ID FTHFD_MOUSE Reviewed; 902 AA. AC Q8R0Y6; DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 05-APR-2011, entry version 90. DE RecName: Full=10-formyltetrahydrofolate dehydrogenase; DE Short=10-FTHFDH; DE EC=1.5.1.6; DE AltName: Full=Aldehyde dehydrogenase family 1 member L1; GN Name=Aldh1l1; Synonyms=Fthfd; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Liver; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + NADP(+) + H(2)O = CC tetrahydrofolate + CO(2) + NADPH. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: In the N-terminal section; belongs to the GART family. CC -!- SIMILARITY: In the C-terminal section; belongs to the aldehyde CC dehydrogenase family. ALDH1L subfamily. CC -!- SIMILARITY: Contains 1 acyl carrier domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC025939; AAH25939.1; -; mRNA. DR EMBL; BC028817; AAH28817.1; -; mRNA. DR EMBL; BC030722; AAH30722.1; -; mRNA. DR EMBL; BC030723; AAH30723.1; -; mRNA. DR EMBL; BC030727; AAH30727.1; -; mRNA. DR EMBL; BC030730; AAH30730.1; -; mRNA. DR IPI; IPI00153317; -. DR RefSeq; NP_081682.1; NM_027406.1. DR UniGene; Mm.30035; -. DR ProteinModelPortal; Q8R0Y6; -. DR SMR; Q8R0Y6; 1-402, 405-902. DR STRING; Q8R0Y6; -. DR PhosphoSite; Q8R0Y6; -. DR PRIDE; Q8R0Y6; -. DR Ensembl; ENSMUST00000032175; ENSMUSP00000032175; ENSMUSG00000030088. DR GeneID; 107747; -. DR KEGG; mmu:107747; -. DR UCSC; uc009cxl.1; mouse. DR CTD; 107747; -. DR MGI; MGI:1340024; Aldh1l1. DR HOGENOM; HBG315849; -. DR HOVERGEN; HBG051668; -. DR InParanoid; Q8R0Y6; -. DR OMA; EDSIHDQ; -. DR PhylomeDB; Q8R0Y6; -. DR BRENDA; 1.5.1.6; 244. DR NextBio; 359368; -. DR ArrayExpress; Q8R0Y6; -. DR Bgee; Q8R0Y6; -. DR CleanEx; MM_ALDH1L1; -. DR Genevestigator; Q8R0Y6; -. DR GermOnline; ENSMUSG00000030088; Mus musculus. DR GO; GO:0005739; C:mitochondrion; IDA:MGI. DR GO; GO:0000036; F:acyl carrier activity; IEA:InterPro. DR GO; GO:0048037; F:cofactor binding; IEA:InterPro. DR GO; GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IEA:EC. DR GO; GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro. DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro. DR GO; GO:0009258; P:10-formyltetrahydrofolate catabolic process; IEA:InterPro. DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro. DR GO; GO:0055114; P:oxidation-reduction process; IEA:UniProtKB-KW. DR InterPro; IPR011407; 10_FTHF_DH. DR InterPro; IPR009081; Acyl_carrier_prot-like. DR InterPro; IPR016161; Ald_DH/histidinol_DH. DR InterPro; IPR016163; Ald_DH_C. DR InterPro; IPR016160; Ald_DH_CS. DR InterPro; IPR016162; Ald_DH_N. DR InterPro; IPR015590; Aldehyde_DH_dom. DR InterPro; IPR005793; Formyl_trans_C. DR InterPro; IPR002376; Formyl_transf_N. DR InterPro; IPR011034; Formyl_transferase_C-like. DR InterPro; IPR001555; GART_AS. DR InterPro; IPR006163; Phsphopanteth-bd. DR Gene3D; G3DSA:1.10.1200.10; ACP_like; 1. DR Gene3D; G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1. DR Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1. DR Gene3D; G3DSA:3.10.25.10; Formyl_trans_C; 1. DR Gene3D; G3DSA:3.40.50.170; Formyl_transf_N; 1. DR Pfam; PF00171; Aldedh; 1. DR Pfam; PF02911; Formyl_trans_C; 1. DR Pfam; PF00551; Formyl_trans_N; 1. DR Pfam; PF00550; PP-binding; 1. DR PIRSF; PIRSF036489; 10-FTHFDH; 1. DR SUPFAM; SSF47336; ACP_like; 1. DR SUPFAM; SSF53720; Aldehyde_DH/Histidinol_DH; 1. DR SUPFAM; SSF50486; FMT_C_like; 1. DR SUPFAM; SSF53328; formyl_transf; 1. DR PROSITE; PS50075; ACP_DOMAIN; 1. DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1. DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1. DR PROSITE; PS00373; GART; 1. DR PROSITE; PS00012; PHOSPHOPANTETHEINE; FALSE_NEG. PE 2: Evidence at transcript level; KW Cytoplasm; NADP; One-carbon metabolism; Oxidoreductase; KW Phosphopantetheine; Phosphoprotein. FT CHAIN 1 902 10-formyltetrahydrofolate dehydrogenase. FT /FTId=PRO_0000199420. FT DOMAIN 323 392 Acyl carrier. FT REGION 1 203 GART. FT REGION 417 902 Aldehyde dehydrogenase. FT ACT_SITE 106 106 Proton donor (By similarity). FT ACT_SITE 673 673 By similarity. FT ACT_SITE 707 707 By similarity. FT SITE 142 142 Essential for catalytic activity (By FT similarity). FT MOD_RES 354 354 O-(pantetheine 4'-phosphoryl)serine (By FT similarity). FT MOD_RES 613 613 Phosphothreonine (By similarity). SQ SEQUENCE 902 AA; 98709 MW; 9B5526A7FB41909E CRC64; MKIAVIGQSL FGQEVYCQLR KEGHEVVGVF TIPDKDGKAD PLGLEAEKDG VPVFKFPRWR ARGQALPEVV AKYQALGAEL NVLPFCSQFI PMEVINAPRH GSIIYHPSLL PRHRGASAIN WTLIHGDKKG GFTIFWADDG LDTGDLLLQK ECDVLPDDTV STLYNRFLFP EGIKGMVQAV RLIAEGTAPR RPQPEEGATY EGIQKKETAM INWDQPAEAI HNWIRGNDKV PGAWTEACGQ KLTFFNSTLN TSGLVAQGEA LPIPGAHRPG LVTKAGLILF GNDDRMLLVK NIQLEDGKMM PASQFFKGSA SSALELTEEE LATAEAVRSS WMRILPNVPE VEDSTDFFKS GAASVDVVRL VEEVKELCDG LELENEDVYM ATTFGDFIQL LVRKLRGEDG ESECVINYVE KAVKKLTLQM PYQLFIGGEF VDAEGAKTYS TINPTDGSVI CQVSLAQVSD VDKAVAAAKE AFENGLWGKI NARDRGRLLY RLADLMEQHQ EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI QGATIPINQA RPNRNLTLTK KEPVGVCGIV IPWNYPLMML SWKTAACLAA GNTVVIKPAQ VTPLTALKFA ELTLKAGIPK GVVNILPGSG SLVGQRLSDH PDVRKIGFTG STEVGKHIMK SCALSNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF FNKGENCIAA GRLFVEDSIH DQFVQKVVEE VGKMKIGNPL DRDTNHGPQN HEAHLRKLVE YCQRGVKEGA TLVCGGNQVP RPGFFFQPTV FTDVEDHMYI AKEESFGPIM IISRFADGDV DAVLSRANAT EFGLASGVFT RDINKALYVS DKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRIKTVTF EY //