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Q8R0W0

- EPIPL_MOUSE

UniProt

Q8R0W0 - EPIPL_MOUSE

Protein

Epiplakin

Gene

Eppk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epiplakin
    Gene namesi
    Name:Eppk1
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2386306. Eppk1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 65486548EpiplakinPRO_0000078146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1537 – 15371Phosphoserine1 Publication
    Modified residuei2430 – 24301PhosphoserineBy similarity
    Modified residuei2508 – 25081PhosphoserineBy similarity
    Modified residuei2606 – 26061Phosphoserine1 Publication
    Modified residuei2705 – 27051Phosphoserine1 Publication
    Modified residuei2707 – 27071PhosphoserineBy similarity
    Modified residuei2945 – 29451PhosphoserineBy similarity
    Modified residuei3023 – 30231PhosphoserineBy similarity
    Modified residuei3121 – 31211Phosphoserine1 Publication
    Modified residuei3220 – 32201Phosphoserine1 Publication
    Modified residuei3636 – 36361Phosphoserine1 Publication
    Modified residuei3735 – 37351Phosphoserine1 Publication
    Modified residuei3737 – 37371PhosphoserineBy similarity
    Modified residuei3975 – 39751PhosphoserineBy similarity
    Modified residuei4053 – 40531PhosphoserineBy similarity
    Modified residuei4151 – 41511Phosphoserine1 Publication
    Modified residuei4250 – 42501Phosphoserine1 Publication
    Modified residuei4252 – 42521PhosphoserineBy similarity
    Modified residuei4490 – 44901PhosphoserineBy similarity
    Modified residuei4568 – 45681PhosphoserineBy similarity
    Modified residuei4666 – 46661Phosphoserine1 Publication
    Modified residuei4765 – 47651Phosphoserine1 Publication
    Modified residuei5181 – 51811Phosphoserine1 Publication
    Modified residuei5280 – 52801Phosphoserine1 Publication
    Modified residuei5282 – 52821PhosphoserineBy similarity
    Modified residuei5520 – 55201PhosphoserineBy similarity
    Modified residuei5598 – 55981PhosphoserineBy similarity
    Modified residuei5696 – 56961Phosphoserine1 Publication
    Modified residuei5795 – 57951Phosphoserine1 Publication
    Modified residuei6211 – 62111Phosphoserine1 Publication
    Modified residuei6310 – 63101Phosphoserine1 Publication
    Modified residuei6312 – 63121PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8R0W0.
    PRIDEiQ8R0W0.

    PTM databases

    PhosphoSiteiQ8R0W0.

    Expressioni

    Tissue specificityi

    High levels in skin, small intestine and salivary gland. Lower levels in lung, uterus and liver. Not detected in brain, kidney, muscle, heart or spleen. In skin, expressed in all epidermal layers but not in the dermis. In intestine, expressed exclusively in the epithelial cell layer of the villi. In liver, expressed at hepatocyte margins.1 Publication

    Gene expression databases

    CleanExiMM_EPPK1.
    GenevestigatoriQ8R0W0.

