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Protein

Protein Z-dependent protease inhibitor

Gene

Serpina10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei265Essential for interaction with PROZ1
Sitei318Essential for interaction with PROZ1
Sitei412 – 413Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Z-dependent protease inhibitor
Short name:
PZ-dependent protease inhibitor
Short name:
PZI
Alternative name(s):
Serpin A10
Gene namesi
Name:Serpina10
Synonyms:Zpi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2667725. Serpina10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi96M → A: 2-fold decrease in rates of factor Xa inhibition. 1 Publication1
Mutagenesisi99D → A: 5-fold decrease in rates of factor Xa inhibition. 1 Publication1
Mutagenesisi263D → A: No change in rates of factor Xa inhibition. 1 Publication1
Mutagenesisi264K → A: No change in rates of factor Xa inhibition. 1 Publication1
Mutagenesisi265Y → A: 50-fold decrease in rates of factor Xa inhibition. 1 Publication1
Mutagenesisi318D → A: 400-fold decrease in rates of factor Xa inhibition. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003248322 – 448Protein Z-dependent protease inhibitorAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)2 Publications1
Glycosylationi184N-linked (GlcNAc...)1 Publication1
Glycosylationi278N-linked (GlcNAc...)1 Publication1
Glycosylationi299N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R121.
PeptideAtlasiQ8R121.
PRIDEiQ8R121.

PTM databases

iPTMnetiQ8R121.
PhosphoSitePlusiQ8R121.

Expressioni

Tissue specificityi

Detectable in liver, but not in heart, brain, spleen, lung, kidney, skeletal muscle or testes.1 Publication

Gene expression databases

BgeeiENSMUSG00000061947.
GenevisibleiQ8R121. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048357.

Structurei

Secondary structure

1448
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi71 – 75Combined sources5
Helixi77 – 97Combined sources21
Beta strandi102 – 104Combined sources3
Helixi106 – 119Combined sources14
Helixi123 – 132Combined sources10
Helixi135 – 138Combined sources4
Helixi144 – 157Combined sources14
Beta strandi164 – 173Combined sources10
Helixi180 – 189Combined sources10
Beta strandi194 – 197Combined sources4
Helixi202 – 216Combined sources15
Turni217 – 219Combined sources3
Beta strandi234 – 242Combined sources9
Beta strandi246 – 248Combined sources3
Helixi252 – 254Combined sources3
Beta strandi256 – 265Combined sources10
Beta strandi267 – 284Combined sources18
Turni285 – 288Combined sources4
Beta strandi289 – 296Combined sources8
Helixi297 – 299Combined sources3
Beta strandi300 – 307Combined sources8
Helixi313 – 316Combined sources4
Turni317 – 319Combined sources3
Helixi322 – 330Combined sources9
Beta strandi333 – 342Combined sources10
Beta strandi344 – 351Combined sources8
Helixi353 – 358Combined sources6
Helixi363 – 365Combined sources3
Turni372 – 374Combined sources3
Beta strandi385 – 394Combined sources10
Beta strandi417 – 419Combined sources3
Beta strandi424 – 430Combined sources7
Turni431 – 434Combined sources4
Beta strandi435 – 444Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AJTX-ray2.50A22-448[»]
ProteinModelPortaliQ8R121.
SMRiQ8R121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 157Heparin-bindingBy similarityAdd BLAST18

