytosis.1 Publication

GO - Molecular functioni

  1. neurotransmitter transporter activity Source: UniProtKB
  2. SNARE binding Source: MGI

GO - Biological processi

  1. insulin secretion Source: UniProtKB
  2. regulation of neurotransmitter secretion Source: MGI
  3. synaptic vesicle exocytosis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-3
Alternative name(s):
Complexin III
Short name:
CPX III
Gene namesi
Name:Cplx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2384571. Cplx3.

Subcellular locationi

Membrane; Lipid-anchor. Cell junctionsynapse. Cell membrane; Lipid-anchor
Note: Enriched at the synaptic terminal.1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytosol Source: MGI
  3. membrane Source: UniProtKB
  4. plasma membrane Source: MGI
  5. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Complexin-3PRO_0000239273Add
BLAST
Propeptidei156 – 1583Removed in mature formPRO_0000240234

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei155 – 1551Cysteine methyl ester1 Publication
Lipidationi155 – 1551S-farnesyl cysteine1 Publication

Post-translational modificationi

Farnesylation mediates presynaptic targeting.

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ8R1B5.
PaxDbiQ8R1B5.
PRIDEiQ8R1B5.

Expressioni

Tissue specificityi

Present in many brain regions, including hippocampus and cerebellum. In the retina, present both at conventional amacrine cell synapses and at photoreceptor ribbon synapses (at protein level).1 Publication

Developmental stagei

In the brain, expression starts at P6 and increases to reach a plateau at P20.1 Publication

Gene expression databases

BgeeiQ8R1B5.
CleanExiMM_CPLX3.
GenevestigatoriQ8R1B5.

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046748.

Structurei

3D structure databases

ProteinModelPortaliQ8R1B5.
SMRiQ8R1B5. Positions 44-82.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili39 – 7436 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG38928.
GeneTreeiENSGT00490000043378.
HOGENOMiHOG000111927.
HOVERGENiHBG060856.
InParanoidiQ8R1B5.
KOiK15295.
OMAiTENCSLM.
OrthoDBiEOG70CR8H.
PhylomeDBiQ8R1B5.
TreeFamiTF331867.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R1B5-1 [UniParc]FASTAAdd to Basket

« Hide

MAFMVKSMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ    50
LVEEKMERDA QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQLAGGDVE 100
LPRELAKMIE EDTEEEEDKA SVLGQLASLP GLDLSSLKDK AQTTLGDLKQ 150
SAEKCHIM 158
Length:158
Mass (Da):17,586
Last modified:June 1, 2002 - v1
Checksum:iE452E829DC019A70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY264290 mRNA. Translation: AAP22133.1.
AK044211 mRNA. Translation: BAC31818.1.
BC016632 mRNA. Translation: AAH16632.1.
BC024854 mRNA. Translation: AAH24854.1.
BC033343 mRNA. Translation: AAH33343.1.
CCDSiCCDS23226.1.
RefSeqiNP_666335.1. NM_146223.3.
UniGeneiMm.35242.

Genome annotation databases

EnsembliENSMUST00000045068; ENSMUSP00000046748; ENSMUSG00000039714.
GeneIDi235415.
KEGGimmu:235415.
UCSCiuc009pvg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY264290 mRNA. Translation: AAP22133.1 .
AK044211 mRNA. Translation: BAC31818.1 .
BC016632 mRNA. Translation: AAH16632.1 .
BC024854 mRNA. Translation: AAH24854.1 .
BC033343 mRNA. Translation: AAH33343.1 .
CCDSi CCDS23226.1.
RefSeqi NP_666335.1. NM_146223.3.
UniGenei Mm.35242.

3D structure databases

ProteinModelPortali Q8R1B5.
SMRi Q8R1B5. Positions 44-82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000046748.

Proteomic databases

MaxQBi Q8R1B5.
PaxDbi Q8R1B5.
PRIDEi Q8R1B5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045068 ; ENSMUSP00000046748 ; ENSMUSG00000039714 .
GeneIDi 235415.
KEGGi mmu:235415.
UCSCi uc009pvg.2. mouse.

Organism-specific databases

CTDi 594855.
MGIi MGI:2384571. Cplx3.

Phylogenomic databases

eggNOGi NOG38928.
GeneTreei ENSGT00490000043378.
HOGENOMi HOG000111927.
HOVERGENi HBG060856.
InParanoidi Q8R1B5.
KOi K15295.
OMAi TENCSLM.
OrthoDBi EOG70CR8H.
PhylomeDBi Q8R1B5.
TreeFami TF331867.

Miscellaneous databases

NextBioi 382652.
PROi Q8R1B5.
SOURCEi Search...

Gene expression databases

Bgeei Q8R1B5.
CleanExi MM_CPLX3.
Genevestigatori Q8R1B5.

Family and domain databases

InterProi IPR008849. Synaphin.
[Graphical view ]
PANTHERi PTHR16705. PTHR16705. 1 hit.
Pfami PF05835. Synaphin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structurally and functionally unique complexins at retinal ribbon synapses."
    Reim K., Wegmeyer H., Brandstaetter J.H., Xue M., Rosenmund C., Dresbach T., Hofmann K., Brose N.
    J. Cell Biol. 169:669-680(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-155, METHYLATION AT CYS-155, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiCPLX3_MOUSE
AccessioniPrimary (citable) accession number: Q8R1B5
Secondary accession number(s): Q96AW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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