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Protein

Epiplakin

Gene

Eppk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:16382146, PubMed:20926261, PubMed:18285451, PubMed:25232867, PubMed:25617501, PubMed:23599337). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:16382146, PubMed:20926261). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity (PubMed:23599337). In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption (PubMed:18285451). During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (PubMed:25232867, PubMed:25617501).6 Publications

GO - Molecular functioni

  • keratin filament binding Source: UniProtKB
  • poly(A) RNA binding Source: MGI

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • intermediate filament bundle assembly Source: UniProtKB
  • intermediate filament organization Source: UniProtKB
  • negative regulation of cell migration Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of keratinocyte migration Source: UniProtKB
  • negative regulation of keratinocyte proliferation Source: UniProtKB
  • negative regulation of wound healing Source: UniProtKB
  • positive regulation of epithelial cell proliferation involved in wound healing Source: UniProtKB
  • regulation of epithelial cell differentiation Source: UniProtKB
  • regulation of epithelium regeneration Source: UniProtKB
  • wound healing Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epiplakin1 Publication
Gene namesi
Name:Eppk1Imported
Synonyms:EPPK
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2386306. Eppk1.

Subcellular locationi

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB
  • basal part of cell Source: UniProtKB
  • cell-cell junction Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junction

Pathology & Biotechi

Disruption phenotypei

Homozygous knockout mice develop normally and are healthy and fertile. Skin of homozygous knockout mice reveal no blistering and fragility. Exhibit slightly enhanced wound closure.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781461 – 6548EpiplakinAdd BLAST6548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphothreonineBy similarity1
Modified residuei1537PhosphoserineCombined sources1
Modified residuei1551PhosphothreonineBy similarity1
Modified residuei2290PhosphoserineCombined sources1
Modified residuei2430PhosphoserineBy similarity1
Modified residuei2508PhosphoserineBy similarity1
Modified residuei2606PhosphoserineCombined sources1
Modified residuei2705PhosphoserineCombined sources1
Modified residuei2805PhosphoserineCombined sources1
Modified residuei2945PhosphoserineBy similarity1
Modified residuei3023PhosphoserineBy similarity1
Modified residuei3121PhosphoserineCombined sources1
Modified residuei3220PhosphoserineCombined sources1
Modified residuei3320PhosphoserineCombined sources1
Modified residuei3636PhosphoserineCombined sources1
Modified residuei3735PhosphoserineCombined sources1
Modified residuei3835PhosphoserineCombined sources1
Modified residuei3975PhosphoserineBy similarity1
Modified residuei4053PhosphoserineBy similarity1
Modified residuei4151PhosphoserineCombined sources1
Modified residuei4250PhosphoserineCombined sources1
Modified residuei4350PhosphoserineCombined sources1
Modified residuei4490PhosphoserineBy similarity1
Modified residuei4568PhosphoserineBy similarity1
Modified residuei4666PhosphoserineCombined sources1
Modified residuei4765PhosphoserineCombined sources1
Modified residuei4865PhosphoserineCombined sources1
Modified residuei5181PhosphoserineCombined sources1
Modified residuei5280PhosphoserineCombined sources1
Modified residuei5380PhosphoserineCombined sources1
Modified residuei5520PhosphoserineBy similarity1
Modified residuei5598PhosphoserineBy similarity1
Modified residuei5696PhosphoserineCombined sources1
Modified residuei5795PhosphoserineCombined sources1
Modified residuei5895PhosphoserineCombined sources1
Modified residuei6211PhosphoserineCombined sources1
Modified residuei6310PhosphoserineCombined sources1
Modified residuei6410PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R0W0.
PeptideAtlasiQ8R0W0.
PRIDEiQ8R0W0.

PTM databases

iPTMnetiQ8R0W0.
PhosphoSitePlusiQ8R0W0.

Expressioni

Tissue specificityi

High levels in skin, small intestine and salivary gland. Lower levels in lung, uterus and liver. Not detected in brain, kidney, muscle, heart or spleen. In skin, expressed in all epidermal layers but not in the dermis. In intestine, expressed exclusively in the epithelial cell layer of the villi. In liver, expressed at hepatocyte margins. Around the region of the wound, expressed in the upper half of the epidermis. Weakly expressed on the basilar side of the suprabasal layer of the epidermis at the wound's edge. Expressed strongly in the upper layer of the epidermis, especially in larger keratinocytes (PubMed:16382146). Expressed in undifferentiated primary keratinocytes (PubMed:18285451). Strongly expressed in ductal cells, and also expressed in acinar cells (PubMed:25232867). Expressed in hepatocytes and cholangiocytes (PubMed:25617501).5 Publications

Inductioni

Up-regulated upon calcium-mediated keratinocyte differentiation (PubMed:18285451). Up-regulated in hepatocytes during liver stress (PubMed:25617501).2 Publications

Gene expression databases

CleanExiMM_EPPK1.

