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Q8R0W0 (EPIPL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epiplakin
Gene names
Name:Eppk1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length6548 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasmcytoskeleton By similarity.

Tissue specificity

High levels in skin, small intestine and salivary gland. Lower levels in lung, uterus and liver. Not detected in brain, kidney, muscle, heart or spleen. In skin, expressed in all epidermal layers but not in the dermis. In intestine, expressed exclusively in the epithelial cell layer of the villi. In liver, expressed at hepatocyte margins. Ref.1

Sequence similarities

Belongs to the plakin or cytolinker family.

Contains 76 plectin repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainCoiled coil
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay Ref.1. Source: MGI

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 65486548Epiplakin
PRO_0000078146

Regions

Repeat41 – 7838Plectin 1
Repeat79 – 11638Plectin 2
Repeat117 – 15438Plectin 3
Repeat155 – 19238Plectin 4
Repeat285 – 32238Plectin 5
Repeat323 – 36038Plectin 6
Repeat362 – 39837Plectin 7
Repeat399 – 43638Plectin 8
Repeat437 – 47034Plectin 9
Repeat611 – 64838Plectin 10
Repeat649 – 68638Plectin 11
Repeat687 – 72438Plectin 12
Repeat725 – 76238Plectin 13
Repeat766 – 80035Plectin 14
Repeat931 – 96838Plectin 15
Repeat969 – 100638Plectin 16
Repeat1007 – 104438Plectin 17
Repeat1224 – 128461Plectin 18
Repeat1285 – 132238Plectin 19
Repeat1323 – 136038Plectin 20
Repeat1361 – 139838Plectin 21
Repeat1402 – 143635Plectin 22
Repeat1572 – 160938Plectin 23
Repeat1610 – 164738Plectin 24
Repeat1648 – 168538Plectin 25
Repeat1686 – 172338Plectin 26
Repeat1727 – 176135Plectin 27
Repeat1898 – 193538Plectin 28
Repeat1936 – 197338Plectin 29
Repeat1974 – 201138Plectin 30
Repeat2012 – 204938Plectin 31
Repeat2225 – 226743Plectin 32
Repeat2268 – 230538Plectin 33
Repeat2306 – 234338Plectin 34
Repeat2344 – 238138Plectin 35
Repeat2385 – 241935Plectin 36
Repeat2740 – 278243Plectin 37
Repeat2783 – 282038Plectin 38
Repeat2821 – 285838Plectin 39
Repeat2859 – 289638Plectin 40
Repeat2900 – 293435Plectin 41
Repeat3255 – 329743Plectin 42
Repeat3298 – 333538Plectin 43
Repeat3336 – 337338Plectin 44
Repeat3374 – 341138Plectin 45
Repeat3415 – 344935Plectin 46
Repeat3770 – 381243Plectin 47
Repeat3813 – 385038Plectin 48
Repeat3851 – 388838Plectin 49
Repeat3889 – 392638Plectin 50
Repeat3930 – 396435Plectin 51
Repeat4285 – 432743Plectin 52
Repeat4328 – 436538Plectin 53
Repeat4366 – 440338Plectin 54
Repeat4404 – 444138Plectin 55
Repeat4445 – 447935Plectin 56
Repeat4800 – 484243Plectin 57
Repeat4843 – 488038Plectin 58
Repeat4881 – 491838Plectin 59
Repeat4919 – 495638Plectin 60
Repeat4960 – 499435Plectin 61
Repeat5315 – 535743Plectin 62
Repeat5358 – 539538Plectin 63
Repeat5396 – 543338Plectin 64
Repeat5434 – 547138Plectin 65
Repeat5475 – 550935Plectin 66
Repeat5830 – 587243Plectin 67
Repeat5873 – 591038Plectin 68
Repeat5911 – 594838Plectin 69
Repeat5949 – 598638Plectin 70
Repeat5990 – 602435Plectin 71
Repeat6345 – 638743Plectin 72
Repeat6388 – 642538Plectin 73
Repeat6426 – 646338Plectin 74
Repeat6464 – 650138Plectin 75
Repeat6505 – 653935Plectin 76
Coiled coil545 – 56521 Potential
Coiled coil851 – 88636 Potential
Coiled coil1819 – 185133 Potential