    Interactioni

    Protein-protein interaction databases

    BioGridi230168. 1 interaction.
    IntActiQ8R0W0. 1 interaction.
    MINTiMINT-1866986.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati41 – 7838Plectin 1Add
    BLAST
    Repeati79 – 11638Plectin 2Add
    BLAST
    Repeati117 – 15438Plectin 3Add
    BLAST
    Repeati155 – 19238Plectin 4Add
    BLAST
    Repeati285 – 32238Plectin 5Add
    BLAST
    Repeati323 – 36038Plectin 6Add
    BLAST
    Repeati362 – 39837Plectin 7Add
    BLAST
    Repeati399 – 43638Plectin 8Add
    BLAST
    Repeati437 – 47034Plectin 9Add
    BLAST
    Repeati611 – 64838Plectin 10Add
    BLAST
    Repeati649 – 68638Plectin 11Add
    BLAST
    Repeati687 – 72438Plectin 12Add
    BLAST
    Repeati725 – 76238Plectin 13Add
    BLAST
    Repeati766 – 80035Plectin 14Add
    BLAST
    Repeati931 – 96838Plectin 15Add
    BLAST
    Repeati969 – 100638Plectin 16Add
    BLAST
    Repeati1007 – 104438Plectin 17Add
    BLAST
    Repeati1224 – 128461Plectin 18Add
    BLAST
    Repeati1285 – 132238Plectin 19Add
    BLAST
    Repeati1323 – 136038Plectin 20Add
    BLAST
    Repeati1361 – 139838Plectin 21Add
    BLAST
    Repeati1402 – 143635Plectin 22Add
    BLAST
    Repeati1572 – 160938Plectin 23Add
    BLAST
    Repeati1610 – 164738Plectin 24Add
    BLAST
    Repeati1648 – 168538Plectin 25Add
    BLAST
    Repeati1686 – 172338Plectin 26Add
    BLAST
    Repeati1727 – 176135Plectin 27Add
    BLAST
    Repeati1898 – 193538Plectin 28Add
    BLAST
    Repeati1936 – 197338Plectin 29Add
    BLAST
    Repeati1974 – 201138Plectin 30Add
    BLAST
    Repeati2012 – 204938Plectin 31Add
    BLAST
    Repeati2225 – 226743Plectin 32Add
    BLAST
    Repeati2268 – 230538Plectin 33Add
    BLAST
    Repeati2306 – 234338Plectin 34Add
    BLAST
    Repeati2344 – 238138Plectin 35Add
    BLAST
    Repeati2385 – 241935Plectin 36Add
    BLAST
    Repeati2740 – 278243Plectin 37Add
    BLAST
    Repeati2783 – 282038Plectin 38Add
    BLAST
    Repeati2821 – 285838Plectin 39Add
    BLAST
    Repeati2859 – 289638Plectin 40Add
    BLAST
    Repeati2900 – 293435Plectin 41Add
    BLAST
    Repeati3255 – 329743Plectin 42Add
    BLAST
    Repeati3298 – 333538Plectin 43Add
    BLAST
    Repeati3336 – 337338Plectin 44Add
    BLAST
    Repeati3374 – 341138Plectin 45Add
    BLAST
    Repeati3415 – 344935Plectin 46Add
    BLAST
    Repeati3770 – 381243Plectin 47Add
    BLAST
    Repeati3813 – 385038Plectin 48Add
    BLAST
    Repeati3851 – 388838Plectin 49Add
    BLAST
    Repeati3889 – 392638Plectin 50Add
    BLAST
    Repeati3930 – 396435Plectin 51Add
    BLAST
    Repeati4285 – 432743Plectin 52Add
    BLAST
    Repeati4328 – 436538Plectin 53Add
    BLAST
    Repeati4366 – 440338Plectin 54Add
    BLAST
    Repeati4404 – 444138Plectin 55Add
    BLAST
    Repeati4445 – 447935Plectin 56Add
    BLAST
    Repeati4800 – 484243Plectin 57Add
    BLAST
    Repeati4843 – 488038Plectin 58Add
    BLAST
    Repeati4881 – 491838Plectin 59Add
    BLAST
    Repeati4919 – 495638Plectin 60Add
    BLAST
    Repeati4960 – 499435Plectin 61Add
    BLAST
    Repeati5315 – 535743Plectin 62Add
    BLAST
    Repeati5358 – 539538Plectin 63Add
    BLAST
    Repeati5396 – 543338Plectin 64Add
    BLAST
    Repeati5434 – 547138Plectin 65Add
    BLAST
    Repeati5475 – 550935Plectin 66Add
    BLAST
    Repeati5830 – 587243Plectin 67Add
    BLAST
    Repeati5873 – 591038Plectin 68Add
    BLAST
    Repeati5911 – 594838Plectin 69Add
    BLAST
    Repeati5949 – 598638Plectin 70Add
    BLAST
    Repeati5990 – 602435Plectin 71Add
    BLAST
    Repeati6345 – 638743Plectin 72Add
    BLAST
    Repeati6388 – 642538Plectin 73Add
    BLAST
    Repeati6426 – 646338Plectin 74Add
    BLAST
    Repeati6464 – 650138Plectin 75Add
    BLAST
    Repeati6505 – 653935Plectin 76Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili545 – 56521Sequence AnalysisAdd
    BLAST
    Coiled coili851 – 88636Sequence AnalysisAdd
    BLAST
    Coiled coili1819 – 185133Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the plakin or cytolinker family.Curated
    Contains 76 plectin repeats.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    HOVERGENiHBG051491.