Interactioni

Subunit structurei

Interacts with KRT5, KRT14 and KRT5/KRT14 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:18285451). Interacts with KRT8 and KRT18 and KRT8/KRT18 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:25617501). Interacts with KRT1, VIM and DES; interaction is stronger with KRT1 than with VIM or DES; interaction is dependent of higher-order structure of intermediate filament (By similarity).By similarity2 Publications

GO - Molecular functioni

  • keratin filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi230168. 1 interactor.
IntActiQ8R0W0. 2 interactors.
MINTiMINT-1866986.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 78Plectin 1Add BLAST38
Repeati79 – 116Plectin 2Add BLAST38
Repeati117 – 154Plectin 3Add BLAST38
Repeati155 – 192Plectin 4Add BLAST38
Repeati285 – 322Plectin 5Add BLAST38
Repeati323 – 360Plectin 6Add BLAST38
Repeati362 – 398Plectin 7Add BLAST37
Repeati399 – 436Plectin 8Add BLAST38
Repeati437 – 470Plectin 9Add BLAST34
Repeati611 – 648Plectin 10Add BLAST38
Repeati649 – 686Plectin 11Add BLAST38
Repeati687 – 724Plectin 12Add BLAST38
Repeati725 – 762Plectin 13Add BLAST38
Repeati766 – 800Plectin 14Add BLAST35
Repeati931 – 968Plectin 15Add BLAST38
Repeati969 – 1006Plectin 16Add BLAST38
Repeati1007 – 1044Plectin 17Add BLAST38
Repeati1224 – 1284Plectin 18Add BLAST61
Repeati1285 – 1322Plectin 19Add BLAST38
Repeati1323 – 1360Plectin 20Add BLAST38
Repeati1361 – 1398Plectin 21Add BLAST38
Repeati1402 – 1436Plectin 22Add BLAST35
Repeati1572 – 1609Plectin 23Add BLAST38
Repeati1610 – 1647Plectin 24Add BLAST38
Repeati1648 – 1685Plectin 25Add BLAST38
Repeati1686 – 1723Plectin 26Add BLAST38
Repeati1727 – 1761Plectin 27Add BLAST35
Repeati1898 – 1935Plectin 28Add BLAST38
Repeati1936 – 1973Plectin 29Add BLAST38
Repeati1974 – 2011Plectin 30Add BLAST38
Repeati2012 – 2049Plectin 31Add BLAST38
Repeati2225 – 2267Plectin 32Add BLAST43
Repeati2268 – 2305Plectin 33Add BLAST38
Repeati2306 – 2343Plectin 34Add BLAST38
Repeati2344 – 2381Plectin 35Add BLAST38
Repeati2385 – 2419Plectin 36Add BLAST35
Repeati2740 – 2782Plectin 37Add BLAST43
Repeati2783 – 2820Plectin 38Add BLAST38
Repeati2821 – 2858Plectin 39Add BLAST38
Repeati2859 – 2896Plectin 40Add BLAST38
Repeati2900 – 2934Plectin 41Add BLAST35
Repeati3255 – 3297Plectin 42Add BLAST43
Repeati3298 – 3335Plectin 43Add BLAST38
Repeati3336 – 3373Plectin 44Add BLAST38
Repeati3374 – 3411Plectin 45Add BLAST38
Repeati3415 – 3449Plectin 46Add BLAST35
Repeati3770 – 3812Plectin 47Add BLAST43
Repeati3813 – 3850Plectin 48Add BLAST38
Repeati3851 – 3888Plectin 49Add BLAST38
Repeati3889 – 3926Plectin 50Add BLAST38
Repeati3930 – 3964Plectin 51Add BLAST35
Repeati4285 – 4327Plectin 52Add BLAST43
Repeati4328 – 4365Plectin 53Add BLAST38
Repeati4366 – 4403Plectin 54Add BLAST38
Repeati4404 – 4441Plectin 55Add BLAST38
Repeati4445 – 4479Plectin 56Add BLAST35
Repeati4800 – 4842Plectin 57Add BLAST43
Repeati4843 – 4880Plectin 58Add BLAST38
Repeati4881 – 4918Plectin 59Add BLAST38
Repeati4919 – 4956Plectin 60Add BLAST38
Repeati4960 – 4994Plectin 61Add BLAST35
Repeati5315 – 5357Plectin 62Add BLAST43
Repeati5358 – 5395Plectin 63Add BLAST38
Repeati5396 – 5433Plectin 64Add BLAST38
Repeati5434 – 5471Plectin 65Add BLAST38
Repeati5475 – 5509Plectin 66Add BLAST35
Repeati5830 – 5872Plectin 67Add BLAST43
Repeati5873 – 5910Plectin 68Add BLAST38
Repeati5911 – 5948Plectin 69Add BLAST38
Repeati5949 – 5986Plectin 70Add BLAST38
Repeati5990 – 6024Plectin 71Add BLAST35
Repeati6345 – 6387Plectin 72Add BLAST43
Repeati6388 – 6425Plectin 73Add BLAST38
Repeati6426 – 6463Plectin 74Add BLAST38
Repeati6464 – 6501Plectin 75Add BLAST38
Repeati6505 – 6539Plectin 76Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 1123Interaction with KRT51 PublicationAdd BLAST1075
Regioni1580 – 6545Interaction with KRT51 PublicationAdd BLAST4966
Regioni2748 – 2940Interaction with KRT141 PublicationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili545 – 565Sequence analysisAdd BLAST21
Coiled coili851 – 886Sequence analysisAdd BLAST36
Coiled coili1819 – 1851Sequence analysisAdd BLAST33

