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Protein

Mitochondrial coenzyme A transporter SLC25A42

Gene

Slc25a42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial coenzyme A transporter SLC25A42
Alternative name(s):
Solute carrier family 25 member 42
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1920345 Slc25a42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei135 – 155Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei186 – 206Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918181 – 318Mitochondrial coenzyme A transporter SLC25A42Add BLAST318

Proteomic databases

MaxQBiQ8R0Y8
PaxDbiQ8R0Y8
PeptideAtlasiQ8R0Y8
PRIDEiQ8R0Y8

PTM databases

iPTMnetiQ8R0Y8
PhosphoSitePlusiQ8R0Y8

Expressioni

Gene expression databases

BgeeiENSMUSG00000002346
CleanExiMM_SLC25A42
GenevisibleiQ8R0Y8 MM

Interactioni

Protein-protein interaction databases

BioGridi215767, 1 interactor
IntActiQ8R0Y8, 2 interactors
MINTiQ8R0Y8
STRINGi10090.ENSMUSP00000065903

Structurei

3D structure databases

ProteinModelPortaliQ8R0Y8
SMRiQ8R0Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 117Solcar 1Add BLAST87
Repeati129 – 214Solcar 2Add BLAST86
Repeati224 – 312Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
GeneTreeiENSGT00880000137904
HOGENOMiHOG000165726
HOVERGENiHBG104402
InParanoidiQ8R0Y8
KOiK15085
OMAiTHDTVGD
OrthoDBiEOG091G0C8S
PhylomeDBiQ8R0Y8
TreeFamiTF314806

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q8R0Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGVQEGSV RLREDAEAVL AGAVSSKRDH RQVLSSLLSG ALAGALAKTA
60 70 80 90 100
VAPLDRTKII FQVSSKRFSA KEAFRLLYFT YLNEGFLSLW RGNSATMVRV
110 120 130 140 150
IPYAAIQFSA HEEYKRILGH YYGFRGEALP PWPRLLAGAL AGTTAASLTY
160 170 180 190 200
PLDLVRARMA VTPKEMYSNI FHVFIRISRE EGLKTLYFGF TPTVLGVIPY
210 220 230 240 250
AGLSFFTYES LKSLHREYSG RPQPYPFERM VFGACAGLIG QSASYPLDVV
260 270 280 290 300
RRRMQTAGVT GHQHGSILST LRSIVREEGA VRGLYKGLSM NWLKGPIAVG
310
ISFTTFDLMQ ILLRRLQS
Length:318
Mass (Da):35,241
Last modified:June 1, 2002 - v1
Checksum:i283500D1C41199BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025937 mRNA Translation: AAH25937.1
BC036140 mRNA Translation: AAH36140.1
CCDSiCCDS40370.1
RefSeqiNP_001007571.1, NM_001007570.2
UniGeneiMm.185413

Genome annotation databases

EnsembliENSMUST00000063788; ENSMUSP00000065903; ENSMUSG00000002346
ENSMUST00000110127; ENSMUSP00000105754; ENSMUSG00000002346
GeneIDi73095
KEGGimmu:73095
UCSCiuc009lzg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiS2542_MOUSE
AccessioniPrimary (citable) accession number: Q8R0Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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