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Q8R0W0

- EPIPL_MOUSE

UniProt

Q8R0W0 - EPIPL_MOUSE

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Protein

Epiplakin

Gene

Eppk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Epiplakin
Gene namesi
Name:Eppk1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2386306. Eppk1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 65486548EpiplakinPRO_0000078146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1537 – 15371Phosphoserine1 Publication
Modified residuei2430 – 24301PhosphoserineBy similarity
Modified residuei2508 – 25081PhosphoserineBy similarity
Modified residuei2606 – 26061Phosphoserine1 Publication
Modified residuei2705 – 27051Phosphoserine1 Publication
Modified residuei2707 – 27071PhosphoserineBy similarity
Modified residuei2945 – 29451PhosphoserineBy similarity
Modified residuei3023 – 30231PhosphoserineBy similarity
Modified residuei3121 – 31211Phosphoserine1 Publication
Modified residuei3220 – 32201Phosphoserine1 Publication
Modified residuei3636 – 36361Phosphoserine1 Publication
Modified residuei3735 – 37351Phosphoserine1 Publication
Modified residuei3737 – 37371PhosphoserineBy similarity
Modified residuei3975 – 39751PhosphoserineBy similarity
Modified residuei4053 – 40531PhosphoserineBy similarity
Modified residuei4151 – 41511Phosphoserine1 Publication
Modified residuei4250 – 42501Phosphoserine1 Publication
Modified residuei4252 – 42521PhosphoserineBy similarity
Modified residuei4490 – 44901PhosphoserineBy similarity
Modified residuei4568 – 45681PhosphoserineBy similarity
Modified residuei4666 – 46661Phosphoserine1 Publication
Modified residuei4765 – 47651Phosphoserine1 Publication
Modified residuei5181 – 51811Phosphoserine1 Publication
Modified residuei5280 – 52801Phosphoserine1 Publication
Modified residuei5282 – 52821PhosphoserineBy similarity
Modified residuei5520 – 55201PhosphoserineBy similarity
Modified residuei5598 – 55981PhosphoserineBy similarity
Modified residuei5696 – 56961Phosphoserine1 Publication
Modified residuei5795 – 57951Phosphoserine1 Publication
Modified residuei6211 – 62111Phosphoserine1 Publication
Modified residuei6310 – 63101Phosphoserine1 Publication
Modified residuei6312 – 63121PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R0W0.
PRIDEiQ8R0W0.

PTM databases

PhosphoSiteiQ8R0W0.

Expressioni

Tissue specificityi

High levels in skin, small intestine and salivary gland. Lower levels in lung, uterus and liver. Not detected in brain, kidney, muscle, heart or spleen. In skin, expressed in all epidermal layers but not in the dermis. In intestine, expressed exclusively in the epithelial cell layer of the villi. In liver, expressed at hepatocyte margins.1 Publication

Gene expression databases

CleanExiMM_EPPK1.
GenevestigatoriQ8R0W0.

