Reviewed, UniProtKB/Swiss-Prot Q8R127 (SCPDH_MOUSE)

Names and origin

Protein names

Recommended name:
    Probable saccharopine dehydrogenase
    EC=1.5.1.9

Gene names

Name:

Sccpdh

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH.
Pathway	Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.
Sequence similarities	Belongs to the saccharopine dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Probable saccharopine dehydrogenase		PRO_0000212841

Sequences

	Sequence		Length	Mass (Da)
	Q8R127-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: FCC63118BFCEE7E4	FASTA	429	47,129
	10 20 30 40 50 60 MATEQRPFHL VVFGASGFTG QFVTEEVARE QIASEQSSRL PWAVAGRSKE KLQQVLEKAA 70 80 90 100 110 120 QKLGRPSLSS EVGVIICDIS NPASLDEMAK QAKLVLNCVG PYRFYGEPVV KACIENGTSC 130 140 150 160 170 180 IDICGEPQFL ELMHAKYHEK AAEKGVYIIG SSGFDSIPAD LGVLYTRNQM NGTLTAVESF 190 200 210 220 230 240 LTINTGPEGL CIHDGTWKSA IYGFGDKGSL RKLRSVSCLK PVPIVGTKLK RRWPVSYCRE 250 260 270 280 290 300 LNSYSIPFLG SDISVVKRTQ RYLHENLEDS PVQYAAYVTV GGITSVIKLM FAGLFFLFFV 310 320 330 340 350 360 KFSIGRQLLI KFPWLFSFGY FSKQGPTQKQ MDETSFTMTF FGQGYSHGTC VEKNKPNIRI 370 380 390 400 410 420 CTQVKGPEAG YVATPIAMVQ AAMTFLSDAS DLPKGGGVFT PGAAFSRTKL IDRLNKHGIE FSVISSSEV

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum, Corpora quadrigemina and Lung.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK042919 mRNA. Translation: BAC31405.1. AK046033 mRNA. Translation: BAC32578.1. AK077695 mRNA. Translation: BAC36962.1. AK082803 mRNA. Translation: BAC38628.1. AK166018 mRNA. Translation: BAE38523.1. BC025803 mRNA. Translation: AAH25803.1.
IPI	IPI00153266.
RefSeq	NP_848768.1.
UniGene	Mm.136458
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8R127.
Proteomic databases
PRIDE	Q8R127.
Genome annotation databases
Ensembl	ENSMUSG00000038936. Mus musculus. [Contig view]
GeneID	109232.
KEGG	mmu:109232.
Organism-specific databases
MGI	MGI:1924486. Sccpdh.
Phylogenomic databases
HOGENOM	Q8R127.
HOVERGEN	Q8R127.
OMA	Q8R127. GTSCIDI.
Enzyme and pathway databases
BRENDA	1.5.1.9. 244.
Gene expression databases
ArrayExpress	Q8R127.
Bgee	Q8R127.
CleanEx	MM_SCCPDH.
GermOnline	ENSMUSG00000038936. Mus musculus.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR005097. Saccharopine_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF03435. Saccharop_dh. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	361807.
SOURCE	Search...

Entry information

Entry name

SCPDH_MOUSE

Accession

Primary (citable) accession number: Q8R127
Secondary accession number(s): Q3TMB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)