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Protein

Cytosolic 10-formyltetrahydrofolate dehydrogenase

Gene

Aldh1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Proton donorBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Sitei142 – 1421Essential for catalytic activityBy similarity
Active sitei673 – 6731Proton acceptorPROSITE-ProRule annotation
Active sitei707 – 7071Proton donorBy similarity
Binding sitei757 – 7571NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi571 – 5733NADPBy similarity
Nucleotide bindingi597 – 6004NADPBy similarity
Nucleotide bindingi630 – 6356NADPBy similarity
Nucleotide bindingi650 – 6512NADPBy similarity
Nucleotide bindingi804 – 8063NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-MMU-196757. Metabolism of folate and pterines.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
Short name:
10-FTHFDH
Short name:
FDH
Alternative name(s):
Aldehyde dehydrogenase family 1 member L1
Gene namesi
Name:Aldh1l1
Synonyms:Fthfd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1340024. Aldh1l1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 902902Cytosolic 10-formyltetrahydrofolate dehydrogenasePRO_0000199420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei38 – 381N6-succinyllysineCombined sources
Modified residuei354 – 3541O-(pantetheine 4'-phosphoryl)serine; alternatePROSITE-ProRule annotation
Modified residuei354 – 3541Phosphoserine; alternateCombined sources
Modified residuei629 – 6291PhosphoserineBy similarity
Modified residuei631 – 6311PhosphoserineBy similarity
Modified residuei767 – 7671N6-succinyllysineCombined sources
Modified residuei825 – 8251PhosphoserineBy similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiQ8R0Y6.
PaxDbiQ8R0Y6.
PeptideAtlasiQ8R0Y6.
PRIDEiQ8R0Y6.

PTM databases

iPTMnetiQ8R0Y6.
PhosphoSiteiQ8R0Y6.
SwissPalmiQ8R0Y6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030088.
CleanExiMM_ALDH1L1.
ExpressionAtlasiQ8R0Y6. baseline and differential.
GenevisibleiQ8R0Y6. MM.

Interactioni

Protein-protein interaction databases

BioGridi223535. 1 interaction.
IntActiQ8R0Y6. 7 interactions.
MINTiMINT-1856176.
STRINGi10090.ENSMUSP00000032175.

Structurei

3D structure databases

ProteinModelPortaliQ8R0Y6.
SMRiQ8R0Y6. Positions 1-402, 405-902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini323 – 39270Acyl carrierPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 203203GARTAdd
BLAST
Regioni88 – 903Substrate bindingBy similarity
Regioni417 – 902486Aldehyde dehydrogenaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the GART family.Curated
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.Curated
Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOVERGENiHBG051668.
InParanoidiQ8R0Y6.
KOiK00289.
OMAiMASTFGD.
OrthoDBiEOG091G05E8.
PhylomeDBiQ8R0Y6.
TreeFamiTF354242.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.10.25.10. 1 hit.
3.40.309.10. 1 hit.
3.40.50.170. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR011407. 10_FTHF_DH.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR009081. PP-bd_ACP.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036489. 10-FTHFDH. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF53720. SSF53720. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R0Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAVIGQSL FGQEVYCQLR KEGHEVVGVF TIPDKDGKAD PLGLEAEKDG
60 70 80 90 100
VPVFKFPRWR ARGQALPEVV AKYQALGAEL NVLPFCSQFI PMEVINAPRH
110 120 130 140 150
GSIIYHPSLL PRHRGASAIN WTLIHGDKKG GFTIFWADDG LDTGDLLLQK
160 170 180 190 200
ECDVLPDDTV STLYNRFLFP EGIKGMVQAV RLIAEGTAPR RPQPEEGATY
210 220 230 240 250
EGIQKKETAM INWDQPAEAI HNWIRGNDKV PGAWTEACGQ KLTFFNSTLN
260 270 280 290 300
TSGLVAQGEA LPIPGAHRPG LVTKAGLILF GNDDRMLLVK NIQLEDGKMM
310 320 330 340 350
PASQFFKGSA SSALELTEEE LATAEAVRSS WMRILPNVPE VEDSTDFFKS
360 370 380 390 400
GAASVDVVRL VEEVKELCDG LELENEDVYM ATTFGDFIQL LVRKLRGEDG
410 420 430 440 450
ESECVINYVE KAVKKLTLQM PYQLFIGGEF VDAEGAKTYS TINPTDGSVI
460 470 480 490 500
CQVSLAQVSD VDKAVAAAKE AFENGLWGKI NARDRGRLLY RLADLMEQHQ
510 520 530 540 550
EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI QGATIPINQA
560 570 580 590 600
RPNRNLTLTK KEPVGVCGIV IPWNYPLMML SWKTAACLAA GNTVVIKPAQ
610 620 630 640 650
VTPLTALKFA ELTLKAGIPK GVVNILPGSG SLVGQRLSDH PDVRKIGFTG
660 670 680 690 700
STEVGKHIMK SCALSNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF
710 720 730 740 750
FNKGENCIAA GRLFVEDSIH DQFVQKVVEE VGKMKIGNPL DRDTNHGPQN
760 770 780 790 800
HEAHLRKLVE YCQRGVKEGA TLVCGGNQVP RPGFFFQPTV FTDVEDHMYI
810 820 830 840 850
AKEESFGPIM IISRFADGDV DAVLSRANAT EFGLASGVFT RDINKALYVS
860 870 880 890 900
DKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRIKTVTF

