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Protein

NFX1-type zinc finger-containing protein 1

Gene

Znfx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1291 – 1313NF-X1-type 1Add BLAST23
Zinc fingeri1375 – 1393NF-X1-type 2Add BLAST19
Zinc fingeri1433 – 1455NF-X1-type 3Add BLAST23
Zinc fingeri1463 – 1480NF-X1-type 4Add BLAST18

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
NFX1-type zinc finger-containing protein 1
Gene namesi
Name:Znfx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2138982. Znfx1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507961 – 1909NFX1-type zinc finger-containing protein 1Add BLAST1909

Proteomic databases

EPDiQ8R151.
MaxQBiQ8R151.
PaxDbiQ8R151.
PeptideAtlasiQ8R151.
PRIDEiQ8R151.

PTM databases

iPTMnetiQ8R151.
PhosphoSitePlusiQ8R151.
SwissPalmiQ8R151.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039501.
CleanExiMM_ZNFX1.
ExpressionAtlasiQ8R151. baseline and differential.
GenevisibleiQ8R151. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8R151. 2 interactors.
MINTiMINT-4099298.
STRINGi10090.ENSMUSP00000049404.

Structurei

3D structure databases

ProteinModelPortaliQ8R151.
SMRiQ8R151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili939 – 964Sequence analysisAdd BLAST26
Coiled coili1733 – 1764Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi802 – 812Poly-GluAdd BLAST11
Compositional biasi832 – 835Poly-Glu4
Compositional biasi1281 – 1557Cys-richAdd BLAST277

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1291 – 1313NF-X1-type 1Add BLAST23
Zinc fingeri1375 – 1393NF-X1-type 2Add BLAST19
Zinc fingeri1433 – 1455NF-X1-type 3Add BLAST23
Zinc fingeri1463 – 1480NF-X1-type 4Add BLAST18