Amino acid modifications

Modified residue15371Phosphoserine Ref.3
Modified residue24301Phosphoserine By similarity
Modified residue25081Phosphoserine By similarity
Modified residue26061Phosphoserine Ref.3
Modified residue27051Phosphoserine Ref.4
Modified residue27071Phosphoserine By similarity
Modified residue29451Phosphoserine By similarity
Modified residue30231Phosphoserine By similarity
Modified residue31211Phosphoserine Ref.3
Modified residue32201Phosphoserine Ref.4
Modified residue36361Phosphoserine Ref.3
Modified residue37351Phosphoserine Ref.4
Modified residue37371Phosphoserine By similarity
Modified residue39751Phosphoserine By similarity
Modified residue40531Phosphoserine By similarity
Modified residue41511Phosphoserine Ref.3
Modified residue42501Phosphoserine Ref.4
Modified residue42521Phosphoserine By similarity
Modified residue44901Phosphoserine By similarity
Modified residue45681Phosphoserine By similarity
Modified residue46661Phosphoserine Ref.3
Modified residue47651Phosphoserine Ref.4
Modified residue51811Phosphoserine Ref.3
Modified residue52801Phosphoserine Ref.4
Modified residue52821Phosphoserine By similarity
Modified residue55201Phosphoserine By similarity
Modified residue55981Phosphoserine By similarity
Modified residue56961Phosphoserine Ref.3
Modified residue57951Phosphoserine Ref.4
Modified residue62111Phosphoserine Ref.3
Modified residue63101Phosphoserine Ref.4
Modified residue63121Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8R0W0 [UniParc].

Last modified August 15, 2003. Version 2.
Checksum: 9162C07AFCA157B6

FASTA6,548724,646
        10         20         30         40         50         60 
MNGQAPPHDV VVANGTEKFI VPKIKKNQLG ASTPSRPQAE AALPTTARSI AGVYVEASGQ 

        70         80         90        100        110        120 
TQSIYAAIKQ GLLPTGLGLT LLEAQAATGG LVDLAQGQLL PVSEALRRGL VGLELKEKLL 

       130        140        150        160        170        180 
AAERAVTGYP DPYGGEKLSL FQAIKKEVVD RTLGWRLLEA QLATGGLVDP TQGVQVAPEL 

       190        200        210        220        230        240 
ACQQGLLDKE TWLSLVESEP SMGTPGFSDP NTLEQLPYSV LLGRCVQDPS SGLPLLPLKT 

       250        260        270        280        290        300 
TFHTLAGAAS ASMLLEAGVL NEEMVRDLQE GMLVVSDVGT RPEVRRYLEG TGGLAGVVLL 

       310        320        330        340        350        360 
PGGHKKSFFQ ATVEHLVSKG IALQLLEAQA ATRTLVHPTT GQRLWVEEAV KAGLVGPELH 

       370        380        390        400        410        420 
EQLLVAEQAV TGYYDPFSSS RIPVFQAMKK GLVDQPLALR LLDAQLATGG LICPARRFRL 

       430        440        450        460        470        480 
PLEAALRFGC LDEETRQRLS QAMGFSDPTT HDRLGYEQLL ALSVTDPETG LAFLPLPGMS 

       490        500        510        520        530        540 
HANEPQGPTF IDHCTRQALS KATTSISVGR YQGRPVSLWE LLFSESVPVK KRAMLAQRHQ 

       550        560        570        580        590        600 
EGALSVEELA AELKNIVEQA AATAKVTFAG LRDTVTPGEL LKAEIINQDL FEQLERGQTS 

       610        620        630        640        650        660 
AQDVGSLDSV QRYLQGTGSI AGLLLPDSQE RLSIYEARSK GLLRPGTALI LLEAQAATGF 

       670        680        690        700        710        720 
IIDPKENKRY SVEEALRAGV IGPDVYAKLL SAEHAVTGYT DPYSGEQISL FQAMQRDLIV 

       730        740        750        760        770        780 
RDHGIRLLEA QIATGGVIDP VHSHRVPVDV AYQRGYFDQI LNSILLDPSD DTKGFFDPNT 

       790        800        810        820        830        840 
HENLTYLQLL ERCVHDSETG LHLLPLSSTR PQLVDSSTRQ AFQKLLLSVK YGRFRGQRVS 

