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Protein

Synaptogyrin-3

Gene

Syngr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release.1 Publication

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
  • SH2 domain binding Source: MGI

GO - Biological processi

  • positive regulation of transporter activity Source: UniProtKB
  • substantia nigra development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-3
Gene namesi
Name:Syngr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1341881. Syngr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • neuromuscular junction Source: UniProtKB
  • synapse Source: MGI
  • synaptic vesicle Source: UniProtKB
  • synaptic vesicle membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Synaptogyrin-3PRO_0000183997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R191.
PaxDbiQ8R191.
PeptideAtlasiQ8R191.
PRIDEiQ8R191.

PTM databases

iPTMnetiQ8R191.
PhosphoSiteiQ8R191.

Expressioni

Tissue specificityi

Found in the brain across the dorsal and ventral corpus striatum as well as in the cortex.1 Publication

Gene expression databases

BgeeiQ8R191.
CleanExiMM_SYNGR3.
GenevisibleiQ8R191. MM.

Interactioni

Subunit structurei

Interacts (via N-terminus) with SLC6A3 (via N-terminus).1 Publication

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
  • SH2 domain binding Source: MGI

Protein-protein interaction databases

BioGridi203607. 1 interaction.
IntActiQ8R191. 2 interactions.
STRINGi10090.ENSMUSP00000007236.

Structurei

3D structure databases

ProteinModelPortaliQ8R191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 172153MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptogyrin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4016. Eukaryota.
ENOG4111F8S. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiQ8R191.
OMAiANQWQQT.
OrthoDBiEOG7VTDQ1.
PhylomeDBiQ8R191.
TreeFamiTF320995.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGASFGAGR AGAAFDPVSF ARRPQTLLRV VSWVFSIAVF GPIVNEGYVN
60 70 80 90 100
SDSGPELRCV FNGNAGACRF GVVLGLGAFI ACVAFLLLDV RFQQISSVRD
110 120 130 140 150
RRRAVLLDLG FSGVWSFLWF VGFCFLTNQW QRTTPGPGTA QAGDAARAAI
160 170 180 190 200
AFSFFSILSW VALTVKALQR FRLGTDMSLF ATDQLGTGAA QAYPGYPVGS
210 220
GVEGTETYQS PPFTETLDTS SKGYQVPAY
Length:229
Mass (Da):24,561
Last modified:June 1, 2002 - v1
Checksum:iE04C00555B8A3C08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711F → L in AAD28556 (PubMed:10383386).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117207 mRNA. Translation: AAD28556.1.
AK048753 mRNA. Translation: BAC33444.1.
AK081164 mRNA. Translation: BAC38151.1.
AK082167 mRNA. Translation: BAC38430.1.
BC025022 mRNA. Translation: AAH25022.1.
CCDSiCCDS28491.1.
RefSeqiNP_035652.2. NM_011522.3.
UniGeneiMm.26032.

Genome annotation databases

EnsembliENSMUST00000007236; ENSMUSP00000007236; ENSMUSG00000007021.
GeneIDi20974.
KEGGimmu:20974.
UCSCiuc008axq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117207 mRNA. Translation: AAD28556.1.
AK048753 mRNA. Translation: BAC33444.1.
AK081164 mRNA. Translation: BAC38151.1.
AK082167 mRNA. Translation: BAC38430.1.
BC025022 mRNA. Translation: AAH25022.1.
CCDSiCCDS28491.1.
RefSeqiNP_035652.2. NM_011522.3.
UniGeneiMm.26032.

3D structure databases

ProteinModelPortaliQ8R191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203607. 1 interaction.
IntActiQ8R191. 2 interactions.
STRINGi10090.ENSMUSP00000007236.

PTM databases

iPTMnetiQ8R191.
PhosphoSiteiQ8R191.

Proteomic databases

MaxQBiQ8R191.
PaxDbiQ8R191.
PeptideAtlasiQ8R191.
PRIDEiQ8R191.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007236; ENSMUSP00000007236; ENSMUSG00000007021.
GeneIDi20974.
KEGGimmu:20974.
UCSCiuc008axq.1. mouse.

Organism-specific databases

CTDi9143.
MGIiMGI:1341881. Syngr3.

Phylogenomic databases

eggNOGiKOG4016. Eukaryota.
ENOG4111F8S. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiQ8R191.
OMAiANQWQQT.
OrthoDBiEOG7VTDQ1.
PhylomeDBiQ8R191.
TreeFamiTF320995.

Miscellaneous databases

ChiTaRSiSyngr3. mouse.
PROiQ8R191.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R191.
CleanExiMM_SYNGR3.
GenevisibleiQ8R191. MM.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Synaptogyrins regulate Ca2+-dependent exocytosis in PC12 cells."
    Sugita S., Janz R., Suedhof T.C.
    J. Biol. Chem. 274:18893-18901(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 11-22; 92-99 AND 133-147, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. "Characterization of synaptogyrin 3 as a new synaptic vesicle protein."
    Belizaire R., Komanduri C., Wooten K., Chen M., Thaller C., Janz R.
    J. Comp. Neurol. 470:266-281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3."
    Egana L.A., Cuevas R.A., Baust T.B., Parra L.A., Leak R.K., Hochendoner S., Pena K., Quiroz M., Hong W.C., Dorostkar M.M., Janz R., Sitte H.H., Torres G.E.
    J. Neurosci. 29:4592-4604(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLC6A3, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSNG3_MOUSE
AccessioniPrimary (citable) accession number: Q8R191
Secondary accession number(s): Q9WVG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.