Domaini

Plectin repeats are important for the binding to keratin and VIM and controls intermediate filament networks organization.By similarity

Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated
Contains 76 plectin repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG051491.
InParanoidiQ8R0W0.

Family and domain databases

Gene3Di3.90.1290.10. 16 hits.
InterProiIPR001101. Plectin_repeat.
[Graphical view]
PfamiPF00681. Plectin. 45 hits.
[Graphical view]
SMARTiSM00250. PLEC. 77 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 16 hits.

Sequencei

Sequence statusi: Complete.

Q8R0W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGQAPPHDV VVANGTEKFI VPKIKKNQLG ASTPSRPQAE AALPTTARSI
60 70 80 90 100
AGVYVEASGQ TQSIYAAIKQ GLLPTGLGLT LLEAQAATGG LVDLAQGQLL
110 120 130 140 150
PVSEALRRGL VGLELKEKLL AAERAVTGYP DPYGGEKLSL FQAIKKEVVD
160 170 180 190 200
RTLGWRLLEA QLATGGLVDP TQGVQVAPEL ACQQGLLDKE TWLSLVESEP
210 220 230 240 250
SMGTPGFSDP NTLEQLPYSV LLGRCVQDPS SGLPLLPLKT TFHTLAGAAS
260 270 280 290 300
ASMLLEAGVL NEEMVRDLQE GMLVVSDVGT RPEVRRYLEG TGGLAGVVLL
310 320 330 340 350
PGGHKKSFFQ ATVEHLVSKG IALQLLEAQA ATRTLVHPTT GQRLWVEEAV
360 370 380 390 400
KAGLVGPELH EQLLVAEQAV TGYYDPFSSS RIPVFQAMKK GLVDQPLALR
410 420 430 440 450
LLDAQLATGG LICPARRFRL PLEAALRFGC LDEETRQRLS QAMGFSDPTT
460 470 480 490 500
HDRLGYEQLL ALSVTDPETG LAFLPLPGMS HANEPQGPTF IDHCTRQALS
510 520 530 540 550
KATTSISVGR YQGRPVSLWE LLFSESVPVK KRAMLAQRHQ EGALSVEELA
560 570 580 590 600
AELKNIVEQA AATAKVTFAG LRDTVTPGEL LKAEIINQDL FEQLERGQTS
610 620 630 640 650
AQDVGSLDSV QRYLQGTGSI AGLLLPDSQE RLSIYEARSK GLLRPGTALI
660 670 680 690 700
LLEAQAATGF IIDPKENKRY SVEEALRAGV IGPDVYAKLL SAEHAVTGYT
710 720 730 740 750
DPYSGEQISL FQAMQRDLIV RDHGIRLLEA QIATGGVIDP VHSHRVPVDV
760 770 780 790 800
AYQRGYFDQI LNSILLDPSD DTKGFFDPNT HENLTYLQLL ERCVHDSETG
810 820 830 840 850
LHLLPLSSTR PQLVDSSTRQ AFQKLLLSVK YGRFRGQRVS AWELVNSEYF
860 870 880 890 900
TEDRRRQLLQ RYRQRKITLE QVTQLLEKEM RRWTDITLPA LQGQVTAYQL
910 920 930 940 950
LEAHIINQEL LDQVLTGTIS PDALLQVGDV HRYLRGSGTV GGVLLKPSNQ
960 970 980 990 1000
RISLYQAMKQ KLLPPSTALA LLEAQAATGT ITDPCSMETL SVDEAVCRGV
1010 1020 1030 1040 1050
VGAEVYGKLK RAEHSITGYR DPFSGKKVSL FRAMKKGLVP VEQATRLLEA
1060 1070 1080 1090 1100
QVSTGGVVDP TTHLHLPMPV AVQRGCIDRE MEAALSRSPE TFPTPDGRGH
1110 1120 1130 1140 1150
TSYAQLLEHC LQDKASGLHL LPLTEDAPNV PTDTQIQETL QASAGTEDGL
1160 1170 1180 1190 1200
SLWDLLTSCH FTEEQRRGYL EDVKVGKISV PQLQNTVRSW VHSAKLLARA
1210 1220 1230 1240 1250
RITVPGPRGE VPATWLRDAG IITQETLEAL AQGMQSPDEV AKQPTVKVCL
1260 1270 1280 1290 1300
WGTGCVAGVL LQPSGTKLSI AQAVRDGLLP TGLGQQLLEA QVASGFLVNP
1310 1320 1330 1340 1350
LTNQRLSVEG AVKAGLVGME QSEHLRQVEK AVTGYSDPFS GGSLSLWQAM
1360 1370 1380 1390 1400
EKGLVTQSEA FPLLQVQLAT GGVVDPVHGV HLPQEVAYKL GLLDEQTSRV
1410 1420 1430 1440 1450
LTATGKENKL FFDPNSREKV TYQQLRELCV LDADTGLWLL PLPQGTVLEV
1460 1470 1480 1490 1500
DDHTAVALRA MKVPINMGRF QGHSVSLWDL LHSEYVGAEK RRELVALCCS
1510 1520 1530 1540 1550
GRAAALRQVI GMLTTLVEAA EKQPSQATFK GLRKQVSAGD LFRSQLITKQ
1560 1570 1580 1590 1600
TLDELNQGKR TVQEVTEMDS VRRSLEGGNF IAGVLIQDTK EKMSIPEALR
1610 1620 1630 1640 1650
RHILRPGTAL VLLEAQAATG FIIDPVENRK LTVEQAFQAG MFGKETYMKL
1660 1670 1680 1690 1700
LSAERAVTGY TDPYTGEQIS LFQAMQRDLI VRDHGIRLLE AQIATGGIID
1710 1720 1730 1740 1750
PVHSHRVPVD VAYQRGYFNE EMNRILSDPS DDTKGFFDPN THENLTYLQL
1760 1770 1780 1790 1800
LERCVEDPET GLYMLEIVKK GETYTYIDEA TRQALTSRTV KMYVGKFAGQ
1810 1820 1830 1840 1850
TVSVWDLLSS QYFTEGRRRK LLREYRAQNI GLENLLEVIT STVEETEKQS
1860 1870 1880 1890 1900
QIFKVPGIHG DVTAAELFNS GILNKKTLDA LRSGDRGFQD LRWLEDVRVY
1910 1920 1930 1940 1950
LEGSNYIAGV IAPLTQKVMS FYEASREELI PAGFAAQMLE AQAATGYLMD
1960 1970 1980 1990 2000
PCTNQRLCVD EAIAAGLVGE DLRERLVNAE MAAKGYKDPA TGETIPLYQA
2010 2020 2030 2040 2050
MERKLVGREE ALRLLEVQVA TGGVIDPRHH HRVPLDTACQ RGCMCDDSLV
2060 2070 2080 2090 2100
LIADQKHMRK RFVDPNTQEK VTYQELQDRC QREEKSGWAL FPVVKDKKDI
