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Protein

T-cell immunoglobulin and mucin domain-containing protein 2

Gene

Timd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation.1 Publication

GO - Molecular functioni

  • ferritin receptor activity Source: MGI

GO - Biological processi

  • iron ion import Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell immunoglobulin and mucin domain-containing protein 2
Short name:
TIMD-2
Alternative name(s):
T-cell immunoglobulin mucin receptor 2
Short name:
TIM-2
T-cell membrane protein 2
Gene namesi
Name:Timd2
Synonyms:Tim2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2159681. Timd2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 231ExtracellularSequence analysisAdd BLAST210
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 305CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • cell surface Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004209922 – 305T-cell immunoglobulin and mucin domain-containing protein 2Add BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 109PROSITE-ProRule annotation1 Publication
Disulfide bondi50 ↔ 61PROSITE-ProRule annotation1 Publication
Disulfide bondi56 ↔ 108PROSITE-ProRule annotation1 Publication
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R183.
PRIDEiQ8R183.

PTM databases

iPTMnetiQ8R183.
PhosphoSitePlusiQ8R183.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060891.

Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 28Combined sources4
Beta strandi33 – 35Combined sources3
Helixi41 – 44Combined sources4
Beta strandi49 – 54Combined sources6
Helixi56 – 59Combined sources4
Turni60 – 63Combined sources4
Beta strandi64 – 68Combined sources5
Beta strandi70 – 78Combined sources9
Helixi87 – 89Combined sources3
Beta strandi94 – 98Combined sources5
Helixi101 – 103Combined sources3
Beta strandi105 – 111Combined sources7
Beta strandi118 – 128Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OR7X-ray1.50A/B20-129[»]
ProteinModelPortaliQ8R183.
SMRiQ8R183.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R183.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 125Ig-like V-typeAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 206Thr-richAdd BLAST75

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000010109.
HOVERGENiHBG073424.
InParanoidiQ8R183.
KOiK20413.
PhylomeDBiQ8R183.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQIQVFISG LILLLPGAVE SHTAVQGLAG HPVTLPCIYS THLGGIVPMC
60 70 80 90 100
WGLGECRHSY CIRSLIWTNG YTVTHQRNSL YQLKGNISEG NVSLTIENTV
110 120 130 140 150
VGDGGPYCCV VEIPGAFHFV DYMLEVKPEI STSPPTRPTA TGRPTTISTR
160 170 180 190 200
STHVPTSTRV STSTSPTPAH TETYKPEATT FYPDQTTAEV TETLPDTPAD
210 220 230 240 250
WHNTVTSSDD PWDDNTEVIP PQKPQKNLNK GFYVGISIAA LLILMLLSTM
260 270 280 290 300
VITRYVVMKR KSESLSFVAF PISKIGASPK KVVERTRCED QVYIIEDTPY

PEEES
Length:305
Mass (Da):33,504
Last modified:June 1, 2002 - v1
Checksum:i4105D75D99F541AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80L → R in AAL35772 (PubMed:11725301).Curated1
Sequence conflicti80L → R in AAL35773 (PubMed:11725301).Curated1
Sequence conflicti196D → S in AAL35772 (PubMed:11725301).Curated1
Sequence conflicti196D → S in AAL35773 (PubMed:11725301).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399827 mRNA. Translation: AAL35772.1.
AF399828 mRNA. Translation: AAL35773.1.
BC025096 mRNA. Translation: AAH25096.1.
CCDSiCCDS24582.1.
RefSeqiNP_001154827.1. NM_001161355.1.
NP_001154828.1. NM_001161356.1.
NP_599010.4. NM_134249.5.
UniGeneiMm.234654.

Genome annotation databases

GeneIDi171284.
KEGGimmu:171284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399827 mRNA. Translation: AAL35772.1.
AF399828 mRNA. Translation: AAL35773.1.
BC025096 mRNA. Translation: AAH25096.1.
CCDSiCCDS24582.1.
RefSeqiNP_001154827.1. NM_001161355.1.
NP_001154828.1. NM_001161356.1.
NP_599010.4. NM_134249.5.
UniGeneiMm.234654.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OR7X-ray1.50A/B20-129[»]
ProteinModelPortaliQ8R183.
SMRiQ8R183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060891.

PTM databases

iPTMnetiQ8R183.
PhosphoSitePlusiQ8R183.

Proteomic databases

PaxDbiQ8R183.
PRIDEiQ8R183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171284.
KEGGimmu:171284.

Organism-specific databases

CTDi171284.
MGIiMGI:2159681. Timd2.

Phylogenomic databases

HOGENOMiHOG000010109.
HOVERGENiHBG073424.
InParanoidiQ8R183.
KOiK20413.
PhylomeDBiQ8R183.

Miscellaneous databases

EvolutionaryTraceiQ8R183.
PROiQ8R183.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIMD2_MOUSE
AccessioniPrimary (citable) accession number: Q8R183
Secondary accession number(s): Q8VBW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma. The human genomic locus appears to lack the Timd2 gene.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.