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Q8R154 (Q8R154_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Trim24 EMBL AAH25482.1 MGI 109275
OrganismMus musculus (Mouse) EMBL AAH25482.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length516 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   DomainZinc-finger SAAS SAAS019786
   LigandMetal-binding
Zinc
Gene Ontology (GO)
   Biological_processcalcium ion homeostasis

Inferred from mutant phenotype PubMed 18287084. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 18026104. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 10562550PubMed 18026104. Source: MGI

positive regulation of gene expression

Inferred from mutant phenotype PubMed 18026104. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from genetic interaction PubMed 7744009. Source: MGI

protein autophosphorylation

Inferred from direct assay PubMed 10562550. Source: MGI

protein phosphorylation

Inferred from direct assay PubMed 10562550. Source: MGI

regulation of signal transduction by p53 class mediator

Inferred from genetic interaction PubMed 19556538. Source: MGI

regulation of vitamin D receptor signaling pathway

Inferred from mutant phenotype PubMed 18287084. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 11331580. Source: MGI

nuclear euchromatin

Inferred from direct assay PubMed 10318760PubMed 10525195. Source: MGI

nucleus

Inferred from direct assay PubMed 10318760PubMed 10525195. Source: MGI

perichromatin fibrils

Inferred from direct assay PubMed 10318760. Source: MGI

   Molecular_functionchromatin binding

Inferred from direct assay PubMed 10318760. Source: MGI

ligand-dependent nuclear receptor binding

Inferred from direct assay PubMed 15322135. Source: MGI

protein binding

Inferred from physical interaction PubMed 11331592PubMed 8978696. Source: MGI

protein kinase activity

Inferred from direct assay PubMed 10562550. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 18026104. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAH25482.1

Sequences

Sequence LengthMass (Da)Tools
Q8R154 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 3B20FB95ED64F299

FASTA51657,114
        10         20         30         40         50         60 
PRVRGRVGQN VPRQTTIKPN PLQMAFLAQQ AIKQWQISSV QAPPTTASSS SSTPSSPTIT 

        70         80         90        100        110        120 
SAAGYDGKAF SSPMIDLSAP VGGSYNLPSL PDIDCSSTIM LDNIARKDTG VDHAQPRPPS 

       130        140        150        160        170        180 
NRTVQSPNSS VPSPGLAGPV TMTSVHPPIR SPSASSVGSR GSSGSSSKPA GADSTHKVPV 

       190        200        210        220        230        240 
VMLEPIRIKQ ENSGPPENYD FPVVIVKQES DEESRPQNTN YPRSILTSLL LNSSQSSASE 

       250        260        270        280        290        300 
ETVLRSDAPD STGDQPGLHQ ENSSNGKSEW SDASQKSPVH VGETRKEDDP NEDWCAVCQN 

       310        320        330        340        350        360 
GGELLCCEKC PKVFHLTCHV PTLTNFPSGE WICTFCRDLS KPEVDYDCDV PSHHSEKRKS 

       370        380        390        400        410        420 
EGLTKLTPID KRKCERLLLF LYCHEMSLAF QDPVPLTVPD YYKIIKNPMD LSTIKKRLQE 

       430        440        450        460        470        480 
DYCMYTKPED FVADFRLIFQ NCAEFNEPDS EVANAGIKLE SYFEELLKNL YPEKRFPKVE 

       490        500        510 
FRHEAEDCKF SDDSDDDFVQ PRKKRLKSTE DRQLLK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Mix FVB/N EMBL AAH25482.1.
Tissue: Mammary tumor. WAP-TGF alpha model. 7 months old EMBL AAH25482.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC025482 mRNA. Translation: AAH25482.1.
UniGeneMm.41063.

3D structure databases

ProteinModelPortalQ8R154.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000031859.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:109275. Trim24.

Phylogenomic databases

HOGENOMHOG000252971.
HOVERGENHBG054599.
InParanoidQ8R154.

Gene expression databases

GenevestigatorQ8R154.

Family and domain databases

Gene3D1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRIM24. mouse.
SOURCESearch...

Entry information

Entry nameQ8R154_MOUSE
AccessionPrimary (citable) accession number: Q8R154
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)