       850        860        870        880        890        900 
AWELVNSEYF TEDRRRQLLQ RYRQRKITLE QVTQLLEKEM RRWTDITLPA LQGQVTAYQL 

       910        920        930        940        950        960 
LEAHIINQEL LDQVLTGTIS PDALLQVGDV HRYLRGSGTV GGVLLKPSNQ RISLYQAMKQ 

       970        980        990       1000       1010       1020 
KLLPPSTALA LLEAQAATGT ITDPCSMETL SVDEAVCRGV VGAEVYGKLK RAEHSITGYR 

      1030       1040       1050       1060       1070       1080 
DPFSGKKVSL FRAMKKGLVP VEQATRLLEA QVSTGGVVDP TTHLHLPMPV AVQRGCIDRE 

      1090       1100       1110       1120       1130       1140 
MEAALSRSPE TFPTPDGRGH TSYAQLLEHC LQDKASGLHL LPLTEDAPNV PTDTQIQETL 

      1150       1160       1170       1180       1190       1200 
QASAGTEDGL SLWDLLTSCH FTEEQRRGYL EDVKVGKISV PQLQNTVRSW VHSAKLLARA 

      1210       1220       1230       1240       1250       1260 
RITVPGPRGE VPATWLRDAG IITQETLEAL AQGMQSPDEV AKQPTVKVCL WGTGCVAGVL 

      1270       1280       1290       1300       1310       1320 
LQPSGTKLSI AQAVRDGLLP TGLGQQLLEA QVASGFLVNP LTNQRLSVEG AVKAGLVGME 

      1330       1340       1350       1360       1370       1380 
QSEHLRQVEK AVTGYSDPFS GGSLSLWQAM EKGLVTQSEA FPLLQVQLAT GGVVDPVHGV 

      1390       1400       1410       1420       1430       1440 
HLPQEVAYKL GLLDEQTSRV LTATGKENKL FFDPNSREKV TYQQLRELCV LDADTGLWLL 

      1450       1460       1470       1480       1490       1500 
PLPQGTVLEV DDHTAVALRA MKVPINMGRF QGHSVSLWDL LHSEYVGAEK RRELVALCCS 

      1510       1520       1530       1540       1550       1560 
GRAAALRQVI GMLTTLVEAA EKQPSQATFK GLRKQVSAGD LFRSQLITKQ TLDELNQGKR 

      1570       1580       1590       1600       1610       1620 
TVQEVTEMDS VRRSLEGGNF IAGVLIQDTK EKMSIPEALR RHILRPGTAL VLLEAQAATG 

      1630       1640       1650       1660       1670       1680 
FIIDPVENRK LTVEQAFQAG MFGKETYMKL LSAERAVTGY TDPYTGEQIS LFQAMQRDLI 

      1690       1700       1710       1720       1730       1740 
VRDHGIRLLE AQIATGGIID PVHSHRVPVD VAYQRGYFNE EMNRILSDPS DDTKGFFDPN 

      1750       1760       1770       1780       1790       1800 
THENLTYLQL LERCVEDPET GLYMLEIVKK GETYTYIDEA TRQALTSRTV KMYVGKFAGQ 

      1810       1820       1830       1840       1850       1860 
TVSVWDLLSS QYFTEGRRRK LLREYRAQNI GLENLLEVIT STVEETEKQS QIFKVPGIHG 

      1870       1880       1890       1900       1910       1920 
DVTAAELFNS GILNKKTLDA LRSGDRGFQD LRWLEDVRVY LEGSNYIAGV IAPLTQKVMS 

      1930       1940       1950       1960       1970       1980 
FYEASREELI PAGFAAQMLE AQAATGYLMD PCTNQRLCVD EAIAAGLVGE DLRERLVNAE 

      1990       2000       2010       2020       2030       2040 
MAAKGYKDPA TGETIPLYQA MERKLVGREE ALRLLEVQVA TGGVIDPRHH HRVPLDTACQ 

      2050       2060       2070       2080       2090       2100 
RGCMCDDSLV LIADQKHMRK RFVDPNTQEK VTYQELQDRC QREEKSGWAL FPVVKDKKDI 

      2110       2120       2130       2140       2150       2160 
EYVDEATKRA LEAEQVEVTV GRYRGQRRSV WELLNSEYVS EEKKMELVRL YKEDTTRALQ 

