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Protein

Kelch-like protein 36

Gene

Klhl36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 36
Gene namesi
Name:Klhl36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2385305. Klhl36.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Kelch-like protein 36PRO_0000274692Add
BLAST

Proteomic databases

EPDiQ8R124.
MaxQBiQ8R124.
PaxDbiQ8R124.
PRIDEiQ8R124.

PTM databases

PhosphoSiteiQ8R124.

Expressioni

Gene expression databases

BgeeiQ8R124.
GenevisibleiQ8R124. MM.

Interactioni

Subunit structurei

Interacts with CUL3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034287.

Structurei

3D structure databases

ProteinModelPortaliQ8R124.
SMRiQ8R124. Positions 13-249, 271-590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 11268BTBPROSITE-ProRule annotationAdd
BLAST
Domaini147 – 249103BACKAdd
BLAST
Repeati294 – 34350Kelch 1Add
BLAST
Repeati344 – 39552Kelch 2Add
BLAST
Repeati396 – 44247Kelch 3Add
BLAST
Repeati444 – 49148Kelch 4Add
BLAST
Repeati492 – 54453Kelch 5Add
BLAST
Repeati545 – 59349Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ8R124.
KOiK13958.
OMAiAVDFCCE.
OrthoDBiEOG73V6JX.
PhylomeDBiQ8R124.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030585. KLHL36.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF246. PTHR24412:SF246. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASKQMRVS RPYKISESSK VYHWPDHSTA VLQRLNEQRL HGLFCDVVLV
60 70 80 90 100
VEEQQVPAHR NLLAVCSDYF NSMFTLGMRE AFQKEVELVG TSYVGLKAVV
110 120 130 140 150
DFLYSSELEL DGSNIDYILE TAHLLQIWTV VDFCCEYLEQ EVSEDNYLYL
160 170 180 190 200
QELASIYSLK RLDAFIDSFV LSHFSTLSFT PDFLQSISVQ KLCVYLSSGQ
210 220 230 240 250
VQHKWEYDLL QVALQWLTQQ PEREVHTRRV LENIRFPLFP EDILLQRVKL
260 270 280 290 300
AMCSLLPSEA NGEGFVEEAM HYHNSLVAQP VLQTKRTLLR SEECLLFVGG
310 320 330 340 350
EVSERCLELS DDTCYLDTKN EQWVKETSLP ARRSHHCVAV LGGFIFIAGG
360 370 380 390 400
SFSRDNGGNA ASNLLYRYDP RRKQWIKVAS MNQRRVDFYL ASIEDMLVAV
410 420 430 440 450
GGRNENGALS SVETYSPKTN SWTYVAGLPR FTYGHAGTIY KDFVYISGGH
460 470 480 490 500
DYQIGPYRKN LLCYDHRTDV WEERRPMTTA RGWHSMCSLG DSIYSIGGSD
510 520 530 540 550
DHMESMERFD VLGVEAYSPQ CNQWTRVAPL LQANSESGVA VWQGRIYILG
560 570 580 590 600
GYSWESTAFS RAVQVYDSEA NRWSRGPDLP NAIAGVSACV CALNPRLEEK
610
KKRNKDKCQD RGQ
Length:613
Mass (Da):69,950
Last modified:June 1, 2002 - v1
Checksum:i4A87476330E5B3DC
GO

Sequence cautioni

The sequence BAD21385.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti372 – 3721R → C in BAE33936 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131135 mRNA. Translation: BAD21385.1. Different initiation.
AK157027 mRNA. Translation: BAE33936.1.
BC025816 mRNA. Translation: AAH25816.1.
CCDSiCCDS22713.1.
RefSeqiNP_666331.1. NM_146219.1.
UniGeneiMm.86446.

Genome annotation databases

EnsembliENSMUST00000034287; ENSMUSP00000034287; ENSMUSG00000031828.
GeneIDi234796.
KEGGimmu:234796.
UCSCiuc009nql.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131135 mRNA. Translation: BAD21385.1. Different initiation.
AK157027 mRNA. Translation: BAE33936.1.
BC025816 mRNA. Translation: AAH25816.1.
CCDSiCCDS22713.1.
RefSeqiNP_666331.1. NM_146219.1.
UniGeneiMm.86446.

3D structure databases

ProteinModelPortaliQ8R124.
SMRiQ8R124. Positions 13-249, 271-590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034287.

PTM databases

PhosphoSiteiQ8R124.

Proteomic databases

EPDiQ8R124.
MaxQBiQ8R124.
PaxDbiQ8R124.
PRIDEiQ8R124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034287; ENSMUSP00000034287; ENSMUSG00000031828.
GeneIDi234796.
KEGGimmu:234796.
UCSCiuc009nql.1. mouse.

Organism-specific databases

CTDi79786.
MGIiMGI:2385305. Klhl36.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ8R124.
KOiK13958.
OMAiAVDFCCE.
OrthoDBiEOG73V6JX.
PhylomeDBiQ8R124.
TreeFamiTF328485.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8R124.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R124.
GenevisibleiQ8R124. MM.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030585. KLHL36.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF246. PTHR24412:SF246. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
    DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiKLH36_MOUSE
AccessioniPrimary (citable) accession number: Q8R124
Secondary accession number(s): Q3U0B9, Q6KAS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.