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Protein

Vacuolar protein sorting-associated protein 37C

Gene

Vps37c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37C
Alternative name(s):
ESCRT-I complex subunit VPS37C
Gene namesi
Name:Vps37c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147661. Vps37c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121991 – 352Vacuolar protein sorting-associated protein 37CAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by TBK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R105.
PaxDbiQ8R105.
PeptideAtlasiQ8R105.
PRIDEiQ8R105.

PTM databases

iPTMnetiQ8R105.
PhosphoSitePlusiQ8R105.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048832.
CleanExiMM_VPS37C.
GenevisibleiQ8R105. MM.

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2. Interacts with CEP55 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223239. 1 interactor.
IntActiQ8R105. 1 interactor.
STRINGi10090.ENSMUSP00000085264.

Structurei

3D structure databases

ProteinModelPortaliQ8R105.
SMRiQ8R105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 167VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 350Pro-richAdd BLAST191

Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGiKOG3270. Eukaryota.
ENOG4111UJN. LUCA.
GeneTreeiENSGT00530000063123.
HOGENOMiHOG000234744.
HOVERGENiHBG073355.
InParanoidiQ8R105.
KOiK12185.
OMAiGYSWSPQ.
OrthoDBiEOG091G0GMF.
PhylomeDBiQ8R105.
TreeFamiTF321840.

Family and domain databases

InterProiView protein in InterPro
IPR037202. ESCRT_assembly_dom.
IPR009851. Mod_r.
PfamiView protein in Pfam
PF07200. Mod_r. 1 hit.
SUPFAMiSSF140111. SSF140111. 1 hit.
PROSITEiView protein in PROSITE
PS51314. VPS37_C. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R105-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGLKDKTLQ ELEEMQNDPE AIARLALESP EVQDLQLERE MALATNRSLA
60 70 80 90 100
EQNLEFQGPL EISRSNLSDK YQELRKLVER CQEQKAKLEK FSSALQPGTL
110 120 130 140 150
LDLLQIEGMK IEEESEAMAE KFLEGEVPLE TFLESFSSMR TLLHLRRVRV
160 170 180 190 200
EKLQDVVRRP RALPELAGDV PPKRPPPPRP VPQATPPETE EQPPQPSVVT
210 220 230 240 250
PYPLPYSPSP GLPVGPTAQG ALQPAPFPVV AQPSSYGGPL GPYPSPHPGP
260 270 280 290 300
RAMVGYSWSP QRSGPPQPGY PTAPTSTSGP GYPLVGGRTP GPGYPQQSPY
310 320 330 340 350
LPSGNKPPYP TQPQLPGFPG QPQPPVPPQP PYPPGTTPSY GFHPPGPAWP

RY
Length:352
Mass (Da):38,453
Last modified:June 1, 2002 - v1
Checksum:iCA3F793154A6BB95
GO
Isoform 2 (identifier: Q8R105-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Show »
Length:244
Mass (Da):26,129
Checksum:iE84D0A13F964ECDD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297301 – 108Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158833 mRNA. Translation: BAE34687.1.
AK159309 mRNA. Translation: BAE34977.1.
BC025865 mRNA. Translation: AAH25865.1.
CCDSiCCDS29585.1. [Q8R105-1]
RefSeqiNP_852068.1. NM_181403.2. [Q8R105-1]
XP_006526635.1. XM_006526572.3. [Q8R105-1]
XP_006526636.1. XM_006526573.3. [Q8R105-1]
XP_006526637.1. XM_006526574.3. [Q8R105-1]
XP_006526638.1. XM_006526575.1. [Q8R105-1]
XP_011245412.1. XM_011247110.2. [Q8R105-1]
UniGeneiMm.19091.

Genome annotation databases

EnsembliENSMUST00000087951; ENSMUSP00000085264; ENSMUSG00000048832. [Q8R105-1]
GeneIDi107305.
KEGGimmu:107305.
UCSCiuc008gqr.1. mouse. [Q8R105-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVP37C_MOUSE
AccessioniPrimary (citable) accession number: Q8R105
Secondary accession number(s): Q3TY76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2002
Last modified: December 20, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families