2110 2120 2130 2140 2150
EYVDEATKRA LEAEQVEVTV GRYRGQRRSV WELLNSEYVS EEKKMELVRL
2160 2170 2180 2190 2200
YKEDTTRALQ KVVELILQMI ADKERRSRQL WFRGLRTQVT AEELLRSEVI
2210 2220 2230 2240 2250
TKQTLEDLEE GRTTVDQIER KEDVKRYLKG TSCIAGVLVP VQGEPGRQEK
2260 2270 2280 2290 2300
MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV
2310 2320 2330 2340 2350
GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ
2360 2370 2380 2390 2400
IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD TKGFFDPNTH
2410 2420 2430 2440 2450
ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP
2460 2470 2480 2490 2500
GTGDFQGQSI SVWELLFYRE VPESLRQDLL RCYQAGGLTV HDVTTTLTSL
2510 2520 2530 2540 2550
LARAKDGSPR GDPQGALGKA TMEVKRGHLR GHEVPVWDIL TSNYVSRDTR
2560 2570 2580 2590 2600
KELLAQFSSG SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA
2610 2620 2630 2640 2650
RGSGTSPDEG DAQDSSESAR QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL
2660 2670 2680 2690 2700
FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE RLSKVSFPGL
2710 2720 2730 2740 2750
RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA
2760 2770 2780 2790 2800
GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN
2810 2820 2830 2840 2850
NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR
2860 2870 2880 2890 2900
DLIVRDHGIR LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA
2910 2920 2930 2940 2950
DPGDDTKGFF DPNTHENLTY LQLLRRCVRD PETGFYMLQL AGKGSSVHHL
2960 2970 2980 2990 3000
SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL RQDLLRRYQA
3010 3020 3030 3040 3050
GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK RGHLRGHXVP
3060 3070 3080 3090 3100
VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK
3110 3120 3130 3140 3150
PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH
3160 3170 3180 3190 3200
RGQFRDQQVS VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII
3210 3220 3230 3240 3250
EETEERLSKV SFPGLRRQVS ASELCTSGIL DRDTMRELAQ GTKTIHEVTE
3260 3270 3280 3290 3300
MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL
3310 3320 3330 3340 3350
LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD
3360 3370 3380 3390 3400
PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA
3410 3420 3430 3440 3450
YQRGYFDEDM NSILADPGDD TKGFFDPNTH ENLTYLQLLR RCVRDPETGF
3460 3470 3480 3490 3500
YMLQLAGKGS SVHHLSEELR RALREARVTP GTGDFQGQSI SVWELLFYRE
3510 3520 3530 3540 3550
VPESLRQDLL RRYQAGGLTV HDVTTTLTSL LARAKDGSPR XDPQGALGKA
3560 3570 3580 3590 3600
TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG SLTLPMLKRR
3610 3620 3630 3640 3650
LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR
3660 3670 3680 3690 3700
QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG
3710 3720 3730 3740 3750
KLGVMELVSL LTQIIEETEE RLSKVSFPGL RRQVSASELC TSGILDRDTM
3760 3770 3780 3790 3800
RELAQGTKTI HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ
3810 3820 3830 3840 3850
AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ
3860 3870 3880 3890 3900
EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR LLEAQIATGG
3910 3920 3930 3940 3950
VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY
3960 3970 3980 3990 4000
LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF
4010 4020 4030 4040 4050
QGQSISVWEL LFYREVPESL RQDLLRRYQA GGLTVHDVTT TLTSLLARAK
4060 4070 4080 4090 4100
DGSPRXDPQG ALGKATMEVK RGHLRGHXVP VWDILTSNYV SRDTRKELLA
4110 4120 4130 4140 4150
QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ QDTGARGSGT
4160 4170 4180 4190 4200
SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS VWKVLFSSYL
4210 4220 4230 4240 4250
SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS
4260 4270 4280 4290 4300
ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP
4310 4320 4330 4340 4350
VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS
4360 4370 4380 4390 4400
VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVR
