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Protein

Synaptogyrin-3

Gene

Syngr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulated exocytosis (PubMed:10383386). May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal (PubMed:19357284).2 Publications

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
  • SH2 domain binding Source: MGI

GO - Biological processi

  • positive regulation of transporter activity Source: UniProtKB
  • regulated exocytosis Source: UniProtKB
  • substantia nigra development Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-3Curated
Gene namesi
Name:Syngr3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1341881. Syngr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839971 – 229Synaptogyrin-3Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8R191.
PaxDbiQ8R191.
PeptideAtlasiQ8R191.
PRIDEiQ8R191.

PTM databases

iPTMnetiQ8R191.
PhosphoSitePlusiQ8R191.

Expressioni

Tissue specificityi

Specifically expressed in brain. Found in the brain across the dorsal and ventral corpus striatum as well as in the cortex.2 Publications

Developmental stagei

Expression increases during brain development from P2 to adult (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000007021.
CleanExiMM_SYNGR3.
GenevisibleiQ8R191. MM.

Interactioni

Subunit structurei

Interacts (via N-terminus) with SLC6A3 (via N-terminus) (PubMed:19357284). May interact with VMAT2 (PubMed:19357284).1 Publication

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
  • SH2 domain binding Source: MGI

Protein-protein interaction databases

BioGridi203607. 1 interactor.
IntActiQ8R191. 2 interactors.
STRINGi10090.ENSMUSP00000007236.

Structurei

3D structure databases

ProteinModelPortaliQ8R191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 172MARVELPROSITE-ProRule annotationAdd BLAST153

Sequence similaritiesi

Belongs to the synaptogyrin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4016. Eukaryota.
ENOG4111F8S. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiQ8R191.
OMAiANQWQQT.
OrthoDBiEOG091G0GG2.
PhylomeDBiQ8R191.
TreeFamiTF320995.

Family and domain databases

InterProiView protein in InterPro
IPR008253. Marvel.
IPR016579. Synaptogyrin.
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiView protein in Pfam
PF01284. MARVEL. 1 hit.
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiView protein in PROSITE
PS51225. MARVEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGASFGAGR AGAAFDPVSF ARRPQTLLRV VSWVFSIAVF GPIVNEGYVN
60 70 80 90 100
SDSGPELRCV FNGNAGACRF GVVLGLGAFI ACVAFLLLDV RFQQISSVRD
110 120 130 140 150
RRRAVLLDLG FSGVWSFLWF VGFCFLTNQW QRTTPGPGTA QAGDAARAAI
160 170 180 190 200
AFSFFSILSW VALTVKALQR FRLGTDMSLF ATDQLGTGAA QAYPGYPVGS
210 220
GVEGTETYQS PPFTETLDTS SKGYQVPAY
Length:229
Mass (Da):24,561
Last modified:June 1, 2002 - v1
Checksum:iE04C00555B8A3C08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171F → L in AAD28556 (PubMed:10383386).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117207 mRNA. Translation: AAD28556.1.
AK048753 mRNA. Translation: BAC33444.1.
AK081164 mRNA. Translation: BAC38151.1.
AK082167 mRNA. Translation: BAC38430.1.
BC025022 mRNA. Translation: AAH25022.1.
CCDSiCCDS28491.1.
RefSeqiNP_035652.2. NM_011522.3.
UniGeneiMm.26032.

Genome annotation databases

EnsembliENSMUST00000007236; ENSMUSP00000007236; ENSMUSG00000007021.
GeneIDi20974.
KEGGimmu:20974.
UCSCiuc008axq.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSNG3_MOUSE
AccessioniPrimary (citable) accession number: Q8R191
Secondary accession number(s): Q9WVG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families