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Q8R197 (SAST_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
S-acyl fatty acid synthase thioesterase, medium chain
EC=3.1.2.14
Alternative name(s):
Oleoyl-ACP hydrolase
Thioesterase II
Thioesterase domain-containing protein 1
Gene names
Name:Olah
Synonyms:Thedc1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) By similarity.

Catalytic activity

Oleoyl-[acyl-carrier-protein] + H2O = [acyl-carrier-protein] + oleate.

Sequence similarities

Belongs to the thioesterase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265S-acyl fatty acid synthase thioesterase, medium chain
PRO_0000180359

Sites

Active site1011 By similarity
Active site2371 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8R197 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 8D235D7E82C8C300

FASTA26530,250
        10         20         30         40         50         60 
METAVYAKST RNEKVLNCLC QKPDALFKLI CFPWAGGGST HFAKWGRKIN GLLEVHAVRL 

        70         80         90        100        110        120 
AGRETRFEEP FSNDIYQIAE EVVTALLPII RDKAFAFFGH SFGSYIAFIT ALHLKEKYKM 

       130        140        150        160        170        180 
EPLHIFVSSA SAPHSEFRPQ VPDINKLSEE QIRDHLLIFG GTPKHLIEDQ DFLKQCIPLL 

       190        200        210        220        230        240 
KADVDIVKKF IFDKPSKALL SRDITCFIGS EDVVKDIEGW KDITSGKFDV LKLPGDHFYL 

       250        260 
MEPNNEDFIK NYIVKCLELS SLDYF

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Egg and Oviduct.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK087571 mRNA. Translation: BAC39932.1.
AK136031 mRNA. Translation: BAE22784.1.
BC025001 mRNA. Translation: AAH25001.1.
IPIIPI00153328.
RefSeqNP_666033.1. NM_145921.1.
UniGeneMm.13808.

3D structure databases

ProteinModelPortalQ8R197.
SMRQ8R197. Positions 21-257.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8R197.

Proteomic databases

PRIDEQ8R197.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027955; ENSMUSP00000027955; ENSMUSG00000026645.
ENSMUST00000115087; ENSMUSP00000110739; ENSMUSG00000026645.
GeneID99035.
KEGGmmu:99035.

Organism-specific databases

CTD55301.
MGIMGI:2139018. Olah.

Phylogenomic databases

GeneTreeENSGT00390000015518.
HOGENOMHBG756950.
HOVERGENHBG015455.
InParanoidQ8R197.
OMASCDLTCF.
OrthoDBEOG4F1X42.
PhylomeDBQ8R197.

Gene expression databases

ArrayExpressQ8R197.
BgeeQ8R197.
CleanExMM_OLAH.
GenevestigatorQ8R197.
GermOnlineENSMUSG00000026645. Mus musculus.

Family and domain databases

InterProIPR012223. TEII.
IPR001031. Thioesterase.
[Graphical view]
KOK01071.
PANTHERPTHR11487. TEII. 1 hit.
PfamPF00975. Thioesterase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio353765.
SOURCESearch...

Entry information

Entry nameSAST_MOUSE
AccessionPrimary (citable) accession number: Q8R197
Secondary accession number(s): Q3UWY0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2002
Last modified: November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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