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Q8R154

- Q8R154_MOUSE

UniProt

Q8R154 - Q8R154_MOUSE

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Protein
Submitted name:

Trim24 protein

Gene

Trim24

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. ligand-dependent nuclear receptor binding Source: MGI
  3. protein kinase activity Source: MGI
  4. sequence-specific DNA binding Source: MGI
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. calcium ion homeostasis Source: MGI
  2. negative regulation of cell proliferation Source: MGI
  3. negative regulation of transcription, DNA-templated Source: MGI
  4. positive regulation of gene expression Source: MGI
  5. positive regulation of transcription, DNA-templated Source: MGI
  6. protein autophosphorylation Source: MGI
  7. protein phosphorylation Source: MGI
  8. regulation of signal transduction by p53 class mediator Source: MGI
  9. regulation of vitamin D receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Trim24 proteinImported
Gene namesi
Name:Trim24Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109275. Trim24.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear euchromatin Source: MGI
  3. nucleus Source: MGI
  4. perichromatin fibrils Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8R154.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031859.

Structurei

3D structure databases

ProteinModelPortaliQ8R154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

HOGENOMiHOG000252971.
HOVERGENiHBG054599.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8R154-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PRVRGRVGQN VPRQTTIKPN PLQMAFLAQQ AIKQWQISSV QAPPTTASSS
60 70 80 90 100
SSTPSSPTIT SAAGYDGKAF SSPMIDLSAP VGGSYNLPSL PDIDCSSTIM
110 120 130 140 150
LDNIARKDTG VDHAQPRPPS NRTVQSPNSS VPSPGLAGPV TMTSVHPPIR
160 170 180 190 200
SPSASSVGSR GSSGSSSKPA GADSTHKVPV VMLEPIRIKQ ENSGPPENYD
210 220 230 240 250
FPVVIVKQES DEESRPQNTN YPRSILTSLL LNSSQSSASE ETVLRSDAPD
260 270 280 290 300
STGDQPGLHQ ENSSNGKSEW SDASQKSPVH VGETRKEDDP NEDWCAVCQN
310 320 330 340 350
GGELLCCEKC PKVFHLTCHV PTLTNFPSGE WICTFCRDLS KPEVDYDCDV
360 370 380 390 400
PSHHSEKRKS EGLTKLTPID KRKCERLLLF LYCHEMSLAF QDPVPLTVPD
410 420 430 440 450
YYKIIKNPMD LSTIKKRLQE DYCMYTKPED FVADFRLIFQ NCAEFNEPDS
460 470 480 490 500
EVANAGIKLE SYFEELLKNL YPEKRFPKVE FRHEAEDCKF SDDSDDDFVQ
510
PRKKRLKSTE DRQLLK
Length:516
Mass (Da):57,114
Last modified:June 1, 2002 - v1
Checksum:i3B20FB95ED64F299
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025482 mRNA. Translation: AAH25482.1.
UniGeneiMm.41063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025482 mRNA. Translation: AAH25482.1 .
UniGenei Mm.41063.

3D structure databases

ProteinModelPortali Q8R154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000031859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:109275. Trim24.

Phylogenomic databases

HOGENOMi HOG000252971.
HOVERGENi HBG054599.

Miscellaneous databases

ChiTaRSi Trim24. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8R154.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Mix FVB/NImported.
    Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.

Entry informationi

Entry nameiQ8R154_MOUSE
AccessioniPrimary (citable) accession number: Q8R154
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)