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Protein

Mitochondrial coenzyme A transporter SLC25A42

Gene

Slc25a42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial coenzyme A transporter SLC25A42
Alternative name(s):
Solute carrier family 25 member 42
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1920345. Slc25a42.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei135 – 155Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei186 – 206Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918181 – 318Mitochondrial coenzyme A transporter SLC25A42Add BLAST318

Proteomic databases

MaxQBiQ8R0Y8.
PaxDbiQ8R0Y8.
PeptideAtlasiQ8R0Y8.
PRIDEiQ8R0Y8.

PTM databases

PhosphoSitePlusiQ8R0Y8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002346.
CleanExiMM_SLC25A42.
GenevisibleiQ8R0Y8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8R0Y8. 1 interactor.
MINTiMINT-1861655.
STRINGi10090.ENSMUSP00000065903.

Structurei

3D structure databases

ProteinModelPortaliQ8R0Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 117Solcar 1Add BLAST87
Repeati129 – 214Solcar 2Add BLAST86
Repeati224 – 312Solcar 3Add BLAST89

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ8R0Y8.
KOiK15085.
OMAiEYSGRPQ.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ8R0Y8.
TreeFamiTF314806.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR014762. DNA_mismatch_repair_CS.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R0Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGVQEGSV RLREDAEAVL AGAVSSKRDH RQVLSSLLSG ALAGALAKTA
60 70 80 90 100
VAPLDRTKII FQVSSKRFSA KEAFRLLYFT YLNEGFLSLW RGNSATMVRV
110 120 130 140 150
IPYAAIQFSA HEEYKRILGH YYGFRGEALP PWPRLLAGAL AGTTAASLTY
160 170 180 190 200
PLDLVRARMA VTPKEMYSNI FHVFIRISRE EGLKTLYFGF TPTVLGVIPY
210 220 230 240 250
AGLSFFTYES LKSLHREYSG RPQPYPFERM VFGACAGLIG QSASYPLDVV
260 270 280 290 300
RRRMQTAGVT GHQHGSILST LRSIVREEGA VRGLYKGLSM NWLKGPIAVG
310
ISFTTFDLMQ ILLRRLQS
Length:318
Mass (Da):35,241
Last modified:June 1, 2002 - v1
Checksum:i283500D1C41199BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025937 mRNA. Translation: AAH25937.1.
BC036140 mRNA. Translation: AAH36140.1.
CCDSiCCDS40370.1.
RefSeqiNP_001007571.1. NM_001007570.2.
UniGeneiMm.185413.

Genome annotation databases

EnsembliENSMUST00000063788; ENSMUSP00000065903; ENSMUSG00000002346.
ENSMUST00000110127; ENSMUSP00000105754; ENSMUSG00000002346.
GeneIDi73095.
KEGGimmu:73095.
UCSCiuc009lzg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025937 mRNA. Translation: AAH25937.1.
BC036140 mRNA. Translation: AAH36140.1.
CCDSiCCDS40370.1.
RefSeqiNP_001007571.1. NM_001007570.2.
UniGeneiMm.185413.

3D structure databases

ProteinModelPortaliQ8R0Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R0Y8. 1 interactor.
MINTiMINT-1861655.
STRINGi10090.ENSMUSP00000065903.

PTM databases

PhosphoSitePlusiQ8R0Y8.

Proteomic databases

MaxQBiQ8R0Y8.
PaxDbiQ8R0Y8.
PeptideAtlasiQ8R0Y8.
PRIDEiQ8R0Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063788; ENSMUSP00000065903; ENSMUSG00000002346.
ENSMUST00000110127; ENSMUSP00000105754; ENSMUSG00000002346.
GeneIDi73095.
KEGGimmu:73095.
UCSCiuc009lzg.2. mouse.

Organism-specific databases

CTDi284439.
MGIiMGI:1920345. Slc25a42.

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
HOVERGENiHBG104402.
InParanoidiQ8R0Y8.
KOiK15085.
OMAiEYSGRPQ.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ8R0Y8.
TreeFamiTF314806.

Miscellaneous databases

ChiTaRSiSlc25a42. mouse.
PROiQ8R0Y8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002346.
CleanExiMM_SLC25A42.
GenevisibleiQ8R0Y8. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR014762. DNA_mismatch_repair_CS.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2542_MOUSE
AccessioniPrimary (citable) accession number: Q8R0Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.