    Family and domain databases

    Gene3Di3.90.1290.10. 16 hits.
    InterProiIPR001101. Plectin_repeat.
    [Graphical view]
    PfamiPF00681. Plectin. 38 hits.
    [Graphical view]
    SMARTiSM00250. PLEC. 77 hits.
    [Graphical view]
    SUPFAMiSSF75399. SSF75399. 16 hits.

    Sequencei

    Sequence statusi: Complete.

    Q8R0W0-1 [UniParc]FASTAAdd to Basket

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    MNGQAPPHDV VVANGTEKFI VPKIKKNQLG ASTPSRPQAE AALPTTARSI     50
    AGVYVEASGQ TQSIYAAIKQ GLLPTGLGLT LLEAQAATGG LVDLAQGQLL 100
    PVSEALRRGL VGLELKEKLL AAERAVTGYP DPYGGEKLSL FQAIKKEVVD 150
    RTLGWRLLEA QLATGGLVDP TQGVQVAPEL ACQQGLLDKE TWLSLVESEP 200
    SMGTPGFSDP NTLEQLPYSV LLGRCVQDPS SGLPLLPLKT TFHTLAGAAS 250
    ASMLLEAGVL NEEMVRDLQE GMLVVSDVGT RPEVRRYLEG TGGLAGVVLL 300
    PGGHKKSFFQ ATVEHLVSKG IALQLLEAQA ATRTLVHPTT GQRLWVEEAV 350
    KAGLVGPELH EQLLVAEQAV TGYYDPFSSS RIPVFQAMKK GLVDQPLALR 400
    LLDAQLATGG LICPARRFRL PLEAALRFGC LDEETRQRLS QAMGFSDPTT 450
    HDRLGYEQLL ALSVTDPETG LAFLPLPGMS HANEPQGPTF IDHCTRQALS 500
    KATTSISVGR YQGRPVSLWE LLFSESVPVK KRAMLAQRHQ EGALSVEELA 550
    AELKNIVEQA AATAKVTFAG LRDTVTPGEL LKAEIINQDL FEQLERGQTS 600
    AQDVGSLDSV QRYLQGTGSI AGLLLPDSQE RLSIYEARSK GLLRPGTALI 650
    LLEAQAATGF IIDPKENKRY SVEEALRAGV IGPDVYAKLL SAEHAVTGYT 700
    DPYSGEQISL FQAMQRDLIV RDHGIRLLEA QIATGGVIDP VHSHRVPVDV 750
    AYQRGYFDQI LNSILLDPSD DTKGFFDPNT HENLTYLQLL ERCVHDSETG 800
    LHLLPLSSTR PQLVDSSTRQ AFQKLLLSVK YGRFRGQRVS AWELVNSEYF 850
    TEDRRRQLLQ RYRQRKITLE QVTQLLEKEM RRWTDITLPA LQGQVTAYQL 900
    LEAHIINQEL LDQVLTGTIS PDALLQVGDV HRYLRGSGTV GGVLLKPSNQ 950
    RISLYQAMKQ KLLPPSTALA LLEAQAATGT ITDPCSMETL SVDEAVCRGV 1000
    VGAEVYGKLK RAEHSITGYR DPFSGKKVSL FRAMKKGLVP VEQATRLLEA 1050
    QVSTGGVVDP TTHLHLPMPV AVQRGCIDRE MEAALSRSPE TFPTPDGRGH 1100
    TSYAQLLEHC LQDKASGLHL LPLTEDAPNV PTDTQIQETL QASAGTEDGL 1150
    SLWDLLTSCH FTEEQRRGYL EDVKVGKISV PQLQNTVRSW VHSAKLLARA 1200
    RITVPGPRGE VPATWLRDAG IITQETLEAL AQGMQSPDEV AKQPTVKVCL 1250
    WGTGCVAGVL LQPSGTKLSI AQAVRDGLLP TGLGQQLLEA QVASGFLVNP 1300
    LTNQRLSVEG AVKAGLVGME QSEHLRQVEK AVTGYSDPFS GGSLSLWQAM 1350
    EKGLVTQSEA FPLLQVQLAT GGVVDPVHGV HLPQEVAYKL GLLDEQTSRV 1400
    LTATGKENKL FFDPNSREKV TYQQLRELCV LDADTGLWLL PLPQGTVLEV 1450
    DDHTAVALRA MKVPINMGRF QGHSVSLWDL LHSEYVGAEK RRELVALCCS 1500
    GRAAALRQVI GMLTTLVEAA EKQPSQATFK GLRKQVSAGD LFRSQLITKQ 1550
    TLDELNQGKR TVQEVTEMDS VRRSLEGGNF IAGVLIQDTK EKMSIPEALR 1600
    RHILRPGTAL VLLEAQAATG FIIDPVENRK LTVEQAFQAG MFGKETYMKL 1650
    LSAERAVTGY TDPYTGEQIS LFQAMQRDLI VRDHGIRLLE AQIATGGIID 1700
    PVHSHRVPVD VAYQRGYFNE EMNRILSDPS DDTKGFFDPN THENLTYLQL 1750
    LERCVEDPET GLYMLEIVKK GETYTYIDEA TRQALTSRTV KMYVGKFAGQ 1800
    TVSVWDLLSS QYFTEGRRRK LLREYRAQNI GLENLLEVIT STVEETEKQS 1850
    QIFKVPGIHG DVTAAELFNS GILNKKTLDA LRSGDRGFQD LRWLEDVRVY 1900
    LEGSNYIAGV IAPLTQKVMS FYEASREELI PAGFAAQMLE AQAATGYLMD 1950
    PCTNQRLCVD EAIAAGLVGE DLRERLVNAE MAAKGYKDPA TGETIPLYQA 2000
    MERKLVGREE ALRLLEVQVA TGGVIDPRHH HRVPLDTACQ RGCMCDDSLV 2050
    LIADQKHMRK RFVDPNTQEK VTYQELQDRC QREEKSGWAL FPVVKDKKDI 2100
    EYVDEATKRA LEAEQVEVTV GRYRGQRRSV WELLNSEYVS EEKKMELVRL 2150