      2170       2180       2190       2200       2210       2220 
KVVELILQMI ADKERRSRQL WFRGLRTQVT AEELLRSEVI TKQTLEDLEE GRTTVDQIER 

      2230       2240       2250       2260       2270       2280 
KEDVKRYLKG TSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI 

      2290       2300       2310       2320       2330       2340 
IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVR 

      2350       2360       2370       2380       2390       2400 
DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD TKGFFDPNTH 

      2410       2420       2430       2440       2450       2460 
ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP GTGDFQGQSI 

      2470       2480       2490       2500       2510       2520 
SVWELLFYRE VPESLRQDLL RCYQAGGLTV HDVTTTLTSL LARAKDGSPR GDPQGALGKA 

      2530       2540       2550       2560       2570       2580 
TMEVKRGHLR GHEVPVWDIL TSNYVSRDTR KELLAQFSSG SLTLPMLKRR LTTIIEEAEE 

      2590       2600       2610       2620       2630       2640 
TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR QQQEQTLRAT TMQVHRGQFR 

      2650       2660       2670       2680       2690       2700 
DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE RLSKVSFPGL 

      2710       2720       2730       2740       2750       2760 
RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP 

      2770       2780       2790       2800       2810       2820 
GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ 

      2830       2840       2850       2860       2870       2880 
EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR LLEAQIATGG VIDPVHSHRV 

      2890       2900       2910       2920       2930       2940 
PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY LQLLRRCVRD PETGFYMLQL 

      2950       2960       2970       2980       2990       3000 
AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL RQDLLRRYQA 

      3010       3020       3030       3040       3050       3060 
GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK RGHLRGHXVP VWDILTSNYV 

      3070       3080       3090       3100       3110       3120 
SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ QDTGARGSGT 

      3130       3140       3150       3160       3170       3180 
SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS VWKVLFSSYL SETRREELLA 

      3190       3200       3210       3220       3230       3240 
QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS ASELCTSGIL DRDTMRELAQ 

      3250       3260       3270       3280       3290       3300 
GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL 

      3310       3320       3330       3340       3350       3360 
LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF 

      3370       3380       3390       3400       3410       3420 
QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD 

      3430       3440       3450       3460       3470       3480 
TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP 

      3490       3500       3510       3520       3530       3540 
GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV HDVTTTLTSL LARAKDGSPR 

      3550       3560       3570       3580       3590       3600 
XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG SLTLPMLKRR 

      3610       3620       3630       3640       3650       3660 
LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR QQQEQTLRAT 

      3670       3680       3690       3700       3710       3720 
TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE 

      3730       3740       3750       3760       3770       3780 
RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA 

      3790       3800       3810       3820       3830       3840 
GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV 

      3850       3860       3870       3880       3890       3900 
AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR LLEAQIATGG 

      3910       3920       3930       3940       3950       3960 
VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY LQLLRRCVRD 

      3970       3980       3990       4000       4010       4020 
PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL 

      4030       4040       4050       4060       4070       4080 
RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK RGHLRGHXVP 

      4090       4100       4110       4120       4130       4140 
VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ 

      4150       4160       4170       4180       4190       4200 
QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS VWKVLFSSYL 

      4210       4220       4230       4240       4250       4260 
SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS ASELCTSGIL 

      4270       4280       4290       4300       4310       4320 
DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG 

      4330       4340       4350       4360       4370       4380 
VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD 

      4390       4400       4410       4420       4430       4440 
PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM 

      4450       4460       4470       4480       4490       4500 
NSILADPGDD TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR 

      4510       4520       4530       4540       4550       4560 
RALREARVTP GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV HDVTTTLTSL 

      4570       4580       4590       4600       4610       4620 
LARAKDGSPR XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG 

      4630       4640       4650       4660       4670       4680 
SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR 

      4690       4700       4710       4720       4730       4740 
QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL 

      4750       4760       4770       4780       4790       4800 
LTQIIEETEE RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK 

      4810       4820       4830       4840       4850       4860 
RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN 

      4870       4880       4890       4900       4910       4920 
NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR 

      4930       4940       4950       4960       4970       4980 
LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY 

      4990       5000       5010       5020       5030       5040 
LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL 

      5050       5060       5070       5080       5090       5100 
LFYREVPESL RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK 

