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Protein

Mitochondrial coenzyme A transporter SLC25A42

Gene

Slc25a42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial coenzyme A transporter SLC25A42
Alternative name(s):
Solute carrier family 25 member 42
Gene namesi
Name:Slc25a42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1920345. Slc25a42.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Mitochondrial coenzyme A transporter SLC25A42PRO_0000291818Add
BLAST

Proteomic databases

MaxQBiQ8R0Y8.
PaxDbiQ8R0Y8.
PeptideAtlasiQ8R0Y8.
PRIDEiQ8R0Y8.

PTM databases

PhosphoSiteiQ8R0Y8.

Expressioni

Gene expression databases

BgeeiQ8R0Y8.
CleanExiMM_SLC25A42.
GenevisibleiQ8R0Y8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8R0Y8. 1 interaction.
MINTiMINT-1861655.
STRINGi10090.ENSMUSP00000065903.

Structurei

3D structure databases

ProteinModelPortaliQ8R0Y8.
SMRiQ8R0Y8. Positions 34-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 11787Solcar 1Add
BLAST
Repeati129 – 21486Solcar 2Add
BLAST
Repeati224 – 31289Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ8R0Y8.
KOiK15085.
OMAiEYSGRPQ.
OrthoDBiEOG7XM2Z1.
PhylomeDBiQ8R0Y8.
TreeFamiTF314806.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR014762. DNA_mismatch_repair_CS.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R0Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGVQEGSV RLREDAEAVL AGAVSSKRDH RQVLSSLLSG ALAGALAKTA
60 70 80 90 100
VAPLDRTKII FQVSSKRFSA KEAFRLLYFT YLNEGFLSLW RGNSATMVRV
110 120 130 140 150
IPYAAIQFSA HEEYKRILGH YYGFRGEALP PWPRLLAGAL AGTTAASLTY
160 170 180 190 200
PLDLVRARMA VTPKEMYSNI FHVFIRISRE EGLKTLYFGF TPTVLGVIPY
210 220 230 240 250
AGLSFFTYES LKSLHREYSG RPQPYPFERM VFGACAGLIG QSASYPLDVV
260 270 280 290 300
RRRMQTAGVT GHQHGSILST LRSIVREEGA VRGLYKGLSM NWLKGPIAVG
310
ISFTTFDLMQ ILLRRLQS
Length:318
Mass (Da):35,241
Last modified:June 1, 2002 - v1
Checksum:i283500D1C41199BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025937 mRNA. Translation: AAH25937.1.
BC036140 mRNA. Translation: AAH36140.1.
CCDSiCCDS40370.1.
RefSeqiNP_001007571.1. NM_001007570.2.
UniGeneiMm.185413.

Genome annotation databases

EnsembliENSMUST00000063788; ENSMUSP00000065903; ENSMUSG00000002346.
ENSMUST00000110127; ENSMUSP00000105754; ENSMUSG00000002346.
GeneIDi73095.
KEGGimmu:73095.
UCSCiuc009lzg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025937 mRNA. Translation: AAH25937.1.
BC036140 mRNA. Translation: AAH36140.1.
CCDSiCCDS40370.1.
RefSeqiNP_001007571.1. NM_001007570.2.
UniGeneiMm.185413.

3D structure databases

ProteinModelPortaliQ8R0Y8.
SMRiQ8R0Y8. Positions 34-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R0Y8. 1 interaction.
MINTiMINT-1861655.
STRINGi10090.ENSMUSP00000065903.

PTM databases

PhosphoSiteiQ8R0Y8.

Proteomic databases

MaxQBiQ8R0Y8.
PaxDbiQ8R0Y8.
PeptideAtlasiQ8R0Y8.
PRIDEiQ8R0Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063788; ENSMUSP00000065903; ENSMUSG00000002346.
ENSMUST00000110127; ENSMUSP00000105754; ENSMUSG00000002346.
GeneIDi73095.
KEGGimmu:73095.
UCSCiuc009lzg.2. mouse.

Organism-specific databases

CTDi284439.
MGIiMGI:1920345. Slc25a42.

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ8R0Y8.
KOiK15085.
OMAiEYSGRPQ.
OrthoDBiEOG7XM2Z1.
PhylomeDBiQ8R0Y8.
TreeFamiTF314806.

Miscellaneous databases

ChiTaRSiSlc25a42. mouse.
PROiQ8R0Y8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R0Y8.
CleanExiMM_SLC25A42.
GenevisibleiQ8R0Y8. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR014762. DNA_mismatch_repair_CS.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Liver.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiS2542_MOUSE
AccessioniPrimary (citable) accession number: Q8R0Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.