4410 4420 4430 4440 4450
DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD
4460 4470 4480 4490 4500
TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR
4510 4520 4530 4540 4550
RALREARVTP GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV
4560 4570 4580 4590 4600
HDVTTTLTSL LARAKDGSPR XDPQGALGKA TMEVKRGHLR GHXVPVWDIL
4610 4620 4630 4640 4650
TSNYVSRDTR KELLAQFSSG SLTLPMLKRR LTTIIEEAEE TQESKPKPRD
4660 4670 4680 4690 4700
ASLKQQDTGA RGSGTSPDEG DAQDSSESAR QQQEQTLRAT TMQVHRGQFR
4710 4720 4730 4740 4750
DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE
4760 4770 4780 4790 4800
RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK
4810 4820 4830 4840 4850
RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA
4860 4870 4880 4890 4900
ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD
4910 4920 4930 4940 4950
QISLFQAMQR DLIVRDHGIR LLEAQIATGG VIDPVHSHRV PVDVAYQRGY
4960 4970 4980 4990 5000
FDEDMNSILA DPGDDTKGFF DPNTHENLTY LQLLRRCVRD PETGFYMLQL
5010 5020 5030 5040 5050
AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL
5060 5070 5080 5090 5100
RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK
5110 5120 5130 5140 5150
RGHLRGHXVP VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII
5160 5170 5180 5190 5200
EEAEETQESK PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ
5210 5220 5230 5240 5250
TLRATTMQVH RGQFRDQQVS VWKVLFSSYL SETRREELLA QHLAGKLGVM
5260 5270 5280 5290 5300
ELVSLLTQII EETEERLSKV SFPGLRRQVS ASELCTSGIL DRDTMRELAQ
5310 5320 5330 5340 5350
GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG
5360 5370 5380 5390 5400
VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS
5410 5420 5430 5440 5450
AERAVTGYTD PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV
5460 5470 5480 5490 5500
HSHRVPVDVA YQRGYFDEDM NSILADPGDD TKGFFDPNTH ENLTYLQLLR
5510 5520 5530 5540 5550
RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP GTGDFQGQSI
5560 5570 5580 5590 5600
SVWELLFYRE VPESLRQDLL RRYQAGGLTV HDVTTTLTSL LARAKDGSPR
5610 5620 5630 5640 5650
XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG
5660 5670 5680 5690 5700
SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG
5710 5720 5730 5740 5750
DAQDSSESAR QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR
5760 5770 5780 5790 5800
EELLAQHLAG KLGVMELVSL LTQIIEETEE RLSKVSFPGL RRQVSASELC
5810 5820 5830 5840 5850
TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP
5860 5870 5880 5890 5900
GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV
5910 5920 5930 5940 5950
AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR
5960 5970 5980 5990 6000
LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF
6010 6020 6030 6040 6050
DPNTHENLTY LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE
6060 6070 6080 6090 6100
ARVTPGTGDF QGQSISVWEL LFYREVPESL RQDLLRRYQA GGLTVHDVTT
6110 6120 6130 6140 6150
TLTSLLARAK DGSPREDPQG ALGKATMEVK RGHLRGHVVP VWDILTSNYV
6160 6170 6180 6190 6200
SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ
6210 6220 6230 6240 6250
QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS
6260 6270 6280 6290 6300
VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV
6310 6320 6330 6340 6350
SFPGLRRQVS ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG
6360 6370 6380 6390 6400
SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI
6410 6420 6430 6440 6450
IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF
6460 6470 6480 6490 6500
QAMQRDLIVK NHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDQEM
6510 6520 6530 6540
NSILADPGDD TKGFFDPNTH ENLTYLQLLQ RATIDPETGL LFLSLSKG
Length:6,548
Mass (Da):724,646
Last modified:August 15, 2003 - v2
Checksum:i9162C07AFCA157B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY312170 mRNA. Translation: AAP70316.1.
BC026387 mRNA. Translation: AAH26387.1.
RefSeqiNP_659097.2. NM_144848.2.
UniGeneiMm.259929.

