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Protein

Palmitoyltransferase ZDHHC3

Gene

Zdhhc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (PubMed:15229235). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (PubMed:16129400). May also palmitoylate DLG4, DNAJC5 and SNAP25 (PubMed:15603741, PubMed:25253725).4 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei157S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: UniProtKB
  • protein targeting Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.225 3474

Protein family/group databases

TCDBi9.B.37.2.1 the huntington-interacting protein 14 (hip14) family

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC3Curated (EC:2.3.1.2254 Publications)
Alternative name(s):
GABA-A receptor-associated membrane protein 1Imported
Golgi-specific DHHC zinc finger protein1 Publication
Zinc finger DHHC domain-containing protein 3Imported
Short name:
DHHC-31 Publication
Gene namesi
Name:Zdhhc3Imported
Synonyms:Godz1 Publication, Gramp1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926134 Zdhhc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 72LumenalSequence analysis4
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 171CytoplasmicSequence analysisAdd BLAST78
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 214LumenalSequence analysisAdd BLAST22
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 299CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi157C → S: Abolishes activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128631 – 299Palmitoyltransferase ZDHHC3Add BLAST299

Post-translational modificationi

Autopalmitoylated.3 Publications

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ8R173
PaxDbiQ8R173
PeptideAtlasiQ8R173
PRIDEiQ8R173

PTM databases

iPTMnetiQ8R173
PhosphoSitePlusiQ8R173
SwissPalmiQ8R173

Expressioni

Tissue specificityi

Widely expressed, with highest levels in brain. In the brain, expressed only in neurons (at protein level).3 Publications

Gene expression databases

BgeeiENSMUSG00000025786
CleanExiMM_ZDHHC3
ExpressionAtlasiQ8R173 baseline and differential
GenevisibleiQ8R173 MM

Interactioni

Protein-protein interaction databases

IntActiQ8R173, 1 interactor
MINTiQ8R173
STRINGi10090.ENSMUSP00000117392

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 177DHHCPROSITE-ProRule annotationAdd BLAST52

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000118083
HOVERGENiHBG056583
InParanoidiQ8R173
KOiK20029
OMAiRAWCVKD
OrthoDBiEOG091G0CME
PhylomeDBiQ8R173
TreeFamiTF319798

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLIPTHHFR DIERKPEYLQ PEKCAPPPFP GPAGAMWFIR DGCGIACAIV
60 70 80 90 100
TWFLVLYAEF VVLFVMLVPS RDYAYSIING IVFNLLAFLA LASHCRAMLT
110 120 130 140 150
DPGAVPKGNA TKEFIESLQL KPGQVVYKCP KCCSIKPDRA HHCSVCKRCI
160 170 180 190 200
RKMDHHCPWV NNCVGENNQK YFVLFTMYIA LISLHALIMV GFHFLHCFEE
210 220 230 240 250
DWTKCSSFSP PTTVILLILL CFEALLFLIF TSVMFGTQVH SICTDETGIE
260 270 280 290
QLKKEERRWA KKTKWMNMKA VFGHPFSLGW ASPFATPDQG KADPYQYVV
Length:299
Mass (Da):34,041
Last modified:June 1, 2002 - v1
Checksum:iBA93F65828A3B36C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246E → G in BAC37939 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088044 mRNA Translation: BAC02941.1
AY166672 mRNA Translation: AAO27359.1
AK080541 mRNA Translation: BAC37939.1
BC025126 mRNA Translation: AAH25126.1
BC052464 mRNA Translation: AAH52464.1
CCDSiCCDS23654.1
RefSeqiNP_081193.2, NM_026917.5
UniGeneiMm.28300

Genome annotation databases

EnsembliENSMUST00000147563; ENSMUSP00000117392; ENSMUSG00000025786
GeneIDi69035
KEGGimmu:69035
UCSCiuc009sfq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZDHC3_MOUSE
AccessioniPrimary (citable) accession number: Q8R173
Secondary accession number(s): Q6EMK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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