    YKEDTTRALQ KVVELILQMI ADKERRSRQL WFRGLRTQVT AEELLRSEVI 2200
    TKQTLEDLEE GRTTVDQIER KEDVKRYLKG TSCIAGVLVP VQGEPGRQEK 2250
    MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV 2300
    GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ 2350
    IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD TKGFFDPNTH 2400
    ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP 2450
    GTGDFQGQSI SVWELLFYRE VPESLRQDLL RCYQAGGLTV HDVTTTLTSL 2500
    LARAKDGSPR GDPQGALGKA TMEVKRGHLR GHEVPVWDIL TSNYVSRDTR 2550
    KELLAQFSSG SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA 2600
    RGSGTSPDEG DAQDSSESAR QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL 2650
    FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE RLSKVSFPGL 2700
    RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA 2750
    GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN 2800
    NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR 2850
    DLIVRDHGIR LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA 2900
    DPGDDTKGFF DPNTHENLTY LQLLRRCVRD PETGFYMLQL AGKGSSVHHL 2950
    SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL RQDLLRRYQA 3000
    GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK RGHLRGHXVP 3050
    VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK 3100
    PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH 3150
    RGQFRDQQVS VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII 3200
    EETEERLSKV SFPGLRRQVS ASELCTSGIL DRDTMRELAQ GTKTIHEVTE 3250
    MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL 3300
    LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD 3350
    PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA 3400
    YQRGYFDEDM NSILADPGDD TKGFFDPNTH ENLTYLQLLR RCVRDPETGF 3450
    YMLQLAGKGS SVHHLSEELR RALREARVTP GTGDFQGQSI SVWELLFYRE 3500
    VPESLRQDLL RRYQAGGLTV HDVTTTLTSL LARAKDGSPR XDPQGALGKA 3550
    TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG SLTLPMLKRR 3600
    LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG DAQDSSESAR 3650
    QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR EELLAQHLAG 3700
    KLGVMELVSL LTQIIEETEE RLSKVSFPGL RRQVSASELC TSGILDRDTM 3750
    RELAQGTKTI HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ 3800
    AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ 3850
    EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR LLEAQIATGG 3900
    VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF DPNTHENLTY 3950
    LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE ARVTPGTGDF 4000
    QGQSISVWEL LFYREVPESL RQDLLRRYQA GGLTVHDVTT TLTSLLARAK 4050
    DGSPRXDPQG ALGKATMEVK RGHLRGHXVP VWDILTSNYV SRDTRKELLA 4100
    QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ QDTGARGSGT 4150
    SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS VWKVLFSSYL 4200
    SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV SFPGLRRQVS 4250
    ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP 4300
    VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI IDPVNNRRLS 4350
    VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF QAMQRDLIVR 4400
    DHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDEDM NSILADPGDD 4450
