Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Angiopoietin-related protein 6

Gene

Angptl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 6
Alternative name(s):
Angiopoietin-like protein 6
Angiopoietin-related growth factor
Gene namesi
Name:Angptl6
Synonyms:Agf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1917976. Angptl6.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 457433Angiopoietin-related protein 6PRO_0000009129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi247 ↔ 274PROSITE-ProRule annotation
Disulfide bondi397 ↔ 410PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8R0Z6.
PaxDbiQ8R0Z6.
PRIDEiQ8R0Z6.

PTM databases

iPTMnetiQ8R0Z6.
PhosphoSiteiQ8R0Z6.

Expressioni

Tissue specificityi

Highly expressed in the liver, specifically in hepatocytes, and weakly in the heart. Expressed in hematopoietic cells, platelets and mast cells, and detected at wounded skin.1 Publication

Gene expression databases

BgeeiQ8R0Z6.
CleanExiMM_ANGPTL6.
GenevisibleiQ8R0Z6. MM.

Interactioni

Protein-protein interaction databases

BioGridi214222. 1 interaction.
STRINGi10090.ENSMUSP00000035784.

Structurei

3D structure databases

ProteinModelPortaliQ8R0Z6.
SMRiQ8R0Z6. Positions 242-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini238 – 456219Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili51 – 7727Sequence analysisAdd
BLAST
Coiled coili126 – 16439Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ8R0Z6.
OMAiAVCWSGP.
OrthoDBiEOG7X9G60.
PhylomeDBiQ8R0Z6.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R0Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTARLRKLQ LLLLLGAWRA LGGAARCRVT LVLSPQKATS AVCRSSEATQ
60 70 80 90 100
DSELATLRMR LGRHEELLRA LQRRAAEGGA LADEVRALRE HSLTLNTRLG
110 120 130 140 150
QLRAQLQQEA RAEPDLGAEP AAALGLLAER ALDAEAEARR TTARLQQLDA
160 170 180 190 200
QLREHAQLMS QHSSLLGRLQ RACAGPERGQ QQVLPLPLAP LVPLSLVGSA
210 220 230 240 250
SNTSRRLDQT PEHQREQSLR QQGPPSSLLP TGHLAVPTRP VGPWRDCAEA
260 270 280 290 300
HGAGHWQSGV YDLRLGRRVV AVWCEQQQEG GGWTVIQRRQ DGSVNFFTNW
310 320 330 340 350
QHYKAGFGRP EGEYWLGLEP VHQVTSRGDH ELLILLEDWG GRAARAHYDS
360 370 380 390 400
FSLEPESDHY RLRLGQYHGD AGDSLSWHND KPFSTVDRDR DSYSGNCALY
410 420 430 440 450
HRGGWWYHAC AHSNLNGVWY HGGHYRSRYQ DGVYWAEFRG GAYSLKKAVM

LTRLVRL
Length:457
Mass (Da):51,095
Last modified:June 1, 2002 - v1
Checksum:iB7C4289E3FEC6C3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054065 mRNA. Translation: BAB91249.1.
BC025904 mRNA. Translation: AAH25904.1.
CCDSiCCDS22886.1.
RefSeqiNP_660136.1. NM_145154.2.
UniGeneiMm.34019.

Genome annotation databases

EnsembliENSMUST00000043726; ENSMUSP00000035784; ENSMUSG00000038742.
GeneIDi70726.
KEGGimmu:70726.
UCSCiuc009ojj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054065 mRNA. Translation: BAB91249.1.
BC025904 mRNA. Translation: AAH25904.1.
CCDSiCCDS22886.1.
RefSeqiNP_660136.1. NM_145154.2.
UniGeneiMm.34019.

3D structure databases

ProteinModelPortaliQ8R0Z6.
SMRiQ8R0Z6. Positions 242-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214222. 1 interaction.
STRINGi10090.ENSMUSP00000035784.

PTM databases

iPTMnetiQ8R0Z6.
PhosphoSiteiQ8R0Z6.

Proteomic databases

MaxQBiQ8R0Z6.
PaxDbiQ8R0Z6.
PRIDEiQ8R0Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043726; ENSMUSP00000035784; ENSMUSG00000038742.
GeneIDi70726.
KEGGimmu:70726.
UCSCiuc009ojj.1. mouse.

Organism-specific databases

CTDi83854.
MGIiMGI:1917976. Angptl6.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ8R0Z6.
OMAiAVCWSGP.
OrthoDBiEOG7X9G60.
PhylomeDBiQ8R0Z6.
TreeFamiTF336658.

Miscellaneous databases

NextBioi332159.
PROiQ8R0Z6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R0Z6.
CleanExiMM_ANGPTL6.
GenevisibleiQ8R0Z6. MM.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration."
    Oike Y., Yasunaga K., Ito Y., Matsumoto S., Maekawa H., Morisada T., Arai F., Nakagata N., Takeya M., Masuho Y., Suda T.
    Proc. Natl. Acad. Sci. U.S.A. 100:9494-9499(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "Angiopoietin-related growth factor (AGF) promotes angiogenesis."
    Oike Y., Ito Y., Maekawa H., Morisada T., Kubota Y., Akao M., Urano T., Yasunaga K., Suda T.
    Blood 103:3760-3765(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: FUNCTION.

Entry informationi

Entry nameiANGL6_MOUSE
AccessioniPrimary (citable) accession number: Q8R0Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2002
Last modified: January 20, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.