      5110       5120       5130       5140       5150       5160 
RGHLRGHXVP VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK 

      5170       5180       5190       5200       5210       5220 
PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS 

      5230       5240       5250       5260       5270       5280 
VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS 

      5290       5300       5310       5320       5330       5340 
ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK 

      5350       5360       5370       5380       5390       5400 
MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS 

      5410       5420       5430       5440       5450       5460 
AERAVTGYTD PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA 

      5470       5480       5490       5500       5510       5520 
YQRGYFDEDM NSILADPGDD TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS 

      5530       5540       5550       5560       5570       5580 
SVHHLSEELR RALREARVTP GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV 

      5590       5600       5610       5620       5630       5640 
HDVTTTLTSL LARAKDGSPR XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR 

      5650       5660       5670       5680       5690       5700 
KELLAQFSSG SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG 

      5710       5720       5730       5740       5750       5760 
DAQDSSESAR QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG 

      5770       5780       5790       5800       5810       5820 
KLGVMELVSL LTQIIEETEE RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI 

      5830       5840       5850       5860       5870       5880 
HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA 

      5890       5900       5910       5920       5930       5940 
ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR 

      5950       5960       5970       5980       5990       6000 
DLIVRDHGIR LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF 

      6010       6020       6030       6040       6050       6060 
DPNTHENLTY LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF 

      6070       6080       6090       6100       6110       6120 
QGQSISVWEL LFYREVPESL RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPREDPQG 

      6130       6140       6150       6160       6170       6180 
ALGKATMEVK RGHLRGHVVP VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII 

      6190       6200       6210       6220       6230       6240 
EEAEETQESK PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH 

      6250       6260       6270       6280       6290       6300 
RGQFRDQQVS VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV 

      6310       6320       6330       6340       6350       6360 
SFPGLRRQVS ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP 

      6370       6380       6390       6400       6410       6420 
VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV 

      6430       6440       6450       6460       6470       6480 
GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVK NHGIRLLEAQ IATGGVIDPV 

      6490       6500       6510       6520       6530       6540 
HSHRVPVDVA YQRGYFDQEM NSILADPGDD TKGFFDPNTH ENLTYLQLLQ RATIDPETGL 


LFLSLSKG 

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References

« Hide 'large scale' references
[1]"Epiplakin gene analysis in mouse reveals a single exon encoding a 725-kDa protein with expression restricted to epithelial tissues."
Spazierer D., Fuchs P., Proell V., Janda L., Oehler S., Fischer I., Hauptmann R., Wiche G.
J. Biol. Chem. 278:31657-31666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: C57BL/6J.
Tissue: Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6318-6548.
Tissue: Salivary gland.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1537; SER-2606; SER-3121; SER-3636; SER-4151; SER-4666; SER-5181; SER-5696 AND SER-6211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2705; SER-3220; SER-3735; SER-4250; SER-4765; SER-5280; SER-5795 AND SER-6310, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY312170 mRNA. Translation: AAP70316.1.
BC026387 mRNA. Translation: AAH26387.1.
RefSeqNP_659097.2. NM_144848.2.
UniGeneMm.259929.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid230168. 1 interaction.
IntActQ8R0W0. 1 interaction.
MINTMINT-1866986.

PTM databases

PhosphoSiteQ8R0W0.

Proteomic databases

MaxQBQ8R0W0.
PRIDEQ8R0W0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID223650.
KEGGmmu:223650.
UCSCuc007wio.1. mouse.

Organism-specific databases

CTD83481.
MGIMGI:2386306. Eppk1.

Phylogenomic databases

HOVERGENHBG051491.

Gene expression databases

CleanExMM_EPPK1.
GenevestigatorQ8R0W0.

Family and domain databases

Gene3D3.90.1290.10. 16 hits.
InterProIPR001101. Plectin_repeat.
[Graphical view]
PfamPF00681. Plectin. 38 hits.
[Graphical view]
SMARTSM00250. PLEC. 77 hits.
[Graphical view]
SUPFAMSSF75399. SSF75399. 16 hits.
ProtoNetSearch...

Other

NextBio376784.
PROQ8R0W0.
SOURCESearch...

Entry information

Entry nameEPIPL_MOUSE
AccessionPrimary (citable) accession number: Q8R0W0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot