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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

Eif3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-72649 Translation initiation complex formation
R-MMU-72689 Formation of a pool of free 40S subunits
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8UniRule annotation
eIF3 p110UniRule annotation
Gene namesi
Name:Eif3c
Synonyms:Eif3s8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1926966 Eif3c

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002594251 – 911Eukaryotic translation initiation factor 3 subunit CAdd BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei13PhosphoserineUniRule annotationBy similarity1
Modified residuei15PhosphoserineUniRule annotationBy similarity1
Modified residuei16PhosphoserineUniRule annotationBy similarity1
Modified residuei18PhosphoserineUniRule annotationBy similarity1
Modified residuei39PhosphoserineCombined sources1
Modified residuei99N6-acetyllysineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei522PhosphothreonineCombined sources1
Modified residuei641N6-acetyllysineCombined sources1
Modified residuei907PhosphoserineUniRule annotationBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation is enhanced upon serum stimulation.UniRule annotation

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8R1B4
MaxQBiQ8R1B4
PaxDbiQ8R1B4
PeptideAtlasiQ8R1B4
PRIDEiQ8R1B4

PTM databases

iPTMnetiQ8R1B4
PhosphoSitePlusiQ8R1B4
SwissPalmiQ8R1B4

Expressioni

Gene expression databases

BgeeiENSMUSG00000030738
ExpressionAtlasiQ8R1B4 baseline and differential
GenevisibleiQ8R1B4 MM

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with ALKBH4, IFIT1 and IFIT2 (By similarity).UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207913, 3 interactors
IntActiQ8R1B4, 1 interactor
MINTiQ8R1B4
STRINGi10090.ENSMUSP00000032992

Structurei

3D structure databases

ProteinModelPortaliQ8R1B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini671 – 847PCIPROSITE-ProRule annotationAdd BLAST177

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi164 – 189Asp/Glu-rich (acidic)Add BLAST26
Compositional biasi241 – 244Poly-Glu4
Compositional biasi289 – 292Poly-Glu4

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1076 Eukaryota
ENOG410XRU3 LUCA
GeneTreeiENSGT00390000017900
HOGENOMiHOG000029414
HOVERGENiHBG035174
InParanoidiQ8R1B4
KOiK03252
OMAiVVMHRSE
OrthoDBiEOG091G02A3
PhylomeDBiQ8R1B4
TreeFamiTF101520

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_03002 eIF3c, 1 hit
InterProiView protein in InterPro
IPR027516 EIF3C
IPR008905 EIF3C_N_dom
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05470 eIF-3c_N, 1 hit
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R1B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFFTTGSD SESESSLSGE ELVTKPVSGN YGKQPLLLSE DEEDTKRVVR
60 70 80 90 100
SAKDKRFEEL TNLIRTIRNA MKIRDVTKCL EEFELLGKAY GKAKSIVDKE
110 120 130 140 150
GVPRFYIRIL ADLEDYLNEL WEDKEGKKKM NKNNAKALST LRQKIRKYNR
160 170 180 190 200
DFESHITNYK QNPEQSADED AEKNEEDSEG SSDEDEDEDG VGNTTFLKKK
210 220 230 240 250
QESSGESRKF HKKMEDDDED SEDSEDEEWD TSSTSSDSDS EEEEGKQTVL
260 270 280 290 300
ASKFLKKAPT TEEDKKAAEK KREDKAKKKH DRKSKRLDEE EEDNEGGEWE
310 320 330 340 350
RVRGGVPLVK EKPKMFAKGT EITHAVVIKK LNEILQVRGK KGTDRATQIE
360 370 380 390 400
LLQLLVQIAA ENNLGVGVIV KIKFNIIASL YDYNPNLATY MKPEMWQMCL
410 420 430 440 450
DCINELMDTL VAHSNIFVGE NILEESENLH NFDQPLRVRG CILTLVERMD
460 470 480 490 500
EEFTKIMQNT DPHSQEYVEH LKDEAQVCAI IERVQRYLEE KGTTEEICQI
510 520 530 540 550
YLRRILHTYY KFDYKAHQRQ LTPPEGSSKS EQDQAENEGE DSAVLMERLC
560 570 580 590 600
KYIYAKDRTD RIRTCAILCH IYHHALHSRW YQARDLMLMS HLQDNIQHAD
610 620 630 640 650
PPVQILYNRT MVQLGICAFR QGLTKDAHNA LLDIQSSGRA KELLGQGLLL
660 670 680 690 700
RSLQERNQEQ EKVERRRQVP FHLHINLELL ECVYLVSAML LEIPYMAAHE
710 720 730 740 750
SDARRRMISK QFHHQLRVGE RQPLLGPPES MREHVVAASK AMKMGDWKTC
760 770 780 790 800
HSFIINEKMN GKVWDLFPEA DKVRTMLVRK IQEESLRTYL FTYSSVYDSI
810 820 830 840 850
SMETLSDMFE LDLPTVHSII SKMIINEELM ASLDQPTQTV VMHRTEPTAQ
860 870 880 890 900
QNLALQLAEK LGSLVENNER VFDHKQGTYG GYFRDQKDGY RKNEGYMRRG
910
GYRQQQSQTA Y
Length:911
Mass (Da):105,531
Last modified:June 1, 2002 - v1
Checksum:iA88282C5B4C55AEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111A → T in AAH25032 (PubMed:15489334).Curated1
Sequence conflicti894E → L in AAH25032 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160078 mRNA Translation: BAE35610.1
BC024855 mRNA Translation: AAH24855.1
BC025032 mRNA Translation: AAH25032.1
CCDSiCCDS21832.1
RefSeqiNP_666312.1, NM_146200.1
UniGeneiMm.22776

Genome annotation databases

EnsembliENSMUST00000032992; ENSMUSP00000032992; ENSMUSG00000030738
GeneIDi56347
KEGGimmu:56347
UCSCiuc009jrw.1 mouse

Entry informationi

Entry nameiEIF3C_MOUSE
AccessioniPrimary (citable) accession number: Q8R1B4
Secondary accession number(s): Q8R3M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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