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Protein

Cytosolic 10-formyltetrahydrofolate dehydrogenase

Gene

Aldh1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

The phosphoserine observed at Ser-354 in PubMed:17242355 may result from secondary neutral loss of pantetheine from the phosphodiester linked cofactor.Curated

Catalytic activityi

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Proton donorBy similarity1
Binding sitei142SubstrateBy similarity1
Sitei142Essential for catalytic activityBy similarity1
Active sitei673Proton acceptorPROSITE-ProRule annotation1
Active sitei707Proton donorBy similarity1
Binding sitei757NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi571 – 573NADPBy similarity3
Nucleotide bindingi597 – 600NADPBy similarity4
Nucleotide bindingi630 – 635NADPBy similarity6
Nucleotide bindingi650 – 651NADPBy similarity2
Nucleotide bindingi804 – 806NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processOne-carbon metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-196757 Metabolism of folate and pterines

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
Short name:
10-FTHFDH
Short name:
FDH
Alternative name(s):
Aldehyde dehydrogenase family 1 member L1
Gene namesi
Name:Aldh1l1
Synonyms:Fthfd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1340024 Aldh1l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994201 – 902Cytosolic 10-formyltetrahydrofolate dehydrogenaseAdd BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei38N6-succinyllysineCombined sources1
Modified residuei354O-(pantetheine 4'-phosphoryl)serine; alternatePROSITE-ProRule annotationCurated1
Modified residuei354Phosphoserine; alternateCombined sources1
Modified residuei629PhosphoserineBy similarity1
Modified residuei631PhosphoserineBy similarity1
Modified residuei660N6-succinyllysineBy similarity1
Modified residuei767N6-succinyllysineCombined sources1
Modified residuei825PhosphoserineBy similarity1
Modified residuei882N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiQ8R0Y6
PaxDbiQ8R0Y6
PeptideAtlasiQ8R0Y6
PRIDEiQ8R0Y6

PTM databases

iPTMnetiQ8R0Y6
PhosphoSitePlusiQ8R0Y6
SwissPalmiQ8R0Y6

Expressioni

Gene expression databases

BgeeiENSMUSG00000030088
CleanExiMM_ALDH1L1
ExpressionAtlasiQ8R0Y6 baseline and differential
GenevisibleiQ8R0Y6 MM

Interactioni

Protein-protein interaction databases

BioGridi223535, 2 interactors
IntActiQ8R0Y6, 7 interactors
MINTiQ8R0Y6
STRINGi10090.ENSMUSP00000032175

Structurei

3D structure databases

ProteinModelPortaliQ8R0Y6
SMRiQ8R0Y6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 395CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 203GARTAdd BLAST203
Regioni88 – 90Substrate bindingBy similarity3
Regioni417 – 902Aldehyde dehydrogenaseAdd BLAST486

Sequence similaritiesi

In the N-terminal section; belongs to the GART family.Curated
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.Curated

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOVERGENiHBG051668
InParanoidiQ8R0Y6
KOiK00289
OMAiYMATTFG
OrthoDBiEOG091G05E8
PhylomeDBiQ8R0Y6
TreeFamiTF354242

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.25.10, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR011407 10_FTHF_DH
IPR036736 ACP-like_sf
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
IPR009081 PP-bd_ACP
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
PIRSFiPIRSF036489 10-FTHFDH, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
SSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
PS50075 CARRIER, 1 hit
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R0Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAVIGQSL FGQEVYCQLR KEGHEVVGVF TIPDKDGKAD PLGLEAEKDG
60 70 80 90 100
VPVFKFPRWR ARGQALPEVV AKYQALGAEL NVLPFCSQFI PMEVINAPRH
110 120 130 140 150
GSIIYHPSLL PRHRGASAIN WTLIHGDKKG GFTIFWADDG LDTGDLLLQK
160 170 180 190 200
ECDVLPDDTV STLYNRFLFP EGIKGMVQAV RLIAEGTAPR RPQPEEGATY
210 220 230 240 250
EGIQKKETAM INWDQPAEAI HNWIRGNDKV PGAWTEACGQ KLTFFNSTLN
260 270 280 290 300
TSGLVAQGEA LPIPGAHRPG LVTKAGLILF GNDDRMLLVK NIQLEDGKMM
310 320 330 340 350
PASQFFKGSA SSALELTEEE LATAEAVRSS WMRILPNVPE VEDSTDFFKS
360 370 380 390 400
GAASVDVVRL VEEVKELCDG LELENEDVYM ATTFGDFIQL LVRKLRGEDG
410 420 430 440 450
ESECVINYVE KAVKKLTLQM PYQLFIGGEF VDAEGAKTYS TINPTDGSVI
460 470 480 490 500
CQVSLAQVSD VDKAVAAAKE AFENGLWGKI NARDRGRLLY RLADLMEQHQ
510 520 530 540 550
EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI QGATIPINQA
560 570 580 590 600
RPNRNLTLTK KEPVGVCGIV IPWNYPLMML SWKTAACLAA GNTVVIKPAQ
610 620 630 640 650
VTPLTALKFA ELTLKAGIPK GVVNILPGSG SLVGQRLSDH PDVRKIGFTG
660 670 680 690 700
STEVGKHIMK SCALSNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF
710 720 730 740 750
FNKGENCIAA GRLFVEDSIH DQFVQKVVEE VGKMKIGNPL DRDTNHGPQN
760 770 780 790 800
HEAHLRKLVE YCQRGVKEGA TLVCGGNQVP RPGFFFQPTV FTDVEDHMYI
810 820 830 840 850
AKEESFGPIM IISRFADGDV DAVLSRANAT EFGLASGVFT RDINKALYVS
860 870 880 890 900
DKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRIKTVTF

EY
Length:902
Mass (Da):98,709
Last modified:June 1, 2002 - v1
Checksum:i9B5526A7FB41909E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025939 mRNA Translation: AAH25939.1
BC028817 mRNA Translation: AAH28817.1
BC030722 mRNA Translation: AAH30722.1
BC030723 mRNA Translation: AAH30723.1
BC030727 mRNA Translation: AAH30727.1
BC030730 mRNA Translation: AAH30730.1
CCDSiCCDS20361.1
RefSeqiNP_081682.1, NM_027406.1
XP_006505342.1, XM_006505279.3
UniGeneiMm.30035

Genome annotation databases

EnsembliENSMUST00000032175; ENSMUSP00000032175; ENSMUSG00000030088
ENSMUST00000130418; ENSMUSP00000114304; ENSMUSG00000030088
GeneIDi107747
KEGGimmu:107747
UCSCiuc009cxl.1 mouse

Entry informationi

Entry nameiAL1L1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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