Genome annotation databases

GeneIDi223650.
KEGGimmu:223650.
UCSCiuc007wio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY312170 mRNA. Translation: AAP70316.1.
BC026387 mRNA. Translation: AAH26387.1.
RefSeqiNP_659097.2. NM_144848.2.
UniGeneiMm.259929.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230168. 1 interactor.
IntActiQ8R0W0. 2 interactors.
MINTiMINT-1866986.

PTM databases

iPTMnetiQ8R0W0.
PhosphoSitePlusiQ8R0W0.

Proteomic databases

MaxQBiQ8R0W0.
PeptideAtlasiQ8R0W0.
PRIDEiQ8R0W0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi223650.
KEGGimmu:223650.
UCSCiuc007wio.1. mouse.

Organism-specific databases

CTDi83481.
MGIiMGI:2386306. Eppk1.

Phylogenomic databases

HOVERGENiHBG051491.
InParanoidiQ8R0W0.

Miscellaneous databases

PROiQ8R0W0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_EPPK1.

Family and domain databases

Gene3Di3.90.1290.10. 16 hits.
InterProiIPR001101. Plectin_repeat.
[Graphical view]
PfamiPF00681. Plectin. 45 hits.
[Graphical view]
SMARTiSM00250. PLEC. 77 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 16 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiEPIPL_MOUSE
AccessioniPrimary (citable) accession number: Q8R0W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.