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG101138.
InParanoidiQ8R121.
KOiK04525.
OMAiKFRCHIL.
OrthoDBiEOG091G0ION.
PhylomeDBiQ8R121.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVASSLFLP VLLTEVWLVT SFNLSSHSPE ASVHLESQDY ENQTWEEYTR
60 70 80 90 100
TDPREEEEEE EEKEEGKDEE YWLRASQQLS NETSSFGFNL LRKISMRHDG
110 120 130 140 150
NVIFSPFGLS VAMVNLMLGT KGETKVQIEN GLNLQALSQA GPLILPALFK
160 170 180 190 200
KVKETFSSNR DLGLSQGSFA FIHKDFDIKE TYFNLSKKYF DIEYVSINFQ
210 220 230 240 250
NSSQARGLIN HCIVKETEGK IPKLFDEINP ETKLILVDYV LFKGKWLTPF
260 270 280 290 300
DPSFTEADTF HLDKYRAIKV PMMYREGNFT STFDKKFRCH ILKLPYQGNA
310 320 330 340 350
TMLVVLMEKT GDYLALEDYL TVDLVETWLQ NMKTRKMEVF FPKFKLNQRY
360 370 380 390 400
EMHELLKQMG IRRLFSTSAD LSELSAMARN LQVSRVLQQS VLEVDERGTE
410 420 430 440
AVSGTLSEII AYSMPPAIKV NRPFHFIIYE EMSRMLLFLG RVVNPTVL
Length:448
Mass (Da):51,797
Last modified:June 1, 2002 - v1
Checksum:iC7948A64BBA65B3F
GO
Isoform 2 (identifier: Q8R121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-298: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:394
Mass (Da):45,298
Checksum:i3E0F429D3552F30F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014439245 – 298Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324633 mRNA. Translation: AAP87100.1.
BC018416 mRNA. Translation: AAH18416.1.
BC025821 mRNA. Translation: AAH25821.1.
CCDSiCCDS26134.1. [Q8R121-1]
CCDS79150.1. [Q8R121-2]
RefSeqiNP_001288333.1. NM_001301404.1. [Q8R121-2]
NP_659083.2. NM_144834.4. [Q8R121-1]
UniGeneiMm.29094.

Genome annotation databases

EnsembliENSMUST00000044231; ENSMUSP00000048357; ENSMUSG00000061947. [Q8R121-1]
ENSMUST00000121625; ENSMUSP00000113644; ENSMUSG00000061947. [Q8R121-2]
GeneIDi217847.
KEGGimmu:217847.
UCSCiuc007ovz.2. mouse. [Q8R121-1]
uc011yra.2. mouse. [Q8R121-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324633 mRNA. Translation: AAP87100.1.
BC018416 mRNA. Translation: AAH18416.1.
BC025821 mRNA. Translation: AAH25821.1.
CCDSiCCDS26134.1. [Q8R121-1]
CCDS79150.1. [Q8R121-2]
RefSeqiNP_001288333.1. NM_001301404.1. [Q8R121-2]
NP_659083.2. NM_144834.4. [Q8R121-1]
UniGeneiMm.29094.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AJTX-ray2.50A22-448[»]
ProteinModelPortaliQ8R121.
SMRiQ8R121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048357.

Protein family/group databases

MEROPSiI04.005.

PTM databases

iPTMnetiQ8R121.
PhosphoSitePlusiQ8R121.

Proteomic databases

PaxDbiQ8R121.
PeptideAtlasiQ8R121.
PRIDEiQ8R121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044231; ENSMUSP00000048357; ENSMUSG00000061947. [Q8R121-1]
ENSMUST00000121625; ENSMUSP00000113644; ENSMUSG00000061947. [Q8R121-2]
GeneIDi217847.
KEGGimmu:217847.
UCSCiuc007ovz.2. mouse. [Q8R121-1]
uc011yra.2. mouse. [Q8R121-2]

Organism-specific databases

CTDi51156.
MGIiMGI:2667725. Serpina10.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG101138.
InParanoidiQ8R121.
KOiK04525.
OMAiKFRCHIL.
OrthoDBiEOG091G0ION.
PhylomeDBiQ8R121.
TreeFamiTF343094.

Miscellaneous databases

PROiQ8R121.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061947.
GenevisibleiQ8R121. MM.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZPI_MOUSE
AccessioniPrimary (citable) accession number: Q8R121
Secondary accession number(s): Q8VCV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.