    TKGFFDPNTH ENLTYLQLLR RCVRDPETGF YMLQLAGKGS SVHHLSEELR 4500
    RALREARVTP GTGDFQGQSI SVWELLFYRE VPESLRQDLL RRYQAGGLTV 4550
    HDVTTTLTSL LARAKDGSPR XDPQGALGKA TMEVKRGHLR GHXVPVWDIL 4600
    TSNYVSRDTR KELLAQFSSG SLTLPMLKRR LTTIIEEAEE TQESKPKPRD 4650
    ASLKQQDTGA RGSGTSPDEG DAQDSSESAR QQQEQTLRAT TMQVHRGQFR 4700
    DQQVSVWKVL FSSYLSETRR EELLAQHLAG KLGVMELVSL LTQIIEETEE 4750
    RLSKVSFPGL RRQVSASELC TSGILDRDTM RELAQGTKTI HEVTEMDSVK 4800
    RYLGGSSCIA GVLVPVQGEP GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA 4850
    ATGFIIDPVN NRRLSVEEAV AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD 4900
    QISLFQAMQR DLIVRDHGIR LLEAQIATGG VIDPVHSHRV PVDVAYQRGY 4950
    FDEDMNSILA DPGDDTKGFF DPNTHENLTY LQLLRRCVRD PETGFYMLQL 5000
    AGKGSSVHHL SEELRRALRE ARVTPGTGDF QGQSISVWEL LFYREVPESL 5050
    RQDLLRRYQA GGLTVHDVTT TLTSLLARAK DGSPRXDPQG ALGKATMEVK 5100
    RGHLRGHXVP VWDILTSNYV SRDTRKELLA QFSSGSLTLP MLKRRLTTII 5150
    EEAEETQESK PKPRDASLKQ QDTGARGSGT SPDEGDAQDS SESARQQQEQ 5200
    TLRATTMQVH RGQFRDQQVS VWKVLFSSYL SETRREELLA QHLAGKLGVM 5250
    ELVSLLTQII EETEERLSKV SFPGLRRQVS ASELCTSGIL DRDTMRELAQ 5300
    GTKTIHEVTE MDSVKRYLGG SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG 5350
    VLRPGTALVL LEAQAATGFI IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS 5400
    AERAVTGYTD PYTGDQISLF QAMQRDLIVR DHGIRLLEAQ IATGGVIDPV 5450
    HSHRVPVDVA YQRGYFDEDM NSILADPGDD TKGFFDPNTH ENLTYLQLLR 5500
    RCVRDPETGF YMLQLAGKGS SVHHLSEELR RALREARVTP GTGDFQGQSI 5550
    SVWELLFYRE VPESLRQDLL RRYQAGGLTV HDVTTTLTSL LARAKDGSPR 5600
    XDPQGALGKA TMEVKRGHLR GHXVPVWDIL TSNYVSRDTR KELLAQFSSG 5650
    SLTLPMLKRR LTTIIEEAEE TQESKPKPRD ASLKQQDTGA RGSGTSPDEG 5700
    DAQDSSESAR QQQEQTLRAT TMQVHRGQFR DQQVSVWKVL FSSYLSETRR 5750
    EELLAQHLAG KLGVMELVSL LTQIIEETEE RLSKVSFPGL RRQVSASELC 5800
    TSGILDRDTM RELAQGTKTI HEVTEMDSVK RYLGGSSCIA GVLVPVQGEP 5850
    GRQEKMSIYQ AMWKGVLRPG TALVLLEAQA ATGFIIDPVN NRRLSVEEAV 5900
    AAGVVGGEIQ EKLLSAERAV TGYTDPYTGD QISLFQAMQR DLIVRDHGIR 5950
    LLEAQIATGG VIDPVHSHRV PVDVAYQRGY FDEDMNSILA DPGDDTKGFF 6000
    DPNTHENLTY LQLLRRCVRD PETGFYMLQL AGKGSSVHHL SEELRRALRE 6050
    ARVTPGTGDF QGQSISVWEL LFYREVPESL RQDLLRRYQA GGLTVHDVTT 6100
    TLTSLLARAK DGSPREDPQG ALGKATMEVK RGHLRGHVVP VWDILTSNYV 6150
    SRDTRKELLA QFSSGSLTLP MLKRRLTTII EEAEETQESK PKPRDASLKQ 6200
    QDTGARGSGT SPDEGDAQDS SESARQQQEQ TLRATTMQVH RGQFRDQQVS 6250
    VWKVLFSSYL SETRREELLA QHLAGKLGVM ELVSLLTQII EETEERLSKV 6300
    SFPGLRRQVS ASELCTSGIL DRDTMRELAQ GTKTIHEVTE MDSVKRYLGG 6350
    SSCIAGVLVP VQGEPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFI 6400
    IDPVNNRRLS VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGDQISLF 6450
    QAMQRDLIVK NHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YQRGYFDQEM 6500
    NSILADPGDD TKGFFDPNTH ENLTYLQLLQ RATIDPETGL LFLSLSKG 6548
    Length:6,548
    Mass (Da):724,646
    Last modified:August 15, 2003 - v2
    Checksum:i9162C07AFCA157B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY312170 mRNA. Translation: AAP70316.1.
    BC026387 mRNA. Translation: AAH26387.1.
    RefSeqiNP_659097.2. NM_144848.2.
    UniGeneiMm.259929.

