Q8R116 (NOTUM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein notum homolog
EC=3.-.-.-

Gene names

Name:

Notum

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May deacetylate GlcNAc residues on cell surface glycans Potential.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the pectinacetylesterase family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8R116-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8R116-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
     176-185: NPHWWNANMV → MVGSPDPCYS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 503	484	Protein notum homolog		PRO_0000318756
Regions
	Compositional bias	33 – 60	28	Pro-rich
Sites
	Active site	239	1	Charge relay system By similarity
	Active site	347	1	Charge relay system By similarity
	Active site	396	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 175	175	Missing in isoform 2.		VSP_031295
	Alternative sequence	176 – 185	10	NPHWWNANMV → MVGSPDPCYS in isoform 2.		VSP_031296
Experimental info
	Sequence conflict	483	1	T → M in AAH25832. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 9C92182D2F9DEDAF	FASTA	503	56,584
	10 20 30 40 50 60 MGGEVRVLLL LGLLHWVGGS EGRKTWRRRG QQPPQPPPPP PLPQRAEVEP GAGQPVESFP 70 80 90 100 110 120 LDFTAVEGNM DSFMAQVKSL AQSLYPCSAQ QLNEDLRLHL LLNTSVTCND GSPAGYYLKE 130 140 150 160 170 180 SKGSRRWLLF LEGGWYCFNR ENCDSRYSTM RRLMSSKDWP HTRTGTGILS SQPEENPHWW 190 200 210 220 230 240 NANMVFIPYC SSDVWSGASP KSDKNEYAFM GSLIIQEVVR ELLGKGLSGA KVLLLAGSSA 250 260 270 280 290 300 GGTGVLLNVD RVAELLEELG YPSIQVRGLA DSGWFLDNKQ YRRSDCIDTI NCAPTDAIRR 310 320 330 340 350 360 GIRYWSGMVP ERCQRQFKEG EEWNCFFGYK VYPTLRCPVF VVQWLFDEAQ LTVDNVHLTG 370 380 390 400 410 420 QPVQEGQWLY IQNLGRELRG TLKDVQASFA PACLSHEIII RSYWTDVQVK GTSLPRALHC 430 440 450 460 470 480 WDRSFHDSHK ASKTPMKGCP FHLVDSCPWP HCNPSCPTIR DQFTGQEMNV AQFLMHMGFD 490 500 VQTVAQQQGM EPSKLLGMLS NGN
	Isoform 2 [UniParc]. Checksum: 9D57068FB45E5F83	FASTA	328	36,756
	10 20 30 40 50 60 MVGSPDPCYS FIPYCSSDVW SGASPKSDKN EYAFMGSLII QEVVRELLGK GLSGAKVLLL 70 80 90 100 110 120 AGSSAGGTGV LLNVDRVAEL LEELGYPSIQ VRGLADSGWF LDNKQYRRSD CIDTINCAPT 130 140 150 160 170 180 DAIRRGIRYW SGMVPERCQR QFKEGEEWNC FFGYKVYPTL RCPVFVVQWL FDEAQLTVDN 190 200 210 220 230 240 VHLTGQPVQE GQWLYIQNLG RELRGTLKDV QASFAPACLS HEIIIRSYWT DVQVKGTSLP 250 260 270 280 290 300 RALHCWDRSF HDSHKASKTP MKGCPFHLVD SCPWPHCNPS CPTIRDQFTG QEMNVAQFLM 310 320 HMGFDVQTVA QQQGMEPSKL LGMLSNGN

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: FVB/N. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL663030 Genomic DNA. Translation: CAM27104.1. BC025832 mRNA. Translation: AAH25832.1.
IPI	IPI00648961. IPI00652187.
RefSeq	NP_780472.3. NM_175263.4.
UniGene	Mm.32839.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8R116.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000106177; ENSMUSP00000101783; ENSMUSG00000042988. ENSMUST00000106178; ENSMUSP00000101784; ENSMUSG00000042988.
GeneID	77583.
KEGG	mmu:77583.
UCSC	uc007mty.2. mouse. uc007mtz.2. mouse.
Organism-specific databases
CTD	147111.
MGI	MGI:1924833. Notum.
Phylogenomic databases
eggNOG	roNOG04832.
GeneTree	ENSGT00390000015892.
HOGENOM	HBG446237.
HOVERGEN	HBG061551.
InParanoid	Q8R116.
OMA	KDVPASF.
Gene expression databases
ArrayExpress	Q8R116.
Bgee	Q8R116.
CleanEx	MM_NOTUM.
Genevestigator	Q8R116.
Family and domain databases
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

NOTUM_MOUSE

Accession

Primary (citable) accession number: Q8R116
Secondary accession number(s): A2ABZ5, A2ABZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	September 21, 2011
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program