Interactioni

Protein-protein interaction databases

BioGridi230168. 1 interaction.
IntActiQ8R0W0. 1 interaction.
MINTiMINT-1866986.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 7838Plectin 1Add
BLAST
Repeati79 – 11638Plectin 2Add
BLAST
Repeati117 – 15438Plectin 3Add
BLAST
Repeati155 – 19238Plectin 4Add
BLAST
Repeati285 – 32238Plectin 5Add
BLAST
Repeati323 – 36038Plectin 6Add
BLAST
Repeati362 – 39837Plectin 7Add
BLAST
Repeati399 – 43638Plectin 8Add
BLAST
Repeati437 – 47034Plectin 9Add
BLAST
Repeati611 – 64838Plectin 10Add
BLAST
Repeati649 – 68638Plectin 11Add
BLAST
Repeati687 – 72438Plectin 12Add
BLAST
Repeati725 – 76238Plectin 13Add
BLAST
Repeati766 – 80035Plectin 14Add
BLAST
Repeati931 – 96838Plectin 15Add
BLAST
Repeati969 – 100638Plectin 16Add
BLAST
Repeati1007 – 104438Plectin 17Add
BLAST
Repeati1224 – 128461Plectin 18Add
BLAST
Repeati1285 – 132238Plectin 19Add
BLAST
Repeati1323 – 136038Plectin 20Add
BLAST
Repeati1361 – 139838Plectin 21Add
BLAST
Repeati1402 – 143635Plectin 22Add
BLAST
Repeati1572 – 160938Plectin 23Add
BLAST
Repeati1610 – 164738Plectin 24Add
BLAST
Repeati1648 – 168538Plectin 25Add
BLAST
Repeati1686 – 172338Plectin 26Add
BLAST
Repeati1727 – 176135Plectin 27Add
BLAST
Repeati1898 – 193538Plectin 28Add
BLAST
Repeati1936 – 197338Plectin 29Add
BLAST
Repeati1974 – 201138Plectin 30Add
BLAST
Repeati2012 – 204938Plectin 31Add
BLAST
Repeati2225 – 226743Plectin 32Add
BLAST
Repeati2268 – 230538Plectin 33Add
BLAST
Repeati2306 – 234338Plectin 34Add
BLAST
Repeati2344 – 238138Plectin 35Add
BLAST
Repeati2385 – 241935Plectin 36Add
BLAST
Repeati2740 – 278243Plectin 37Add
BLAST
Repeati2783 – 282038Plectin 38Add
BLAST
Repeati2821 – 285838Plectin 39Add
BLAST
Repeati2859 – 289638Plectin 40Add
BLAST
Repeati2900 – 293435Plectin 41Add
BLAST
Repeati3255 – 329743Plectin 42Add
BLAST
Repeati3298 – 333538Plectin 43Add
BLAST
Repeati3336 – 337338Plectin 44Add
BLAST
Repeati3374 – 341138Plectin 45Add
BLAST
Repeati3415 – 344935Plectin 46Add
BLAST
Repeati3770 – 381243Plectin 47Add
BLAST
Repeati3813 – 385038Plectin 48Add
BLAST
Repeati3851 – 388838Plectin 49Add
BLAST
Repeati3889 – 392638Plectin 50Add
BLAST
Repeati3930 – 396435Plectin 51Add
BLAST
Repeati4285 – 432743Plectin 52Add
BLAST
Repeati4328 – 436538Plectin 53Add
BLAST
Repeati4366 – 440338Plectin 54Add
BLAST
Repeati4404 – 444138Plectin 55Add
BLAST
Repeati4445 – 447935Plectin 56Add
BLAST
Repeati4800 – 484243Plectin 57Add
BLAST
Repeati4843 – 488038Plectin 58Add
BLAST
Repeati4881 – 491838Plectin 59Add
BLAST
Repeati4919 – 495638Plectin 60Add
BLAST
Repeati4960 – 499435Plectin 61Add
BLAST
Repeati5315 – 535743Plectin 62Add
BLAST
Repeati5358 – 539538Plectin 63Add
BLAST
Repeati5396 – 543338Plectin 64Add
BLAST
Repeati5434 – 547138Plectin 65Add
BLAST
Repeati5475 – 550935Plectin 66Add
BLAST
Repeati5830 – 587243Plectin 67Add
BLAST
Repeati5873 – 591038Plectin 68Add
BLAST
Repeati5911 – 594838Plectin 69Add
BLAST
Repeati5949 – 598638Plectin 70Add
BLAST
Repeati5990 – 602435Plectin 71Add
BLAST
Repeati6345 – 638743Plectin 72Add
BLAST
Repeati6388 – 642538Plectin 73Add
BLAST
Repeati6426 – 646338Plectin 74Add
BLAST
Repeati6464 – 650138Plectin 75Add
BLAST
Repeati6505 – 653935Plectin 76Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili545 – 56521Sequence AnalysisAdd
BLAST
Coiled coili851 – 88636Sequence AnalysisAdd
BLAST
Coiled coili1819 – 185133Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated
Contains 76 plectin repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG051491.
InParanoidiQ8R0W0.

Family and domain databases

Gene3Di3.90.1290.10. 16 hits.
InterProiIPR001101. Plectin_repeat.
[Graphical view]
PfamiPF00681. Plectin. 38 hits.
[Graphical view]
SMARTiSM00250. PLEC. 77 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 16 hits.