    Genome annotation databases

    GeneIDi223650.
    KEGGimmu:223650.
    UCSCiuc007wio.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY312170 mRNA. Translation: AAP70316.1 .
    BC026387 mRNA. Translation: AAH26387.1 .
    RefSeqi NP_659097.2. NM_144848.2.
    UniGenei Mm.259929.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230168. 1 interaction.
    IntActi Q8R0W0. 1 interaction.
    MINTi MINT-1866986.

    PTM databases

    PhosphoSitei Q8R0W0.

    Proteomic databases

    MaxQBi Q8R0W0.
    PRIDEi Q8R0W0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 223650.
    KEGGi mmu:223650.
    UCSCi uc007wio.1. mouse.

    Organism-specific databases

    CTDi 83481.
    MGIi MGI:2386306. Eppk1.

    Phylogenomic databases

    HOVERGENi HBG051491.

    Miscellaneous databases

    NextBioi 376784.
    PROi Q8R0W0.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_EPPK1.
    Genevestigatori Q8R0W0.

    Family and domain databases

    Gene3Di 3.90.1290.10. 16 hits.
    InterProi IPR001101. Plectin_repeat.
    [Graphical view ]
    Pfami PF00681. Plectin. 38 hits.
    [Graphical view ]
    SMARTi SM00250. PLEC. 77 hits.
    [Graphical view ]
    SUPFAMi SSF75399. SSF75399. 16 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Epiplakin gene analysis in mouse reveals a single exon encoding a 725-kDa protein with expression restricted to epithelial tissues."
      Spazierer D., Fuchs P., Proell V., Janda L., Oehler S., Fischer I., Hauptmann R., Wiche G.
      J. Biol. Chem. 278:31657-31666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6JImported.
      Tissue: Skin1 Publication.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6318-6548.
      Tissue: Salivary glandImported.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1537; SER-2606; SER-3121; SER-3636; SER-4151; SER-4666; SER-5181; SER-5696 AND SER-6211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2705; SER-3220; SER-3735; SER-4250; SER-4765; SER-5280; SER-5795 AND SER-6310, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiEPIPL_MOUSE
    AccessioniPrimary (citable) accession number: Q8R0W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3