EY
Length:902
Mass (Da):98,709
Last modified:June 1, 2002 - v1
Checksum:i9B5526A7FB41909E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025939 mRNA. Translation: AAH25939.1.
BC028817 mRNA. Translation: AAH28817.1.
BC030722 mRNA. Translation: AAH30722.1.
BC030723 mRNA. Translation: AAH30723.1.
BC030727 mRNA. Translation: AAH30727.1.
BC030730 mRNA. Translation: AAH30730.1.
CCDSiCCDS20361.1.
RefSeqiNP_081682.1. NM_027406.1.
XP_006505342.1. XM_006505279.2.
UniGeneiMm.30035.

Genome annotation databases

EnsembliENSMUST00000032175; ENSMUSP00000032175; ENSMUSG00000030088.
ENSMUST00000130418; ENSMUSP00000114304; ENSMUSG00000030088.
GeneIDi107747.
KEGGimmu:107747.
UCSCiuc009cxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025939 mRNA. Translation: AAH25939.1.
BC028817 mRNA. Translation: AAH28817.1.
BC030722 mRNA. Translation: AAH30722.1.
BC030723 mRNA. Translation: AAH30723.1.
BC030727 mRNA. Translation: AAH30727.1.
BC030730 mRNA. Translation: AAH30730.1.
CCDSiCCDS20361.1.
RefSeqiNP_081682.1. NM_027406.1.
XP_006505342.1. XM_006505279.2.
UniGeneiMm.30035.

3D structure databases

ProteinModelPortaliQ8R0Y6.
SMRiQ8R0Y6. Positions 1-402, 405-902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223535. 1 interaction.
IntActiQ8R0Y6. 7 interactions.
MINTiMINT-1856176.
STRINGi10090.ENSMUSP00000032175.

PTM databases

iPTMnetiQ8R0Y6.
PhosphoSiteiQ8R0Y6.
SwissPalmiQ8R0Y6.

Proteomic databases

MaxQBiQ8R0Y6.
PaxDbiQ8R0Y6.
PeptideAtlasiQ8R0Y6.
PRIDEiQ8R0Y6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032175; ENSMUSP00000032175; ENSMUSG00000030088.
ENSMUST00000130418; ENSMUSP00000114304; ENSMUSG00000030088.
GeneIDi107747.
KEGGimmu:107747.
UCSCiuc009cxl.1. mouse.

Organism-specific databases

CTDi10840.
MGIiMGI:1340024. Aldh1l1.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOVERGENiHBG051668.
InParanoidiQ8R0Y6.
KOiK00289.
OMAiMASTFGD.
OrthoDBiEOG091G05E8.
PhylomeDBiQ8R0Y6.
TreeFamiTF354242.

Enzyme and pathway databases

ReactomeiR-MMU-196757. Metabolism of folate and pterines.

Miscellaneous databases

ChiTaRSiAldh1l1. mouse.
PROiQ8R0Y6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030088.
CleanExiMM_ALDH1L1.
ExpressionAtlasiQ8R0Y6. baseline and differential.
GenevisibleiQ8R0Y6. MM.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.10.25.10. 1 hit.
3.40.309.10. 1 hit.
3.40.50.170. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR011407. 10_FTHF_DH.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR009081. PP-bd_ACP.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036489. 10-FTHFDH. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF53720. SSF53720. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1L1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.