Sequencei

Sequence statusi: Complete.

Q8R0W0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNGQAPPHDV VVANGTEKFI VPKIKKNQLG ASTPSRPQAE AALPTTARSI
60 70 80 90 100
AGVYVEASGQ TQSIYAAIKQ GLLPTGLGLT LLEAQAATGG LVDLAQGQLL
110 120 130 140 150
PVSEALRRGL VGLELKEKLL AAERAVTGYP DPYGGEKLSL FQAIKKEVVD
160 170 180 190 200
RTLGWRLLEA QLATGGLVDP TQGVQVAPEL ACQQGLLDKE TWLSLVESEP
210 220 230 240 250
SMGTPGFSDP NTLEQLPYSV LLGRCVQDPS SGLPLLPLKT TFHTLAGAAS
260 270 280 290 300
ASMLLEAGVL NEEMVRDLQE GMLVVSDVGT RPEVRRYLEG TGGLAGVVLL
310 320 330 340 350
PGGHKKSFFQ ATVEHLVSKG IALQLLEAQA ATRTLVHPTT GQRLWVEEAV
360 370 380 390 400
KAGLVGPELH EQLLVAEQAV TGYYDPFSSS RIPVFQAMKK GLVDQPLALR
410 420 430 440 450
LLDAQLATGG LICPARRFRL PLEAALRFGC LDEETRQRLS QAMGFSDPTT
460 470 480 490 500
HDRLGYEQLL ALSVTDPETG LAFLPLPGMS HANEPQGPTF IDHCTRQALS
510 520 530 540 550
KATTSISVGR YQGRPVSLWE LLFSESVPVK KRAMLAQRHQ EGALSVEELA
560 570 580 590 600
AELKNIVEQA AATAKVTFAG LRDTVTPGEL LKAEIINQDL FEQLERGQTS
610 620 630 640 650
AQDVGSLDSV QRYLQGTGSI AGLLLPDSQE RLSIYEARSK GLLRPGTALI
660 670 680 690 700
LLEAQAATGF IIDPKENKRY SVEEALRAGV IGPDVYAKLL SAEHAVTGYT
710 720 730 740 750
DPYSGEQISL FQAMQRDLIV RDHGIRLLEA QIATGGVIDP VHSHRVPVDV
760 770 780 790 800
AYQRGYFDQI LNSILLDPSD DTKGFFDPNT HENLTYLQLL ERCVHDSETG
810 820 830 840 850
LHLLPLSSTR PQLVDSSTRQ AFQKLLLSVK YGRFRGQRVS AWELVNSEYF
860 870 880 890 900
TEDRRRQLLQ RYRQRKITLE QVTQLLEKEM RRWTDITLPA LQGQVTAYQL
910 920 930 940 950
LEAHIINQEL LDQVLTGTIS PDALLQVGDV HRYLRGSGTV GGVLLKPSNQ
960 970 980 990 1000
RISLYQAMKQ KLLPPSTALA LLEAQAATGT ITDPCSMETL SVDEAVCRGV
1010 1020 1030 1040 1050
VGAEVYGKLK RAEHSITGYR DPFSGKKVSL FRAMKKGLVP VEQATRLLEA
1060 1070 1080 1090 1100
QVSTGGVVDP TTHLHLPMPV AVQRGCIDRE MEAALSRSPE TFPTPDGRGH
1110 1120 1130 1140 1150
TSYAQLLEHC LQDKASGLHL LPLTEDAPNV PTDTQIQETL QASAGTEDGL
1160 1170 1180 1190 1200
SLWDLLTSCH FTEEQRRGYL EDVKVGKISV PQLQNTVRSW VHSAKLLARA
1210 1220 1230 1240 1250
RITVPGPRGE VPATWLRDAG IITQETLEAL AQGMQSPDEV AKQPTVKVCL
1260 1270 1280 1290 1300
WGTGCVAGVL LQPSGTKLSI AQAVRDGLLP TGLGQQLLEA QVASGFLVNP
1310 1320 1330 1340 1350
LTNQRLSVEG AVKAGLVGME QSEHLRQVEK AVTGYSDPFS GGSLSLWQAM
1360 1370 1380 1390 1400
EKGLVTQSEA FPLLQVQLAT GGVVDPVHGV HLPQEVAYKL GLLDEQTSRV
1410 1420 1430 1440 1450
LTATGKENKL FFDPNSREKV TYQQLRELCV LDADTGLWLL PLPQGTVLEV
1460 1470 1480 1490 1500
DDHTAVALRA MKVPINMGRF QGHSVSLWDL LHSEYVGAEK RRELVALCCS
1510 1520 1530 1540 1550
GRAAALRQVI GMLTTLVEAA EKQPSQATFK GLRKQVSAGD LFRSQLITKQ
1560 1570 1580 1590 1600
TLDELNQGKR TVQEVTEMDS VRRSLEGGNF IAGVLIQDTK EKMSIPEALR
1610 1620 1630 1640 1650
RHILRPGTAL VLLEAQAATG FIIDPVENRK LTVEQAFQAG MFGKETYMKL
1660 1670 1680 1690 1700
LSAERAVTGY TDPYTGEQIS LFQAMQRDLI VRDHGIRLLE AQIATGGIID
1710 1720 1730 1740 1750
PVHSHRVPVD VAYQRGYFNE EMNRILSDPS DDTKGFFDPN THENLTYLQL
1760 1770 1780 1790 1800
LERCVEDPET GLYMLEIVKK GETYTYIDEA TRQALTSRTV KMYVGKFAGQ
1810 1820 1830 1840 1850
TVSVWDLLSS QYFTEGRRRK LLREYRAQNI GLENLLEVIT STVEETEKQS
1860 1870 1880 1890 1900
QIFKVPGIHG DVTAAELFNS GILNKKTLDA LRSGDRGFQD LRWLEDVRVY
1910 1920 1930 1940 1950
LEGSNYIAGV IAPLTQKVMS FYEASREELI PAGFAAQMLE AQAATGYLMD
1960 1970 1980 1990 2000
PCTNQRLCVD EAIAAGLVGE DLRERLVNAE MAAKGYKDPA TGETIPLYQA
2010 2020 2030 2040 2050
MERKLVGREE ALRLLEVQVA TGGVIDPRHH HRVPLDTACQ RGCMCDDSLV
2060 2070 2080 2090 2100
LIADQKHMRK RFVDPNTQEK VTYQELQDRC QREEKSGWAL FPVVKDKKDI
2110 2120 2130 2140 2150
EYVDEATKRA LEAEQVEVTV GRYRGQRRSV WELLNSEYVS EEKKMELVRL
2160 2170 2180 2190 2200
YKEDTTRALQ KVVELILQMI ADKERRSRQL WFRGLRTQVT AEELLRSEVI
2210 2220 2230 2240 2250
TKQTLEDLEE GRTTVDQIER KEDVKRYLKG TSCIAGVLVP VQGEPGRQEK
2260 2270 2280 2290 2300
MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV
2310 2320 2330 2340 2350
GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ
2360 2370 2380 2390 2400
IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD TKGFFDPNTH
2410 2420 2430 2440 2450
ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP
2460 2470 2480 2490 2500
GTGDFQGQSI SVWELLFYRE VPESLRQDLL RCYQAGGLTV HDVTTTLTSL
2510 2520 2530 2540 2550
LARAKDGSPR GDPQGALGKA TMEVKRGHLR GHEVPVWDIL TSNYVSRDTR
2560 2570 2580 2590 2600
KELLAQFSSG SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA
2610 2620 2630 2640 2650
RGSGTSPDEG DAQDSSESAR QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL
2660 2670 2680 2690 2700
FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE RLSKVSFPGL
2710 2720 2730 2740 2750
RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA
2760 2770 2780 2790 2800
GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN
2810 2820 2830 2840 2850
NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR
2860 2870 2880 2890 2900
DLIVRDHGIR LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA
2910 2920 2930 2940 2950
DPGDDTKGFF DPNTHENLTY LQLLRRCVRD PETGFYMLQL AGKGSSVHHL
2960 2970 2980 2990 3000
SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL RQDLLRRYQA
3010 3020 3030 3040 3050
GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK RGHLRGHXVP
3060 3070 3080 3090 3100
VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK
3110 3120 3130 3140 3150
PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH
3160 3170 3180 3190 3200
RGQFRDQQVS VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII
3210 3220 3230 3240 3250
EETEERLSKV SFPGLRRQVS ASELCTSGIL DRDTMRELAQ GTKTIHEVTE
3260 3270 3280 3290 3300
MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL
3310 3320 3330 3340 3350
LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD
3360 3370 3380 3390 3400
PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA
3410 3420 3430 3440 3450
YQRGYFDEDM NSILADPGDD TKGFFDPNTH ENLTYLQLLR RCVRDPETGF
3460 3470 3480 3490 3500
YMLQLAGKGS SVHHLSEELR RALREARVTP GTGDFQGQSI SVWELLFYRE
3510 3520 3530 3540 3550
VPESLRQDLL RRYQAGGLTV HDVTTTLTSL LARAKDGSPR XDPQGALGKA
3560 3570 3580 3590 3600
TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG SLTLPMLKRR
3610 3620 3630 3640 3650
LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR
3660 3670 3680 3690 3700
QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG
3710 3720 3730 3740 3750
KLGVMELVSL LTQIIEETEE RLSKVSFPGL RRQVSASELC TSGILDRDTM
3760 3770 3780 3790 3800
RELAQGTKTI HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ
3810 3820 3830 3840 3850
AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ
3860 3870 3880 3890 3900
EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR LLEAQIATGG
3910 3920 3930 3940 3950
VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY
3960 3970 3980 3990 4000
LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF
4010 4020 4030 4040 4050
QGQSISVWEL LFYREVPESL RQDLLRRYQA GGLTVHDVTT TLTSLLARAK
4060 4070 4080 4090 4100
DGSPRXDPQG ALGKATMEVK RGHLRGHXVP VWDILTSNYV SRDTRKELLA
4110 4120 4130 4140 4150
QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ QDTGARGSGT
4160 4170 4180 4190 4200
SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS VWKVLFSSYL
4210 4220 4230 4240 4250
SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS
4260 4270 4280 4290 4300
ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP
4310 4320 4330 4340 4350
VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS
4360 4370 4380 4390 4400
VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVR
4410 4420 4430 4440 4450
DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD
4460 4470 4480 4490 4500
TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR
4510 4520 4530 4540 4550
RALREARVTP GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV
4560 4570 4580 4590 4600
HDVTTTLTSL LARAKDGSPR XDPQGALGKA TMEVKRGHLR GHXVPVWDIL
4610 4620 4630 4640 4650
TSNYVSRDTR KELLAQFSSG SLTLPMLKRR LTTIIEEAEE TQESKPKPRD
4660 4670 4680 4690 4700
ASLKQQDTGA RGSGTSPDEG DAQDSSESAR QQQEQTLRAT TMQVHRGQFR
4710 4720 4730 4740 4750
DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE
4760 4770 4780 4790 4800
RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK
4810 4820 4830 4840 4850
RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA
4860 4870 4880 4890 4900
ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD
4910 4920 4930 4940 4950
QISLFQAMQR DLIVRDHGIR LLEAQIATGG VIDPVHSHRV PVDVAYQRGY
4960 4970 4980 4990 5000
FDEDMNSILA DPGDDTKGFF DPNTHENLTY LQLLRRCVRD PETGFYMLQL
5010 5020 5030 5040 5050
AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL
5060 5070 5080 5090 5100
RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK
5110 5120 5130 5140 5150
RGHLRGHXVP VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII
5160 5170 5180 5190 5200
EEAEETQESK PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ
5210 5220 5230 5240 5250
TLRATTMQVH RGQFRDQQVS VWKVLFSSYL SETRREELLA QHLAGKLGVM
5260 5270 5280 5290 5300
ELVSLLTQII EETEERLSKV SFPGLRRQVS ASELCTSGIL DRDTMRELAQ
5310 5320 5330 5340 5350
GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG
5360 5370 5380 5390 5400
VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS
5410 5420 5430 5440 5450
AERAVTGYTD PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV
5460 5470 5480 5490 5500
HSHRVPVDVA YQRGYFDEDM NSILADPGDD TKGFFDPNTH ENLTYLQLLR
5510 5520 5530 5540 5550
RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP GTGDFQGQSI
5560 5570 5580 5590 5600
SVWELLFYRE VPESLRQDLL RRYQAGGLTV HDVTTTLTSL LARAKDGSPR
5610 5620 5630 5640 5650
XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG
5660 5670 5680 5690 5700
SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG
5710 5720 5730 5740 5750
DAQDSSESAR QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR
5760 5770 5780 5790 5800
EELLAQHLAG KLGVMELVSL LTQIIEETEE RLSKVSFPGL RRQVSASELC
5810 5820 5830 5840 5850
TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP
5860 5870 5880 5890 5900
GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV
5910 5920 5930 5940 5950
AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR
5960 5970 5980 5990 6000
LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF
6010 6020 6030 6040 6050
DPNTHENLTY LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE
6060 6070 6080 6090 6100
ARVTPGTGDF QGQSISVWEL LFYREVPESL RQDLLRRYQA GGLTVHDVTT
6110 6120 6130 6140 6150
TLTSLLARAK DGSPREDPQG ALGKATMEVK RGHLRGHVVP VWDILTSNYV
6160 6170 6180 6190 6200
SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ
6210 6220 6230 6240 6250
QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS
6260 6270 6280 6290 6300
VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV
6310 6320 6330 6340 6350
SFPGLRRQVS ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG
6360 6370 6380 6390 6400
SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI
6410 6420 6430 6440 6450
IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF
6460 6470 6480 6490 6500
QAMQRDLIVK NHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDQEM
6510 6520 6530 6540
NSILADPGDD TKGFFDPNTH ENLTYLQLLQ RATIDPETGL LFLSLSKG
Length:6,548
Mass (Da):724,646
Last modified:August 15, 2003 - v2
Checksum:i9162C07AFCA157B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY312170 mRNA. Translation: AAP70316.1.
BC026387 mRNA. Translation: AAH26387.1.
RefSeqiNP_659097.2. NM_144848.2.
UniGeneiMm.259929.

Genome annotation databases

GeneIDi223650.
KEGGimmu:223650.
UCSCiuc007wio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY312170 mRNA. Translation: AAP70316.1 .
BC026387 mRNA. Translation: AAH26387.1 .
RefSeqi NP_659097.2. NM_144848.2.
UniGenei Mm.259929.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230168. 1 interaction.
IntActi Q8R0W0. 1 interaction.
MINTi MINT-1866986.

PTM databases

PhosphoSitei Q8R0W0.

Proteomic databases

MaxQBi Q8R0W0.
PRIDEi Q8R0W0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 223650.
KEGGi mmu:223650.
UCSCi uc007wio.1. mouse.

Organism-specific databases

CTDi 83481.
MGIi MGI:2386306. Eppk1.

Phylogenomic databases

HOVERGENi HBG051491.
InParanoidi Q8R0W0.

Miscellaneous databases

NextBioi 376784.
PROi Q8R0W0.
SOURCEi Search...

Gene expression databases

CleanExi MM_EPPK1.
Genevestigatori Q8R0W0.

Family and domain databases

Gene3Di 3.90.1290.10. 16 hits.
InterProi IPR001101. Plectin_repeat.
[Graphical view ]
Pfami PF00681. Plectin. 38 hits.
[Graphical view ]
SMARTi SM00250. PLEC. 77 hits.
[Graphical view ]
SUPFAMi SSF75399. SSF75399. 16 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epiplakin gene analysis in mouse reveals a single exon encoding a 725-kDa protein with expression restricted to epithelial tissues."
    Spazierer D., Fuchs P., Proell V., Janda L., Oehler S., Fischer I., Hauptmann R., Wiche G.
    J. Biol. Chem. 278:31657-31666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6JImported.
    Tissue: Skin1 Publication.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6318-6548.
    Tissue: Salivary glandImported.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1537; SER-2606; SER-3121; SER-3636; SER-4151; SER-4666; SER-5181; SER-5696 AND SER-6211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2705; SER-3220; SER-3735; SER-4250; SER-4765; SER-5280; SER-5795 AND SER-6310, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiEPIPL_MOUSE
AccessioniPrimary (citable) accession number: Q8R0W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3