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1807. Eukaryota.
COG1112. LUCA.
GeneTreeiENSGT00810000125415.
HOGENOMiHOG000231023.
HOVERGENiHBG052201.
InParanoidiQ8R151.
OMAiKGMYCIG.
OrthoDBiEOG091G04KI.
TreeFamiTF323611.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR000967. Znf_NFX1.
SMARTiView protein in SMART
SM00438. ZnF_NFX. 5 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8R151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDRRPHLEA RPRNPPANHR GPMDGELPPR ARNQTNNPAA TNHAGRHLRA
60 70 80 90 100
SNHPAPFRQR EERFRAMGRN PHQGRRNQEG HTSDEARDQR QSQNDTRRRN
110 120 130 140 150
DDQEGRSHRP PWSSDTFQQW HTPPQKPGEQ PQQTKRLGYK FLESLLQKEP
160 170 180 190 200
SEVAITLATS LGLKELLSHS SMKPSFLQLI CQVLRKACSS RIDRQSILHV
210 220 230 240 250
LGILNNSKFL RVCLPAYVVG MITEPSPDIR NQYPEHISNI ISLLQDLVSV
260 270 280 290 300
FPASSMQETS MLISLLPTSL NALRASGVDI EEETEKNLEK VQAIIKYLQE
310 320 330 340 350
KRRQGSLRVD TYTLVQAEAE GEVESYRAMP IYPTYNEVHL DEKPFLRPNI
360 370 380 390 400
ISGKYESTAV YLDTHFRLLR EDFVRPLREG ILKLLQSFED QCLRKRKFDD
410 420 430 440 450
IRIYFDARII TPMCSASGIV YKVQFDTKPL KLVRWQNSKR LLYGSLVCMS
460 470 480 490 500
KDNFETFLFA TVSNREHEDL CQGIVQLCFN EQSQQLLADV QPSDSFLMVE
510 520 530 540 550
TTAYFEAYRH VLEGLQEVQE EDVPFQRNIV QCDSYVRNPR YLLMGGRYDF
560 570 580 590 600
TPLMENPSAM RKSLRGAEAL RHPRINVFDF GQWPSKEALK LDDSQMEALQ
610 620 630 640 650
FALTKELAII QGPPGTGKTY VGLKIVQALL TNKSVWQINT QTFPILVVCY
660 670 680 690 700
TNHALDQFLE GIYGCQKTSI VRVGGRSNSE ILKQFTLREL RNKREFRRTL
710 720 730 740 750
PMHLRRAYMS IVTEMKESEQ KLQEGAQTLE CTMHGVLREQ HLEKYISAQH
760 770 780 790 800
WESLMSGPVQ DADWVCVQPS KHSMILEWLG LGVGSFTQSA SPAGPENTAQ
810 820 830 840 850
AEGEEEEEGE EEGSLIEIAE EADLIQADRV IEEEEVVRPR RRKKEENGTD
860 870 880 890 900
QELAKMLLAM RLDQEVPGTT AGPEQATEEW ETQRGQKKKM KRRVKVELRK
910 920 930 940 950
LNTMTKAEAN GIQDVWQLDL SSRWQLYRLW LQMYQADTRR RILSYERQYR
960 970 980 990 1000
TWAERMAELR LQEDLHILKD AEVVGMTTTG AAKYRQILQQ VEPRIVIVEE
1010 1020 1030 1040 1050
AAEVLEAHTI ATLSKACQHL ILIGDHQQLR PSANVYDLAK NFNLEVSLFE
1060 1070 1080 1090 1100
RLVKVNIPFV RLNYQHRMRP EIARLLTPHI YQDLENHPSV LKYEQIKGVS
1110 1120 1130 1140 1150
SNLFFVEHNF PEQEIQEGKS HQNQHEAHFV VELCQYLLCQ EYLPSQITIL
1160 1170 1180 1190 1200
TTYTGQLFCL RKLMPVKTFA GIKVHVVDKY QGEENDIILL SLVRSNQEGK
1210 1220 1230 1240 1250
VGFLQIPNRI CVALSRAKKG MYCIGNMQML AKVPLWSRII HTLRENNQIG
1260 1270 1280 1290 1300
PSLRLCCQNH PETHTLVSKA SDFQKVPEGG CSRPCEFRLA CGHVCTRACH
1310 1320 1330 1340 1350
PYDSSHKEFQ CMKPCQKVLC QDGHRCPNVC FQECQPCQVK VPKIILKCGH
1360 1370 1380 1390 1400
KQMVPCSMSE SEFCCQEPCS KILRCGHRCS HLCGEDCVRL CSERVTVELK
1410 1420 1430 1440 1450
CGHSQLVKCG NVEDIKYGLP VKCTTKCDTT LDCGHPCPGS CHSCFEGRFH
1460 1470 1480 1490 1500
ERCQQPCKRL LICSHKCQEP CTGECPPCQR TCQNRCVHSQ CKKKCGELCS
1510 1520 1530 1540 1550
PCVEPCVWRC QHYQCTKLCS EPCNRPPCYV PCTKLLACGH PCIGLCGEPC
1560 1570 1580 1590 1600
PKKCRVCQPD EVTQIFFGFE DEPDARFVQL EDCSHIFEVQ ALDRFMNEQK
1610 1620 1630 1640 1650
DDEVAIKLKV CPICQVPIRK NLRYGTSIKQ RLEEIEIVKE KIQGSAGEIS
1660 1670 1680 1690 1700
TSQEQLKALL KSKTLFHQLR PEEFLILQEK LAQKNLSVKD LGLVENSIRF
1710 1720 1730 1740 1750
YDHLANLEGS LEKVHCGEQQ SVRTRLEQVH EWLAKKRLSF SSQELSDLQS
1760 1770 1780 1790 1800
EIQRLTYLVN LLMRCKMAEK VKGSIAEEVS SIRNILEKTS KFTQEDEQLV
1810 1820 1830 1840 1850
QKKMDALKTT LPCSGLGISD EERVQIVTAM GVPRGHWFKC PNGHIYVITE
1860 1870 1880 1890 1900
CGGAMQRSTC PECQEVIGGE NHTLERSNHL ASEMDGAQHP AWSNTANNFM

NFEEIHRMM
Length:1,909
Mass (Da):218,828
Last modified:July 27, 2011 - v3
Checksum:i0F566F1DE54F5140
GO

Sequence cautioni

The sequence AAH25488 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE34040 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212V → I in BAE29390 (PubMed:16141072).Curated1
Sequence conflicti394R → G in BAE29390 (PubMed:16141072).Curated1
Sequence conflicti1130V → L in BAE34040 (PubMed:16141072).Curated1
Sequence conflicti1793T → N in BAE34040 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591711 Genomic DNA. Translation: CAM17309.1.
CH466551 Genomic DNA. Translation: EDL06496.1.
AK149249 mRNA. Translation: BAE28771.1.
AK150223 mRNA. Translation: BAE29390.1.
AK157301 mRNA. Translation: BAE34040.1. Different initiation.
BC025488 mRNA. Translation: AAH25488.1. Different initiation.
CCDSiCCDS38337.1.
RefSeqiNP_001028368.2. NM_001033196.2.
XP_006500519.1. XM_006500456.3.
UniGeneiMm.297074.

Genome annotation databases

EnsembliENSMUST00000048988; ENSMUSP00000049404; ENSMUSG00000039501.
GeneIDi98999.
KEGGimmu:98999.
UCSCiuc008nzc.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiZNFX1_MOUSE
AccessioniPrimary (citable) accession number: Q8R151
Secondary accession number(s): A2A5R3
, Q3U016, Q3UD71, Q3UEZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot