Q8R0W0 (EPIPL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Epiplakin

Gene names

Name:

Eppk1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	6548 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	High levels in skin, small intestine and salivary gland. Lower levels in lung, uterus and liver. Not detected in brain, kidney, muscle, heart or spleen. In skin, expressed in all epidermal layers but not in the dermis. In intestine, expressed exclusively in the epithelial cell layer of the villi. In liver, expressed at hepatocyte margins. Ref.1
Sequence similarities	Belongs to the plakin or cytolinker family. Contains 76 plectin repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: MGI cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 6548	6548	Epiplakin		PRO_0000078146
Regions
	Repeat	41 – 78	38	Plectin 1
	Repeat	79 – 116	38	Plectin 2
	Repeat	117 – 154	38	Plectin 3
	Repeat	155 – 192	38	Plectin 4
	Repeat	285 – 322	38	Plectin 5
	Repeat	323 – 360	38	Plectin 6
	Repeat	362 – 398	37	Plectin 7
	Repeat	399 – 436	38	Plectin 8
	Repeat	437 – 470	34	Plectin 9
	Repeat	611 – 648	38	Plectin 10
	Repeat	649 – 686	38	Plectin 11
	Repeat	687 – 724	38	Plectin 12
	Repeat	725 – 762	38	Plectin 13
	Repeat	766 – 800	35	Plectin 14
	Repeat	931 – 968	38	Plectin 15
	Repeat	969 – 1006	38	Plectin 16
	Repeat	1007 – 1044	38	Plectin 17
	Repeat	1224 – 1284	61	Plectin 18
	Repeat	1285 – 1322	38	Plectin 19
	Repeat	1323 – 1360	38	Plectin 20
	Repeat	1361 – 1398	38	Plectin 21
	Repeat	1402 – 1436	35	Plectin 22
	Repeat	1572 – 1609	38	Plectin 23
	Repeat	1610 – 1647	38	Plectin 24
	Repeat	1648 – 1685	38	Plectin 25
	Repeat	1686 – 1723	38	Plectin 26
	Repeat	1727 – 1761	35	Plectin 27
	Repeat	1898 – 1935	38	Plectin 28
	Repeat	1936 – 1973	38	Plectin 29
	Repeat	1974 – 2011	38	Plectin 30
	Repeat	2012 – 2049	38	Plectin 31
	Repeat	2225 – 2267	43	Plectin 32
	Repeat	2268 – 2305	38	Plectin 33
	Repeat	2306 – 2343	38	Plectin 34
	Repeat	2344 – 2381	38	Plectin 35
	Repeat	2385 – 2419	35	Plectin 36
	Repeat	2740 – 2782	43	Plectin 37
	Repeat	2783 – 2820	38	Plectin 38
	Repeat	2821 – 2858	38	Plectin 39
	Repeat	2859 – 2896	38	Plectin 40
	Repeat	2900 – 2934	35	Plectin 41
	Repeat	3255 – 3297	43	Plectin 42
	Repeat	3298 – 3335	38	Plectin 43
	Repeat	3336 – 3373	38	Plectin 44
	Repeat	3374 – 3411	38	Plectin 45
	Repeat	3415 – 3449	35	Plectin 46
	Repeat	3770 – 3812	43	Plectin 47
	Repeat	3813 – 3850	38	Plectin 48
	Repeat	3851 – 3888	38	Plectin 49
	Repeat	3889 – 3926	38	Plectin 50
	Repeat	3930 – 3964	35	Plectin 51
	Repeat	4285 – 4327	43	Plectin 52
	Repeat	4328 – 4365	38	Plectin 53
	Repeat	4366 – 4403	38	Plectin 54
	Repeat	4404 – 4441	38	Plectin 55
	Repeat	4445 – 4479	35	Plectin 56
	Repeat	4800 – 4842	43	Plectin 57
	Repeat	4843 – 4880	38	Plectin 58
	Repeat	4881 – 4918	38	Plectin 59
	Repeat	4919 – 4956	38	Plectin 60
	Repeat	4960 – 4994	35	Plectin 61
	Repeat	5315 – 5357	43	Plectin 62
	Repeat	5358 – 5395	38	Plectin 63
	Repeat	5396 – 5433	38	Plectin 64
	Repeat	5434 – 5471	38	Plectin 65
	Repeat	5475 – 5509	35	Plectin 66
	Repeat	5830 – 5872	43	Plectin 67
	Repeat	5873 – 5910	38	Plectin 68
	Repeat	5911 – 5948	38	Plectin 69
	Repeat	5949 – 5986	38	Plectin 70
	Repeat	5990 – 6024	35	Plectin 71
	Repeat	6345 – 6387	43	Plectin 72
	Repeat	6388 – 6425	38	Plectin 73
	Repeat	6426 – 6463	38	Plectin 74
	Repeat	6464 – 6501	38	Plectin 75
	Repeat	6505 – 6539	35	Plectin 76
	Coiled coil	545 – 565	21	Potential
	Coiled coil	851 – 886	36	Potential
	Coiled coil	1819 – 1851	33	Potential
Amino acid modifications
	Modified residue	2430	1	Phosphoserine By similarity
	Modified residue	2508	1	Phosphoserine By similarity
	Modified residue	2705	1	Phosphoserine By similarity
	Modified residue	2707	1	Phosphoserine By similarity
	Modified residue	2945	1	Phosphoserine By similarity
	Modified residue	3023	1	Phosphoserine By similarity
	Modified residue	3735	1	Phosphoserine By similarity
	Modified residue	3737	1	Phosphoserine By similarity
	Modified residue	3975	1	Phosphoserine By similarity
	Modified residue	4053	1	Phosphoserine By similarity
	Modified residue	4250	1	Phosphoserine By similarity
	Modified residue	4252	1	Phosphoserine By similarity
	Modified residue	4490	1	Phosphoserine By similarity
	Modified residue	4568	1	Phosphoserine By similarity
	Modified residue	5280	1	Phosphoserine By similarity
	Modified residue	5282	1	Phosphoserine By similarity
	Modified residue	5520	1	Phosphoserine By similarity
	Modified residue	5598	1	Phosphoserine By similarity
	Modified residue	6310	1	Phosphoserine Ref.3 Ref.4 Ref.5
	Modified residue	6312	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R0W0 [UniParc]. Last modified August 15, 2003. Version 2. Checksum: 9162C07AFCA157B6	FASTA	6,548	724,646
	10 20 30 40 50 60 MNGQAPPHDV VVANGTEKFI VPKIKKNQLG ASTPSRPQAE AALPTTARSI AGVYVEASGQ 70 80 90 100 110 120 TQSIYAAIKQ GLLPTGLGLT LLEAQAATGG LVDLAQGQLL PVSEALRRGL VGLELKEKLL 130 140 150 160 170 180 AAERAVTGYP DPYGGEKLSL FQAIKKEVVD RTLGWRLLEA QLATGGLVDP TQGVQVAPEL 190 200 210 220 230 240 ACQQGLLDKE TWLSLVESEP SMGTPGFSDP NTLEQLPYSV LLGRCVQDPS SGLPLLPLKT 250 260 270 280 290 300 TFHTLAGAAS ASMLLEAGVL NEEMVRDLQE GMLVVSDVGT RPEVRRYLEG TGGLAGVVLL 310 320 330 340 350 360 PGGHKKSFFQ ATVEHLVSKG IALQLLEAQA ATRTLVHPTT GQRLWVEEAV KAGLVGPELH 370 380 390 400 410 420 EQLLVAEQAV TGYYDPFSSS RIPVFQAMKK GLVDQPLALR LLDAQLATGG LICPARRFRL 430 440 450 460 470 480 PLEAALRFGC LDEETRQRLS QAMGFSDPTT HDRLGYEQLL ALSVTDPETG LAFLPLPGMS 490 500 510 520 530 540 HANEPQGPTF IDHCTRQALS KATTSISVGR YQGRPVSLWE LLFSESVPVK KRAMLAQRHQ 550 560 570 580 590 600 EGALSVEELA AELKNIVEQA AATAKVTFAG LRDTVTPGEL LKAEIINQDL FEQLERGQTS 610 620 630 640 650 660 AQDVGSLDSV QRYLQGTGSI AGLLLPDSQE RLSIYEARSK GLLRPGTALI LLEAQAATGF 670 680 690 700 710 720 IIDPKENKRY SVEEALRAGV IGPDVYAKLL SAEHAVTGYT DPYSGEQISL FQAMQRDLIV 730 740 750 760 770 780 RDHGIRLLEA QIATGGVIDP VHSHRVPVDV AYQRGYFDQI LNSILLDPSD DTKGFFDPNT 790 800 810 820 830 840 HENLTYLQLL ERCVHDSETG LHLLPLSSTR PQLVDSSTRQ AFQKLLLSVK YGRFRGQRVS 850 860 870 880 890 900 AWELVNSEYF TEDRRRQLLQ RYRQRKITLE QVTQLLEKEM RRWTDITLPA LQGQVTAYQL 910 920 930 940 950 960 LEAHIINQEL LDQVLTGTIS PDALLQVGDV HRYLRGSGTV GGVLLKPSNQ RISLYQAMKQ 970 980 990 1000 1010 1020 KLLPPSTALA LLEAQAATGT ITDPCSMETL SVDEAVCRGV VGAEVYGKLK RAEHSITGYR 1030 1040 1050 1060 1070 1080 DPFSGKKVSL FRAMKKGLVP VEQATRLLEA QVSTGGVVDP TTHLHLPMPV AVQRGCIDRE 1090 1100 1110 1120 1130 1140 MEAALSRSPE TFPTPDGRGH TSYAQLLEHC LQDKASGLHL LPLTEDAPNV PTDTQIQETL 1150 1160 1170 1180 1190 1200 QASAGTEDGL SLWDLLTSCH FTEEQRRGYL EDVKVGKISV PQLQNTVRSW VHSAKLLARA 1210 1220 1230 1240 1250 1260 RITVPGPRGE VPATWLRDAG IITQETLEAL AQGMQSPDEV AKQPTVKVCL WGTGCVAGVL 1270 1280 1290 1300 1310 1320 LQPSGTKLSI AQAVRDGLLP TGLGQQLLEA QVASGFLVNP LTNQRLSVEG AVKAGLVGME 1330 1340 1350 1360 1370 1380 QSEHLRQVEK AVTGYSDPFS GGSLSLWQAM EKGLVTQSEA FPLLQVQLAT GGVVDPVHGV 1390 1400 1410 1420 1430 1440 HLPQEVAYKL GLLDEQTSRV LTATGKENKL FFDPNSREKV TYQQLRELCV LDADTGLWLL 1450 1460 1470 1480 1490 1500 PLPQGTVLEV DDHTAVALRA MKVPINMGRF QGHSVSLWDL LHSEYVGAEK RRELVALCCS 1510 1520 1530 1540 1550 1560 GRAAALRQVI GMLTTLVEAA EKQPSQATFK GLRKQVSAGD LFRSQLITKQ TLDELNQGKR 1570 1580 1590 1600 1610 1620 TVQEVTEMDS VRRSLEGGNF IAGVLIQDTK EKMSIPEALR RHILRPGTAL VLLEAQAATG 1630 1640 1650 1660 1670 1680 FIIDPVENRK LTVEQAFQAG MFGKETYMKL LSAERAVTGY TDPYTGEQIS LFQAMQRDLI 1690 1700 1710 1720 1730 1740 VRDHGIRLLE AQIATGGIID PVHSHRVPVD VAYQRGYFNE EMNRILSDPS DDTKGFFDPN 1750 1760 1770 1780 1790 1800 THENLTYLQL LERCVEDPET GLYMLEIVKK GETYTYIDEA TRQALTSRTV KMYVGKFAGQ 1810 1820 1830 1840 1850 1860 TVSVWDLLSS QYFTEGRRRK LLREYRAQNI GLENLLEVIT STVEETEKQS QIFKVPGIHG 1870 1880 1890 1900 1910 1920 DVTAAELFNS GILNKKTLDA LRSGDRGFQD LRWLEDVRVY LEGSNYIAGV IAPLTQKVMS 1930 1940 1950 1960 1970 1980 FYEASREELI PAGFAAQMLE AQAATGYLMD PCTNQRLCVD EAIAAGLVGE DLRERLVNAE 1990 2000 2010 2020 2030 2040 MAAKGYKDPA TGETIPLYQA MERKLVGREE ALRLLEVQVA TGGVIDPRHH HRVPLDTACQ 2050 2060 2070 2080 2090 2100 RGCMCDDSLV LIADQKHMRK RFVDPNTQEK VTYQELQDRC QREEKSGWAL FPVVKDKKDI 2110 2120 2130 2140 2150 2160 EYVDEATKRA LEAEQVEVTV GRYRGQRRSV WELLNSEYVS EEKKMELVRL YKEDTTRALQ 2170 2180 2190 2200 2210 2220 KVVELILQMI ADKERRSRQL WFRGLRTQVT AEELLRSEVI TKQTLEDLEE GRTTVDQIER 2230 2240 2250 2260 2270 2280 KEDVKRYLKG TSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI 2290 2300 2310 2320 2330 2340 IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVR 2350 2360 2370 2380 2390 2400 DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD TKGFFDPNTH 2410 2420 2430 2440 2450 2460 ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP GTGDFQGQSI 2470 2480 2490 2500 2510 2520 SVWELLFYRE VPESLRQDLL RCYQAGGLTV HDVTTTLTSL LARAKDGSPR GDPQGALGKA 2530 2540 2550 2560 2570 2580 TMEVKRGHLR GHEVPVWDIL TSNYVSRDTR KELLAQFSSG SLTLPMLKRR LTTIIEEAEE 2590 2600 2610 2620 2630 2640 TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR QQQEQTLRAT TMQVHRGQFR 2650 2660 2670 2680 2690 2700 DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE RLSKVSFPGL 2710 2720 2730 2740 2750 2760 RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP 2770 2780 2790 2800 2810 2820 GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ 2830 2840 2850 2860 2870 2880 EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR LLEAQIATGG VIDPVHSHRV 2890 2900 2910 2920 2930 2940 PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY LQLLRRCVRD PETGFYMLQL 2950 2960 2970 2980 2990 3000 AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL RQDLLRRYQA 3010 3020 3030 3040 3050 3060 GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK RGHLRGHXVP VWDILTSNYV 3070 3080 3090 3100 3110 3120 SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ QDTGARGSGT 3130 3140 3150 3160 3170 3180 SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS VWKVLFSSYL SETRREELLA 3190 3200 3210 3220 3230 3240 QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS ASELCTSGIL DRDTMRELAQ 3250 3260 3270 3280 3290 3300 GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL 3310 3320 3330 3340 3350 3360 LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF 3370 3380 3390 3400 3410 3420 QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD 3430 3440 3450 3460 3470 3480 TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP 3490 3500 3510 3520 3530 3540 GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV HDVTTTLTSL LARAKDGSPR 3550 3560 3570 3580 3590 3600 XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG SLTLPMLKRR 3610 3620 3630 3640 3650 3660 LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR QQQEQTLRAT 3670 3680 3690 3700 3710 3720 TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE 3730 3740 3750 3760 3770 3780 RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA 3790 3800 3810 3820 3830 3840 GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV 3850 3860 3870 3880 3890 3900 AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR LLEAQIATGG 3910 3920 3930 3940 3950 3960 VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY LQLLRRCVRD 3970 3980 3990 4000 4010 4020 PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL 4030 4040 4050 4060 4070 4080 RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK RGHLRGHXVP 4090 4100 4110 4120 4130 4140 VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ 4150 4160 4170 4180 4190 4200 QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS VWKVLFSSYL 4210 4220 4230 4240 4250 4260 SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS ASELCTSGIL 4270 4280 4290 4300 4310 4320 DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG 4330 4340 4350 4360 4370 4380 VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD 4390 4400 4410 4420 4430 4440 PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM 4450 4460 4470 4480 4490 4500 NSILADPGDD TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR 4510 4520 4530 4540 4550 4560 RALREARVTP GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV HDVTTTLTSL 4570 4580 4590 4600 4610 4620 LARAKDGSPR XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG 4630 4640 4650 4660 4670 4680 SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR 4690 4700 4710 4720 4730 4740 QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL 4750 4760 4770 4780 4790 4800 LTQIIEETEE RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK 4810 4820 4830 4840 4850 4860 RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN 4870 4880 4890 4900 4910 4920 NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR 4930 4940 4950 4960 4970 4980 LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY 4990 5000 5010 5020 5030 5040 LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL 5050 5060 5070 5080 5090 5100 LFYREVPESL RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK 5110 5120 5130 5140 5150 5160 RGHLRGHXVP VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK 5170 5180 5190 5200 5210 5220 PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS 5230 5240 5250 5260 5270 5280 VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS 5290 5300 5310 5320 5330 5340 ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK 5350 5360 5370 5380 5390 5400 MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS 5410 5420 5430 5440 5450 5460 AERAVTGYTD PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA 5470 5480 5490 5500 5510 5520 YQRGYFDEDM NSILADPGDD TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS 5530 5540 5550 5560 5570 5580 SVHHLSEELR RALREARVTP GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV 5590 5600 5610 5620 5630 5640 HDVTTTLTSL LARAKDGSPR XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR 5650 5660 5670 5680 5690 5700 KELLAQFSSG SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG 5710 5720 5730 5740 5750 5760 DAQDSSESAR QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG 5770 5780 5790 5800 5810 5820 KLGVMELVSL LTQIIEETEE RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI 5830 5840 5850 5860 5870 5880 HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA 5890 5900 5910 5920 5930 5940 ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR 5950 5960 5970 5980 5990 6000 DLIVRDHGIR LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF 6010 6020 6030 6040 6050 6060 DPNTHENLTY LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF 6070 6080 6090 6100 6110 6120 QGQSISVWEL LFYREVPESL RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPREDPQG 6130 6140 6150 6160 6170 6180 ALGKATMEVK RGHLRGHVVP VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII 6190 6200 6210 6220 6230 6240 EEAEETQESK PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH 6250 6260 6270 6280 6290 6300 RGQFRDQQVS VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV 6310 6320 6330 6340 6350 6360 SFPGLRRQVS ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP 6370 6380 6390 6400 6410 6420 VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV 6430 6440 6450 6460 6470 6480 GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVK NHGIRLLEAQ IATGGVIDPV 6490 6500 6510 6520 6530 6540 HSHRVPVDVA YQRGYFDQEM NSILADPGDD TKGFFDPNTH ENLTYLQLLQ RATIDPETGL LFLSLSKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Epiplakin gene analysis in mouse reveals a single exon encoding a 725-kDa protein with expression restricted to epithelial tissues." Spazierer D., Fuchs P., Proell V., Janda L., Oehler S., Fischer I., Hauptmann R., Wiche G. J. Biol. Chem. 278:31657-31666(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: C57BL/6J. Tissue: Skin.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6318-6548. Tissue: Salivary gland.
[3]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6310, MASS SPECTROMETRY. Tissue: Liver.
[4]	"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis." Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H. J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6310, MASS SPECTROMETRY. Tissue: Liver.
[5]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6310, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY312170 mRNA. Translation: AAP70316.1. BC026387 mRNA. Translation: AAH26387.1.
IPI	IPI00320459.
RefSeq	NP_659097.2. NM_144848.2.
UniGene	Mm.259929.
3D structure databases
ProteinModelPortal	Q8R0W0.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1866986.
PTM databases
PhosphoSite	Q8R0W0.
Proteomic databases
PRIDE	Q8R0W0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	223650.
KEGG	mmu:223650.
UCSC	uc007wio.1. mouse.
Organism-specific databases
CTD	83481.
MGI	MGI:2386306. Eppk1.
Phylogenomic databases
HOVERGEN	HBG051491.
Gene expression databases
CleanEx	MM_EPPK1.
Genevestigator	Q8R0W0.
Family and domain databases
InterPro	IPR001101. Plectin_repeat. [Graphical view]
Pfam	PF00681. Plectin. 38 hits. [Graphical view]
SMART	SM00250. PLEC. 77 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	376784.
SOURCE	Search...

Entry information

Entry name

EPIPL_MOUSE

Accession

Primary (citable) accession number: Q8R0W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	August 15, 2003
Last modified:	May 29, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program